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BR0111692A - Processo para preparação de polipeptìdeo il-18 fisiologicamente ativo - Google Patents

Processo para preparação de polipeptìdeo il-18 fisiologicamente ativo

Info

Publication number
BR0111692A
BR0111692A BR0111692-4A BR0111692A BR0111692A BR 0111692 A BR0111692 A BR 0111692A BR 0111692 A BR0111692 A BR 0111692A BR 0111692 A BR0111692 A BR 0111692A
Authority
BR
Brazil
Prior art keywords
polypeptide
physiologically active
preparing physiologically
preparing
activating
Prior art date
Application number
BR0111692-4A
Other languages
English (en)
Inventor
Kyung O Johanson
Roberth B Kirkpatrick
Alan R Shatzman
Yen Sen Ho
Patrik Mcdevitt
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR0111692A publication Critical patent/BR0111692A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE POLIPEPTìDEO IL-18 FISIOLOGICAMENTE ATIVO". Um processo para produção de um polipeptídeo fisiologicamente ativo, compreendendo contato de um polipeptídeo precursor com uma enzima de ativação, ou co-expressão de polipeptídeo com uma protease de ativação.
BR0111692-4A 2000-06-15 2001-06-11 Processo para preparação de polipeptìdeo il-18 fisiologicamente ativo BR0111692A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21183200P 2000-06-15 2000-06-15
US22412800P 2000-08-10 2000-08-10
US26492301P 2001-01-20 2001-01-20
PCT/US2001/018804 WO2001098455A2 (en) 2000-06-15 2001-06-11 Method for preparing a physiologically active il-18 polypeptide

Publications (1)

Publication Number Publication Date
BR0111692A true BR0111692A (pt) 2005-08-30

Family

ID=27395664

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0111692-4A BR0111692A (pt) 2000-06-15 2001-06-11 Processo para preparação de polipeptìdeo il-18 fisiologicamente ativo

Country Status (24)

Country Link
US (2) US7186528B2 (pt)
EP (1) EP1292697B1 (pt)
JP (1) JP5121109B2 (pt)
KR (1) KR20030022144A (pt)
CN (1) CN100390281C (pt)
AR (1) AR033979A1 (pt)
AT (1) ATE437234T1 (pt)
AU (2) AU8044201A (pt)
BR (1) BR0111692A (pt)
CA (1) CA2412730C (pt)
CZ (1) CZ20024085A3 (pt)
DE (1) DE60139316D1 (pt)
DK (1) DK1292697T3 (pt)
ES (1) ES2329875T3 (pt)
HU (1) HUP0501002A3 (pt)
IL (2) IL153422A0 (pt)
MX (1) MXPA02012292A (pt)
MY (1) MY136526A (pt)
NO (1) NO330682B1 (pt)
NZ (1) NZ522845A (pt)
PL (2) PL208592B1 (pt)
PT (1) PT1292697E (pt)
SI (1) SI1292697T1 (pt)
WO (1) WO2001098455A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL151044A0 (en) * 2000-02-10 2003-04-10 Abbott Lab Antibodies that bind human interleukin-18 and methods of making and using
DE602004025799D1 (de) 2003-04-15 2010-04-15 Glaxosmithkline Llc Humane il-18 substitutionsmutanten und deren konjugate
AU2004266213A1 (en) * 2003-08-15 2005-03-03 University Of Florida Identification of porphyromonas gingivalis virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
WO2005049847A1 (en) * 2003-11-24 2005-06-02 Novo Nordisk A/S Fusion proteins and methods of cleavage of such proteins
ES2322605T3 (es) * 2004-08-20 2009-06-23 Smithkline Beecham Corporation Tratamiento de la mucositis oral e intestinal mediante la administracion de il-18 humano.
JP2010503680A (ja) 2006-09-14 2010-02-04 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア ヒトｉｌ−１８による調節ｔ細胞のモジュレーション
AR065803A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Uso de un polipeptido de il- 18 humana y un anticuerpo anti- cd para preparar unmedicamento
NZ729395A (en) 2014-08-07 2018-04-27 Hyogo College Medicine Therapeutic agent for cancer which comprises combination of il-18 and molecule-targeting antibody
JP2019023165A (ja) * 2015-12-11 2019-02-14 国立大学法人京都大学 インターロイキン−１８活性阻害剤
MX2020002542A (es) 2017-09-06 2020-07-20 Univ Yale Variantes de interleucina-18 y metodos de uso.
KR20200080749A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법
AU2023226512A1 (en) 2022-02-23 2024-08-29 Bright Peak Therapeutics Ag Immune antigen specific il-18 immunocytokines and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5985863A (en) * 1996-09-12 1999-11-16 Vertex Pharmaceuticals, Inc. Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor
US5192324A (en) 1982-02-18 1993-03-09 Howmedica Inc. Bone prosthesis with porous coating
ATE247708T1 (de) * 1986-10-02 2003-09-15 Massachusetts Inst Technology Verfahren zur regulierung der metabolischen stabilität von proteinen
US5212058A (en) 1990-05-09 1993-05-18 Massachusetts Institute Of Technology Nucleic acid encoding ubiquitin-specific proteases
ES2071315T3 (es) 1990-05-09 1995-06-16 Massachusetts Inst Technology Proteasa especifica de ubiquitina.
US5914254A (en) * 1993-08-02 1999-06-22 Celtrix Pharmaceuticals, Inc. Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
US6110701A (en) 1994-04-08 2000-08-29 Merck Frosst Canada & Co. DNA encoding precursor of interleukin-1β converting enzyme--related cysteine proteinase II (ICErel -II)
US5552536A (en) 1994-04-08 1996-09-03 Merck Frosst Canada, Inc. DNA encoding precursor of interleukin-1 beta converting enzyme - related cysteine proteinase III (ice rel-III)
EP0692536B1 (en) 1994-07-14 2000-11-22 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo IFN-Y production inducing protein and monoclonal antibody of the same
JP2724987B2 (ja) 1994-11-15 1998-03-09 株式会社林原生物化学研究所 インターフェロン−γの産生を誘導するポリペプチド
TW464656B (en) 1994-11-15 2001-11-21 Hayashibara Biochem Lab Interferon-gamma production inducing polypeptide monoclonal antibody, and agent for interferon-gamma susceptive disease
US6074050A (en) 1997-12-03 2000-06-13 Hewlett-Packard Company Method and apparatus for venting an ink container
CA2238885A1 (en) 1995-12-29 1997-07-10 Incyte Pharmaceuticals, Inc. Nucleic acids encoding interferon gamma inducing factor-2
JPH1080270A (ja) * 1996-07-19 1998-03-31 Hayashibara Biochem Lab Inc ポリペプチドをプロセッシングする酵素
JP4010606B2 (ja) * 1996-07-25 2007-11-21 株式会社林原生物化学研究所 ポリペプチドの製造方法
TW515843B (en) 1996-07-25 2003-01-01 Hayashibara Biochem Lab Process for producing an active polypeptide inducing interferon-γ production
US6054487A (en) * 1997-03-18 2000-04-25 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids
WO1999037793A1 (en) * 1998-01-23 1999-07-29 Novo Nordisk A/S Process for making desired polypeptides in yeast

Also Published As

Publication number Publication date
IL153422A0 (en) 2003-07-06
WO2001098455A2 (en) 2001-12-27
HUP0501002A3 (en) 2010-01-28
JP5121109B2 (ja) 2013-01-16
HUP0501002A2 (en) 2006-01-30
AU8044201A (en) 2002-01-02
EP1292697A2 (en) 2003-03-19
DE60139316D1 (de) 2009-09-03
PL366134A1 (en) 2005-01-24
PT1292697E (pt) 2009-10-28
DK1292697T3 (da) 2009-11-16
PL208592B1 (pl) 2011-05-31
ES2329875T3 (es) 2009-12-02
US20030143198A1 (en) 2003-07-31
MY136526A (en) 2008-10-31
US7442526B2 (en) 2008-10-28
HK1055138A1 (en) 2003-12-24
EP1292697B1 (en) 2009-07-22
EP1292697A4 (en) 2005-08-10
NO20026002L (no) 2003-02-12
KR20030022144A (ko) 2003-03-15
CA2412730A1 (en) 2001-12-27
US20060177422A1 (en) 2006-08-10
CZ20024085A3 (cs) 2003-05-14
ATE437234T1 (de) 2009-08-15
NO20026002D0 (no) 2002-12-13
MXPA02012292A (es) 2003-04-25
WO2001098455A3 (en) 2002-08-08
CA2412730C (en) 2011-08-16
IL153422A (en) 2011-03-31
NZ522845A (en) 2005-07-29
AR033979A1 (es) 2004-01-21
JP2004523204A (ja) 2004-08-05
CN100390281C (zh) 2008-05-28
AU2001280442B2 (en) 2005-10-27
SI1292697T1 (sl) 2009-12-31
CN1436246A (zh) 2003-08-13
NO330682B1 (no) 2011-06-06
US7186528B2 (en) 2007-03-06

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: GLAXOSMITHKLINE LLC (US)

Free format text: NOME ALTERADO DE: SMITHKLINE BEECHAM CORPORATION

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2232 DE 15/10/2013.