|
GB9008850D0
(en)
*
|
1990-04-19 |
1990-06-13 |
Janssen Pharmaceutica Nv |
Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones
|
|
AU672182B2
(en)
*
|
1991-11-27 |
1996-09-26 |
Novo Nordisk A/S |
Piperidine derivatives and their use in treating psychosis
|
|
US5378714A
(en)
*
|
1991-11-27 |
1995-01-03 |
Novo Nordisk A/S |
Antipsychotic piperidine derivatives
|
|
ES2050069B1
(es)
*
|
1992-07-10 |
1994-12-16 |
Vita Invest Sa |
Procedimiento para la obtencion de 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-il)piperidino)etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido(1,2-a) pirimidin-4-ona.
|
|
DK60793D0
(da)
*
|
1993-05-26 |
1993-05-26 |
Novo Nordisk As |
Kemiske forbindelser, deres fremstilling og anvendelse
|
|
DK60593D0
(da)
*
|
1993-05-26 |
1993-05-26 |
Novo Nordisk As |
Kemiske forbindelser, deres fremstilling og anvendelse
|
|
SG47445A1
(en)
|
1993-11-19 |
1998-04-17 |
Janssen Pharmaceutica Nv |
Microencapsulated 3-piperidinyl-substituted1 1 2-benzisoxazoles and 1 2-benzisothiazoles
|
|
DK0730594T3
(da)
*
|
1993-11-23 |
2000-03-27 |
Janssen Pharmaceutica Nv |
9-hydroxy-pyrido{1,2-a}pyrimidin-4-on-ether-derivater
|
|
ES2085234B1
(es)
*
|
1994-02-24 |
1997-01-16 |
Vita Invest Sa |
Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
|
|
TW487572B
(en)
*
|
1996-05-20 |
2002-05-21 |
Janssen Pharmaceutica Nv |
Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
|
|
US6028083A
(en)
*
|
1997-07-25 |
2000-02-22 |
Hoechst Marion Roussel, Inc. |
Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
|
|
UA72189C2
(uk)
*
|
1997-11-17 |
2005-02-15 |
Янссен Фармацевтика Н.В. |
Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
|
|
ES2141671B1
(es)
*
|
1997-12-26 |
2001-01-01 |
Vita Invest Sa |
Compuesto pirimidinico activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
|
|
AU3984899A
(en)
|
1998-05-18 |
1999-12-06 |
Sepracor, Inc. |
(-)-hydroxyrisperidone compositions and methods
|
|
AU3900499A
(en)
|
1998-05-18 |
1999-12-06 |
Sepracor, Inc. |
(+)-hydroxyrisperidone compositions and methods
|
|
US6342488B1
(en)
|
1998-08-18 |
2002-01-29 |
Sepracor, Inc. |
Phosphonorisperidone and sulforisperidone compositions and methods
|
|
ES2197801B1
(es)
*
|
2002-03-05 |
2005-03-16 |
Ferrer Internacional,S.A |
Procedimiento de obtencion de la 3-(2-(4-(6-fluoro-benzo(d)isoxazol-3-il) piperidin-1-il)-etil)-2-metil-6,7,8,9-tetrahidro-4h-pirido-(1,2-a ) pirimidin-4-ona.
|
|
KR20040025224A
(ko)
*
|
2002-09-18 |
2004-03-24 |
주식회사 대웅 |
2-(2-메틸-4-옥소-6,7,8,9-테트라하이드로-4H-피리도[1,2-a]피리미딘-3-일)아세트알데히드 및 그 제조방법
|
|
AU2003288017A1
(en)
|
2002-11-13 |
2004-06-03 |
Synthon B.V. |
Process for making risperidone and intermediates therefor
|
|
CN101014601B
(zh)
*
|
2004-09-09 |
2011-09-14 |
詹森药业有限公司 |
制备9-羟基-3-(2-羟基乙基)-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮及其晶体
|
|
US20070197591A1
(en)
|
2005-12-12 |
2007-08-23 |
Sandra Boom |
Use of paliperidone for the treatment of a mental disorder in a psychiatric patient with reduced hepatic function
|
|
EP2133351A3
(en)
*
|
2006-08-14 |
2010-01-13 |
Teva Pharmaceutical Industries Ltd. |
Crystal form of 9-hydroxy-risperidone (paliperidone)
|
|
TW200825077A
(en)
|
2006-08-14 |
2008-06-16 |
Teva Pharma |
Crystal forms of 9-hydroxy-risperidone (paliperidone)
|
|
EP2133352A3
(en)
*
|
2006-08-14 |
2010-01-13 |
Teva Pharmaceutical Industries Ltd. |
Crystal form of 9-hydroxy-risperidone (paliperidone)
|
|
US7820816B2
(en)
|
2006-08-23 |
2010-10-26 |
Teva Pharmaceutical Industries Ltd. |
Process for the synthesis of CMHTP and intermediates thereof
|
|
WO2008024415A2
(en)
*
|
2006-08-23 |
2008-02-28 |
Teva Pharmaceutical Insustries Ltd. |
Process for the synthesis of cmhtp and intermediates thereof
|
|
US8071767B2
(en)
|
2007-01-08 |
2011-12-06 |
Actavis Group Ptc Ehf |
Process for preparation of 9-hydroxy-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-A]pyrimidin-4-one hydrochloride
|
|
CN101641353B
(zh)
*
|
2007-04-19 |
2012-05-23 |
长春健欣生物医药科技开发有限公司 |
用于治疗精神疾病的新颖化合物及其制备方法和用途
|
|
WO2009010988A1
(en)
*
|
2007-07-19 |
2009-01-22 |
Natco Pharma Limited |
An improved, industrially viable process for the preparation of high purity paliperidone
|
|
US20090036470A1
(en)
*
|
2007-07-27 |
2009-02-05 |
Jiri Bartl |
Paliperidone derivatives
|
|
WO2009045489A2
(en)
*
|
2007-10-03 |
2009-04-09 |
Teva Pharmaceutical Industries Ltd. |
Process for the synthesis of cmhtp, a paliperidone intermediate
|
|
KR20100091959A
(ko)
*
|
2007-10-09 |
2010-08-19 |
시플라 리미티드 |
팔리페리돈 및 그의 약학적으로 허용가능한 염의 제조방법 및 상기 제조방법에 사용되는 중간체
|
|
WO2009074333A1
(en)
*
|
2007-12-10 |
2009-06-18 |
Synthon B.V. |
Synthesis of paliperidone
|
|
AU2009227507A1
(en)
*
|
2008-02-05 |
2009-09-24 |
Watson Pharma Private Limited |
An improved process for preparation of paliperidone
|
|
EP2285804A4
(en)
*
|
2008-04-21 |
2011-09-14 |
Glenmark Generics Ltd |
METHOD FOR MANUFACTURING PALIPERIDONE INTERMEDIATES
|
|
WO2009144288A1
(en)
*
|
2008-05-29 |
2009-12-03 |
Inke, S.A. |
Process to prepare paliperidone and intermediates thereof
|
|
US8481729B2
(en)
|
2008-06-16 |
2013-07-09 |
Msn Laboratories Limited |
Processes for the preparation of paliperidone
|
|
EP2321311B1
(en)
*
|
2008-07-11 |
2012-09-19 |
Synthon B.V. |
Synthesis of paliperidone
|
|
EP2318405A2
(en)
|
2008-07-11 |
2011-05-11 |
Synthon B.V. |
Paliperidone ketone
|
|
SI22856A
(sl)
*
|
2008-07-31 |
2010-02-26 |
Krka, Tovarna Zdravil, D.D., Novo Mesto |
Proces za pripravo paliperidona
|
|
EP2161019A1
(en)
|
2008-09-05 |
2010-03-10 |
KRKA, D.D., Novo Mesto |
Prolonged release multiparticulate pharmaceutical composition comprising paliperidone
|
|
EP2199293A1
(en)
|
2008-12-22 |
2010-06-23 |
Chemo Ibérica, S.A. |
One-step process for preparing paliperidone and its oxalate salt
|
|
EP2202234A1
(en)
|
2008-12-24 |
2010-06-30 |
Laboratorios Lesvi, S.L. |
Purification of paliperidone
|
|
ATE544766T1
(de)
|
2009-07-13 |
2012-02-15 |
Krka |
Verfahren zur synthese von paliperidon
|
|
WO2011018246A2
(en)
|
2009-08-13 |
2011-02-17 |
Synthon B.V. |
Controlled release paliperidone composition
|
|
EP2343296A1
(en)
|
2009-12-01 |
2011-07-13 |
Chemo Ibérica, S.A. |
A process for the purification of paliperidone
|
|
US20120259116A1
(en)
*
|
2009-12-17 |
2012-10-11 |
Rajiv Kumar |
Novel Process for the Preparation of Paliperidone
|
|
US8088594B2
(en)
*
|
2010-03-16 |
2012-01-03 |
Saladax Biomedical Inc. |
Risperidone immunoassay
|
|
WO2012035554A1
(en)
*
|
2010-09-14 |
2012-03-22 |
Megafine Pharma (P) Ltd. |
An improved process for the preparation of highly pure paliperidone
|
|
NO3034079T3
(nl)
|
2010-11-15 |
2018-06-09 |
|
|
|
CN102153552B
(zh)
*
|
2011-03-01 |
2012-08-22 |
吉林大学 |
两种帕潘立酮药物共晶及其制备方法
|
|
CN102206210B
(zh)
*
|
2011-04-01 |
2014-07-02 |
常州市第四制药厂有限公司 |
一种6-氟-3-(4-哌啶基)-1,2-苯并异噁唑盐酸盐的生产方法
|
|
US20140206667A1
(en)
|
2012-11-14 |
2014-07-24 |
Michela Gallagher |
Methods and compositions for treating schizophrenia
|
|
NZ722077A
(en)
|
2013-12-20 |
2021-12-24 |
Agenebio Inc |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
CN113264939A
(zh)
|
2015-06-19 |
2021-08-17 |
艾吉因生物股份有限公司 |
用于治疗认知损害的苯并二氮杂环庚三烯衍生物、组合物和方法
|
|
US20180170941A1
(en)
|
2016-12-19 |
2018-06-21 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
US11505555B2
(en)
|
2016-12-19 |
2022-11-22 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
WO2019162746A1
(en)
*
|
2018-02-21 |
2019-08-29 |
Zenvision Pharma Llp |
Novel derivatives of paliperidone and process for the preparation thereof
|
|
US11414425B2
(en)
|
2018-06-19 |
2022-08-16 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
US20240132513A1
(en)
|
2022-08-19 |
2024-04-25 |
Agenebio, Inc. |
Benzazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
CN116003404B
(zh)
*
|
2022-12-14 |
2024-10-01 |
杭州同舟生物技术有限公司 |
一种利培酮人工半抗原、人工抗原及其制备方法和应用
|