NL300194I2 - Nieuwe tricyclische verbindingen. - Google Patents

Nieuwe tricyclische verbindingen.

Info

Publication number: NL300194I2
Authority: NL; Netherlands
Prior art keywords: alkyl; amino; alkoxy; halogen; optionally substituted
Prior art date: 1989-11-28

Application number

NL300194C

Other languages

English (en)

Other versions

NL300194I1 (nl

Original Assignee

Roche Palo Alto Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-28

Filing date

2005-04-20

Publication date

2005-07-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23755479&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL300194(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-04-20 Application filed by Roche Palo Alto Llc filed Critical Roche Palo Alto Llc

2005-07-01 Publication of NL300194I2 publication Critical patent/NL300194I2/nl

2005-07-01 Publication of NL300194I1 publication Critical patent/NL300194I1/nl

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Nutrition Science (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Saccharide Compounds (AREA)

NL300194C 1989-11-28 2005-04-20 Nieuwe tricyclische verbindingen. NL300194I1 (nl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US44208289A	1989-11-28	1989-11-28

Publications (2)

Publication Number	Publication Date
NL300194I2 true NL300194I2 (nl)	2005-07-01
NL300194I1 NL300194I1 (nl)	2005-07-01

Family

ID=23755479

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL300194C NL300194I1 (nl)	1989-11-28	2005-04-20	Nieuwe tricyclische verbindingen.

Country Status (23)

Country	Link
US (1)	US5202333A (nl)
EP (1)	EP0430190B1 (nl)
JP (1)	JPH0662607B2 (nl)
KR (1)	KR970007917B1 (nl)
AT (1)	ATE124698T1 (nl)
AU (1)	AU642178B2 (nl)
BR (1)	BR1100680A (nl)
CA (1)	CA2030718C (nl)
DE (2)	DE122005000027I2 (nl)
DK (1)	DK0430190T3 (nl)
ES (1)	ES2075121T3 (nl)
FI (1)	FI98367C (nl)
HK (1)	HK36097A (nl)
HU (1)	HU218654B (nl)
IE (1)	IE68434B1 (nl)
IL (2)	IL96486A (nl)
LU (1)	LU91162I2 (nl)
NL (1)	NL300194I1 (nl)
NO (2)	NO175309C (nl)
NZ (1)	NZ236225A (nl)
PL (3)	PL166277B1 (nl)
PT (1)	PT96001B (nl)
ZA (1)	ZA909529B (nl)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ236225A (en) *	1989-11-28	1992-09-25	Syntex Inc	Azabicyclic-substituted isoquinoline derivatives, intermediates and pharmaceutical compositions
US5491148A (en) *	1991-04-26	1996-02-13	Syntex (U.S.A.) Inc.	Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists
EP0919245A3 (en)	1991-09-20	2000-11-15	Glaxo Group Limited	NK-1 receptor antagonist and a systemic antiinflammatory corticosteroid for the treatment of emesis
US6582728B1 (en) *	1992-07-08	2003-06-24	Inhale Therapeutic Systems, Inc.	Spray drying of macromolecules to produce inhaleable dry powders
US6673335B1 (en) *	1992-07-08	2004-01-06	Nektar Therapeutics	Compositions and methods for the pulmonary delivery of aerosolized medicaments
AU688283B2 (en) *	1992-09-29	1998-03-12	Novartis Ag	Pulmonary delivery of active fragments of parathyroid hormone
US20030113273A1 (en) *	1996-06-17	2003-06-19	Patton John S.	Methods and compositions for pulmonary delivery of insulin
EP2036541A1 (en) *	1994-03-07	2009-03-18	Nektar Therapeutics	Methods and compositions for pulmonary delivery of insulin
GB2288732B (en) *	1994-04-13	1998-04-29	Quadrant Holdings Cambridge	Pharmaceutical compositions
NZ285664A (en) *	1994-05-18	1998-07-28	Inhale Therapeutic Syst	Dry powder interferon composition adapted for pulmonary delivery
US5567818A (en) *	1994-07-08	1996-10-22	Syntex (U.S.A.) Inc.	Processes for preparing 2-(1-azabicyclo[2.2.2]oct-3-yl)-1H-benz[de] isoquinolin-1-one derivatives and intermediates useful therein
US5510486A (en) *	1994-07-26	1996-04-23	Syntex (U.S.A.) Inc.	Process for preparing 2-(1-azabicyclo 2.2.2!oct-3-yl)-2,3,3A,4,5,6-hexahydro-1H-benz de!isoquinolin-1-one
US5492914A (en) *	1994-07-28	1996-02-20	Syntex (U.S.A.) Inc.	2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]is[2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof
US6290991B1 (en) *	1994-12-02	2001-09-18	Quandrant Holdings Cambridge Limited	Solid dose delivery vehicle and methods of making same
US5723103A (en) *	1994-12-09	1998-03-03	Vanderbilt University	Substituted benzamides and radioligand analogs and methods of use
US20030035778A1 (en) *	1997-07-14	2003-02-20	Robert Platz	Methods and compositions for the dry powder formulation of interferon
US6565885B1 (en) *	1997-09-29	2003-05-20	Inhale Therapeutic Systems, Inc.	Methods of spray drying pharmaceutical compositions
US6309623B1 (en) *	1997-09-29	2001-10-30	Inhale Therapeutic Systems, Inc.	Stabilized preparations for use in metered dose inhalers
US20060165606A1 (en)	1997-09-29	2006-07-27	Nektar Therapeutics	Pulmonary delivery particles comprising water insoluble or crystalline active agents
DE60042446D1 (de) *	1999-02-18	2009-08-06	Novasearch Ag	Verwendung von antagonisten der 5-ht3-rezeptoren zur behandlung von muskuloeskeletalen erkrankungen
DK1280520T4 (en)	2000-05-10	2018-06-25	Novartis Ag	Phospholipid based powders for drug delivery
US8404217B2 (en)	2000-05-10	2013-03-26	Novartis Ag	Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en)	2000-05-10	2011-01-18	Novartis Ag	Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US20050042194A1 (en)	2000-05-11	2005-02-24	A.P. Pharma, Inc.	Semi-solid delivery vehicle and pharmaceutical compositions
EP1284732A2 (en) *	2000-05-18	2003-02-26	Glaxo Group Limited	Method for treating functional dyspepsia using alosetron
KR20040100835A (ko)	2001-02-15	2004-12-02	킹 파머슈티칼스 리서치 앤드 디벨로프먼트 아이엔씨	안정된 제약및 갑상선 내분비 호르몬 구성물 및 그제조방법
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
SI1458360T1 (sl)	2001-12-19	2011-08-31	Novartis Ag	Pulmonalno dajanje aminoglikozidov
JP2005525357A (ja)	2002-02-20	2005-08-25	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	α７ニコチン性アセチルコリン受容体活性を伴うアザ二環式化合物
US20030187017A1 (en) *	2002-11-14	2003-10-02	Mangel Allen Wayne	Method for treating functional dyspepsia
AU2003302072A1 (en) *	2002-11-15	2004-06-15	Helsinn Healthcare Sa	Palonosetron for the treatment of chemotherapy-induced emesis
US8598219B2 (en)	2003-01-30	2013-12-03	Helsinn Healthcare Sa	Liquid pharmaceutical formulations of palonosetron
JO2735B1 (en) *	2003-01-30	2013-09-15	هيلسين هيلث كير أس ايه.	Liquid pharmaceutical formations of balloonosterone
MY143789A (en)	2003-02-18	2011-07-15	Helsinn Healthcare Sa	Use of palonosetron treating post- operative nausea and vomiting
US20060167072A1 (en) *	2004-01-30	2006-07-27	Helsinn Healthcare Sa	Liquid pharmaceutical formulations of palonosetron
CN100336508C (zh) *	2005-02-23	2007-09-12	重庆医药工业研究院有限责任公司	一种稳定的帕洛诺司琼注射液
US20070031342A1 (en) *	2005-06-22	2007-02-08	Nektar Therapeutics	Sustained release microparticles for pulmonary delivery
US20080004260A1 (en) *	2006-06-29	2008-01-03	Transcept Pharmaceuticals, Inc.	Compositions of 5-HT3 antagonists and dopamine D2 antagonists for treatment of dopamine-associated chronic conditions
US8614225B2 (en) *	2006-08-30	2013-12-24	Dr. Reddy's Laboratories Limited	Process for the purification of palonosetron or its salt
EP1960397A2 (en) *	2006-10-23	2008-08-27	Sicor Inc.	Crystalline forms of palonosetron hydrochloride
EP1940366B9 (en) *	2006-10-24	2009-12-02	Helsinn Healthcare S.A.	Soft capsules comprising palonosetron hydrochloride having improved stability and bioavailability
US20100105724A1 (en) *	2006-12-07	2010-04-29	Helsinn Healthcare Sa	Crystalline and amorphous forms of palonosetron hydrochloride
EP2155199A4 (en) *	2007-05-29	2011-08-24	Chemagis Ltd	NEW PALONOSETRONIC SALTS AND METHOD FOR THEIR PREPARATION AND CLEANING
US20090227623A1 (en) *	2007-09-15	2009-09-10	Protia, Llc	Deuterium-enriched palosetron
CN101157691B (zh) *	2007-10-18	2011-01-12	杭州九源基因工程有限公司	一种盐酸帕洛诺司琼的生产工艺
AR069625A1 (es)	2007-12-13	2010-02-03	Glenmark Generics Ltd	Base libre de palonosetron y procedimiento para su preparacion
WO2009087643A1 (en) *	2008-01-11	2009-07-16	Natco Pharma Limited	Novel crystalline forms of palonosetron hydrochloride
WO2009136405A1 (en) *	2008-05-05	2009-11-12	Natco Pharma Limited	High purity palonosetron base and its solid state characteristics
US20100048607A1 (en) *	2008-08-25	2010-02-25	Chandrashekhar Kocherlakota	Formulations comprising palonosetron
US20100099701A1 (en) *	2008-10-20	2010-04-22	Auspex Pharmaceuticals, Inc.	Isoquinolinone modulators of 5-ht3 receptors
EP2364312A4 (en) *	2008-11-11	2012-05-02	Reddys Lab Ltd Dr	SYNTHESIS OF CRYSTALLINE PALONOSETRON CHLORHYDRATE
US20100143461A1 (en) *	2008-12-08	2010-06-10	Ben-Zion Solomon	Palonosetron formulation
BRPI0922189A2 (pt) *	2008-12-11	2018-10-23	A P Pharma Inc	"métodos para aumentar a estabilidade de poliortoésteres e suas formulações".
CN101851233B (zh) *	2009-04-03	2013-03-06	四川滇虹医药开发有限公司	盐酸帕洛诺司琼和其前体化合物及制备
CN101849904A (zh) *	2009-04-03	2010-10-06	南京长澳医药科技有限公司	一种帕洛诺司琼注射液及其制备方法
US20100298397A1 (en) *	2009-05-19	2010-11-25	Singh Nikhilesh N	Method of treatment of obsessive compulsive disorder with ondansetron
PT2432467T (pt)	2009-05-20	2018-04-04	Inst Nat Sante Rech Med	Antagonistas recetores de serotina 5-ht3 para utilização no tratamento de distúrbios vestibulares lesionais
EP2253316B1 (en)	2009-05-20	2013-08-14	INSERM (Institut National de la Santé et de la Recherche Médicale)	Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
WO2011001400A2 (en)	2009-06-30	2011-01-06	Ranbaxy Laboratories Limited	Processes for the preparation of form i and form ii of palonosetron hydrochloride
NZ597613A (en) *	2009-07-14	2014-01-31	Albany Molecular Res Inc	5-ht3 receptor modulators, methods of making, and use thereof
WO2011013095A1 (en)	2009-07-31	2011-02-03	Ranbaxy Laboratories Limited	Processes for the preparation of palonosetron
WO2011058427A1 (en) *	2009-11-13	2011-05-19	Helsinn Healthcare S.A.	Palonosetron metabolites
RS53491B1 (sr)	2009-11-18	2015-02-27	Helsinn Healthcare Sa	Kompozicije za lečenje centralno posredovane mučnine i povraćanja
EP2722045B1 (en)	2009-11-18	2016-07-06	Helsinn Healthcare SA	Compositions for treating centrally mediated nausea and vomiting
EP2744497B1 (en)	2011-10-18	2016-04-06	Helsinn Healthcare SA	Therapeutic combinations of netupitant and palonosetron
CN102688185B (zh) *	2012-06-01	2013-07-10	齐鲁制药(海南)有限公司	一种稳定的帕洛诺司琼注射液及其制备方法
WO2015099381A1 (ko)	2013-12-23	2015-07-02	주식회사 삼양바이오팜	팔로노세트론을 함유하는 약학 조성물
WO2017044693A1 (en)	2015-09-11	2017-03-16	Chase Pharmaceuticals Corporation	Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
IL270104B (en)	2017-04-24	2022-07-01	Chase Therapeutics Corp	A combination of pramipexole and a 5ht3 antagonist for use in the treatment of depression
WO2019038656A1 (en)	2017-08-21	2019-02-28	Leiutis Pharmaceuticals Pvt, Ltd	NEW TRIPLE COMBINATION FORMULATIONS FOR ANTIEMETIC THERAPY
EP4385497A1 (en)	2022-12-12	2024-06-19	Alfred E. Tiefenbacher (GmbH & Co. KG)	Antioxidant-free fixed dose combination of netupitant and palonosetron
EP4633612A1 (en)	2022-12-12	2025-10-22	Alfred E. Tiefenbacher (GmbH & Co. KG)	Fixed dose combination comprising netupitant and palonosetron
EP4633608A1 (en)	2022-12-12	2025-10-22	Alfred E. Tiefenbacher (GmbH & Co. KG)	Antioxidant-free fixed dose combination of netupitant and palonosetron
EP4385500A1 (en)	2022-12-12	2024-06-19	Alfred E. Tiefenbacher (GmbH & Co. KG)	Fixed dose combination comprising netupitant and palonosetron

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3341528A (en) *	1963-11-07	1967-09-12	Warner Lambert Pharmaceutical	Substituted benzoquinolines
US3896132A (en) *	1969-08-19	1975-07-22	Hoffmann La Roche	Process for preparing 1,2,3,8,9,9a-hexahydro-5,6-dialkoxy-1-alkyl-benzo(d,e)quinolin-7-ore compounds
US4309543A (en) *	1980-03-17	1982-01-05	Dynapol	Process for preparing cyclic amides
EP0093488A3 (en) *	1982-03-18	1984-05-23	Beecham Group Plc	Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them
US4571396A (en) *	1984-04-16	1986-02-18	Warner-Lambert Company	Antibacterial agents
WO1988004292A1 (en) *	1986-12-11	1988-06-16	The Upjohn Company	Antipsychotic amino-polyhydro-benz-(iso)quinolines and intermediates
ATE108791T1 (de) *	1987-11-04	1994-08-15	Beecham Group Plc	Neue 4-oxobenzotriazine und 4-oxochinazoline.
NZ236225A (en) *	1989-11-28	1992-09-25	Syntex Inc	Azabicyclic-substituted isoquinoline derivatives, intermediates and pharmaceutical compositions
AU7618991A (en) *	1990-05-14	1991-11-14	Syntex (U.S.A.) Inc.	Novel tricyclic compounds
US5189041A (en) *	1990-11-16	1993-02-23	Syntex (U.S.A.) Inc.	Tricyclic 5-ht3 receptor antagonists

1990
- 1990-11-27 NZ NZ236225A patent/NZ236225A/en unknown
- 1990-11-27 IL IL9648690A patent/IL96486A/en active Protection Beyond IP Right Term
- 1990-11-27 DE DE200512000027 patent/DE122005000027I2/de active Active
- 1990-11-27 EP EP90122689A patent/EP0430190B1/en not_active Expired - Lifetime
- 1990-11-27 PL PL90303661A patent/PL166277B1/pl unknown
- 1990-11-27 HU HU670/90A patent/HU218654B/hu active Protection Beyond IP Right Term
- 1990-11-27 FI FI905839A patent/FI98367C/fi active Protection Beyond IP Right Term
- 1990-11-27 AU AU66963/90A patent/AU642178B2/en not_active Expired
- 1990-11-27 IL IL11062290A patent/IL110622A/en not_active IP Right Cessation
- 1990-11-27 NO NO905120A patent/NO175309C/no not_active IP Right Cessation
- 1990-11-27 DK DK90122689.4T patent/DK0430190T3/da active
- 1990-11-27 JP JP2328764A patent/JPH0662607B2/ja not_active Expired - Fee Related
- 1990-11-27 PT PT96001A patent/PT96001B/pt not_active IP Right Cessation
- 1990-11-27 PL PL90303660A patent/PL166267B1/pl unknown
- 1990-11-27 AT AT90122689T patent/ATE124698T1/de active
- 1990-11-27 DE DE69020694T patent/DE69020694T2/de not_active Expired - Lifetime
- 1990-11-27 CA CA002030718A patent/CA2030718C/en not_active Expired - Lifetime
- 1990-11-27 KR KR1019900019275A patent/KR970007917B1/ko not_active Expired - Lifetime
- 1990-11-27 PL PL90287961A patent/PL166272B1/pl unknown
- 1990-11-27 ZA ZA909529A patent/ZA909529B/xx unknown
- 1990-11-27 IE IE426990A patent/IE68434B1/en not_active IP Right Cessation
- 1990-11-27 ES ES90122689T patent/ES2075121T3/es not_active Expired - Lifetime
1991
- 1991-05-22 US US07/704,565 patent/US5202333A/en not_active Expired - Lifetime
1997
- 1997-03-20 HK HK36097A patent/HK36097A/en not_active IP Right Cessation
- 1997-05-08 BR BR1100680-3A patent/BR1100680A/pt active IP Right Grant
2005
- 2005-04-18 LU LU91162C patent/LU91162I2/fr unknown
- 2005-04-20 NL NL300194C patent/NL300194I1/nl unknown
- 2005-09-21 NO NO2005023C patent/NO2005023I2/no unknown

Also Published As

Publication number	Publication date
NO905120D0 (no)	1990-11-27
KR910009699A (ko)	1991-06-28
EP0430190A3 (en)	1992-01-22
HUT56368A (en)	1991-08-28
NO2005023I1 (no)	2005-10-03
LU91162I2 (fr)	2005-06-20
PL287961A1 (en)	1991-12-02
HU907660D0 (en)	1991-06-28
DE69020694D1 (de)	1995-08-10
NO2005023I2 (no)	2009-10-05
IL96486A0 (en)	1991-08-16
CA2030718A1 (en)	1991-05-29
ATE124698T1 (de)	1995-07-15
NO175309B (no)	1994-06-20
PL166272B1 (pl)	1995-04-28
KR970007917B1 (ko)	1997-05-17
IL110622A (en)	1995-03-30
EP0430190A2 (en)	1991-06-05
HK36097A (en)	1997-03-27
NL300194I1 (nl)	2005-07-01
IE904269A1 (en)	1991-06-05
FI905839L (fi)	1991-05-29
FI905839A0 (fi)	1990-11-27
PL166277B1 (pl)	1995-04-28
EP0430190B1 (en)	1995-07-05
IL96486A (en)	1995-03-30
HU218654B (hu)	2000-10-28
JPH03176486A (ja)	1991-07-31
ZA909529B (en)	1992-08-26
PT96001B (pt)	1998-01-30
FI98367B (fi)	1997-02-28
NO905120L (no)	1991-05-29
PL166267B1 (pl)	1995-04-28
FI98367C (fi)	1997-06-10
BR1100680A (pt)	2000-02-08
IE68434B1 (en)	1996-06-12
ES2075121T3 (es)	1995-10-01
DE122005000027I2 (de)	2006-03-16
JPH0662607B2 (ja)	1994-08-17
NO175309C (no)	1994-09-28
DE69020694T2 (de)	1996-01-18
DE122005000027I1 (de)	2005-08-04
PT96001A (pt)	1991-09-30
NZ236225A (en)	1992-09-25
US5202333A (en)	1993-04-13
AU642178B2 (en)	1993-10-14
AU6696390A (en)	1991-06-06
DK0430190T3 (da)	1995-08-21
CA2030718C (en)	1998-05-12

Publication	Publication Date	Title
NL300194I1 (nl)	2005-07-01	Nieuwe tricyclische verbindingen.
EA200100553A1 (ru)	2001-12-24	Замещенные бициклические производные, полезные в качестве противораковых агентов
EA200000391A1 (ru)	2000-12-25	Производные тиенопиримидина и тиенопиридина, полезные в качестве противораковых агентов
EA200200873A1 (ru)	2003-04-24	Новые пиперазиновые производные
TR199801782T2 (xx)	1998-12-21	Kinoksalindionlar
PT753301E (pt)	2003-08-29	Combinacao de um benzimidazole tendo actividade antagonista da angiotensina ii com um diuretico
EP0604354A3 (en)	1995-02-08	Antidepressant and anti-Parkinson's disease compounds.
DK0641770T3 (da)	1998-06-02	Hidtil ukendte forbindelser med blodpladeaggegationsinhiberende aktivitet
RU95104939A (ru)	1996-10-27	Тетрациклические соединения, способ их получения и промежуточные соединения для этого и применение их в качестве противоопухолевых веществ
ID25477A (id)	2000-10-05	Turunan-turunan spiropiperidin
EP0604352A3 (en)	1995-02-08	Aryl substituted heterocyclic compounds.
EP0604355A3 (en)	1995-02-08	Alkyl substituted heterocyclic compounds.
DE69402703D1 (de)	1997-05-22	3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND
AP2000002009A0 (en)	2000-12-31	Tetrahydronaphthyridinyl-carboxamides having anti-convulsant activity.
WO1997029077A1 (fr)	1997-08-14	Derives amides substitues
ATE264320T1 (de)	2004-04-15	5-aminoalkyl- und 5-aminocarbonylsubstituierte indole