PT753301E - Combinacao de um benzimidazole tendo actividade antagonista da angiotensina ii com um diuretico - Google Patents

Combinacao de um benzimidazole tendo actividade antagonista da angiotensina ii com um diuretico

Info

Publication number: PT753301E
Authority: PT; Portugal
Prior art keywords: sup; group; compound; activity; combination
Prior art date: 1993-06-07

Application number

PT96115146T

Other languages

English (en)

Inventor

Yoshiyuki Inada

Keiji Kubo

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-07

Filing date

1994-06-07

Publication date

2003-08-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15153791&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT753301(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-06-07 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2003-08-29 Publication of PT753301E publication Critical patent/PT753301E/pt

Links

230000001882 diuretic effect Effects 0.000 title abstract 2
HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
CZGUSIXMZVURDU-UHFFFAOYSA-N 3-azaniumyl-4-[[1-[[1-[[1-[[1-[[1-[2-[(1-carboxylato-2-phenylethyl)carbamoyl]pyrrolidin-1-yl]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diam Chemical compound C=1N=CNC=1CC(C(=O)N1C(CCC1)C(=O)NC(CC=1C=CC=CC=1)C(O)=O)NC(=O)C(C(C)CC)NC(=O)C(NC(=O)C(NC(=O)C(CCCN=C(N)N)NC(=O)C(N)CC(O)=O)C(C)C)CC1=CC=C(O)C=C1 CZGUSIXMZVURDU-UHFFFAOYSA-N 0.000 title 1
239000002934 diuretic Substances 0.000 title 1
230000000694 effects Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
102000005862 Angiotensin II Human genes 0.000 abstract 2
101800000733 Angiotensin-2 Proteins 0.000 abstract 2
CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 abstract 2
229950006323 angiotensin ii Drugs 0.000 abstract 2
150000001450 anions Chemical class 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
230000002213 calciumantagonistic effect Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

PT96115146T 1993-06-07 1994-06-07 Combinacao de um benzimidazole tendo actividade antagonista da angiotensina ii com um diuretico PT753301E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP13552493		1993-06-07

Publications (1)

Publication Number	Publication Date
PT753301E true PT753301E (pt)	2003-08-29

Family

ID=15153791

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96115146T PT753301E (pt)	1993-06-07	1994-06-07	Combinacao de um benzimidazole tendo actividade antagonista da angiotensina ii com um diuretico

Country Status (9)

Country	Link
EP (6)	EP1306089B1 (pt)
AT (4)	ATE372115T1 (pt)
CA (1)	CA2125251C (pt)
CY (1)	CY2370B1 (pt)
DE (4)	DE69435022T2 (pt)
DK (1)	DK0753301T3 (pt)
ES (1)	ES2193217T3 (pt)
PT (1)	PT753301E (pt)
SG (1)	SG45336A1 (pt)

Families Citing this family (28)

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WO1995033456A2 (en) *	1994-06-07	1995-12-14	Telor Ophthalmic Pharmaceuticals, Inc.	Reducing intraocular pressure using aryloxy- and aryl-acetic acids
US5763491A (en) *	1994-12-09	1998-06-09	The Regents Of The University Of California	Method for enhancing outflow of aqueous humor in treatment of glaucoma
US6228873B1 (en)	1994-12-09	2001-05-08	The Regents Of The University Of California	Method for enhancing outflow of aqueous humor in treatment of glaucoma
ATE199495T1 (de) *	1994-12-14	2001-03-15	Enbalt Trading Ltd	Pharmazeutische zubereitung zur direktverpressung
DE69617235T2 (de) *	1995-06-07	2002-07-25	G.D. Searle & Co., Chicago	Epoxysteroide aldosteronantagonist und angiotensin ii rezeptor antagonist kombinationstherapie zur behandlung von congestivem herzversagen
WO1996040256A1 (en) *	1995-06-07	1996-12-19	G.D. Searle & Co.	Method to treat cardiofibrosis with a combination of an angiotensin ii antagonist and spironolactone
AU6158096A (en) *	1995-06-07	1996-12-30	G.D. Searle & Co.	Spironolactone and angiotensin ii antagonist combination the rapy for treatment of congestive heart failure
EP1813286A3 (en) *	1996-04-05	2008-04-16	Takeda Pharmaceutical Company Limited	Pharmaceutical composition containing a compound having angiotensin II antagonistic activity in combination with another compound
WO1999012534A1 (en) *	1997-09-10	1999-03-18	Ono Pharmaceutical Co., Ltd.	Peroxisome proliferator-activated receptor controllers
SK285863B6 (sk) *	1998-07-10	2007-10-04	Novartis Ag	Kombinovaná farmaceutická kompozícia obsahujúca AT1-antagonistu valsartan a amlodipín
JP4000505B2 (ja) *	1999-12-01	2007-10-31	第一三共株式会社	緑内障を治療するための併用剤
WO2001055093A1 (en) *	2000-01-25	2001-08-02	Japan Tobacco Inc.	N-arylhydrazide compounds and use thereof as drugs
WO2002034263A1 (en) *	2000-10-25	2002-05-02	Takeda Chemical Industries, Ltd.	Preventives/remedies for portal hypertension
AU2002226365A1 (en) *	2000-12-01	2002-06-11	Novartis Ag	Combinations of an angiotensin receptor antagonist and an anti-hypertensive drug or a statin, for the treatment of sexual dysfunction
WO2003047573A1 (en) *	2001-12-03	2003-06-12	Takeda Chemical Industries, Ltd.	Insulin resistance improving agents
CA2469616A1 (en)	2001-12-12	2003-06-19	James W. Aiken	Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists
EG24716A (en)	2002-05-17	2010-06-07	Novartis Ag	Combination of organic compounds
KR101194453B1 (ko) *	2003-01-31	2012-10-24	다이이찌 산쿄 가부시키가이샤	동맥 경화 및 고혈압증의 예방 및 치료를 위한 의약
ES2334029T3 (es)	2003-05-15	2010-03-04	Roskamp Research Llc	Procedimiento para producir medicamentos para reducir la deposicion de amiloide, la neurotoxicidad de amiloide y la microgliosis.
GB0322552D0 (en)	2003-09-26	2003-10-29	Astrazeneca Uk Ltd	Therapeutic treatment
DK2214666T3 (da)	2007-10-05	2014-01-27	Alzheimer S Inst Of America Inc	Fremgangsmåde til reducering af amyloid-afsætning, amyloid-neurotoksicitet og mikrogliose med (-)-nilvadipin-enantiomer
KR20110038145A (ko)	2008-07-31	2011-04-13	다케다 야쿠힌 고교 가부시키가이샤	고형 약학 조성물
AR073380A1 (es)	2008-09-25	2010-11-03	Takeda Pharmaceutical	Composicion farmaceutica solida. comprimido multicapa
DE102008059206A1 (de)	2008-11-27	2010-06-10	Bayer Schering Pharma Aktiengesellschaft	Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum
US9387249B2 (en)	2008-12-23	2016-07-12	Takeda Pharmaceutical Company Limited	Methods of treating hypertension with at least one angiotensin II receptor blocker and chlorthalidone
EP2424501A2 (en) *	2009-04-30	2012-03-07	Takeda Pharmaceutical Company Limited	Solid preparation
TR201004754A1 (tr) *	2010-06-11	2012-01-23	Sanovel �La� San. Ve T�C. A.�.	Yeni Farmasötik Kombinasyonlar
BR112014027618A2 (pt)	2012-05-07	2017-06-27	Bayer Pharma AG	processo para a fabricação de uma forma de dosagem farmacêutica compreendendo nifedipina e candesartan cilexetil

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IL95975A (en)	1989-10-24	1997-06-10	Takeda Chemical Industries Ltd	N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
US5196444A (en) *	1990-04-27	1993-03-23	Takeda Chemical Industries, Ltd.	1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
EP0461039B1 (fr) *	1990-06-08	1998-09-16	Hoechst Marion Roussel	Dérivés du benzimidazole, leur procédé de préparation, les intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant
ATE177634T1 (de) *	1990-12-14	1999-04-15	Smithkline Beecham Corp	Angiotensin-ii-rezeptor blockierende zusammensetzungen
FR2673427B1 (fr) *	1991-03-01	1993-06-18	Sanofi Elf	Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
IL102183A (en) *	1991-06-27	1999-11-30	Takeda Chemical Industries Ltd	Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
TW300219B (pt) *	1991-09-14	1997-03-11	Hoechst Ag
TW284688B (pt) *	1991-11-20	1996-09-01	Takeda Pharm Industry Co Ltd
GB2270841A (en) *	1992-09-09	1994-03-30	Merck & Co Inc	Compositions for Treating vascular restenosis
WO1994009778A1 (en) *	1992-10-26	1994-05-11	Merck & Co., Inc.	Combinations of angiotensin-ii receptor antagonists and diuretics
DK0743852T3 (da) *	1994-02-08	2005-10-17	Novartis Ag	Behandling af glaukom med normalt tryk med valsartan

1994
- 1994-06-06 CA CA002125251A patent/CA2125251C/en not_active Expired - Lifetime
- 1994-06-07 DK DK96115146T patent/DK0753301T3/da active
- 1994-06-07 EP EP03001570A patent/EP1306089B1/en not_active Expired - Lifetime
- 1994-06-07 AT AT03001569T patent/ATE372115T1/de not_active IP Right Cessation
- 1994-06-07 EP EP03001569A patent/EP1306088B1/en not_active Expired - Lifetime
- 1994-06-07 DE DE69435022T patent/DE69435022T2/de not_active Expired - Lifetime
- 1994-06-07 PT PT96115146T patent/PT753301E/pt unknown
- 1994-06-07 EP EP96115146A patent/EP0753301B1/en not_active Revoked
- 1994-06-07 AT AT96115146T patent/ATE239471T1/de active
- 1994-06-07 DE DE69432644T patent/DE69432644T2/de not_active Expired - Lifetime
- 1994-06-07 AT AT94108687T patent/ATE311188T1/de not_active IP Right Cessation
- 1994-06-07 ES ES96115146T patent/ES2193217T3/es not_active Expired - Lifetime
- 1994-06-07 EP EP94108687A patent/EP0628313B1/en not_active Expired - Lifetime
- 1994-06-07 AT AT03001570T patent/ATE372116T1/de not_active IP Right Cessation
- 1994-06-07 EP EP07014995A patent/EP1844774A3/en not_active Ceased
- 1994-06-07 DE DE69435021T patent/DE69435021T2/de not_active Expired - Lifetime
- 1994-06-07 DE DE69434560T patent/DE69434560T2/de not_active Expired - Lifetime
- 1994-06-07 SG SG1996003825A patent/SG45336A1/en unknown
- 1994-06-07 EP EP10178599A patent/EP2277520A3/en not_active Withdrawn
2003
- 2003-08-04 CY CY0300054A patent/CY2370B1/xx unknown

Also Published As

Publication number	Publication date
SG45336A1 (en)	1998-01-16
ATE311188T1 (de)	2005-12-15
DE69432644T2 (de)	2003-11-27
CY2370B1 (en)	2004-06-04
EP2277520A2 (en)	2011-01-26
DE69434560D1 (de)	2006-01-05
DE69432644D1 (de)	2003-06-12
EP1306088B1 (en)	2007-09-05
DK0753301T3 (da)	2003-07-21
DE69435022T2 (de)	2008-05-29
ATE372116T1 (de)	2007-09-15
CA2125251A1 (en)	1994-12-08
DE69434560T2 (de)	2006-06-08
ATE372115T1 (de)	2007-09-15
DE69435021T2 (de)	2008-05-29
EP1306088A1 (en)	2003-05-02
EP0753301A1 (en)	1997-01-15
EP2277520A3 (en)	2011-08-24
EP0628313B1 (en)	2005-11-30
ATE239471T1 (de)	2003-05-15
ES2193217T3 (es)	2003-11-01
EP0753301B1 (en)	2003-05-07
DE69435022D1 (de)	2007-10-18
EP1844774A3 (en)	2008-08-20
EP0628313A1 (en)	1994-12-14
EP1844774A2 (en)	2007-10-17
DE69435021D1 (de)	2007-10-18
CA2125251C (en)	2005-04-26
EP1306089B1 (en)	2007-09-05
EP1306089A1 (en)	2003-05-02

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ATE306261T1 (de)	2005-10-15	Antithrombosemittel
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