MXPA05011018A - Compuestos de 4-fenil piperidna y sus usos como moduladores de receptores opioides. - Google Patents
Compuestos de 4-fenil piperidna y sus usos como moduladores de receptores opioides.Info
- Publication number
- MXPA05011018A MXPA05011018A MXPA05011018A MXPA05011018A MXPA05011018A MX PA05011018 A MXPA05011018 A MX PA05011018A MX PA05011018 A MXPA05011018 A MX PA05011018A MX PA05011018 A MXPA05011018 A MX PA05011018A MX PA05011018 A MXPA05011018 A MX PA05011018A
- Authority
- MX
- Mexico
- Prior art keywords
- derivatives
- disorders
- phenyl
- disease states
- conditions
- Prior art date
Links
- UTBULQCHEUWJNV-UHFFFAOYSA-N 4-phenylpiperidine Chemical class C1CNCCC1C1=CC=CC=C1 UTBULQCHEUWJNV-UHFFFAOYSA-N 0.000 title abstract 2
- 102000003840 Opioid Receptors Human genes 0.000 title abstract 2
- 108090000137 Opioid Receptors Proteins 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 6
- 201000010099 disease Diseases 0.000 abstract 3
- 208000019901 Anxiety disease Diseases 0.000 abstract 2
- 230000036506 anxiety Effects 0.000 abstract 2
- 201000000980 schizophrenia Diseases 0.000 abstract 2
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invencion se refiere a derivados de 4-fenil-piperidina, composiciones farmaceuticas que comprenden tales derivados y procedimientos de usar tales derivados para tratar estados de enfermedad, trastornos y afecciones mediados por un receptor opioide; la presente invencion tambien se refiere particularmente a usar tales derivados para tratar ciertos estados de enfermedad, trastornos y afecciones, por ejemplo sindrome de intestino irritable, adiccion o dependencia de drogas, incluyendo la adiccion a alcohol, depresion, ansiedad, esquizofrenia, ansiedad, esquizofrenia y trastornos de la alimentacion, entre otros numerosos estados de enfermedad, trastornos y afecciones como se describe mas completamente en el presente documento.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46265103P | 2003-04-14 | 2003-04-14 | |
| PCT/IB2004/001161 WO2004089370A1 (en) | 2003-04-14 | 2004-04-01 | 4-phenyl-piperidine compounds and their use as modulators of opioid receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05011018A true MXPA05011018A (es) | 2005-12-12 |
Family
ID=33159858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05011018A MXPA05011018A (es) | 2003-04-14 | 2004-04-01 | Compuestos de 4-fenil piperidna y sus usos como moduladores de receptores opioides. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20040204453A1 (es) |
| EP (1) | EP1615643A1 (es) |
| JP (1) | JP2006522792A (es) |
| AR (1) | AR044016A1 (es) |
| BR (1) | BRPI0409436A (es) |
| CA (1) | CA2522214A1 (es) |
| CL (1) | CL2004000695A1 (es) |
| DO (1) | DOP2004000876A (es) |
| GT (1) | GT200400064A (es) |
| MX (1) | MXPA05011018A (es) |
| NL (1) | NL1025933C2 (es) |
| PA (1) | PA8600001A1 (es) |
| PE (1) | PE20050416A1 (es) |
| TW (1) | TW200423934A (es) |
| UY (1) | UY28263A1 (es) |
| WO (1) | WO2004089370A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA12711A (en) * | 2001-10-22 | 2006-06-27 | Pfizer Prod Inc | 3-AzabicycloÄ3.1.0Ühexane derivatives as opoioid receptor antagonists. |
| US7381721B2 (en) * | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
| JP3984281B2 (ja) | 2003-04-14 | 2007-10-03 | ファイザー・プロダクツ・インク | ３−アザビシクロ〔３，２，１〕オクタン誘導体 |
| US6992090B2 (en) * | 2003-06-16 | 2006-01-31 | Adolor Corporation | Substituted piperidine compounds and methods of their use |
| AR057061A1 (es) * | 2005-06-16 | 2007-11-14 | Altana Pharma Ag | Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos |
| MY145633A (en) * | 2006-03-01 | 2012-03-15 | Theravance Inc | 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| TWI409067B (zh) * | 2007-02-28 | 2013-09-21 | Theravance Inc | ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型 |
| TWI423801B (zh) * | 2007-08-27 | 2014-01-21 | Theravance Inc | 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物 |
| EP2185553B1 (en) * | 2007-08-27 | 2012-06-27 | Theravance, Inc. | Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists |
| ES2364686T3 (es) * | 2007-08-27 | 2011-09-12 | Theravance, Inc. | Compuestos de alquil-8-azabiciclo[3.2.1]octano disustituidos como antagonistas del receptor opioide mu. |
| ES2465621T3 (es) * | 2007-08-27 | 2014-06-06 | Theravance, Inc. | Compuestos de heteroarilalquil-8-azabiciclo[3.2.1]octano, como antagonistas de los receptores opiodes mu |
| AU2012347416B2 (en) | 2011-12-09 | 2016-05-12 | Research Triangle Institute | 1-substituted 4-arylpiperazine as kappa opioid receptor antagonists |
| US20140206667A1 (en) | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| CA2973748C (en) | 2015-01-27 | 2020-04-14 | Medivance Incorporated | Improved medical pad and system for thermotherapy |
| CN109790125B (zh) | 2016-09-16 | 2022-07-05 | 研究三角协会 | 四氢异喹啉κ阿片拮抗剂 |
| WO2018108319A1 (en) * | 2016-12-16 | 2018-06-21 | Laboratorios Del Dr. Esteve, S.A. | Tetrahydropyran and tetrahydrothiopyran amide derivatives having multimodal activity against pain |
| AU2018211057B2 (en) | 2017-01-17 | 2021-12-23 | Mebias Discovery, Inc. | Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same |
| CN110662541B (zh) * | 2017-03-12 | 2023-02-10 | 王晓冬 | 多环胺作为阿片受体调节剂 |
| US11584765B2 (en) | 2017-03-12 | 2023-02-21 | Ecstasy LLC | Polycyclic amines as sigma receptor modulators |
| JP7680053B2 (ja) | 2020-07-01 | 2025-05-20 | エクスタシー・リミテッド・ライアビリティ・カンパニー | オピオイド受容体変調のための多環式アミン |
| WO2024173873A2 (en) * | 2023-02-17 | 2024-08-22 | Mebias Discovery, Inc. | Compounds, compositions, and methods for treating, ameliorating, and/or preventing pain |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4891379A (en) * | 1987-04-16 | 1990-01-02 | Kabushiki Kaisha Kobe Seikosho | Piperidine opioid antagonists |
| GB9912411D0 (en) * | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| WO2003101963A1 (en) * | 2002-05-30 | 2003-12-11 | Eli Lilly And Company | Opioid receptor antagonists |
| US7381721B2 (en) * | 2003-03-17 | 2008-06-03 | Adolor Corporation | Substituted piperidine compounds |
-
2004
- 2004-01-22 US US10/762,447 patent/US20040204453A1/en not_active Abandoned
- 2004-03-31 CL CL200400695A patent/CL2004000695A1/es unknown
- 2004-04-01 JP JP2006506479A patent/JP2006522792A/ja not_active Abandoned
- 2004-04-01 WO PCT/IB2004/001161 patent/WO2004089370A1/en not_active Ceased
- 2004-04-01 MX MXPA05011018A patent/MXPA05011018A/es unknown
- 2004-04-01 CA CA002522214A patent/CA2522214A1/en not_active Abandoned
- 2004-04-01 EP EP04725122A patent/EP1615643A1/en not_active Withdrawn
- 2004-04-01 BR BRPI0409436-0A patent/BRPI0409436A/pt not_active IP Right Cessation
- 2004-04-02 DO DO2004000876A patent/DOP2004000876A/es unknown
- 2004-04-06 GT GT200400064A patent/GT200400064A/es unknown
- 2004-04-12 PA PA20048600001A patent/PA8600001A1/es unknown
- 2004-04-12 PE PE2004000363A patent/PE20050416A1/es not_active Application Discontinuation
- 2004-04-12 UY UY28263A patent/UY28263A1/es not_active Application Discontinuation
- 2004-04-13 NL NL1025933A patent/NL1025933C2/nl not_active IP Right Cessation
- 2004-04-13 AR ARP040101234A patent/AR044016A1/es unknown
- 2004-04-13 US US10/823,026 patent/US20050032837A1/en not_active Abandoned
- 2004-04-13 TW TW093110285A patent/TW200423934A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1615643A1 (en) | 2006-01-18 |
| UY28263A1 (es) | 2004-11-30 |
| CA2522214A1 (en) | 2004-10-21 |
| NL1025933C2 (nl) | 2005-11-23 |
| BRPI0409436A (pt) | 2006-04-18 |
| PA8600001A1 (es) | 2004-12-16 |
| GT200400064A (es) | 2004-11-30 |
| US20040204453A1 (en) | 2004-10-14 |
| JP2006522792A (ja) | 2006-10-05 |
| WO2004089370A1 (en) | 2004-10-21 |
| DOP2004000876A (es) | 2004-10-15 |
| US20050032837A1 (en) | 2005-02-10 |
| AR044016A1 (es) | 2005-08-24 |
| TW200423934A (en) | 2004-11-16 |
| CL2004000695A1 (es) | 2005-02-04 |
| PE20050416A1 (es) | 2005-06-13 |
| NL1025933A1 (nl) | 2004-10-18 |
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