MXPA03010394A - Proceso para la preparacion de esteres de acido carboxilico substituidos por hidrolisis enzimatica. - Google Patents
Proceso para la preparacion de esteres de acido carboxilico substituidos por hidrolisis enzimatica.Info
- Publication number
- MXPA03010394A MXPA03010394A MXPA03010394A MXPA03010394A MXPA03010394A MX PA03010394 A MXPA03010394 A MX PA03010394A MX PA03010394 A MXPA03010394 A MX PA03010394A MX PA03010394 A MXPA03010394 A MX PA03010394A MX PA03010394 A MXPA03010394 A MX PA03010394A
- Authority
- MX
- Mexico
- Prior art keywords
- halogenpent
- alkyl
- carboxylic esters
- ene carboxylic
- preparation
- Prior art date
Links
- 150000001733 carboxylic acid esters Chemical class 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 150000001735 carboxylic acids Chemical class 0.000 abstract 2
- 230000007071 enzymatic hydrolysis Effects 0.000 abstract 2
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 abstract 2
- 238000002955 isolation Methods 0.000 abstract 2
- 108090000371 Esterases Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000006340 racemization Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un proceso para la preparacion de esteres 2(S)-alquil-5-halogenpent-4-en carboxilicos por hidrolisis enzimatica, que comprende las etapas de a) hidrolisis enzimatica de esteres 2-alquil-5-halogenpent-4-en carboxilicos racemicos en medio acuoso y alcalino en la presencia de una esterasa; b ) aislamiento de esteres 2 ( S ) -alquil-5-halogenpent-4-en carboxilicos por extraccih con un solvente organico; c) aislamiento de acidos 2(R)-alquil-5-halogenpent-4-en carboxilicos del medio acuoso-alcalino; d) esterificacion de acidos 2 (R) -alquil-5- halogenpent-4-en carboxilicos, e) subsecuente racemizacion para formar esteres 2-alquil-5-halogenpent-4-en carboxilicos; y f ) regreso del racernato obtenido en la etapa e) a etapa a) , de ser necesario, junto con esteres 2-alquil-5-halogenpent-4-en carboxilicos racemicos frescos. El proceso permite que los R-estereois6meros indeseados se conviertan en loa esteres 2(S)-alquil-5-halogenpent-4-en carboxilicos deseados para evitar producto de desecho de la sintesis.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH8952001 | 2001-05-15 | ||
| PCT/EP2002/004640 WO2002092828A2 (en) | 2001-05-15 | 2002-04-26 | Process for the preparation of substituted carboxylic acid estersby enzymatic hydrolysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03010394A true MXPA03010394A (es) | 2004-03-09 |
Family
ID=4546156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03010394A MXPA03010394A (es) | 2001-05-15 | 2002-04-26 | Proceso para la preparacion de esteres de acido carboxilico substituidos por hidrolisis enzimatica. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7153675B2 (es) |
| EP (1) | EP1412514B1 (es) |
| JP (1) | JP4252803B2 (es) |
| KR (1) | KR100897597B1 (es) |
| CN (1) | CN1279178C (es) |
| AT (1) | ATE458066T1 (es) |
| AU (1) | AU2002310883A1 (es) |
| BR (1) | BR0209657B1 (es) |
| CA (1) | CA2445014C (es) |
| DE (1) | DE60235374D1 (es) |
| IL (2) | IL158586A0 (es) |
| MX (1) | MXPA03010394A (es) |
| PT (1) | PT1412514E (es) |
| WO (1) | WO2002092828A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004052828A1 (ja) * | 2002-12-09 | 2004-06-24 | Asahi Glass Company, Limited | （４ｅ）−５−クロロ−２−イソプロピル−４−ペンテン酸エステルおよびその光学活性体の製造方法 |
| EP1626093A1 (en) * | 2004-08-11 | 2006-02-15 | Dow Global Technologies Inc. | Process for the production of (S)-5-chloro-2-isopropylpent-4-enoic acid esters |
| US20080281125A1 (en) * | 2005-03-09 | 2008-11-13 | Markus Rossler | Process for Preparing Enantiopure E-(2S)-Alkyl-5-Halopent-4-Enoic Acids and Esters |
| DE102005052195A1 (de) | 2005-10-28 | 2007-05-03 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von chiralen Octensäurederivaten |
| AT502992B1 (de) * | 2005-12-27 | 2008-04-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von enantiomerenangereicherten 2-alkyl-5-halogen-pent-4-en-carbonsäuren bzw. -carbonsäureestern |
| EP1958666A1 (en) | 2007-02-13 | 2008-08-20 | Speedel Experimenta AG | Heterocyclic-substituted alkanamides as therapeutic compounds |
| DE102007049039A1 (de) | 2007-10-11 | 2009-04-16 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung |
| WO2011051853A1 (en) | 2009-10-29 | 2011-05-05 | CarboDesign LLC | Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY119161A (en) | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| US5658796A (en) | 1995-06-07 | 1997-08-19 | Seprachem, Inc. | Optical resolution of alkyl chroman-2-carboxylates |
| DE19809649A1 (de) | 1998-03-06 | 1999-09-09 | Hoechst Marion Roussel De Gmbh | Verfahren zur enzymatischen Enantiomeren-Trennung von 3(R)- und 3(S)-Hydroxy-1-methyl-4-(2,4,6-trimethoxyphenyl)-1,2,3,6-tetrahydro-pyridin bzw. der Carbonsäureester |
| AU5518500A (en) * | 1999-07-29 | 2001-02-19 | Speedel Pharma Ag | 2-alkyl-5-halogen-pent-4-ene carboxylic acids and their production |
-
2002
- 2002-04-26 BR BRPI0209657-9A patent/BR0209657B1/pt active IP Right Grant
- 2002-04-26 US US10/477,739 patent/US7153675B2/en not_active Expired - Fee Related
- 2002-04-26 JP JP2002589694A patent/JP4252803B2/ja not_active Expired - Fee Related
- 2002-04-26 KR KR1020037014874A patent/KR100897597B1/ko not_active Expired - Fee Related
- 2002-04-26 CN CNB028099524A patent/CN1279178C/zh not_active Expired - Fee Related
- 2002-04-26 CA CA2445014A patent/CA2445014C/en not_active Expired - Fee Related
- 2002-04-26 AT AT02735305T patent/ATE458066T1/de active
- 2002-04-26 DE DE60235374T patent/DE60235374D1/de not_active Expired - Lifetime
- 2002-04-26 EP EP02735305A patent/EP1412514B1/en not_active Expired - Lifetime
- 2002-04-26 PT PT02735305T patent/PT1412514E/pt unknown
- 2002-04-26 WO PCT/EP2002/004640 patent/WO2002092828A2/en not_active Ceased
- 2002-04-26 AU AU2002310883A patent/AU2002310883A1/en not_active Abandoned
- 2002-04-26 MX MXPA03010394A patent/MXPA03010394A/es active IP Right Grant
- 2002-04-26 IL IL15858602A patent/IL158586A0/xx active IP Right Grant
-
2003
- 2003-10-23 IL IL158586A patent/IL158586A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BR0209657B1 (pt) | 2014-10-21 |
| US7153675B2 (en) | 2006-12-26 |
| JP2004524860A (ja) | 2004-08-19 |
| CN1520461A (zh) | 2004-08-11 |
| IL158586A (en) | 2008-08-07 |
| JP4252803B2 (ja) | 2009-04-08 |
| CA2445014C (en) | 2011-10-11 |
| PT1412514E (pt) | 2010-04-27 |
| US20040132148A1 (en) | 2004-07-08 |
| DE60235374D1 (de) | 2010-04-01 |
| KR100897597B1 (ko) | 2009-05-14 |
| WO2002092828A3 (en) | 2004-02-26 |
| CN1279178C (zh) | 2006-10-11 |
| BR0209657A (pt) | 2004-04-20 |
| ATE458066T1 (de) | 2010-03-15 |
| EP1412514B1 (en) | 2010-02-17 |
| IL158586A0 (en) | 2004-05-12 |
| KR20040026655A (ko) | 2004-03-31 |
| WO2002092828A2 (en) | 2002-11-21 |
| EP1412514A2 (en) | 2004-04-28 |
| WO2002092828A9 (en) | 2004-05-06 |
| AU2002310883A1 (en) | 2002-11-25 |
| CA2445014A1 (en) | 2002-11-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |