MXPA03007348A - Derivados de quinolina, isoquinolina y ftalazina como antagonistas de la hormona de liberacion de gonadotropina. - Google Patents
Derivados de quinolina, isoquinolina y ftalazina como antagonistas de la hormona de liberacion de gonadotropina.Info
- Publication number
- MXPA03007348A MXPA03007348A MXPA03007348A MXPA03007348A MXPA03007348A MX PA03007348 A MXPA03007348 A MX PA03007348A MX PA03007348 A MXPA03007348 A MX PA03007348A MX PA03007348 A MXPA03007348 A MX PA03007348A MX PA03007348 A MXPA03007348 A MX PA03007348A
- Authority
- MX
- Mexico
- Prior art keywords
- gonadotropin
- isoquinoline
- quinoline
- antagonists
- releasing hormone
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 title 2
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 title 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 title 1
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 title 1
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical class C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2001108271 DE10108271A1 (de) | 2001-02-21 | 2001-02-21 | Chinolin-, Isochinolin- und Phthalazinderivate als Antagonisten des Gonadotropin freisetzenden Hormons |
| US27491401P | 2001-03-13 | 2001-03-13 | |
| PCT/EP2002/001882 WO2002066437A1 (de) | 2001-02-21 | 2002-02-21 | Chinolin-, isochinolin- und phthalazinderivate als antagonisten des gonadotropin freisetzenden hormons |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03007348A true MXPA03007348A (es) | 2003-12-04 |
Family
ID=26008581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03007348A MXPA03007348A (es) | 2001-02-21 | 2002-02-21 | Derivados de quinolina, isoquinolina y ftalazina como antagonistas de la hormona de liberacion de gonadotropina. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1362034A1 (es) |
| JP (1) | JP2004528298A (es) |
| CN (1) | CN1496354A (es) |
| AU (1) | AU2002247737B2 (es) |
| BG (1) | BG108165A (es) |
| BR (1) | BR0207451A (es) |
| CA (1) | CA2438709A1 (es) |
| CZ (1) | CZ20032514A3 (es) |
| HU (1) | HUP0303219A2 (es) |
| IL (1) | IL157303A0 (es) |
| MX (1) | MXPA03007348A (es) |
| NO (1) | NO325675B1 (es) |
| NZ (1) | NZ527597A (es) |
| PL (1) | PL367285A1 (es) |
| RU (1) | RU2280031C2 (es) |
| SK (1) | SK11622003A3 (es) |
| WO (1) | WO2002066437A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014243818B2 (en) * | 2013-03-13 | 2017-04-20 | Flatley Discovery Lab, Llc | Pyridazinone compounds and methods for the treatment of cystic fibrosis |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4120646A1 (de) * | 1991-06-22 | 1992-12-24 | Bayer Ag | 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate |
| CA2229201A1 (en) * | 1995-10-19 | 1997-04-24 | Satoshi Sasaki | Quinoline derivatives, their production and use |
| WO1997044041A1 (en) * | 1996-05-20 | 1997-11-27 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
-
2002
- 2002-02-21 CZ CZ20032514A patent/CZ20032514A3/cs unknown
- 2002-02-21 HU HU0303219A patent/HUP0303219A2/hu unknown
- 2002-02-21 BR BR0207451-6A patent/BR0207451A/pt not_active IP Right Cessation
- 2002-02-21 AU AU2002247737A patent/AU2002247737B2/en not_active Ceased
- 2002-02-21 CN CNA028063597A patent/CN1496354A/zh active Pending
- 2002-02-21 EP EP02716803A patent/EP1362034A1/de not_active Withdrawn
- 2002-02-21 MX MXPA03007348A patent/MXPA03007348A/es active IP Right Grant
- 2002-02-21 RU RU2003128647/04A patent/RU2280031C2/ru not_active IP Right Cessation
- 2002-02-21 NZ NZ527597A patent/NZ527597A/en unknown
- 2002-02-21 JP JP2002565954A patent/JP2004528298A/ja active Pending
- 2002-02-21 SK SK1162-2003A patent/SK11622003A3/sk unknown
- 2002-02-21 WO PCT/EP2002/001882 patent/WO2002066437A1/de not_active Ceased
- 2002-02-21 CA CA002438709A patent/CA2438709A1/en not_active Abandoned
- 2002-02-21 PL PL02367285A patent/PL367285A1/xx not_active Application Discontinuation
- 2002-02-21 IL IL15730302A patent/IL157303A0/xx unknown
-
2003
- 2003-08-20 NO NO20033698A patent/NO325675B1/no not_active IP Right Cessation
- 2003-09-09 BG BG108165A patent/BG108165A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2438709A1 (en) | 2002-08-29 |
| PL367285A1 (en) | 2005-02-21 |
| SK11622003A3 (sk) | 2004-01-08 |
| CN1496354A (zh) | 2004-05-12 |
| BR0207451A (pt) | 2004-06-01 |
| WO2002066437A1 (de) | 2002-08-29 |
| HUP0303219A2 (hu) | 2003-12-29 |
| CZ20032514A3 (cs) | 2004-05-12 |
| IL157303A0 (en) | 2004-02-19 |
| JP2004528298A (ja) | 2004-09-16 |
| NO20033698L (no) | 2003-10-20 |
| NZ527597A (en) | 2004-10-29 |
| EP1362034A1 (de) | 2003-11-19 |
| NO20033698D0 (no) | 2003-08-20 |
| BG108165A (en) | 2004-08-31 |
| RU2003128647A (ru) | 2005-03-27 |
| NO325675B1 (no) | 2008-07-07 |
| AU2002247737B2 (en) | 2006-05-18 |
| RU2280031C2 (ru) | 2006-07-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |