MXPA03004932A - 2-anilino-bencimidazoles sustituidos y su uso como inhibidores de nhe. - Google Patents

2-anilino-bencimidazoles sustituidos y su uso como inhibidores de nhe.

Info

Publication number: MXPA03004932A
Authority: MX; Mexico
Prior art keywords: nhe; benzimidazoles; anilino; inhibitors; substituted
Prior art date: 2000-12-05

Application number

MXPA03004932A

Other languages

English (en)

Inventor

Uwe Heinelt

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-05

Filing date

2001-11-22

Publication date

2003-09-10

2001-11-22 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2003-09-10 Publication of MXPA03004932A publication Critical patent/MXPA03004932A/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Toxicology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Tropical Medicine & Parasitology (AREA)
Gastroenterology & Hepatology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heat Sensitive Colour Forming Recording (AREA)
Plural Heterocyclic Compounds (AREA)

MXPA03004932A 2000-12-05 2001-11-22 2-anilino-bencimidazoles sustituidos y su uso como inhibidores de nhe. MXPA03004932A (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10060292A DE10060292A1 (de)	2000-12-05	2000-12-05	Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament
PCT/EP2001/013586 WO2002046169A1 (de)	2000-12-05	2001-11-22	Substituierte 2-anilino-benzimidazole und ihre verwendung als nhe-inhibitoren

Publications (1)

Publication Number	Publication Date
MXPA03004932A true MXPA03004932A (es)	2003-09-10

Family

ID=7665784

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MXPA03004932A MXPA03004932A (es)	2000-12-05	2001-11-22	2-anilino-bencimidazoles sustituidos y su uso como inhibidores de nhe.

Country Status (24)

Country	Link
US (2)	US6686384B2 (es)
EP (1)	EP1341770B1 (es)
JP (1)	JP4323803B2 (es)
KR (1)	KR20030070045A (es)
CN (1)	CN1478081A (es)
AR (1)	AR032778A1 (es)
AT (1)	ATE329906T1 (es)
AU (1)	AU2002219135A1 (es)
BR (1)	BR0115936A (es)
CA (1)	CA2430412A1 (es)
CZ (1)	CZ20031538A3 (es)
DE (2)	DE10060292A1 (es)
EE (1)	EE200300193A (es)
HR (1)	HRP20030449A2 (es)
HU (1)	HUP0400967A3 (es)
IL (1)	IL156161A0 (es)
MX (1)	MXPA03004932A (es)
NO (1)	NO20032490L (es)
NZ (1)	NZ526250A (es)
PL (1)	PL366305A1 (es)
RU (1)	RU2272031C2 (es)
SK (1)	SK6822003A3 (es)
WO (1)	WO2002046169A1 (es)
ZA (1)	ZA200303932B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
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CN1167686C (zh) *	1999-06-22	2004-09-22	神经研究公司	苯并咪唑衍生物和包括这些化合物的药物组合物
DE10163239A1 (de) *	2001-12-21	2003-07-10	Aventis Pharma Gmbh	Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament
US20030187045A1 (en) *	2001-12-21	2003-10-02	Uwe Heinelt	Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic
DE10304294A1 (de) *	2003-02-04	2004-08-12	Aventis Pharma Deutschland Gmbh	N-Substituierte(Benzoimidazol-2-yl)-phenyl, Verfahren zu ihrer Herstellung , ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US20050054705A1 (en) *	2003-02-04	2005-03-10	Aventis Pharma Deutschland Gmbh	N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE10304374A1 (de) *	2003-02-04	2004-08-05	Aventis Pharma Deutschland Gmbh	Neue substituierte 2-Aminoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10341240A1 (de)	2003-09-08	2005-04-07	Aventis Pharma Deutschland Gmbh	Substituierte Thienoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US7470712B2 (en) *	2004-01-21	2008-12-30	Bristol-Myers Squibb Company	Amino-benzazoles as P2Y1 receptor inhibitors
GB0401334D0 (en) *	2004-01-21	2004-02-25	Novartis Ag	Organic compounds
WO2006078907A1 (en) *	2005-01-20	2006-07-27	Amgen Inc.	2-substituted benzimidazole derivatives as vanilloid receptor ligands and their use in treatments
TWI370820B (en) *	2005-04-27	2012-08-21	Takeda Pharmaceutical	Fused heterocyclic compounds
JP2008543915A (ja)	2005-06-21	2008-12-04	ノイロサーチアクティーゼルスカブ	２−（フェニルアミノ）ベンズイミダゾール誘導体及び低コンダクタンスカルシウム依存性カリウムチャネルのモジュレーターとしてのそれらの使用
TW200804345A (en) *	2005-08-30	2008-01-16	Novartis Ag	Substituted benzimidazoles and methods of preparation
US20100056515A1 (en) *	2006-10-25	2010-03-04	Kazuyoshi Aso	Benzimidazole compounds
US20120088737A2 (en) *	2009-10-02	2012-04-12	Ajinomoto Co., Inc	Novel acyl guanidine derivatives
US8604217B2 (en)	2009-11-12	2013-12-10	Selvita S.A.	Compound, a process for its preparation, a pharmaceutical composition, use of a compound, a method for modulating or regulating serine/threonine kinases and a serine/threonine kinases modulating agent
RU2012120784A (ru) *	2009-11-12	2013-12-20	Селвита С.А.	Соединение, способ его получения, фармацевтическая композиция, применение соединения, способ модулирования или регулирования сериновых/треониновых киназ и средство, модулирующее сериновые/треониновые киназы
CN102060780B (zh)	2010-12-27	2014-11-05	雅本化学股份有限公司	2-(n-取代)-氨基苯并咪唑衍生物的制备方法
CN103435554A (zh) *	2013-09-06	2013-12-11	中国药科大学	2-苯氨基苯并咪唑类化合物及其用途
EP3105210B1 (en) *	2014-02-11	2019-01-30	Bayer Pharma Aktiengesellschaft	Benzimidazol-2-amines as midh1 inhibitors
CN105061324B (zh) *	2015-08-14	2017-09-12	广西师范大学	一种2‑芳基‑1,3‑二氢苯并咪唑衍生物及其合成方法和应用
CN109331014B (zh) *	2018-10-29	2021-06-04	南方医科大学南方医院	一种苯并咪唑衍生物在制备治疗心衰药物中的用途
CN112675169A (zh) *	2020-12-23	2021-04-20	南京景瑞康分子医药科技有限公司	Itm-1b4在制备预防和/或治疗肿瘤药物中的应用
EP4565566A1 (en) *	2022-08-01	2025-06-11	Council of Scientific and Industrial Research, an Indian Registered Body Incorporated under Regn. of Soc. Act (Act XXI of 1860)	Substituted benzimidazoles for treating viral diseases

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GB1171904A (en)	1965-10-21	1969-11-26	Unilever Ltd	Anilinobenzimidazoles having Antibacterial Properties
RU2043344C1 (ru) *	1991-05-20	1995-09-10	Курский Государственный Медицинский Институт	N-2-(1- r1-5-r2-6-r3- бензимидазолил)сукцинаминовые кислоты, проявляющие нейролептическую, антигипоксическую и антиаритмическую активность
DE4328869A1 (de) *	1993-08-27	1995-03-02	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19548812A1 (de) *	1995-12-27	1997-07-03	Hoechst Ag	Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikaments zur Atemstimulation
ES2244979T3 (es)	1995-12-28	2005-12-16	Fujisawa Pharmaceutical Co., Ltd.	Derivados de benzimidazol.
JP2000516958A (ja)	1996-08-26	2000-12-19	ジェネティックス・インスチチュート・インコーポレーテッド	ホスホリパーゼ酵素の阻害剤

2000
- 2000-12-05 DE DE10060292A patent/DE10060292A1/de not_active Ceased
2001
- 2001-11-22 MX MXPA03004932A patent/MXPA03004932A/es unknown
- 2001-11-22 EE EEP200300193A patent/EE200300193A/xx unknown
- 2001-11-22 KR KR10-2003-7007467A patent/KR20030070045A/ko not_active Withdrawn
- 2001-11-22 JP JP2002547908A patent/JP4323803B2/ja not_active Expired - Fee Related
- 2001-11-22 RU RU2003120069/04A patent/RU2272031C2/ru not_active IP Right Cessation
- 2001-11-22 AT AT01999563T patent/ATE329906T1/de not_active IP Right Cessation
- 2001-11-22 SK SK682-2003A patent/SK6822003A3/sk unknown
- 2001-11-22 HR HR20030449A patent/HRP20030449A2/hr not_active Application Discontinuation
- 2001-11-22 NZ NZ526250A patent/NZ526250A/en unknown
- 2001-11-22 PL PL01366305A patent/PL366305A1/xx not_active Application Discontinuation
- 2001-11-22 AU AU2002219135A patent/AU2002219135A1/en not_active Abandoned
- 2001-11-22 WO PCT/EP2001/013586 patent/WO2002046169A1/de not_active Ceased
- 2001-11-22 CZ CZ20031538A patent/CZ20031538A3/cs unknown
- 2001-11-22 EP EP01999563A patent/EP1341770B1/de not_active Expired - Lifetime
- 2001-11-22 CA CA002430412A patent/CA2430412A1/en not_active Abandoned
- 2001-11-22 BR BR0115936-4A patent/BR0115936A/pt not_active IP Right Cessation
- 2001-11-22 DE DE50110181T patent/DE50110181D1/de not_active Expired - Lifetime
- 2001-11-22 HU HU0400967A patent/HUP0400967A3/hu unknown
- 2001-11-22 CN CNA018200443A patent/CN1478081A/zh active Pending
- 2001-11-22 IL IL15616101A patent/IL156161A0/xx unknown
- 2001-12-03 AR ARP010105612A patent/AR032778A1/es unknown
- 2001-12-04 US US10/000,028 patent/US6686384B2/en not_active Expired - Fee Related
2003
- 2003-05-20 US US10/441,124 patent/US6958357B2/en not_active Expired - Fee Related
- 2003-05-21 ZA ZA200303932A patent/ZA200303932B/en unknown
- 2003-06-02 NO NO20032490A patent/NO20032490L/no unknown

Also Published As

Publication number	Publication date
NZ526250A (en)	2004-11-26
NO20032490D0 (no)	2003-06-02
US20030191170A1 (en)	2003-10-09
PL366305A1 (en)	2005-01-24
DE10060292A1 (de)	2002-06-20
JP2004517086A (ja)	2004-06-10
RU2272031C2 (ru)	2006-03-20
WO2002046169A1 (de)	2002-06-13
AU2002219135A1 (en)	2002-06-18
BR0115936A (pt)	2003-10-28
DE50110181D1 (de)	2006-07-27
ZA200303932B (en)	2004-04-15
US6686384B2 (en)	2004-02-03
JP4323803B2 (ja)	2009-09-02
CN1478081A (zh)	2004-02-25
HUP0400967A2 (hu)	2004-08-30
EE200300193A (et)	2003-08-15
HUP0400967A3 (en)	2004-10-28
EP1341770B1 (de)	2006-06-14
AR032778A1 (es)	2003-11-26
SK6822003A3 (en)	2003-11-04
US6958357B2 (en)	2005-10-25
IL156161A0 (en)	2003-12-23
CA2430412A1 (en)	2002-06-13
KR20030070045A (ko)	2003-08-27
ATE329906T1 (de)	2006-07-15
CZ20031538A3 (cs)	2003-09-17
NO20032490L (no)	2003-07-22
EP1341770A1 (de)	2003-09-10
US20020132842A1 (en)	2002-09-19
HRP20030449A2 (en)	2005-04-30

Publication	Publication Date	Title
IL148545A0 (en)	2002-09-12	Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof
ZA200205557B (en)	2003-07-11	4-Aminopicolinates and their use as herbicides.
MXPA03002410A (es)	2003-06-19	4-amino-quinazolinas.
MXPA03004932A (es)	2003-09-10	2-anilino-bencimidazoles sustituidos y su uso como inhibidores de nhe.
AU2001240637A1 (en)	2001-11-22	Novel imidazotriazinones and the use thereof
EG23262A (en)	2004-10-31	Delta -pyrrolines.
MXPA03001591A (es)	2003-09-10	Derivados y analogos de 10-aril-11-h-benzo(b) fluorena para uso medicinal.
MXPA03001877A (es)	2003-06-24	2-guanidin-4-arilquinazolinas.
MXPA03002668A (es)	2003-08-20	Guanidinas de sulfonilo.
GB0031417D0 (en)	2001-02-07	The safeguard
MXPA03005714A (es)	2003-10-06	Sulfamidotienopirimidinas.
MXPA03002411A (es)	2003-06-19	4-amino-quinazolinas.
MXPA03005494A (es)	2003-10-06	Benzoilpiridazinas.
AU2000231564A1 (en)	2001-08-27	Phosphororganic compounds and the use thereof
MXPA03002521A (es)	2004-02-12	Triazol-epotilona.
GB0006787D0 (en)	2000-05-10	The ecotruck
GB0024248D0 (en)	2000-11-15	The unibroom
GB0028055D0 (en)	2001-01-03	The conegro
GB0024885D0 (en)	2000-11-22	The space-finder
GB0007510D0 (en)	2000-05-17	D.o.t.t.s
ZA200302241B (en)	2004-03-23	Triazolo-epothilones.
GB0028898D0 (en)	2001-01-10	The sunguard
GB0018537D0 (en)	2000-09-13	The stairbag
GB0022920D0 (en)	2000-11-01	The bricky
GB0007040D0 (en)	2000-05-10	The footwarmer