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MXPA03003952A - Metodo para producir complejo sacaridico de hierro hematinico y producto producido. - Google Patents

Metodo para producir complejo sacaridico de hierro hematinico y producto producido.

Info

Publication number
MXPA03003952A
MXPA03003952A MXPA03003952A MXPA03003952A MXPA03003952A MX PA03003952 A MXPA03003952 A MX PA03003952A MX PA03003952 A MXPA03003952 A MX PA03003952A MX PA03003952 A MXPA03003952 A MX PA03003952A MX PA03003952 A MXPA03003952 A MX PA03003952A
Authority
MX
Mexico
Prior art keywords
complex
iron
saccharidic
hematinic
analytical
Prior art date
Application number
MXPA03003952A
Other languages
English (en)
Inventor
Robert A Mateer
Original Assignee
Chromaceutical Advanced Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chromaceutical Advanced Tech filed Critical Chromaceutical Advanced Tech
Publication of MXPA03003952A publication Critical patent/MXPA03003952A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se describe un metodo para separar y purificar la especie hematinica activa presente en complejos sacaridicos de hierro que comprenden complejo de gluconato ferrico de sodio en sacarosa, complejo de hidroxido ferrico-sacarosa y complejo de sacarato ferrico y otros de forma y funcion similar, tomando como base la separacion del complejo sacaridico de hierro de uno o mas excipientes y, de preferencia liofilizacion. La separacion del complejo sacaridico de hierro permite su cuantificacion analitica; la concentracion o purificacion adicional como un producto novedoso y util; preparacion de formulaciones redisenadas para compuestos farmaceuticos novedosos y utiles; y/o liofilizacion. La capacidad para separar el complejo sacaridico de hierro responsable de la funcion hematinica, incluyendo su forma liofilizada, tambien provee medios para preparar material analitico para verificar y validar su integridad farmacologica, seguridad hacia el paciente y desempeno clinico, asi como el monitoreo analitico, estandarizacion de dispersion de control de calidad con respecto a los procedimientos de fabricacion de hematinicos y el establecimiento de normas para ser utilizadas con el mismo.
MXPA03003952A 2000-11-02 2001-10-31 Metodo para producir complejo sacaridico de hierro hematinico y producto producido. MXPA03003952A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24526900P 2000-11-02 2000-11-02
PCT/US2001/045205 WO2002056826A2 (en) 2000-11-02 2001-10-31 Method for producing purified hematinic iron-saccharidic complex and product produced

Publications (1)

Publication Number Publication Date
MXPA03003952A true MXPA03003952A (es) 2004-09-10

Family

ID=22925992

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03003952A MXPA03003952A (es) 2000-11-02 2001-10-31 Metodo para producir complejo sacaridico de hierro hematinico y producto producido.

Country Status (12)

Country Link
US (3) US6537820B2 (es)
EP (2) EP2275075A3 (es)
JP (2) JP4369120B2 (es)
CN (1) CN1473265B (es)
AU (1) AU2002246556B2 (es)
BR (1) BR0115100A (es)
CA (1) CA2426799A1 (es)
MX (1) MXPA03003952A (es)
PL (1) PL361980A1 (es)
RU (1) RU2259197C2 (es)
WO (1) WO2002056826A2 (es)
ZA (1) ZA200303284B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6929954B2 (en) * 2000-11-02 2005-08-16 Chromaceutical Advanced Technologies, Inc. Method for producing purified hematinic iron-saccharidic complex and product produced
PL361980A1 (en) * 2000-11-02 2004-10-18 Chromaceutical Advanced Technologies Inc. Method for producing purified hematinic iron-saccharidic complex and product produced
US6693211B2 (en) 2002-05-15 2004-02-17 Geneva Pharmaceuticals, Inc. Chemical process
US7169359B2 (en) * 2002-08-26 2007-01-30 Luitpold Pharmaceuticals, Inc. Bioequivalence test for iron-containing formulations
DE10249552A1 (de) 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
US20040092735A1 (en) * 2002-11-08 2004-05-13 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of cefuroxime sodium
US20040161852A1 (en) * 2003-02-14 2004-08-19 Anderson Christopher G. Method of assaying an Fe-Sugar complex
US7964568B2 (en) * 2003-05-30 2011-06-21 Chromaceutical Advanced Technologies, Inc. Synthesis of high molecular weight iron-saccharidic complexes
WO2005094202A2 (en) * 2004-03-16 2005-10-13 Navinta, Llc Iron sucrose complexes and method of manufacture thereof
US7179939B2 (en) * 2004-03-16 2007-02-20 Navinta Llc Sodium ferric gluconate complexes and method of manufacture thereof
EP1756130A1 (de) * 2004-05-17 2007-02-28 Cilag AG Verfahren zur herstellung von eisen (iii) gluconatkomlex
WO2006017263A1 (en) 2004-07-12 2006-02-16 Taro Pharmaceutical Industries Ltd. Topical gel formulation comprising organophosphate insecticide and its preparation thereof
US8158139B2 (en) * 2004-07-12 2012-04-17 Taro Pharmaceuticals North America, Inc. Topical gel formulation comprising organophosphate insecticide and preparation thereof
US20060046964A1 (en) * 2004-09-02 2006-03-02 Andre Morneau Pharmaceutical formulations and methods
CN100528237C (zh) * 2005-04-26 2009-08-19 重庆医药工业研究院有限责任公司 多核的氢氧化铁-糖复合物的制备方法
US7560445B2 (en) 2005-07-06 2009-07-14 Taro Pharmaceuticals North America, Inc. Process for preparing malathion for pharmaceutical use
US20080132465A1 (en) * 2006-12-05 2008-06-05 Vincent Windisch Apparatus and method for isolating iron components from serum
JP5568551B2 (ja) * 2008-05-23 2014-08-06 ホスピラ・インコーポレイテツド 包装済み鉄スクロース製品
WO2010086832A2 (en) * 2009-01-30 2010-08-05 Ecolab Inc. Development of an aluminum hydroxycarboxylate builder
US8202830B2 (en) 2009-01-30 2012-06-19 Ecolab Usa Inc. Development of an aluminum hydroxydicarboxylate builder
US8536106B2 (en) 2010-04-14 2013-09-17 Ecolab Usa Inc. Ferric hydroxycarboxylate as a builder
JP6109733B2 (ja) * 2011-03-22 2017-04-05 積水メディカル株式会社 液体クロマトグラフィー用カラム及びヘモグロビン類の分析方法
GB201304631D0 (en) * 2013-03-14 2013-05-01 Malvern Instr Ltd Monomer detection in protein separation
CN103626807B (zh) * 2013-11-20 2017-07-07 青岛国风药业股份有限公司 一种多糖铁复合物的制备方法及其质量检测方法
US20180231511A1 (en) * 2015-08-18 2018-08-16 Shimadzu Corporation Detector for liquid chromatography
US10258647B2 (en) 2015-09-01 2019-04-16 Particle Dynamics International, Llc Iron-polysaccharide complexes and methods for the preparation thereof
CN107545077A (zh) * 2016-06-23 2018-01-05 中国石油化工股份有限公司 判断二元液液互溶性的方法及装置
CN110476031A (zh) * 2017-04-04 2019-11-19 日东电工株式会社 冷冻干燥体的制造方法及其制造装置
CN109959628B (zh) * 2019-04-29 2020-08-14 中南大学 一种基于极-光谱融合的锌溶液杂质离子浓度检测方法
CN119493134B (zh) * 2024-10-18 2025-08-05 中国科学院合肥物质科学研究院 基于铁原子共振荧光探测临近空间风场、温度和密度的方法及星载铁激光雷达
CN119666963A (zh) * 2024-12-31 2025-03-21 南京明捷生物医药检测有限公司 一种测定羧基麦芽糖铁注射液中二价铁含量的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3275514A (en) 1960-04-12 1966-09-27 Paul D Saltman Process for introduction of metals into the mammalian system
US3367834A (en) 1965-05-04 1968-02-06 Dexter Martin Method and compositions for enhancing the utilization of iron by mammals
US3686397A (en) 1970-05-18 1972-08-22 Mueller Arthur Parenteral iron preparations
US3821192A (en) * 1971-08-18 1974-06-28 Central Pharmacal Co Process for preparing an iron-saccharide complex
SE359447B (es) 1971-10-06 1973-09-03 Astra Laekemedel Ab
US4058621A (en) 1975-02-24 1977-11-15 Peter, Strong & Company, Inc. Iron complexes and foodstuffs containing them
GB1562913A (en) 1976-06-16 1980-03-19 Fisons Ltd Fractionating fluid mixtures of dextrans
US4180567A (en) 1977-09-02 1979-12-25 Pharmachem Corporation Iron preparations and methods of making and administering the same
US4226983A (en) 1977-09-29 1980-10-07 United Kingdom Atomic Energy Authority Preparation of metal complexes
US4370476A (en) 1979-07-17 1983-01-25 Usher Thomas C Dextran polycarboxylic acids, ferric hydroxide complexes
DE3422249A1 (de) 1984-06-15 1985-12-19 Pfeifer & Langen, 5000 Köln Wasserloesliches eisendextran und verfahren zu seiner herstellung
US5746999A (en) * 1984-11-23 1998-05-05 Schering Aktiengesellschaft Magnetic particles for diagnostic purposes
US5254474A (en) 1991-02-25 1993-10-19 The United States Of America As Represented By The Secretary Of The Army Method of assessing thermal processing of food using intrinsically-created compounds
US5624668A (en) * 1995-09-29 1997-04-29 Luitpold Pharmaceuticals, Inc. Iron dextran formulations
AU1117497A (en) * 1995-11-13 1997-06-05 Albany Medical College Analgesic compounds and uses thereof
DE19734293A1 (de) * 1997-08-08 1999-02-11 Boehringer Mannheim Gmbh Verwendung von pharmazeutischen Kombinationspräparaten enthaltend Erythropoietin und Eisenpräparate zur Behandlung von rheumatischen Erkrankungen
US6122836A (en) 1998-05-07 2000-09-26 S.P. Industries, Inc., The Virtis Division Freeze drying apparatus and method employing vapor flow monitoring and/or vacuum pressure control
CN1257931A (zh) * 1998-12-18 2000-06-28 吴光耀 一种可用于人体补铁的铁蛋白及其制备方法和应用
PL361980A1 (en) * 2000-11-02 2004-10-18 Chromaceutical Advanced Technologies Inc. Method for producing purified hematinic iron-saccharidic complex and product produced
PE20021017A1 (es) * 2001-04-03 2002-11-24 Pharmacia Corp Composicion parenteral reconstituible

Also Published As

Publication number Publication date
US20040220141A1 (en) 2004-11-04
RU2003116134A (ru) 2005-01-10
US6773924B2 (en) 2004-08-10
EP1330226A2 (en) 2003-07-30
US20020076821A1 (en) 2002-06-20
AU2002246556B2 (en) 2006-06-01
WO2002056826A3 (en) 2003-02-06
RU2259197C2 (ru) 2005-08-27
CN1473265A (zh) 2004-02-04
US6939715B2 (en) 2005-09-06
US20030153086A1 (en) 2003-08-14
EP1330226A4 (en) 2005-11-23
ZA200303284B (en) 2003-11-04
EP2275075A3 (en) 2011-08-10
BR0115100A (pt) 2003-09-30
US6537820B2 (en) 2003-03-25
CA2426799A1 (en) 2002-07-25
CN1473265B (zh) 2011-10-12
EP2275075A2 (en) 2011-01-19
WO2002056826A2 (en) 2002-07-25
JP4369120B2 (ja) 2009-11-18
JP2009137993A (ja) 2009-06-25
PL361980A1 (en) 2004-10-18
JP2004526132A (ja) 2004-08-26

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