MXPA03002817A - Novedosos 1,2,4-trioxanos sustituidos, utiles como agentes antimalanicos y un procedimiento para su preparacion. - Google Patents
Novedosos 1,2,4-trioxanos sustituidos, utiles como agentes antimalanicos y un procedimiento para su preparacion.Info
- Publication number
- MXPA03002817A MXPA03002817A MXPA03002817A MXPA03002817A MXPA03002817A MX PA03002817 A MXPA03002817 A MX PA03002817A MX PA03002817 A MXPA03002817 A MX PA03002817A MX PA03002817 A MXPA03002817 A MX PA03002817A MX PA03002817 A MXPA03002817 A MX PA03002817A
- Authority
- MX
- Mexico
- Prior art keywords
- trioxanes
- preparation
- useful
- phenyl
- antimalarial
- Prior art date
Links
- 150000004903 1,2,4-trioxanes Chemical class 0.000 title abstract 2
- 239000003430 antimalarial agent Substances 0.000 title abstract 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical class C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 abstract 2
- 230000000078 anti-malarial effect Effects 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- SUHVYOVBIAQZBU-UHFFFAOYSA-N bicyclo[2.2.1]heptane;cycloheptane Chemical class C1CC2CCC1C2.C1CCCCCC1 SUHVYOVBIAQZBU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000001934 cyclohexanes Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
- C07D323/04—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invencion se refiere a una novedosa serie de analogos de 1,2,4-trioxanos antimalaricoc de formula general 7, (ver formula) en donde R representa grupos cicloalquilo seleccionados de los grupos que constan de ciclopentilo, ciclohexilo, cicloheptilo y ciclooctilo o grupos arilo seleccionados de fenilo, 4-bromofenilo y 4-clorofenilo, R1 y R2 representan hidrogeno, grupo alquilo seleccionado de metilo, etilo, propilo y decilo, arilo seleccionado de fenilo o partes de sistemas ciclicos tales como ciclopentano, ciclohexano, ciclohexano sustituido, cicloheptano biciclo (2.2.1) heptano, adamantano y su preparacion; varios de estos novedosos compuestos muestran actividad antimalarica prometedora contra malaria resistente a farmacos multiples en ratones.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2002/000093 WO2003082852A1 (en) | 2002-03-28 | 2002-03-28 | Novel substituted 1,2,4-trioxanes useful as antimalarial agents and a process for the preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03002817A true MXPA03002817A (es) | 2004-05-17 |
Family
ID=28460467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03002817A MXPA03002817A (es) | 2002-03-28 | 2002-03-28 | Novedosos 1,2,4-trioxanos sustituidos, utiles como agentes antimalanicos y un procedimiento para su preparacion. |
Country Status (8)
| Country | Link |
|---|---|
| KR (1) | KR100932997B1 (es) |
| CN (1) | CN100455577C (es) |
| AU (1) | AU2002249561A1 (es) |
| BR (1) | BR0205828A (es) |
| MX (1) | MXPA03002817A (es) |
| MY (1) | MY140860A (es) |
| PE (1) | PE20040604A1 (es) |
| WO (1) | WO2003082852A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007077479A1 (en) | 2005-12-30 | 2007-07-12 | Council Of Scientific And Industrial Research | Spiro-1,2,4-trioxanes as antimalarial agents |
| WO2008038299A1 (en) * | 2006-09-29 | 2008-04-03 | Council Of Scientific & Industrial Research | Substituted 6-(1-aryl ethyl)-i, 2, 4-trioxanes |
| WO2008099415A1 (en) * | 2007-02-13 | 2008-08-21 | Council Of Scientific & Industrial Research | Novel substituted bis-1, 2, 4-trioxanes and a process for preparation thereof |
| AP2633A (en) * | 2008-03-26 | 2013-04-03 | Council Scient Ind Res | Novel hydroxy functionalized 1,2,4-trioxanes as antimalarial agents and a process for the preparation thereof. |
| EP2505583A1 (en) * | 2011-03-29 | 2012-10-03 | Centre National de la Recherche Scientifique | Total synthesis of redox-active 1.4-naphthoquinones and their metabolites and their therapeutic use as antimalarial and schistomicidal agents |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316493B1 (en) * | 1999-12-28 | 2001-11-13 | Council Of Scientific And Industrial Research | Substituted 1,2,4-trioxanes as antimalarial agents and a process of producing the substituted 1,2,4-trioxanes |
-
2002
- 2002-03-28 WO PCT/IN2002/000093 patent/WO2003082852A1/en not_active Ceased
- 2002-03-28 AU AU2002249561A patent/AU2002249561A1/en not_active Abandoned
- 2002-03-28 MX MXPA03002817A patent/MXPA03002817A/es active IP Right Grant
- 2002-03-28 KR KR1020037004606A patent/KR100932997B1/ko not_active Expired - Fee Related
- 2002-03-28 CN CNB028025237A patent/CN100455577C/zh not_active Expired - Fee Related
- 2002-03-28 BR BR0205828-6A patent/BR0205828A/pt not_active Application Discontinuation
-
2003
- 2003-03-28 PE PE2003000318A patent/PE20040604A1/es not_active Application Discontinuation
- 2003-03-28 MY MYPI20031149A patent/MY140860A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100932997B1 (ko) | 2009-12-21 |
| BR0205828A (pt) | 2004-06-29 |
| KR20040094597A (ko) | 2004-11-10 |
| CN1487930A (zh) | 2004-04-07 |
| PE20040604A1 (es) | 2004-09-18 |
| WO2003082852A1 (en) | 2003-10-09 |
| AU2002249561A1 (en) | 2003-10-13 |
| CN100455577C (zh) | 2009-01-28 |
| MY140860A (en) | 2010-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |