AP1546A - Novel substituted 1,2,4-trioxanes, useful as antimalarial agents, and a process for the preparation thereof. - Google Patents
Novel substituted 1,2,4-trioxanes, useful as antimalarial agents, and a process for the preparation thereof.Info
- Publication number
- AP1546A AP1546A APAP/P/2003/002772A AP2003002772A AP1546A AP 1546 A AP1546 A AP 1546A AP 2003002772 A AP2003002772 A AP 2003002772A AP 1546 A AP1546 A AP 1546A
- Authority
- AP
- ARIPO
- Prior art keywords
- trioxanes
- preparation
- phenyl
- useful
- antimalarial
- Prior art date
Links
- 150000004903 1,2,4-trioxanes Chemical class 0.000 title abstract 2
- 239000003430 antimalarial agent Substances 0.000 title abstract 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N Cyclopentane Chemical compound C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical class C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 abstract 2
- 230000000078 anti-malarial effect Effects 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 abstract 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- SUHVYOVBIAQZBU-UHFFFAOYSA-N bicyclo[2.2.1]heptane;cycloheptane Chemical class C1CC2CCC1C2.C1CCCCCC1 SUHVYOVBIAQZBU-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000001934 cyclohexanes Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- DMEGYFMYUHOHGS-UHFFFAOYSA-N heptamethylene Natural products C1CCCCCC1 DMEGYFMYUHOHGS-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms
- C07D323/04—Six-membered rings
- C07D323/06—Trioxane
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
In the present invention relates to a novel series of antimalarial 1,2,4-trioxanes analogues of general formula 7, wherein R represents cycloalkyl groups selected from the groups consisting of cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl or aryl groups selected from phenyl, 4-bromophenyl and 4-chlorophenyl, R1 and R2 represent hydrogen, alkyl group selected from methyl, ethyl, propyl and decyl, aryl selected from phenyl or parts of a cyclic systems such as cyclopentane, cyclohexane, substituted cyclohexane, cycloheptane bicyclo (2.2.1) heptane, adamantane and its preparation thereof; several of these novel compounds show promising antimalarial activity against multidrug resistant malaria in mice.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| APAP/P/2003/002772A AP1546A (en) | 2002-03-28 | 2002-03-28 | Novel substituted 1,2,4-trioxanes, useful as antimalarial agents, and a process for the preparation thereof. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| APAP/P/2003/002772A AP1546A (en) | 2002-03-28 | 2002-03-28 | Novel substituted 1,2,4-trioxanes, useful as antimalarial agents, and a process for the preparation thereof. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP2003002772A0 AP2003002772A0 (en) | 2003-03-31 |
| AP1546A true AP1546A (en) | 2006-01-13 |
Family
ID=28047132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/2003/002772A AP1546A (en) | 2002-03-28 | 2002-03-28 | Novel substituted 1,2,4-trioxanes, useful as antimalarial agents, and a process for the preparation thereof. |
Country Status (1)
| Country | Link |
|---|---|
| AP (1) | AP1546A (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316493B1 (en) * | 1999-12-28 | 2001-11-13 | Council Of Scientific And Industrial Research | Substituted 1,2,4-trioxanes as antimalarial agents and a process of producing the substituted 1,2,4-trioxanes |
-
2002
- 2002-03-28 AP APAP/P/2003/002772A patent/AP1546A/en active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316493B1 (en) * | 1999-12-28 | 2001-11-13 | Council Of Scientific And Industrial Research | Substituted 1,2,4-trioxanes as antimalarial agents and a process of producing the substituted 1,2,4-trioxanes |
Non-Patent Citations (3)
| Title |
|---|
| BIOORGANIC & MEDICINAL CHEMISTRY LETTERS OXFORD GB; * |
| BIORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 2, no. 5, 1992 pp. 497-500; * |
| TETRAHEDRON LETTERS, vol. 31, no. 47, 1990, pp. 6901-6902; * |
Also Published As
| Publication number | Publication date |
|---|---|
| AP2003002772A0 (en) | 2003-03-31 |
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