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MXPA03000226A - Diagnosticos tempranos de enfermedades conformacionales. - Google Patents

Diagnosticos tempranos de enfermedades conformacionales.

Info

Publication number
MXPA03000226A
MXPA03000226A MXPA03000226A MXPA03000226A MXPA03000226A MX PA03000226 A MXPA03000226 A MX PA03000226A MX PA03000226 A MXPA03000226 A MX PA03000226A MX PA03000226 A MXPA03000226 A MX PA03000226A MX PA03000226 A MXPA03000226 A MX PA03000226A
Authority
MX
Mexico
Prior art keywords
diseases
conformational diseases
early diagnosis
conformational
pathogenic conformer
Prior art date
Application number
MXPA03000226A
Other languages
English (en)
Inventor
Claudio Soto
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of MXPA03000226A publication Critical patent/MXPA03000226A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describe un metodo para el diagnostico o deteccion de enfermedades conformacionales, poniendo a prueba un marcador, es decir, el conformador patogenico de dichas enfermedades en una muestra, cuyo metodo comprende un sistema de amplificacion ciclica para incrementar los niveles del conformador patogenico que causa dichas enfermedades; en particular, dichas enfermedades conformacionales transmisibles pueden ser encefalopatias causadas por priones; se describen tambien pruebas, equipos de diagnostico y aparatos basados en dichos metodos.
MXPA03000226A 2000-07-07 2001-06-13 Diagnosticos tempranos de enfermedades conformacionales. MXPA03000226A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00114650 2000-07-07
EP00127892 2000-12-20
EP01102732 2001-02-07
PCT/GB2001/002584 WO2002004954A2 (en) 2000-07-07 2001-06-13 Early diagnosis of conformational diseases

Publications (1)

Publication Number Publication Date
MXPA03000226A true MXPA03000226A (es) 2004-05-21

Family

ID=27223071

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03000226A MXPA03000226A (es) 2000-07-07 2001-06-13 Diagnosticos tempranos de enfermedades conformacionales.

Country Status (30)

Country Link
US (1) US7351526B2 (es)
EP (2) EP1299729B1 (es)
JP (1) JP4790966B2 (es)
KR (1) KR100764981B1 (es)
CN (1) CN1221807C (es)
AR (1) AR029583A1 (es)
AT (2) ATE335204T1 (es)
AU (2) AU6408901A (es)
BG (1) BG66272B1 (es)
BR (1) BRPI0112262B8 (es)
CA (1) CA2413078C (es)
CY (1) CY1109106T1 (es)
CZ (1) CZ304365B6 (es)
DE (2) DE60121958T2 (es)
DK (2) DK1299729T3 (es)
EA (1) EA007391B1 (es)
EE (1) EE05675B1 (es)
ES (2) ES2264691T3 (es)
HR (1) HRP20030033B1 (es)
HU (1) HU228813B1 (es)
IL (2) IL153824A0 (es)
MX (1) MXPA03000226A (es)
NO (1) NO331624B1 (es)
NZ (1) NZ523213A (es)
PL (1) PL211154B1 (es)
PT (2) PT1712920E (es)
RS (1) RS51523B (es)
SI (2) SI1299729T1 (es)
SK (1) SK287768B6 (es)
WO (1) WO2002004954A2 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1373904A1 (de) * 2001-03-13 2004-01-02 Eigen, Manfred, Prof. Dr. Verfahren zur verstärkung der bildung von aggregaten aus proteinuntereinheiten
WO2002097444A2 (en) * 2001-05-31 2002-12-05 Arete Associates Misfolded protein sensor method
US20050026165A1 (en) 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
CA2525517C (en) 2003-06-19 2016-05-31 Applied Research Systems Ars Holding N.V. Use of prion conversion modulating agents
DE10328125A1 (de) * 2003-06-23 2005-01-13 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach spontaner Transformationsreaktion
DE10328830A1 (de) * 2003-06-26 2005-01-20 Roche Diagnostics Gmbh Nachweis von Protease-resistentem Prion-Protein nach asymmetrischer Interaktion
WO2005010533A2 (en) * 2003-07-31 2005-02-03 Hadasit Medical Research Services & Development Ltd. Methods and kits for the detection of prion diseases
KR101166012B1 (ko) 2003-08-13 2012-07-23 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 프리온-특이적 펩티드 시약
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP4568840B2 (ja) * 2004-12-28 2010-10-27 国立大学法人金沢大学 アルツハイマー病の検査方法
WO2006088823A2 (en) * 2005-02-15 2006-08-24 Adlyfe, Inc. Method for detecting misfolded proteins and prions
JP2008537155A (ja) * 2005-04-20 2008-09-11 ボード オブ リージェンツ ザ ユニバーシティー オブ テキサス システム 自動化タンパク質異常折り畳みの周期的増幅によるプリオンの超高感度検出
EP1731911A1 (fr) 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Procédé utile pour la détection d'encéphalopathies
DE102005031429A1 (de) * 2005-07-04 2007-01-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur selektiven Bestimmung pathologischer Proteinablagerungen
WO2007030804A1 (en) 2005-09-09 2007-03-15 Novartis Ag Prion-specific peptoid reagents
US20070281367A1 (en) 2006-05-03 2007-12-06 Applera Corporation Methods, Compositions, and Kits for Quantitating Antibodies
EP2156181B1 (en) 2006-07-28 2015-11-04 Adlyfe, Inc. Peptide probes for diagnostics and therapeutics
WO2008030973A2 (en) * 2006-09-06 2008-03-13 The Board Of Regents Of The University Of Texas System Methods and compositions for the detection of protein folding disorders
EP2179293B1 (en) * 2007-07-20 2014-09-03 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Detection of infectious prion protein by seeded conversion of recombinant prion protein
FR2929290B1 (fr) * 2008-03-27 2010-05-07 Lfb Biotechnologies Methode de detection et/ou de titrage in vitro d'un agent transmissible non conventionnel
US20110124843A1 (en) 2008-05-28 2011-05-26 Incorporated Administrative Agency National Agriculture And Food Research Organization Method for efficiently amplifying abnormal prion protein derived from bse
JP5209711B2 (ja) 2008-05-28 2013-06-12 独立行政法人農業・食品産業技術総合研究機構 羊スクレイピー由来異常プリオン蛋白質の効率的増幅方法
ITMI20081052A1 (it) * 2008-06-10 2009-12-11 Univ Milano Bicocca Liposomi in grado di legare efficacemente il peptide beta-amiloide
FR2935711A1 (fr) * 2008-09-05 2010-03-12 Lfb Biotechnologies Clone cellulaire stable exprimant un prion
JP2013510297A (ja) * 2009-11-04 2013-03-21 ノバルティス アーゲー モノマーからのタンパク質凝集体の分離における結合試薬としての正に荷電した種
US10215763B2 (en) * 2010-05-18 2019-02-26 Board Of Regents Of The University Of Texas System Methods for estimating prion concentration in fluids and tissue by quantitative PMCA
IT1405762B1 (it) 2010-11-25 2014-01-24 Icgeb Proteine ricombinanti con attivita' di inattivazione selettiva di proteine bersaglio
CA2824863A1 (en) * 2011-01-18 2012-07-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for amplification and detection of prions
FR2973114A1 (fr) 2011-03-21 2012-09-28 Ets Francais Du Sang Nanobilles recouvertes de plasminogene comme support direct d'amplification cyclique de la proteine prion prpsc
WO2013056841A1 (en) 2011-10-19 2013-04-25 Inra (Institut National De La Recherche Agronomique) A method for diagnosing tse
WO2015160007A1 (ko) * 2014-04-17 2015-10-22 한림대학교 산학협력단 극미량 병원성 프리온 단백질 검출방법 및 장치
SG10202008464UA (en) 2014-09-11 2020-10-29 Univ Texas Detection of misfolded proteins
WO2016040903A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded amyloid beta protein
WO2016040905A1 (en) 2014-09-11 2016-03-17 Board Of Regents Of The University Of Texas System Detection of misfolded alpha synuclein protein
US10359434B2 (en) 2014-10-22 2019-07-23 Colorado State University Research Foundation In vitro detection of prions in blood
WO2016149537A1 (en) 2015-03-17 2016-09-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bank vole prion protein as a broad-spectrum substrate for rt-quic-based detection and discrimination of prion strains
WO2018213440A1 (en) 2017-05-16 2018-11-22 Amprion, Inc. Detection of misfolded tau protein
US20190353669A1 (en) * 2018-05-16 2019-11-21 Amprion, Inc. Detection of Brain Injury or Neurological Disease using Tau Protein
IL317123A (en) 2018-08-27 2025-01-01 Regeneron Pharma Using Raman Spectroscopy for Downstream Purification
US11598783B1 (en) 2019-10-23 2023-03-07 Colorado State University Research Foundation In vitro detection of prions
WO2021198098A1 (en) 2020-04-03 2021-10-07 Universität Zürich Improved method of detecting biomarkers in a biological sample

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262332A (en) * 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5616871A (en) * 1995-09-28 1997-04-01 Drummond Scientific Company Pipet gun assembly
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
EP0934531B1 (en) * 1996-10-15 2004-08-04 D-Gen Limited Diagnosis of spongiform encephalopathy
EP1210110A4 (en) * 1999-06-29 2003-03-19 Univ Mcgill PRION PROTEIN BINDING PROTEINS, AND USES THEREOF
EP1238290A1 (en) * 1999-12-10 2002-09-11 Misonix Incorporated Ultrasonic horn assembly
JP2008537155A (ja) * 2005-04-20 2008-09-11 ボード オブ リージェンツ ザ ユニバーシティー オブ テキサス システム 自動化タンパク質異常折り畳みの周期的増幅によるプリオンの超高感度検出

Also Published As

Publication number Publication date
WO2002004954A3 (en) 2002-10-24
BG66272B1 (bg) 2012-11-30
PT1299729E (pt) 2006-10-31
DK1712920T3 (da) 2009-05-11
IL153824A (en) 2010-02-17
SI1299729T1 (sl) 2006-10-31
CN1221807C (zh) 2005-10-05
EA007391B1 (ru) 2006-10-27
HUP0301020A2 (hu) 2003-07-28
DE60121958T2 (de) 2007-02-01
EP1712920B1 (en) 2009-03-25
AU2001264089B2 (en) 2006-03-30
ATE426816T1 (de) 2009-04-15
HK1058065A1 (en) 2004-04-30
CZ200336A3 (cs) 2003-06-18
DK1299729T3 (da) 2006-12-04
NO20030059D0 (no) 2003-01-06
PT1712920E (pt) 2009-04-09
YU101202A (sh) 2006-01-16
US7351526B2 (en) 2008-04-01
NO20030059L (no) 2003-03-07
RS51523B (sr) 2011-06-30
HU228813B1 (en) 2013-05-28
SI1712920T1 (sl) 2009-10-31
WO2002004954A2 (en) 2002-01-17
JP2004503748A (ja) 2004-02-05
CA2413078C (en) 2010-08-03
ES2322660T3 (es) 2009-06-24
AU6408901A (en) 2002-01-21
CA2413078A1 (en) 2002-01-17
EP1712920A1 (en) 2006-10-18
ATE335204T1 (de) 2006-08-15
NO331624B1 (no) 2012-02-06
BRPI0112262B8 (pt) 2021-07-27
EE200300005A (et) 2004-08-16
IL153824A0 (en) 2003-07-31
EP1299729B1 (en) 2006-08-02
KR20030036257A (ko) 2003-05-09
CZ304365B6 (cs) 2014-04-02
SK287768B6 (sk) 2011-09-05
CY1109106T1 (el) 2014-07-02
AR029583A1 (es) 2003-07-02
BG107498A (bg) 2003-11-28
SK18582002A3 (sk) 2003-05-02
CN1449497A (zh) 2003-10-15
NZ523213A (en) 2005-01-28
PL360397A1 (en) 2004-09-06
KR100764981B1 (ko) 2007-10-09
DE60121958D1 (de) 2006-09-14
EE05675B1 (et) 2013-08-15
JP4790966B2 (ja) 2011-10-12
US20050064505A1 (en) 2005-03-24
HUP0301020A3 (en) 2010-03-29
PL211154B1 (pl) 2012-04-30
EP1299729A2 (en) 2003-04-09
ES2264691T3 (es) 2007-01-16
DE60138146D1 (de) 2009-05-07
HRP20030033B1 (hr) 2008-04-30
EA200300126A1 (ru) 2003-06-26
BRPI0112262B1 (pt) 2016-08-09
BR0112262A (pt) 2003-05-20
HRP20030033A2 (en) 2004-02-29

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