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MXPA02009888A - Procedimiento novedoso para la sintesis de esteres de n-(s)-1- carboxibutil)-(s)-alanina y la aplicacion en la sintesis de perindopril. - Google Patents

Procedimiento novedoso para la sintesis de esteres de n-(s)-1- carboxibutil)-(s)-alanina y la aplicacion en la sintesis de perindopril.

Info

Publication number
MXPA02009888A
MXPA02009888A MXPA02009888A MXPA02009888A MXPA02009888A MX PA02009888 A MXPA02009888 A MX PA02009888A MX PA02009888 A MXPA02009888 A MX PA02009888A MX PA02009888 A MXPA02009888 A MX PA02009888A MX PA02009888 A MXPA02009888 A MX PA02009888A
Authority
MX
Mexico
Prior art keywords
synthesis
perindopril
carboxybutyl
alanine esters
alanine
Prior art date
Application number
MXPA02009888A
Other languages
English (en)
Inventor
Alain Renaud
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of MXPA02009888A publication Critical patent/MXPA02009888A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

El procedimiento estereoselctivo para la sintesis industrial de los compuestos de la formula (I): (ver formula) en donde R representa un grupo de alquilo de (C1-C6) lineal o ramificado. La aplicacion en la sintesis del perindopril y las sales farmaceuticamente aceptables del mismo.
MXPA02009888A 2000-04-11 2001-04-10 Procedimiento novedoso para la sintesis de esteres de n-(s)-1- carboxibutil)-(s)-alanina y la aplicacion en la sintesis de perindopril. MXPA02009888A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004610A FR2807430B1 (fr) 2000-04-11 2000-04-11 Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril
PCT/FR2001/001088 WO2001056972A1 (fr) 2000-04-11 2001-04-10 Nouveau procede de synthese des esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (1)

Publication Number Publication Date
MXPA02009888A true MXPA02009888A (es) 2004-09-06

Family

ID=8849107

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02009888A MXPA02009888A (es) 2000-04-11 2001-04-10 Procedimiento novedoso para la sintesis de esteres de n-(s)-1- carboxibutil)-(s)-alanina y la aplicacion en la sintesis de perindopril.

Country Status (35)

Country Link
US (1) US6774259B2 (es)
EP (1) EP1272454B1 (es)
JP (1) JP3872344B2 (es)
KR (1) KR100520700B1 (es)
CN (1) CN1176903C (es)
AP (1) AP1417A (es)
AR (1) AR027782A1 (es)
AT (1) ATE362913T1 (es)
AU (2) AU5046701A (es)
BG (1) BG65833B1 (es)
BR (1) BR0109963A (es)
CA (1) CA2405466C (es)
CY (1) CY1106720T1 (es)
CZ (1) CZ302603B6 (es)
DE (1) DE60128554T2 (es)
DK (1) DK1272454T3 (es)
EA (1) EA004265B1 (es)
EE (1) EE05030B1 (es)
ES (1) ES2287114T3 (es)
FR (1) FR2807430B1 (es)
GE (1) GEP20063798B (es)
HR (1) HRP20020887B1 (es)
HU (1) HU229189B1 (es)
ME (1) ME00442B (es)
MX (1) MXPA02009888A (es)
NO (1) NO327970B1 (es)
NZ (1) NZ521846A (es)
OA (1) OA12246A (es)
PL (1) PL346553A1 (es)
PT (1) PT1272454E (es)
RS (1) RS50240B (es)
SK (1) SK287067B6 (es)
UA (1) UA72040C2 (es)
WO (1) WO2001056972A1 (es)
ZA (1) ZA200207689B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2807037B1 (fr) * 2000-03-31 2002-05-10 Adir NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
AU2003224420B2 (en) 2003-02-28 2009-08-06 Les Laboratoires Servier Process for preparation of perindopril and salts thereof
PT1362845E (pt) * 2003-09-01 2009-11-05 Servier Lab Novo processo de síntese dos ésteres da n-((s)-1- carboxibutil)-(s)-alanina e aplicação à síntese do perindopril
DE60303104T2 (de) * 2003-09-30 2006-11-02 Les Laboratoires Servier Verfahren zur Herstellung von N-((S)-1-(Etoxycarbonyl)butyl)-(S)-alanin und Verwendung in der Synthese von Perindopril
ES2240926T3 (es) * 2003-09-30 2005-10-16 Les Laboratoires Servier Procedimiento de sintesis de n-((s)-1-(etoxicarbonil)butil)-(s)-alanina y su utilizacion en la sintesis de perindopril.
DK1729739T3 (en) * 2004-03-29 2016-10-31 Servier Lab PROCESS FOR THE PREPARATION OF A solid pharmaceutical composition.
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof
FI126564B (fi) 2011-02-28 2017-02-15 Andritz Oy Menetelmä ja laitteisto meesan polttamiseksi
CN107098949B (zh) * 2017-04-20 2021-03-16 上药东英（江苏）药业有限公司 一种制备培哚普利叔丁胺盐的绿色合成新工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4296110A (en) * 1980-10-28 1981-10-20 E. I. Du Pont De Nemours And Company Antihypertensive I-substituted cyclic lactam-2-carboxylic acids
US4503043A (en) * 1981-12-07 1985-03-05 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-isoindole-1-carboxylic acids
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620700B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides

Also Published As

Publication number Publication date
PL346553A1 (en) 2001-09-10
RS50240B (sr) 2009-07-15
KR100520700B1 (ko) 2005-10-17
EE05030B1 (et) 2008-06-16
NO20024811L (no) 2002-10-04
US6774259B2 (en) 2004-08-10
HU0101337D0 (en) 2001-06-28
EP1272454B1 (fr) 2007-05-23
ES2287114T3 (es) 2007-12-16
DK1272454T3 (da) 2007-09-17
CN1422245A (zh) 2003-06-04
CY1106720T1 (el) 2012-05-23
ZA200207689B (en) 2003-09-25
JP3872344B2 (ja) 2007-01-24
ATE362913T1 (de) 2007-06-15
HUP0101337A3 (en) 2002-11-28
BG65833B1 (bg) 2010-02-26
BR0109963A (pt) 2003-08-05
CZ302603B6 (cs) 2011-08-03
FR2807430A1 (fr) 2001-10-12
FR2807430B1 (fr) 2002-05-17
EA004265B1 (ru) 2004-02-26
UA72040C2 (en) 2005-01-17
HU229189B1 (hu) 2013-09-30
WO2001056972A1 (fr) 2001-08-09
GEP20063798B (en) 2006-04-25
HK1053300A1 (en) 2003-10-17
AU2001250467B2 (en) 2005-02-17
EE200200586A (et) 2004-04-15
EP1272454A1 (fr) 2003-01-08
CN1176903C (zh) 2004-11-24
EA200201049A1 (ru) 2003-02-27
AU5046701A (en) 2001-08-14
HUP0101337A2 (hu) 2001-11-28
JP2003521530A (ja) 2003-07-15
CA2405466C (fr) 2005-02-15
ME00442B (me) 2011-10-10
AP2002002639A0 (en) 2002-09-30
CA2405466A1 (fr) 2001-08-09
SK14572002A3 (sk) 2003-02-04
CZ20023323A3 (cs) 2003-01-15
BG107250A (bg) 2003-06-30
OA12246A (en) 2003-12-08
AP1417A (en) 2005-05-24
HRP20020887A2 (en) 2004-02-29
NO327970B1 (no) 2009-11-02
HRP20020887B1 (en) 2011-03-31
DE60128554D1 (de) 2007-07-05
NO20024811D0 (no) 2002-10-04
YU76702A (sh) 2006-05-25
AR027782A1 (es) 2003-04-09
US20030109743A1 (en) 2003-06-12
PT1272454E (pt) 2007-08-01
DE60128554T2 (de) 2008-02-21
SK287067B6 (sk) 2009-11-05
NZ521846A (en) 2004-07-30
KR20020093902A (ko) 2002-12-16

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