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MXPA02006249A - Nuevos derivados de azabiciclooctano, utiles en el tratamiento de arritmias cardiacas. - Google Patents

Nuevos derivados de azabiciclooctano, utiles en el tratamiento de arritmias cardiacas.

Info

Publication number
MXPA02006249A
MXPA02006249A MXPA02006249A MXPA02006249A MXPA02006249A MX PA02006249 A MXPA02006249 A MX PA02006249A MX PA02006249 A MXPA02006249 A MX PA02006249A MX PA02006249 A MXPA02006249 A MX PA02006249A MX PA02006249 A MXPA02006249 A MX PA02006249A
Authority
MX
Mexico
Prior art keywords
treatment
new
cardiac arrhythmias
derivatives useful
azabicyclooctane
Prior art date
Application number
MXPA02006249A
Other languages
English (en)
Inventor
Fritiof Ponten
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MXPA02006249A publication Critical patent/MXPA02006249A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/24—Camphidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporcionan compuestos de la formula I, (ver formula) en donde R1, R2, R3 y Ra a Rh tienen los significados dados en la descripcion, los cuales son utiles en la profilaxis y en el tratamiento de arritmias, en particular arritmias auriculares y ventriculares, un procedimiento para la preparacion de compuestos de la formula I y compuestos intermediarios.
MXPA02006249A 1999-12-23 2000-12-19 Nuevos derivados de azabiciclooctano, utiles en el tratamiento de arritmias cardiacas. MXPA02006249A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9904765A SE9904765D0 (sv) 1999-12-23 1999-12-23 Pharmaceutically-useful compounds
PCT/SE2000/002604 WO2001047893A1 (en) 1999-12-23 2000-12-19 New azabicyclooctane derivatives useful in the treatment of cardiac arrhythmias

Publications (1)

Publication Number Publication Date
MXPA02006249A true MXPA02006249A (es) 2004-09-06

Family

ID=20418291

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02006249A MXPA02006249A (es) 1999-12-23 2000-12-19 Nuevos derivados de azabiciclooctano, utiles en el tratamiento de arritmias cardiacas.

Country Status (26)

Country Link
US (1) US6559162B2 (es)
EP (1) EP1244631A1 (es)
JP (1) JP2003519128A (es)
KR (1) KR20020063261A (es)
CN (1) CN1229350C (es)
AR (1) AR026925A1 (es)
AU (1) AU777069B2 (es)
BR (1) BR0016678A (es)
CA (1) CA2394097A1 (es)
CO (1) CO5261611A1 (es)
CZ (1) CZ20022174A3 (es)
EE (1) EE200200305A (es)
HU (1) HUP0301030A3 (es)
IL (1) IL150212A0 (es)
IS (1) IS6438A (es)
MX (1) MXPA02006249A (es)
MY (1) MY133785A (es)
NO (1) NO20023038L (es)
NZ (1) NZ519497A (es)
PL (1) PL357098A1 (es)
RU (1) RU2262505C2 (es)
SE (1) SE9904765D0 (es)
SK (1) SK8912002A3 (es)
UA (1) UA75057C2 (es)
WO (1) WO2001047893A1 (es)
ZA (1) ZA200204310B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9903759D0 (sv) * 1999-10-18 1999-10-18 Astra Ab Pharmaceutically active compounds
ES2275657T3 (es) * 2000-03-20 2007-06-16 MERCK SHARP & DOHME LTD. Derivados de bicicloalquilo puenteados sulfonamido sustituidos.
MXPA04000565A (es) * 2001-07-19 2005-06-17 Cv Therapeutics Inc Compuestos de piperazina sustituidos y su uso como inhibidores de oxidacion de acidos grasos.
US7001909B2 (en) * 2001-07-19 2006-02-21 Cv Therapeutics, Inc. Substituted heterocyclic compounds
MXPA05000434A (es) 2002-07-08 2005-04-19 Ranbaxy Lab Ltd Derivados de hexano [3.1.0] azabiciclo 3,6-disustituido utiles como antagonistas de receptor muscarinico.
US7056924B2 (en) * 2002-07-18 2006-06-06 Cv Therapeutics, Inc. Substituted heterocyclic compounds
US7488748B2 (en) * 2003-01-28 2009-02-10 Ranbaxy Laboratories Limited 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
US7517905B2 (en) 2003-04-09 2009-04-14 Ranbaxy Laboratories Limited Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
EP1626957A1 (en) 2003-04-11 2006-02-22 Ranbaxy Laboratories Limited Azabicyclo derivatives as muscarinic receptor antagonists
NZ544449A (en) * 2003-06-23 2008-10-31 Cv Therapeutics Inc Urea derivatives of piperazines and piperidines as fatty acid oxidation inhibitors
WO2006035303A1 (en) * 2004-09-29 2006-04-06 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
JP4994772B2 (ja) * 2006-10-11 2012-08-08 日本曹達株式会社 ビスアミノールエーテル化合物を用いるピペリジン−４−オン誘導体の製造方法
JP4999061B2 (ja) * 2006-10-11 2012-08-15 日本曹達株式会社 ピペリジン−４−オン誘導体の製造方法
KR20100017687A (ko) * 2007-05-17 2010-02-16 코텍스 파마슈티칼스, 인크. 글루타메이트에 의한 시냅스 반응을 향상시키기 위한 이치환된 아미드 화합물
CN102311439B (zh) * 2010-07-02 2015-11-25 上海药明康德新药开发有限公司 1-取代-3，8-二氮杂双环[3.2.1]辛烷衍生物及制备方法
CN102452981B (zh) * 2010-11-03 2015-08-19 上海药明康德新药开发有限公司 1,3-二取代-3-氮杂双环[3.2.1]辛烷衍生物及制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2428792A1 (de) 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
DE3112055A1 (de) 1981-03-27 1982-10-07 Basf Ag, 6700 Ludwigshafen Bispidinderivate, ihre herstellung und diese enthaltende arzneimittel
DE3234697A1 (de) 1982-09-18 1984-03-22 Kali-Chemie Pharma Gmbh, 3000 Hannover Neue diazabicyclo-(3,3,1)-nonane
GB8516371D0 (en) * 1985-06-28 1985-07-31 Beecham Group Plc Compounds
PT88381B (pt) 1987-09-09 1995-07-06 Kali Chemie Pharma Gmbh Processo para a preparacao de novos compostos 3,7-diazabiciclo{3,3,1} nonano, e de composicoes farmaceuticas que contem estes compostos
DE3732094A1 (de) 1987-09-24 1989-04-06 Basf Ag Bispidinderivate als klasse iii-antiarrhythmika
US5070094A (en) * 1989-09-05 1991-12-03 G. D. Searle & Co. N-benzyltropaneamides
US5110933A (en) 1989-11-13 1992-05-05 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo[3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
US5084572A (en) * 1989-11-13 1992-01-28 Board Of Regents Of Oklahoma State University Salts of 3-azabicyclo [3.3.1]nonanes as antiarrhythmic agents, and precursors thereof
FR2707986B1 (fr) * 1993-07-22 1996-02-23 Smithkline Beecham Labo Pharma Nouveaux composés, leur procédé de préparation et leur utilisation en tant que médicaments.
JP3235913B2 (ja) * 1993-07-30 2001-12-04 エーザイ株式会社 アミノ安息香酸誘導体
US5468858A (en) 1993-10-28 1995-11-21 The Board Of Regents Of Oklahoma State University Physical Sciences N-alkyl and n-acyl derivatives of 3,7-diazabicyclo-[3.3.1]nonanes and selected salts thereof as multi-class antiarrhythmic agents
DE4402931A1 (de) 1994-02-01 1995-08-03 Kali Chemie Pharma Gmbh Neue 3-Phenylsulfonyl-3,7-diazabicyclo[3,3,1] nonan-Verbindungen enthaltende Arzneimittel
EA002270B1 (ru) 1996-03-29 2002-02-28 Пфайзер Инк. Производные 6-фенилпиридил-2-амина
WO1998018788A1 (en) 1996-10-30 1998-05-07 Schering Corporation Piperazino derivatives as neurokinin antagonists
SE9704709D0 (sv) 1997-12-17 1997-12-17 Astra Ab Pharmaceutically active compounds
HUP0202214A3 (en) 1999-04-09 2002-12-28 Astrazeneca Ab Adamantane derivatives, preparation and use thereof
SE9901875D0 (sv) 1999-05-25 1999-05-25 Astra Pharma Prod Novel compounds

Also Published As

Publication number Publication date
NO20023038D0 (no) 2002-06-21
RU2262505C2 (ru) 2005-10-20
EP1244631A1 (en) 2002-10-02
WO2001047893A1 (en) 2001-07-05
AR026925A1 (es) 2003-03-05
US6559162B2 (en) 2003-05-06
AU2565901A (en) 2001-07-09
US20020137766A1 (en) 2002-09-26
PL357098A1 (en) 2004-07-12
BR0016678A (pt) 2002-10-15
EE200200305A (et) 2003-06-16
IS6438A (is) 2002-06-20
KR20020063261A (ko) 2002-08-01
IL150212A0 (en) 2002-12-01
CA2394097A1 (en) 2001-07-05
SK8912002A3 (en) 2003-02-04
UA75057C2 (en) 2006-03-15
HUP0301030A2 (hu) 2003-08-28
AU777069B2 (en) 2004-09-30
SE9904765D0 (sv) 1999-12-23
HUP0301030A3 (en) 2007-03-28
ZA200204310B (en) 2003-08-29
NZ519497A (en) 2004-02-27
CN1434802A (zh) 2003-08-06
RU2002114821A (ru) 2004-01-20
CN1229350C (zh) 2005-11-30
MY133785A (en) 2007-11-30
CO5261611A1 (es) 2003-03-31
CZ20022174A3 (cs) 2002-09-11
JP2003519128A (ja) 2003-06-17
NO20023038L (no) 2002-08-22

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