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MX9804752A - Conjugados covalentes de lipidos-acidos fosfonocarboxilicos, la produccion de los mismos asi como su uso como agentes farmaceuticos antivirales . - Google Patents

Conjugados covalentes de lipidos-acidos fosfonocarboxilicos, la produccion de los mismos asi como su uso como agentes farmaceuticos antivirales .

Info

Publication number
MX9804752A
MX9804752A MX9804752A MX9804752A MX9804752A MX 9804752 A MX9804752 A MX 9804752A MX 9804752 A MX9804752 A MX 9804752A MX 9804752 A MX9804752 A MX 9804752A MX 9804752 A MX9804752 A MX 9804752A
Authority
MX
Mexico
Prior art keywords
phosphono
application
carboxylic acid
acid conjugates
antiviral medicaments
Prior art date
Application number
MX9804752A
Other languages
English (en)
Inventor
Harald Zilch
Dieter Herrmann
Hans-Georg Opitz
Gerd Zimmermann
Edgar Voss
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of MX9804752A publication Critical patent/MX9804752A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
    • C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion se relaciona con: derivados novedosos de lípidos deácidos fosfonocarboxílicos de la formula general (I), los símbolos de la cual se explican en la descripcion; los tautomeros y sus sales fisiologicamente aceptables, de bases inorgánicas y orgánicas; así como los métodos para producir tales derivados y medicamentos que los contienen.
MX9804752A 1995-12-15 1998-06-12 Conjugados covalentes de lipidos-acidos fosfonocarboxilicos, la produccion de los mismos asi como su uso como agentes farmaceuticos antivirales . MX9804752A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19547022A DE19547022A1 (de) 1995-12-15 1995-12-15 Kovalente Lipid-Phosphonocarbonsäure-Konjugate, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel

Publications (1)

Publication Number Publication Date
MX9804752A true MX9804752A (es) 1998-10-31

Family

ID=7780310

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9804752A MX9804752A (es) 1995-12-15 1998-06-12 Conjugados covalentes de lipidos-acidos fosfonocarboxilicos, la produccion de los mismos asi como su uso como agentes farmaceuticos antivirales .

Country Status (25)

Country Link
US (1) US5955452A (es)
EP (1) EP0869817B1 (es)
JP (1) JP2000505784A (es)
KR (1) KR20000064375A (es)
CN (1) CN1209069A (es)
AR (1) AR005065A1 (es)
AT (1) ATE219379T1 (es)
AU (1) AU714922B2 (es)
BR (1) BR9612137A (es)
CA (1) CA2240365A1 (es)
CZ (1) CZ292531B6 (es)
DE (2) DE19547022A1 (es)
ES (1) ES2179222T3 (es)
HU (1) HUP0001524A3 (es)
IL (1) IL124789A (es)
MX (1) MX9804752A (es)
NO (1) NO982755L (es)
NZ (1) NZ325260A (es)
PL (1) PL185115B1 (es)
RU (1) RU2178418C2 (es)
SK (1) SK282035B6 (es)
TR (1) TR199801083T2 (es)
TW (1) TW409128B (es)
WO (1) WO1997022368A2 (es)
ZA (1) ZA9610511B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW343975B (en) * 1995-12-15 1998-11-01 Boehringer Mannheim Gmbh New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents
US6818057B2 (en) 1999-03-02 2004-11-16 Construction Research & Technology Gmbh Retarder for calcium sulfoaluminate cements
US20040172288A1 (en) * 2003-02-27 2004-09-02 Korn Lawrence D. Method for disseminating medical alert information
NZ592357A (en) * 2008-11-06 2013-09-27 Vascular Biogenics Ltd Oxidized lipid compounds and uses thereof
EP2876094A1 (en) 2014-04-03 2015-05-27 Basf Se Cement and calcium sulphate based binder composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4150125A (en) * 1977-09-30 1979-04-17 Abbott Laboratories Triglyceride ester of phosphonoacetic acid having antiviral activity
US5194654A (en) * 1989-11-22 1993-03-16 Vical, Inc. Lipid derivatives of phosphonoacids for liposomal incorporation and method of use
JPH0421694A (ja) * 1990-05-16 1992-01-24 Asahi Chem Ind Co Ltd 新規なヌクレオシド―リン脂質複合体
DE4026265A1 (de) * 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
IT1249063B (it) * 1991-05-28 1995-02-11 Fidia Spa Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva
TW343975B (en) * 1995-12-15 1998-11-01 Boehringer Mannheim Gmbh New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents

Also Published As

Publication number Publication date
DE19547022A1 (de) 1997-06-19
RU2178418C2 (ru) 2002-01-20
JP2000505784A (ja) 2000-05-16
HUP0001524A2 (hu) 2001-05-28
AR005065A1 (es) 1999-04-07
NO982755D0 (no) 1998-06-15
CZ292531B6 (cs) 2003-10-15
NZ325260A (en) 1999-11-29
AU1373197A (en) 1997-07-14
NO982755L (no) 1998-08-14
EP0869817A2 (de) 1998-10-14
US5955452A (en) 1999-09-21
DE59609377D1 (de) 2002-07-25
WO1997022368A2 (de) 1997-06-26
IL124789A0 (en) 1999-01-26
KR20000064375A (ko) 2000-11-06
CZ180998A3 (cs) 1998-09-16
ZA9610511B (en) 1998-06-15
CA2240365A1 (en) 1997-06-26
TW409128B (en) 2000-10-21
AU714922B2 (en) 2000-01-13
ATE219379T1 (de) 2002-07-15
WO1997022368A3 (de) 1997-10-23
PL185115B1 (pl) 2003-02-28
BR9612137A (pt) 1999-07-13
EP0869817B1 (de) 2002-06-19
SK75598A3 (en) 1999-04-13
SK282035B6 (sk) 2001-10-08
PL327138A1 (en) 1998-11-23
ES2179222T3 (es) 2003-01-16
IL124789A (en) 2002-03-10
TR199801083T2 (xx) 1998-10-21
CN1209069A (zh) 1999-02-24
HUP0001524A3 (en) 2001-05-28

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: HEIDELBERG PHARMA HOLDING GMBH

MM Annulment or lapse due to non-payment of fees