MX9709572A - Device for transdermal electrotransport delivery of fentanyl and sufentanil. - Google Patents
Device for transdermal electrotransport delivery of fentanyl and sufentanil.Info
- Publication number
- MX9709572A MX9709572A MX9709572A MX9709572A MX9709572A MX 9709572 A MX9709572 A MX 9709572A MX 9709572 A MX9709572 A MX 9709572A MX 9709572 A MX9709572 A MX 9709572A MX 9709572 A MX9709572 A MX 9709572A
- Authority
- MX
- Mexico
- Prior art keywords
- fentanyl
- sufentanil
- electrotransport
- electrotransport delivery
- transdermal electrotransport
- Prior art date
Links
- 229960002428 fentanyl Drugs 0.000 title abstract 4
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 title abstract 4
- 229960004739 sufentanil Drugs 0.000 title abstract 4
- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 title abstract 3
- -1 halide salt Chemical class 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 abstract 1
- 206010040829 Skin discolouration Diseases 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 229960004379 fentanyl hydrochloride Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000017 hydrogel Substances 0.000 abstract 1
- 230000005012 migration Effects 0.000 abstract 1
- 238000013508 migration Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- LHCBOXPPRUIAQT-UHFFFAOYSA-N n-phenyl-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide;hydrochloride Chemical compound Cl.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 LHCBOXPPRUIAQT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052709 silver Inorganic materials 0.000 abstract 1
- 239000004332 silver Substances 0.000 abstract 1
- 230000037370 skin discoloration Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides an improved electrotransport drug delivery system for analgesic drugs, namely fentanyl and sufentanil. The fentanyl/sufentanil is provided as a water-soluble halide salt (e.g., fentanyl hydrochloride), preferably contained in a hydrogel formulation for use in an electrotransport device (10). In accordance with the present invention, the donor electrode (22) of the electrotransport delivery device (10) is comprised of silver and the donor reservoir (26) is substantially free of supplementary chloride ion sources and contains a predetermined "excess" loading of fentanyl/sufentanil halide to prevent silver ion migration with attendant skin discoloration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60926495A | 1995-06-05 | 1995-06-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9709572A true MX9709572A (en) | 1998-03-31 |
Family
ID=39427893
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9709572A MX9709572A (en) | 1995-06-05 | 1997-12-04 | Device for transdermal electrotransport delivery of fentanyl and sufentanil. |
Country Status (1)
| Country | Link |
|---|---|
| MX (1) | MX9709572A (en) |
-
1997
- 1997-12-04 MX MX9709572A patent/MX9709572A/en not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |