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MX2025001244A - Composiciones de acido ribonucleico de interferencia (arni) contra el angiotensinogeno (agt) y metodos para su uso - Google Patents

Composiciones de acido ribonucleico de interferencia (arni) contra el angiotensinogeno (agt) y metodos para su uso

Info

Publication number
MX2025001244A
MX2025001244A MX2025001244A MX2025001244A MX2025001244A MX 2025001244 A MX2025001244 A MX 2025001244A MX 2025001244 A MX2025001244 A MX 2025001244A MX 2025001244 A MX2025001244 A MX 2025001244A MX 2025001244 A MX2025001244 A MX 2025001244A
Authority
MX
Mexico
Prior art keywords
agt
methods
angiotensinogen
irna compositions
relates
Prior art date
Application number
MX2025001244A
Other languages
English (en)
Inventor
Donald Foster
Gregory Hinkle
Mark K Schlegel
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66770566&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2025001244(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2025001244A publication Critical patent/MX2025001244A/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se relaciona con agentes de ARNi, por ejemplo, agentes de ARN de hebra doble (ARNhd), dirigidos contra el gen AGT. La invención además se relaciona con métodos para usar los agentes de ARNi para inhibir la expresión de un gen AGT y con métodos para prevenir y tratar un trastorno asociado con AGT, por ejemplo, presión arterial elevada.
MX2025001244A 2018-05-14 2020-11-11 Composiciones de acido ribonucleico de interferencia (arni) contra el angiotensinogeno (agt) y metodos para su uso MX2025001244A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862671094P 2018-05-14 2018-05-14
US201862727141P 2018-09-05 2018-09-05
US201962816996P 2019-03-12 2019-03-12
PCT/US2019/032150 WO2019222166A1 (en) 2018-05-14 2019-05-14 Angiotensinogen (agt) irna compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2025001244A true MX2025001244A (es) 2025-03-07

Family

ID=66770566

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020012048A MX421205B (es) 2018-05-14 2019-05-14 Composiciones de acido ribonucleico de interferencia (arni) contra el angiotensinogeno (agt) y metodos para su uso
MX2025001244A MX2025001244A (es) 2018-05-14 2020-11-11 Composiciones de acido ribonucleico de interferencia (arni) contra el angiotensinogeno (agt) y metodos para su uso

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2020012048A MX421205B (es) 2018-05-14 2019-05-14 Composiciones de acido ribonucleico de interferencia (arni) contra el angiotensinogeno (agt) y metodos para su uso

Country Status (30)

Country Link
US (3) US11015201B2 (es)
EP (2) EP4324520A3 (es)
JP (3) JP7346460B2 (es)
KR (2) KR20250171473A (es)
CN (4) CN112313335B (es)
AU (1) AU2019269418B2 (es)
BR (1) BR112020022943A2 (es)
CA (1) CA3100003A1 (es)
CL (3) CL2020002865A1 (es)
CO (1) CO2020015314A2 (es)
DK (1) DK3794122T5 (es)
ES (1) ES2967713T3 (es)
FI (1) FI3794122T3 (es)
HR (1) HRP20231412T1 (es)
HU (1) HUE064073T2 (es)
IL (2) IL292877B2 (es)
LT (1) LT3794122T (es)
MX (2) MX421205B (es)
MY (1) MY198716A (es)
PE (1) PE20210114A1 (es)
PH (1) PH12020551904A1 (es)
PL (1) PL3794122T3 (es)
PT (1) PT3794122T (es)
RS (1) RS64812B1 (es)
SG (1) SG11202011144QA (es)
SI (1) SI3794122T1 (es)
SM (1) SMT202300388T1 (es)
TW (1) TWI851574B (es)
WO (1) WO2019222166A1 (es)
ZA (1) ZA202108348B (es)

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WO2015179724A1 (en) 2014-05-22 2015-11-26 Alnylam Pharmaceuticals, Inc. Angiotensinogen (agt) irna compositions and methods of use thereof
TWI851574B (zh) 2018-05-14 2024-08-11 美商阿尼拉製藥公司 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
WO2021096763A1 (en) * 2019-11-13 2021-05-20 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
WO2021231552A1 (en) * 2020-05-12 2021-11-18 Duke University Compositions and methods for controlling blood pressure
PE20241132A1 (es) * 2021-08-04 2024-05-24 Alnylam Pharmaceuticals Inc Composiciones de arni y metodos para silenciar el angiotensinogeno (agt)
EP4408525A4 (en) * 2021-10-01 2026-01-07 Adarx Pharmaceuticals Inc Angiotensinogen Modulation Compositions and Their Methods of Use
CN120775847A (zh) * 2021-10-20 2025-10-14 厦门甘宝利生物医药有限公司 Agt抑制剂及其用途
IL312811A (en) * 2021-11-16 2024-07-01 Shanghai Argo Biopharmaceutical Co Ltd Composition and method for inhibiting angiotensinogen (agt) protein expression
US20250197853A1 (en) * 2021-11-19 2025-06-19 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting angiotensinogen and pharmaceutical use of sirna
WO2023138650A1 (zh) * 2022-01-20 2023-07-27 上海拓界生物医药科技有限公司 一种dsRNA、其应用及制备方法
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