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PE20241132A1 - Composiciones de arni y metodos para silenciar el angiotensinogeno (agt) - Google Patents

Composiciones de arni y metodos para silenciar el angiotensinogeno (agt)

Info

Publication number
PE20241132A1
PE20241132A1 PE2024000200A PE2024000200A PE20241132A1 PE 20241132 A1 PE20241132 A1 PE 20241132A1 PE 2024000200 A PE2024000200 A PE 2024000200A PE 2024000200 A PE2024000200 A PE 2024000200A PE 20241132 A1 PE20241132 A1 PE 20241132A1
Authority
PE
Peru
Prior art keywords
agt
angiotensinogen
region
compositions
arni
Prior art date
Application number
PE2024000200A
Other languages
English (en)
Inventor
Paul Nioi
James D Mcininch
Mark K Schlegel
Adam Castoreno
Joseph Barry
Original Assignee
Alnylam Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of PE20241132A1 publication Critical patent/PE20241132A1/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Referido a composiciones de ARNi, particularmente, un agente de acido ribonucleico bicatenario (ARNbc) para inhibir la expresion del angiotensinogeno (AGT) en una celula, en donde el agente de ARNbc comprende una cadena de sentido y una cadena de antisentido que forma una region bicatenaria, en donde la cadena de antisentido comprende una region de complementariedad a un ARNm que codifica AGT, y en donde la region de complementariedad comprende al menos 15 nucleotidos contiguos que difieren en no mas de 3 nucleotidos de una cualquiera de las secuencias de nucleotidos de antisentido. Tambien se refiere a una composicion farmaceutica que comprende dicho agente de ARNbc, su uso en el trastorno asociado al tales como presion arterial alta, hipertension, hipertension limitrofe, entre otros.
PE2024000200A 2021-08-04 2022-08-03 Composiciones de arni y metodos para silenciar el angiotensinogeno (agt) PE20241132A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163229085P 2021-08-04 2021-08-04
US202163272769P 2021-10-28 2021-10-28
PCT/US2022/039242 WO2023014765A1 (en) 2021-08-04 2022-08-03 iRNA COMPOSITIONS AND METHODS FOR SILENCING ANGIOTENSINOGEN (AGT)

Publications (1)

Publication Number Publication Date
PE20241132A1 true PE20241132A1 (es) 2024-05-24

Family

ID=83151961

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2024000200A PE20241132A1 (es) 2021-08-04 2022-08-03 Composiciones de arni y metodos para silenciar el angiotensinogeno (agt)

Country Status (13)

Country Link
US (1) US20240392294A1 (es)
EP (1) EP4381071A1 (es)
JP (1) JP2024531914A (es)
KR (1) KR20240042016A (es)
AU (1) AU2022324003A1 (es)
CA (1) CA3228255A1 (es)
CL (1) CL2024000341A1 (es)
CO (1) CO2024001403A2 (es)
IL (1) IL310295A (es)
MX (1) MX2024001445A (es)
PE (1) PE20241132A1 (es)
TW (1) TW202337474A (es)
WO (1) WO2023014765A1 (es)

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JP2024543496A (ja) 2021-11-16 2024-11-21 シャンハイ アルゴ バイオファーマシューティカル カンパニー，リミテッド アンギオテンシノゲン（ａｇｔ）タンパク質の発現を阻害する組成物及び方法
WO2024212956A1 (zh) * 2023-04-14 2024-10-17 苏州炫景生物科技有限公司 抑制agt基因表达的化合物、药物组合物及其用途
WO2024234831A1 (zh) * 2023-05-15 2024-11-21 苏州时安生物技术有限公司 一种用于调节血管紧张素原基因表达的双链rna、其缀合物、药物组合物及用途
AU2024302527A1 (en) 2023-06-13 2025-11-13 Arnatar Therapeutics, Inc Advanced rna targeting (arnatar) for angiotensinogen
AU2024289140A1 (en) * 2023-07-06 2026-01-22 Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd Rnai agent for inhibiting agt gene expression and use thereof
AU2024289123A1 (en) * 2023-07-06 2026-01-29 Rona Bioscience, Limited Dsrna molecule for regulating expression of agt
WO2025029913A2 (en) * 2023-07-31 2025-02-06 Basecure Therapeutics Llc Conjugates of n-acetyl-galactosamine (galnac) and oligonucleotides and uses thereof
CN119585432B (zh) * 2023-08-22 2025-08-12 成都先衍生物技术有限公司 一种靶向AGT基因表达的siRNA及其缀合物和用途
WO2025087237A1 (zh) * 2023-10-23 2025-05-01 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途
WO2025130862A1 (zh) * 2023-12-18 2025-06-26 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途

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