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MX2023006480A - Polipeptidos de interleucina-2 mutante dependientes del ph. - Google Patents

Polipeptidos de interleucina-2 mutante dependientes del ph.

Info

Publication number
MX2023006480A
MX2023006480A MX2023006480A MX2023006480A MX2023006480A MX 2023006480 A MX2023006480 A MX 2023006480A MX 2023006480 A MX2023006480 A MX 2023006480A MX 2023006480 A MX2023006480 A MX 2023006480A MX 2023006480 A MX2023006480 A MX 2023006480A
Authority
MX
Mexico
Prior art keywords
polypeptides
dependent mutant
immunoconjugates
dependent
mutant interleukin
Prior art date
Application number
MX2023006480A
Other languages
English (en)
Inventor
Adrian Hugenmatter
Thomas Hofer
Sylvia Herter
Christian Gassner
Ralf Hosse
Christian Klein
Ekkehard Moessner
Pablo Umaña
Lorenzo Dehò
Florian Limani
Melanie Obba
Bianca Scherer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2023006480A publication Critical patent/MX2023006480A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere en general a polipéptidos de interleucina-2 mutante dependientes del pH que exhiben una unión reducida al receptor de IL-2 a pH neutro y retienen la unión al receptor de IL-2 a pH reducido. Además, la invención se refiere a inmunoconjugados que comprenden dichos polipéptidos de IL-2 mutante dependientes del pH, moléculas de polinucleótidos que codifican los polipéptidos de IL-2 mutante dependientes del pH o inmunoconjugados, y vectores y células huésped que comprenden tales moléculas de polinucleótidos. La invención se refiere además a métodos para producir los polipéptidos de IL-2 mutante dependientes del pH o inmunoconjugados, composiciones farmacéuticas que los comprenden y usos de estos.
MX2023006480A 2020-12-04 2021-12-02 Polipeptidos de interleucina-2 mutante dependientes del ph. MX2023006480A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20211731 2020-12-04
PCT/EP2021/083864 WO2022117692A2 (en) 2020-12-04 2021-12-02 Ph-dependent mutant interleukin-2 polypeptides

Publications (1)

Publication Number Publication Date
MX2023006480A true MX2023006480A (es) 2023-06-19

Family

ID=73726565

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023006480A MX2023006480A (es) 2020-12-04 2021-12-02 Polipeptidos de interleucina-2 mutante dependientes del ph.

Country Status (15)

Country Link
US (1) US20240092853A1 (es)
EP (1) EP4255923A2 (es)
JP (1) JP2023551563A (es)
KR (1) KR20230117122A (es)
CN (1) CN116635403A (es)
AR (2) AR124246A1 (es)
AU (1) AU2021393752A1 (es)
CA (1) CA3197740A1 (es)
CO (1) CO2023007108A2 (es)
CR (1) CR20230219A (es)
IL (1) IL303381A (es)
MX (1) MX2023006480A (es)
PE (1) PE20232045A1 (es)
TW (1) TW202237632A (es)
WO (1) WO2022117692A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2621482B (en) 2020-05-13 2024-09-04 Bonum Therapeutics Inc Compositions of protein complexes and methods of use thereof
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
WO2025242835A1 (en) 2024-05-22 2025-11-27 Ose Immunotherapeutics Molecules comprising masking linkers and uses thereof for the treatment of cancer

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Also Published As

Publication number Publication date
CA3197740A1 (en) 2022-06-09
US20240092853A1 (en) 2024-03-21
CN116635403A (zh) 2023-08-22
JP2023551563A (ja) 2023-12-08
KR20230117122A (ko) 2023-08-07
WO2022117692A3 (en) 2022-10-20
AR129131A2 (es) 2024-07-17
AU2021393752A1 (en) 2023-05-18
IL303381A (en) 2023-08-01
TW202237632A (zh) 2022-10-01
PE20232045A1 (es) 2023-12-27
WO2022117692A2 (en) 2022-06-09
CR20230219A (es) 2023-07-07
AR124246A1 (es) 2023-03-01
CO2023007108A2 (es) 2023-06-30
EP4255923A2 (en) 2023-10-11

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