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MX2021000323A - Enzimas de variante de pantotenato quinasa modificadas geneticamente. - Google Patents

Enzimas de variante de pantotenato quinasa modificadas geneticamente.

Info

Publication number
MX2021000323A
MX2021000323A MX2021000323A MX2021000323A MX2021000323A MX 2021000323 A MX2021000323 A MX 2021000323A MX 2021000323 A MX2021000323 A MX 2021000323A MX 2021000323 A MX2021000323 A MX 2021000323A MX 2021000323 A MX2021000323 A MX 2021000323A
Authority
MX
Mexico
Prior art keywords
enzymes
pank
pantothenate kinase
present
engineered pantothenate
Prior art date
Application number
MX2021000323A
Other languages
English (en)
Inventor
Oscar Alvizo
Nandhitha Subramanian
Agustina Rodriguez-Granillo
Grant Murphy
Margie Tabuga Borra-Garske
Lillian Jasmine Miller
Jessie B Slaton
Aksiniya Lyubenova Petkova
Joshua Kolev
Anna Fryszkowska
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of MX2021000323A publication Critical patent/MX2021000323A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01033—Pantothenate kinase (2.7.1.33)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona enzimas pantotenato quinasa (PanK) modificadas genéticamente, polipéptidos que tienen actividad PanK y polinucleótidos que codifican estas enzimas, así como vectores y células hospederas que comprenden estos polinucleótidos y polipéptidos; también se proporcionan métodos para producir enzimas PanK; la presente invención proporciona además composiciones que comprenden las enzimas PanK y métodos para usar las enzimas PanK modificadas genéticamente; la presente invención encuentra un uso particular en la producción de compuestos farmacéuticos.
MX2021000323A 2018-07-09 2019-07-02 Enzimas de variante de pantotenato quinasa modificadas geneticamente. MX2021000323A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862695587P 2018-07-09 2018-07-09
US201962822301P 2019-03-22 2019-03-22
PCT/US2019/040379 WO2020014050A1 (en) 2018-07-09 2019-07-02 Engineered pantothenate kinase variant enzymes

Publications (1)

Publication Number Publication Date
MX2021000323A true MX2021000323A (es) 2021-03-25

Family

ID=69101223

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021000323A MX2021000323A (es) 2018-07-09 2019-07-02 Enzimas de variante de pantotenato quinasa modificadas geneticamente.

Country Status (11)

Country Link
US (3) US10889806B2 (es)
EP (1) EP3820991A4 (es)
JP (1) JP7491588B2 (es)
KR (1) KR20210031929A (es)
CN (1) CN112673091B (es)
AU (1) AU2019300838B2 (es)
CA (1) CA3103819A1 (es)
IL (1) IL279884B1 (es)
MX (1) MX2021000323A (es)
SG (1) SG11202012136YA (es)
WO (1) WO2020014050A1 (es)

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JP7773906B2 (ja) 2018-07-09 2025-11-20 メルク・シャープ・アンド・ドーム・エルエルシー ４’－エチルヌクレオシド類似体の酵素的合成
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BR112021024819A2 (pt) * 2019-07-02 2022-01-25 Codexis Inc Acetato quinase engenheirada, composição, sequência de polinucleotídeos, vetor de expressão, célula hospedeira, e, método de produção de uma acetato quinase engenheirada
CA3196603A1 (en) * 2020-10-02 2022-04-07 Codexis, Inc. Engineered pantothenate kinase variant enzymes
IL305928A (en) 2021-04-02 2023-11-01 Codexis Inc Transgenic enzymes of acetate kinase variant
WO2025179109A1 (en) * 2024-02-22 2025-08-28 Invizyne Technologies, Inc. In vitro synthesis of coenzyme a and acetyl-coa for cell-free biocatalysis

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Also Published As

Publication number Publication date
WO2020014050A1 (en) 2020-01-16
JP7491588B2 (ja) 2024-05-28
JP2021530216A (ja) 2021-11-11
CA3103819A1 (en) 2020-01-16
US20240425827A1 (en) 2024-12-26
US12110513B2 (en) 2024-10-08
EP3820991A1 (en) 2021-05-19
US20200010815A1 (en) 2020-01-09
AU2019300838B2 (en) 2025-05-29
KR20210031929A (ko) 2021-03-23
EP3820991A4 (en) 2022-07-06
CN112673091A (zh) 2021-04-16
IL279884A (en) 2021-03-01
AU2019300838A1 (en) 2021-01-07
US10889806B2 (en) 2021-01-12
SG11202012136YA (en) 2021-01-28
US20210102179A1 (en) 2021-04-08
CN112673091B (zh) 2025-04-25
IL279884B1 (en) 2025-12-01

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