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MX2023001600A - Variantes de factor viii reducido en cpg y composiciones para usarse en el tratamiento de trastornos de hemostasia. - Google Patents

Variantes de factor viii reducido en cpg y composiciones para usarse en el tratamiento de trastornos de hemostasia.

Info

Publication number
MX2023001600A
MX2023001600A MX2023001600A MX2023001600A MX2023001600A MX 2023001600 A MX2023001600 A MX 2023001600A MX 2023001600 A MX2023001600 A MX 2023001600A MX 2023001600 A MX2023001600 A MX 2023001600A MX 2023001600 A MX2023001600 A MX 2023001600A
Authority
MX
Mexico
Prior art keywords
factor viii
methods
cpg reduced
compositions
treatment
Prior art date
Application number
MX2023001600A
Other languages
English (en)
Inventor
Xavier Anguela
Sam Hsien-I Shen
Original Assignee
Spark Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spark Therapeutics Inc filed Critical Spark Therapeutics Inc
Publication of MX2023001600A publication Critical patent/MX2023001600A/es

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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Abstract

Se dan a conocer variantes de ácido nucleico reducido en CpG que codifican la proteína FVIII, y métodos de uso de las mismas. En modalidades particulares, las variantes de ácido nucleico reducido en CpG que codifican FVIII se expresan con mayor eficiencia por las células, se secretan en niveles incrementados por las células por encima de las proteínas Factor VIII de tipo silvestre, exhiben una expresión y/o actividad potenciadas sobre las proteínas Factor VIII de tipo silvestre, o se empaquetan con más eficiencia en vectores virales.
MX2023001600A 2015-10-30 2018-04-30 Variantes de factor viii reducido en cpg y composiciones para usarse en el tratamiento de trastornos de hemostasia. MX2023001600A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562249001P 2015-10-30 2015-10-30
US201662331872P 2016-05-04 2016-05-04
US201662349532P 2016-06-13 2016-06-13
US201662357874P 2016-07-01 2016-07-01

Publications (1)

Publication Number Publication Date
MX2023001600A true MX2023001600A (es) 2023-03-09

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MX2018005490A MX2018005490A (es) 2015-10-30 2016-10-31 Variantes de factor viii reducido en cpg, composiciones, metodos y usos para el tratamiento de trastornos de hemostasia.
MX2023001600A MX2023001600A (es) 2015-10-30 2018-04-30 Variantes de factor viii reducido en cpg y composiciones para usarse en el tratamiento de trastornos de hemostasia.

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MX2018005490A MX2018005490A (es) 2015-10-30 2016-10-31 Variantes de factor viii reducido en cpg, composiciones, metodos y usos para el tratamiento de trastornos de hemostasia.

Country Status (19)

Country Link
US (3) US20180312571A1 (es)
EP (1) EP3368560A4 (es)
JP (3) JP7088831B2 (es)
KR (1) KR20180090795A (es)
CN (1) CN108368164A (es)
AU (1) AU2016344030B2 (es)
BR (1) BR112018008766A2 (es)
CA (1) CA3002689A1 (es)
CL (1) CL2018001107A1 (es)
CO (1) CO2018005306A2 (es)
IL (1) IL258959B2 (es)
MX (2) MX2018005490A (es)
MY (1) MY190926A (es)
PE (2) PE20231949A1 (es)
PH (1) PH12018501055A1 (es)
RU (1) RU2745506C2 (es)
SA (1) SA518391463B1 (es)
SG (1) SG11201802972UA (es)
WO (1) WO2017075619A1 (es)

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