[go: up one dir, main page]

MX2022001343A - Compuestos y composiciones para tratar trastornos hematologicos. - Google Patents

Compuestos y composiciones para tratar trastornos hematologicos.

Info

Publication number
MX2022001343A
MX2022001343A MX2022001343A MX2022001343A MX2022001343A MX 2022001343 A MX2022001343 A MX 2022001343A MX 2022001343 A MX2022001343 A MX 2022001343A MX 2022001343 A MX2022001343 A MX 2022001343A MX 2022001343 A MX2022001343 A MX 2022001343A
Authority
MX
Mexico
Prior art keywords
compounds
hematological disorders
compositions
treat hematological
treat
Prior art date
Application number
MX2022001343A
Other languages
English (en)
Inventor
Susanta Samajdar
Venkateshwar Rao Gummadi
Kavitha Nellore
Girish Daginakatte
Wesley Roy Balasubramanian
Original Assignee
Aurigene Discovery Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurigene Discovery Tech Ltd filed Critical Aurigene Discovery Tech Ltd
Publication of MX2022001343A publication Critical patent/MX2022001343A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención proporciona métodos para tratar trastornos hematológicos, tales como la leucemia mieloide aguda, mediante el uso de compuestos heterocíclicos sustituidos y sales farmacéuticamente aceptables de estos. Los compuestos inhiben las cinasas IRAK4 y FLT-3.
MX2022001343A 2017-03-31 2019-09-19 Compuestos y composiciones para tratar trastornos hematologicos. MX2022001343A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN201741011785 2017-03-31

Publications (1)

Publication Number Publication Date
MX2022001343A true MX2022001343A (es) 2022-03-17

Family

ID=63677680

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019011158A MX389825B (es) 2017-03-31 2018-03-30 Compuestos y composiciones para tratar trastornos hematologicos.
MX2022001343A MX2022001343A (es) 2017-03-31 2019-09-19 Compuestos y composiciones para tratar trastornos hematologicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019011158A MX389825B (es) 2017-03-31 2018-03-30 Compuestos y composiciones para tratar trastornos hematologicos.

Country Status (25)

Country Link
US (2) US11419875B2 (es)
EP (2) EP3600270B1 (es)
JP (2) JP7333136B2 (es)
KR (3) KR20250065441A (es)
CN (2) CN120267671A (es)
AU (2) AU2018242623B2 (es)
BR (1) BR112019018991A2 (es)
CA (1) CA3056893A1 (es)
DK (1) DK3600270T3 (es)
EA (1) EA201992322A3 (es)
ES (1) ES2950764T3 (es)
FI (1) FI3600270T3 (es)
HR (1) HRP20230657T8 (es)
HU (1) HUE062648T2 (es)
IL (4) IL293783B2 (es)
LT (1) LT3600270T (es)
MX (2) MX389825B (es)
PH (1) PH12019502138A1 (es)
PL (1) PL3600270T3 (es)
PT (1) PT3600270T (es)
RS (1) RS64411B1 (es)
SG (1) SG11201908171TA (es)
SI (1) SI3600270T1 (es)
SM (1) SMT202300236T1 (es)
WO (1) WO2018178947A2 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3466955T1 (sl) 2014-01-13 2021-05-31 Aurigene Discovery Technologies Limited Postopek za pripravo derivatov oksazolo(4,5-B)piridina in tiazolo(4,5-B)piridina kot inhibitorjev IRAK4 za zdravljenje raka
MX389825B (es) 2017-03-31 2025-03-20 Aurigene Discovery Tech Ltd Compuestos y composiciones para tratar trastornos hematologicos.
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
WO2021004533A1 (zh) * 2019-07-10 2021-01-14 南京明德新药研发有限公司 作为irak4和btk多靶点抑制剂的噁唑类化合物
CN112480101B (zh) * 2019-09-12 2022-11-25 中国科学院上海药物研究所 一类irak4激酶抑制剂及其制备和应用
WO2021155841A1 (en) 2020-02-07 2021-08-12 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2021204589A1 (en) 2020-04-07 2021-10-14 Bayer Aktiengesellschaft Substituted thiazolopyridines, salts thereof and their use as herbicidally active substances
MX2023001296A (es) * 2020-08-03 2023-02-22 Curis Inc Composiciones y metodos para tratar enfermedades y trastornos.
MX2023005591A (es) * 2020-11-18 2023-05-29 Curis Inc Metodos de tratamiento de enfermedades y trastornos.
CN116745294A (zh) * 2020-12-25 2023-09-12 南京明德新药研发有限公司 酰胺噁唑类化合物
CN114773331A (zh) * 2021-01-22 2022-07-22 武汉人福创新药物研发中心有限公司 苯并咪唑化合物及其用途
JP2024516353A (ja) * 2021-04-08 2024-04-15 キュリス，インコーポレイテッド がんの治療のための併用療法
CN113402499B (zh) 2021-06-21 2022-05-13 上海勋和医药科技有限公司 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途
TW202328150A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之噻唑并吡啶、其鹽及其作為除草活性物質之用途
TW202328151A (zh) 2021-09-07 2023-07-16 德商拜耳廠股份有限公司 經取代之2,3-二氫[1,3]噻唑并[4,5-b]吡啶、其鹽及其作為除草活性物質之用途
WO2023088435A1 (zh) * 2021-11-19 2023-05-25 成都奥睿药业有限公司 三取代吡啶衍生物的制备及作为芳香烃受体调节物的应用
EP4434981A4 (en) 2021-12-23 2025-08-20 Hangzhou Polymed Biopharmaceuticals Inc FIVE- AND SIX-MEMBERED COMPOUND, ITS PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITION AND ITS USE
WO2024169952A1 (en) 2023-02-16 2024-08-22 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172896A (en) 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
KR100188801B1 (ko) 1990-05-18 1999-06-01 엥겔하르트 라피체 이속사졸-4카복스아미드 및 하이드록시알킬리덴 시아노아세트아미드 및 이들 화합물을 함유하는 약제학적 조성물
GB9217295D0 (en) 1992-08-14 1992-09-30 Wellcome Found Controlled released tablets
US5358970A (en) 1993-08-12 1994-10-25 Burroughs Wellcome Co. Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
GB9315856D0 (en) 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5541231A (en) 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
ES2206965T3 (es) 1997-07-29 2004-05-16 Alcon Laboratories, Inc. Composiciones oftalmicas que contienen polimeros de galactomanana y borato.
US6110973A (en) 1998-01-29 2000-08-29 Sepracor Methods for treating obesity and weight gain using optically pure (-)-bupropion
US8889112B2 (en) 1999-09-16 2014-11-18 Ocularis Pharma, Llc Ophthalmic formulations including selective alpha 1 antagonists
DE10023486C1 (de) 2000-05-09 2002-03-14 Schering Ag Ortho substituierte Anthranilsäureamide und deren Verwendung als Arzneimittel
US20030134836A1 (en) 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
ATE482200T1 (de) 2003-05-01 2010-10-15 Bristol Myers Squibb Co Als kinaseinhibitoren geeignete arylsubstituierte pyrazolamidverbindungen
EP1627869B1 (en) 2003-05-20 2012-05-02 Ajinomoto Co., Inc. Vanilloid receptor modulators
WO2004108133A2 (en) 2003-06-05 2004-12-16 Vertex Pharmaceuticals Incorporated Modulators of vr1 receptor
US20050059744A1 (en) 2003-09-12 2005-03-17 Allergan, Inc. Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions
CA2541299A1 (en) 2003-10-07 2005-04-14 Renovis, Inc. Amide compounds as ion channel ligands and uses thereof
MXPA06012104A (es) 2004-04-22 2007-01-25 Bayer Cropscience Lp Metodo y composicion para controlar malas hierbas.
EP1655297A1 (en) 2004-11-03 2006-05-10 Schering Aktiengesellschaft Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
US7906533B2 (en) 2004-11-03 2011-03-15 Bayer Schering Pharma Ag Nicotinamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors
TW200628159A (en) 2004-11-10 2006-08-16 Synta Pharmaceuticals Corp IL-12 modulatory compounds
US7902356B2 (en) 2004-12-17 2011-03-08 Eli Lilly And Company Thiazolopyridinone derivates as MCH receptor antagonists
AU2005316313B2 (en) 2004-12-17 2011-09-29 Eli Lilly And Company Novel MCH receptor antagonists
EP1674467A1 (en) 2004-12-22 2006-06-28 4Sc Ag 2,5- and 2,6-disubstituted benzazole derivatives useful as protein kinase inhibitors
WO2007058626A1 (en) 2005-11-16 2007-05-24 S*Bio Pte Ltd Indazole compounds
CN101379060B (zh) 2006-02-10 2012-05-23 转化技术制药公司 作为Aurora激酶抑制剂的苯并唑系衍生物、组合物和使用方法
GB0606429D0 (en) 2006-03-30 2006-05-10 Novartis Ag Organic compounds
JP5255559B2 (ja) 2006-03-31 2013-08-07 アボット・ラボラトリーズ インダゾール化合物
WO2007121154A2 (en) 2006-04-11 2007-10-25 Janssen Pharmaceutica, N.V. Substituted benzothiazole kinase inhibitors
US20110021513A1 (en) 2006-09-07 2011-01-27 Biogen Idec Ma Inc. Modulators of interleukin-1 receptor-associated kinase
EP2061786A2 (en) 2006-09-07 2009-05-27 Biogen Idec MA Inc. Indazole derivatives as modulators of interleukin-1 receptor-associated kinase
WO2008061109A2 (en) 2006-11-15 2008-05-22 Forest Laboratories Holdings Limited Indazole derivatives useful as melanin concentrating receptor ligands
EP2121621B1 (en) 2006-12-08 2014-05-07 Exelixis Patent Company LLC Lxr and fxr modulators
JP4785881B2 (ja) 2007-02-27 2011-10-05 大塚製薬株式会社 医薬
CA2690557A1 (en) * 2007-06-14 2008-12-24 Schering Corporation Imidazopyrazines as protein kinase inhibitors
EP2170834B1 (en) 2007-07-16 2014-01-08 AbbVie Inc. Indazoles, benzisoxazoles and benzisothiazoles as inhibitors of protein kinases
US20090069288A1 (en) 2007-07-16 2009-03-12 Breinlinger Eric C Novel therapeutic compounds
US8399448B2 (en) 2007-08-08 2013-03-19 Merck Serono Sa 6-amino-pyrimidine-4-carboxamide derivatives and related compounds which bind to the sphingosine 1-phosphate (S1P) receptor for the treatment of multiple sclerosis
NZ587039A (en) 2008-02-13 2013-01-25 Gilead Connecticut Inc 6-aryl-imidazo[1, 2-a]pyrazine derivatives, method of making, and method of use thereof
US20110178070A1 (en) * 2008-06-24 2011-07-21 Takeda Pharmaceutical Company Limited PI3K/mTOR INHIBITORS
MX2011005234A (es) 2008-11-19 2011-06-01 Schering Corp Inhibidores de diacilglicerol aciltransferasa.
US8283360B2 (en) 2008-12-19 2012-10-09 Merck Sharp & Dohme Corp. Bicyclic heterocyclic derivatives and methods of use thereof
CN102264701A (zh) 2008-12-23 2011-11-30 霍夫曼-拉罗奇有限公司 作为p2x7调节剂的二氢吡啶酮脲
US8765747B2 (en) * 2009-06-12 2014-07-01 Dana-Farber Cancer Institute, Inc. Fused 2-aminothiazole compounds
CN102470127A (zh) * 2009-08-19 2012-05-23 埃姆比特生物科学公司 联芳基化合物和其使用方法
KR101804588B1 (ko) 2009-10-13 2017-12-04 리간드 파마슈티칼스 인코포레이티드 조혈 성장 인자 모방체 소분자 화합물 및 이의 용도
ES2545811T3 (es) 2010-04-22 2015-09-16 Janssen Pharmaceutica Nv Compuestos de indazol útiles como inhibidores de quetohexoquinasa
AU2011245299A1 (en) 2010-04-30 2012-08-30 Merck Sharp & Dohme Corp. Inhibitors of phosphoinositide dependent kinase 1 (PDK1)
BR112012033075B1 (pt) 2010-06-24 2021-06-01 Chemocentryx, Inc Composto piperidina substituído antagonista de receptor c5a, composição farmacêutica, e, uso do composto
KR20190077610A (ko) 2010-07-13 2019-07-03 에프. 호프만-라 로슈 아게 Irak4 조절제로서 피라졸로[1,5a]피리미딘 및 티에노[3,2b]피리미딘 유도체
MX366318B (es) 2010-11-19 2019-07-05 Ligand Pharm Inc Derivados de aminas heterocíclicas que inhiben la transducción de señal mediana por cinasa asociada con el receptor de interleucina-1.
EP2655357B1 (en) 2010-12-20 2016-06-22 Merck Serono S.A. Indazolyl triazole derivatives as irak inhibitors
CN103608017B (zh) 2011-04-12 2017-02-15 美国卫生和人力服务部 用于治疗或预防疟疾的疟原虫表面阴离子通道抑制剂
WO2013042137A1 (en) 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
SI2766359T1 (sl) * 2011-10-14 2016-09-30 Ambit Biosciences Corporation Heterociklične spojine in njihova uporaba kot modulatorjev receptorja tirozin kinaze tipa III
ES2627347T3 (es) 2011-10-20 2017-07-27 Glaxosmithkline Llc Aza-heterociclos bicíclicos sustituidos y análogos como moduladores de sirtuina
GB201119401D0 (en) 2011-11-10 2011-12-21 Ucb Pharma Sa Therapeutic agents
KR101385603B1 (ko) 2012-05-17 2014-04-21 한국원자력의학원 벤조티아졸 유도체 및 암 치료를 위한 그의 용도
WO2014003483A1 (en) 2012-06-29 2014-01-03 Hanmi Pharm. Co., Ltd. Fused pyrimidine derivatives having inhibitory activity on fms kinases
US9085586B2 (en) 2012-07-11 2015-07-21 Nimbus Iris, Inc. IRAK inhibitors and uses thereof
US9334249B2 (en) 2012-11-03 2016-05-10 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
CA2907960C (en) 2013-05-22 2021-10-19 Children's Hospital Medical Center Combination therapy for mds
TWI652014B (zh) 2013-09-13 2019-03-01 美商艾佛艾姆希公司 雜環取代之雙環唑殺蟲劑
TWI667233B (zh) 2013-12-19 2019-08-01 德商拜耳製藥公司 新穎吲唑羧醯胺，其製備方法、含彼等之醫藥製劑及其製造醫藥之用途
EP3092226B1 (en) 2014-01-10 2019-03-13 Aurigene Discovery Technologies Limited Indazole compounds as irak4 inhibitors
SI3466955T1 (sl) 2014-01-13 2021-05-31 Aurigene Discovery Technologies Limited Postopek za pripravo derivatov oksazolo(4,5-B)piridina in tiazolo(4,5-B)piridina kot inhibitorjev IRAK4 za zdravljenje raka
MX2016010056A (es) 2014-02-06 2016-11-15 Abbvie Inc 6-heteroariloxi o 6-ariloxi-quinolina-2-carboxamidas y metodos de uso.
EP3157521A4 (en) 2014-06-20 2018-02-14 Aurigene Discovery Technologies Limited Substituted indazole compounds as irak4 inhibitors
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
KR20180025896A (ko) 2015-07-15 2018-03-09 오리진 디스커버리 테크놀로지스 리미티드 Irak-4 저해제로서 인다졸 및 아자인다졸 화합물
HK1249435A1 (zh) 2015-07-15 2018-11-02 Aurigene Discovery Technologies Limited 作为irak-4抑制剂的取代的氮杂化合物
US10065946B2 (en) * 2015-08-04 2018-09-04 Rigel Pharmaceuticals, Inc. Benzazole compounds and methods for making and using the compounds
CA3038130A1 (en) 2016-10-28 2018-05-03 Children's Hospital Medical Center Treatment of diseases associated with activated irak
MX389825B (es) 2017-03-31 2025-03-20 Aurigene Discovery Tech Ltd Compuestos y composiciones para tratar trastornos hematologicos.
HUE067356T2 (hu) 2017-10-31 2024-10-28 Curis Inc IRAK4 inhibitor és BCL-2 inhibitor kombinációban, rák kezelésére való felhasználásra

Also Published As

Publication number Publication date
IL293783B1 (en) 2023-09-01
CN120267671A (zh) 2025-07-08
IL269536A (en) 2019-11-28
LT3600270T (lt) 2023-08-25
DK3600270T3 (da) 2023-07-10
MX389825B (es) 2025-03-20
JP2020512343A (ja) 2020-04-23
KR20190130023A (ko) 2019-11-20
KR20250065441A (ko) 2025-05-12
KR20240019391A (ko) 2024-02-14
EP3600270A4 (en) 2020-08-26
PT3600270T (pt) 2023-07-25
RS64411B1 (sr) 2023-09-29
EP3600270A2 (en) 2020-02-05
PL3600270T3 (pl) 2023-09-25
SI3600270T1 (sl) 2023-10-30
JP7333136B2 (ja) 2023-08-24
SMT202300236T1 (it) 2023-09-06
EA201992322A2 (ru) 2020-07-31
IL316364A (en) 2024-12-01
IL293783A (en) 2022-08-01
IL293783B2 (en) 2024-01-01
IL305150B1 (en) 2024-11-01
AU2024203943A1 (en) 2024-07-04
AU2018242623A1 (en) 2019-10-17
US20210290628A1 (en) 2021-09-23
EP4252853A2 (en) 2023-10-04
AU2018242623B2 (en) 2024-05-02
HRP20230657T1 (hr) 2023-10-13
SG11201908171TA (en) 2019-10-30
ES2950764T3 (es) 2023-10-13
HRP20230657T8 (hr) 2023-11-10
MX2019011158A (es) 2019-10-17
US11419875B2 (en) 2022-08-23
KR102633530B1 (ko) 2024-02-02
IL269536B (en) 2022-07-01
JP2023154005A (ja) 2023-10-18
EP4252853A3 (en) 2023-12-13
PH12019502138A1 (en) 2020-06-29
EP3600270B1 (en) 2023-06-14
CA3056893A1 (en) 2018-10-04
CN110691589A (zh) 2020-01-14
EA201992322A3 (ru) 2020-09-30
US20220339161A1 (en) 2022-10-27
HUE062648T2 (hu) 2023-11-28
IL305150B2 (en) 2025-03-01
WO2018178947A2 (en) 2018-10-04
IL305150A (en) 2023-10-01
FI3600270T3 (fi) 2023-07-20
NZ757707A (en) 2023-09-29
BR112019018991A2 (pt) 2020-04-14

Similar Documents

Publication Publication Date Title
MX2022001343A (es) Compuestos y composiciones para tratar trastornos hematologicos.
CL2019002734A1 (es) Isoquinolinas como inhibidores de hpk1.
CO2022002759A2 (es) Antagonistas de hpk1 y sus usos
ECSP19003773A (es) Compuestos heterocíclicos como inmunomoduladores
DOP2018000268A (es) Derivados de carbonucleósidos sustituidos útiles como agentes antineoplásicos
MX2023004593A (es) Inhibidores de tirosina cinasa 2 (tyk2) y usos de los mismos.
UY38076A (es) Derivados de tetrahidroquinazolina útiles como agentes anticáncer
CL2019000542A1 (es) Compuestos de tetraciclina y métodos de uso de los mismos.
MX2018007267A (es) Compuestos utiles como inhibidores de cinasa.
CL2017000712A1 (es) Pirimidinonas como inhibidores del factor xia
CR20190566A (es) Inhibidores de quinasay usos de los mismos
NI201700095A (es) Derivados de nucleósidos sustituidos útiles como agentes antineoplásicos
MX2018002986A (es) Compuestos de heteroarilo como inhibidores de cinasas asociadas al receptor de interleucina 1 (irak) y sus usos.
UY37134A (es) Compuestos heteroarilos y composiciones que los contienen útiles como inhibidores de pad4
NZ716392A (en) Fused tricyclic urea compounds as raf kinase and/or raf kinase dimer inhibitors
MX2020001757A (es) Compuestos, sales de los mismos y metodos para el tratamiento de enfermedades.
CL2015000944A1 (es) Compuestos de benceno sustituido
DOP2016000208A (es) Benzimidazol-2-aminas como inhibidores de midh1
DOP2017000066A (es) Compuestos y composiciones como inhibidores de quinasa raf
CO6491087A2 (es) Compuestos de urea que contienen heteroarilo 5,6 bicíclicos como inhibidores de quinasa
DOP2016000308A (es) Compuestos de 1, 3, 4-tiadiazol y uso de los mismos para el tratamiento del cáncer
UY35625A (es) Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa
CR20160070A (es) Compuestos de triazolopiridina, composiciones y métodos de uso de los mismos
MX2020001157A (es) Compuestos y analogos de 1-heterociclil isocromanilo para el tratamiento de trastornos del sistema nervioso central (snc).
MX2018004868A (es) Derivados de la pirrolidina.