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MX2021008434A - Metodos para tratar el cancer con un antagonista de union al eje de pd-1 y una vacuna de arn. - Google Patents

Metodos para tratar el cancer con un antagonista de union al eje de pd-1 y una vacuna de arn.

Info

Publication number
MX2021008434A
MX2021008434A MX2021008434A MX2021008434A MX2021008434A MX 2021008434 A MX2021008434 A MX 2021008434A MX 2021008434 A MX2021008434 A MX 2021008434A MX 2021008434 A MX2021008434 A MX 2021008434A MX 2021008434 A MX2021008434 A MX 2021008434A
Authority
MX
Mexico
Prior art keywords
cancer
rna
individual
methods
binding antagonist
Prior art date
Application number
MX2021008434A
Other languages
English (en)
Inventor
Lars Mueller
Gregg Daniel Fine
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2021008434A publication Critical patent/MX2021008434A/es

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/34—Antigenic peptides
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C12N15/09—Recombinant DNA-technology
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/55511—Organic adjuvants
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/876—Skin, melanoma
    • A—HUMAN NECESSITIES
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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Abstract

La presente divulgación proporciona métodos, usos y kits para tratar el cáncer en un individuo. Los métodos comprenden administrar al individuo un antagonista de unión al eje de PD-1 (tal como un anticuerpo anti-PD-1 o anti-PDL1) y una vacuna de ARN (por ejemplo, una vacuna contra el cáncer personalizada que comprende uno o más polinucleótidos que codifican uno o más neoepítopos resultantes de mutaciones somáticas específicas de cáncer presentes en una muestra tumoral obtenida del individuo). En la presente se proporcionan además moléculas de ARN (por ejemplo, una vacuna contra el cáncer de ARN personalizada que comprende uno o más polinucleótidos que codifican uno o más neoepítopos resultantes de mutaciones somáticas específicas de cáncer presentes en una muestra tumoral obtenida del individuo), así como moléculas de ADN y métodos útiles para la producción o uso de vacunas de ARN.
MX2021008434A 2019-01-14 2020-01-13 Metodos para tratar el cancer con un antagonista de union al eje de pd-1 y una vacuna de arn. MX2021008434A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962792387P 2019-01-14 2019-01-14
US201962795476P 2019-01-22 2019-01-22
US201962887410P 2019-08-15 2019-08-15
PCT/US2020/013353 WO2020150152A1 (en) 2019-01-14 2020-01-13 Methods of treating cancer with a pd-1 axis binding antagonist and an rna vaccine

Publications (1)

Publication Number Publication Date
MX2021008434A true MX2021008434A (es) 2021-09-23

Family

ID=69467803

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021008434A MX2021008434A (es) 2019-01-14 2020-01-13 Metodos para tratar el cancer con un antagonista de union al eje de pd-1 y una vacuna de arn.

Country Status (11)

Country Link
US (1) US20210346485A1 (es)
EP (1) EP3911678A1 (es)
JP (2) JP2022518399A (es)
KR (1) KR20210116525A (es)
CN (2) CN113710702A (es)
AU (1) AU2020208193A1 (es)
CA (1) CA3124837A1 (es)
IL (1) IL284583A (es)
MX (1) MX2021008434A (es)
TW (2) TW202515617A (es)
WO (1) WO2020150152A1 (es)

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CN116650628A (zh) * 2020-01-31 2023-08-29 基因泰克公司 用pd-1轴结合拮抗剂和rna疫苗诱导新表位特异性t细胞的方法
CN115811986A (zh) 2020-04-22 2023-03-17 生物技术欧洲股份公司 冠状病毒疫苗
EP4175664A2 (en) 2020-07-06 2023-05-10 Janssen Biotech, Inc. Prostate neoantigens and their uses
TW202245808A (zh) * 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性ｒｎａ
CN112501201A (zh) * 2021-02-07 2021-03-16 无锡市人民医院 一种用于治疗非小细胞肺癌的rna疫苗及其构建方法
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WO2024002985A1 (en) 2022-06-26 2024-01-04 BioNTech SE Coronavirus vaccine

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