MX2020009462A - Procesos para la preparación de compuestos de pirimidinilciclopentano. - Google Patents
Procesos para la preparación de compuestos de pirimidinilciclopentano.Info
- Publication number
- MX2020009462A MX2020009462A MX2020009462A MX2020009462A MX2020009462A MX 2020009462 A MX2020009462 A MX 2020009462A MX 2020009462 A MX2020009462 A MX 2020009462A MX 2020009462 A MX2020009462 A MX 2020009462A MX 2020009462 A MX2020009462 A MX 2020009462A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- processes
- compounds
- pyrimidinylcyclopentane
- pyrimidinylcyclopentane compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/02—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from isocyanates with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención se relaciona con un proceso para la preparación de un compuesto de fórmula (I), donde R1 es como se define en la presente, que es útil como un intermediario en la preparación de los compuestos farmacéuticos activos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13193030 | 2013-11-15 | ||
| PCT/US2014/065567 WO2015073739A1 (en) | 2013-11-15 | 2014-11-13 | Processes for the preparation of pyrimidinylcyclopentane compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2020009462A true MX2020009462A (es) | 2021-08-31 |
| MX385726B MX385726B (es) | 2025-03-18 |
Family
ID=49582648
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020009462A MX385726B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
| MX2016006299A MX367620B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
| MX2019006959A MX374852B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparacion de compuestos de pirimidinilciclopentano |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016006299A MX367620B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparación de compuestos de pirimidinilciclopentano. |
| MX2019006959A MX374852B (es) | 2013-11-15 | 2014-11-13 | Procesos para la preparacion de compuestos de pirimidinilciclopentano |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US9862689B2 (es) |
| EP (3) | EP3068770B1 (es) |
| JP (4) | JP6374503B2 (es) |
| KR (2) | KR102698200B1 (es) |
| CN (3) | CN112898210B (es) |
| AR (1) | AR098427A1 (es) |
| AU (5) | AU2014348570B2 (es) |
| CA (2) | CA3207199A1 (es) |
| ES (2) | ES2765511T3 (es) |
| HR (2) | HRP20231100T1 (es) |
| HU (1) | HUE063095T2 (es) |
| IL (3) | IL245636B (es) |
| MX (3) | MX385726B (es) |
| MY (2) | MY174153A (es) |
| NZ (1) | NZ720805A (es) |
| PL (2) | PL3068770T3 (es) |
| RU (1) | RU2702355C1 (es) |
| SG (1) | SG10201901578UA (es) |
| SI (1) | SI3068770T1 (es) |
| WO (1) | WO2015073739A1 (es) |
| ZA (2) | ZA201603434B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20231100T1 (hr) | 2013-11-15 | 2023-12-22 | F. Hoffmann - La Roche Ag | Postupci za proizvodnju pirimidinilciklopentan spojeva |
| MX368298B (es) | 2014-09-26 | 2019-09-27 | Hoffmann La Roche | Procesos para preparar compuestos de (ciclopentil [d]pirimidin-4-il)piperazina. |
| CN116172869A (zh) | 2016-08-10 | 2023-05-30 | 豪夫迈·罗氏有限公司 | 包含Akt蛋白激酶抑制剂的药物组合物 |
| GB201802383D0 (en) * | 2018-02-14 | 2018-03-28 | Givaudan Sa | Process |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6545165B1 (en) | 2000-02-04 | 2003-04-08 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
| CA2607927C (en) * | 2005-05-24 | 2014-12-30 | F. Hoffmann-La Roche Ag | Preparation of (s)-4-fluoromethyl-dihydro-furan-2-one |
| CN101198594A (zh) * | 2005-06-22 | 2008-06-11 | 尼科梅德有限责任公司 | 用于制备生产三环苯并咪唑类的中间体的方法 |
| ES2372955T3 (es) * | 2006-07-06 | 2012-01-30 | Array Biopharma, Inc. | Ciclopenta[d]pirimidinas como inhibidores de la proteína cinasa akt. |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| UA95641C2 (xx) | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы |
| WO2009029554A2 (en) | 2007-08-24 | 2009-03-05 | Codexis, Inc. | Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane |
| US8835434B2 (en) * | 2008-01-09 | 2014-09-16 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
| JP5539225B2 (ja) | 2008-01-09 | 2014-07-02 | アレイ バイオファーマ、インコーポレイテッド | Ａｋｔタンパク質キナーゼ阻害剤としての水酸化されたピリミジルシクロペンタン |
| PE20091364A1 (es) * | 2008-01-17 | 2009-10-13 | Novartis Ag | Proceso para la preparacion de inhibidores de nep |
| EP2329013B1 (en) | 2008-08-27 | 2015-10-28 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| US8273554B2 (en) | 2008-08-29 | 2012-09-25 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
| US20110054174A1 (en) * | 2009-08-28 | 2011-03-03 | Stephan Bachmann | Process for the preparation of a glucokinase activator compound |
| WO2011130654A1 (en) * | 2010-04-16 | 2011-10-20 | Genentech, Inc. | Fox03a as predictive biomarker for pi3k/akt kinase pathway inhibitor efficacy |
| WO2012135753A1 (en) * | 2011-04-01 | 2012-10-04 | Genentech, Inc. | Combinations of akt inhibitor compounds and erlotinib, and methods of use |
| CN104520263B (zh) | 2012-05-17 | 2016-11-09 | 基因泰克公司 | 制备氨基酸化合物的方法 |
| CA2873653A1 (en) | 2012-05-17 | 2013-11-21 | Array Biopharma Inc. | Process for making hydroxylated cyclopentylpyrimidine compounds |
| MY170086A (en) * | 2012-05-17 | 2019-07-04 | Genentech Inc | Amorphous form of an akt inhibiting pyrimidinyl - cyclopentane compound, compositions and methods thereof |
| US9416110B2 (en) * | 2012-05-17 | 2016-08-16 | Array Biopharma Inc. | Process for making hydroxylated cyclopentylpyrimidine compounds |
| SG11201407591PA (en) * | 2012-05-17 | 2015-01-29 | Genentech Inc | Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof |
| HRP20231100T1 (hr) | 2013-11-15 | 2023-12-22 | F. Hoffmann - La Roche Ag | Postupci za proizvodnju pirimidinilciklopentan spojeva |
| MX368298B (es) | 2014-09-26 | 2019-09-27 | Hoffmann La Roche | Procesos para preparar compuestos de (ciclopentil [d]pirimidin-4-il)piperazina. |
-
2014
- 2014-11-13 HR HRP20231100TT patent/HRP20231100T1/hr unknown
- 2014-11-13 NZ NZ720805A patent/NZ720805A/en unknown
- 2014-11-13 CN CN202110168758.6A patent/CN112898210B/zh active Active
- 2014-11-13 CN CN201910735465.4A patent/CN110590606B/zh active Active
- 2014-11-13 MX MX2020009462A patent/MX385726B/es unknown
- 2014-11-13 MY MYPI2016000911A patent/MY174153A/en unknown
- 2014-11-13 SG SG10201901578UA patent/SG10201901578UA/en unknown
- 2014-11-13 EP EP14863015.5A patent/EP3068770B1/en active Active
- 2014-11-13 CA CA3207199A patent/CA3207199A1/en active Pending
- 2014-11-13 WO PCT/US2014/065567 patent/WO2015073739A1/en not_active Ceased
- 2014-11-13 PL PL14863015T patent/PL3068770T3/pl unknown
- 2014-11-13 CA CA2930870A patent/CA2930870C/en active Active
- 2014-11-13 AU AU2014348570A patent/AU2014348570B2/en active Active
- 2014-11-13 US US15/036,741 patent/US9862689B2/en active Active
- 2014-11-13 ES ES14863015T patent/ES2765511T3/es active Active
- 2014-11-13 EP EP19204562.3A patent/EP3656764B1/en active Active
- 2014-11-13 KR KR1020227034215A patent/KR102698200B1/ko active Active
- 2014-11-13 KR KR1020167015742A patent/KR102493603B1/ko active Active
- 2014-11-13 HU HUE19204562A patent/HUE063095T2/hu unknown
- 2014-11-13 HR HRP20192340TT patent/HRP20192340T1/hr unknown
- 2014-11-13 CN CN201480072954.1A patent/CN105899492B/zh active Active
- 2014-11-13 MY MYPI2019002660A patent/MY191759A/en unknown
- 2014-11-13 MX MX2016006299A patent/MX367620B/es active IP Right Grant
- 2014-11-13 ES ES19204562T patent/ES2957314T3/es active Active
- 2014-11-13 RU RU2016123365A patent/RU2702355C1/ru active
- 2014-11-13 EP EP23182382.4A patent/EP4282973A3/en active Pending
- 2014-11-13 JP JP2016530862A patent/JP6374503B2/ja active Active
- 2014-11-13 PL PL19204562.3T patent/PL3656764T3/pl unknown
- 2014-11-13 MX MX2019006959A patent/MX374852B/es active IP Right Grant
- 2014-11-13 SI SI201431455T patent/SI3068770T1/sl unknown
- 2014-11-14 AR ARP140104291A patent/AR098427A1/es not_active Application Discontinuation
-
2016
- 2016-05-15 IL IL245636A patent/IL245636B/en active IP Right Grant
- 2016-05-19 ZA ZA2016/03434A patent/ZA201603434B/en unknown
-
2017
- 2017-11-20 JP JP2017222867A patent/JP6634428B2/ja active Active
- 2017-11-30 US US15/827,985 patent/US10435378B2/en active Active
-
2019
- 2019-04-09 AU AU2019202461A patent/AU2019202461B2/en active Active
- 2019-08-28 JP JP2019155667A patent/JP6857219B2/ja active Active
- 2019-08-29 US US16/555,842 patent/US10858324B2/en active Active
- 2019-12-11 IL IL271331A patent/IL271331B/en active IP Right Grant
-
2020
- 2020-05-11 ZA ZA2020/02611A patent/ZA202002611B/en unknown
-
2021
- 2021-02-24 IL IL281072A patent/IL281072B/en unknown
- 2021-03-19 JP JP2021045573A patent/JP7377828B2/ja active Active
- 2021-04-12 AU AU2021202196A patent/AU2021202196A1/en not_active Abandoned
-
2022
- 2022-11-24 AU AU2022275477A patent/AU2022275477A1/en not_active Abandoned
-
2024
- 2024-08-16 AU AU2024205845A patent/AU2024205845A1/en active Pending
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