MX2020008151A - Compuestos de pirazol y su preparacion. - Google Patents
Compuestos de pirazol y su preparacion.Info
- Publication number
- MX2020008151A MX2020008151A MX2020008151A MX2020008151A MX2020008151A MX 2020008151 A MX2020008151 A MX 2020008151A MX 2020008151 A MX2020008151 A MX 2020008151A MX 2020008151 A MX2020008151 A MX 2020008151A MX 2020008151 A MX2020008151 A MX 2020008151A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- preparation
- alkyl
- pyrazole compounds
- haloalkyl
- Prior art date
Links
- 150000003217 pyrazoles Chemical class 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 2
- 206010056370 Congestive cardiomyopathy Diseases 0.000 abstract 2
- 201000010046 Dilated cardiomyopathy Diseases 0.000 abstract 2
- NOIXNOMHHWGUTG-UHFFFAOYSA-N 2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline Chemical class C=1C=C(OCC=2N=C3C=CC=CC3=CC=2)C=CC=1C1=NN(CC(F)(F)F)C=C1C1=CC=NC=C1 NOIXNOMHHWGUTG-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- MSCIISHDSZZFEH-UHFFFAOYSA-N piperidine;urea Chemical class NC(O)=N.C1CCNCC1 MSCIISHDSZZFEH-UHFFFAOYSA-N 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000004665 trialkylsilyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
- B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
- B01J23/72—Copper
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
- B01J27/06—Halogens; Compounds thereof
- B01J27/08—Halides
- B01J27/122—Halides of copper
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La presente invención proporciona procesos para la preparación de compuestos de pirazol sustituidos de la fórmula II, que se pueden usar como productos intermedios para la preparación de compuestos de piperidina urea sustituidos útiles para el tratamiento de la miocardiopatía dilatada (DCM). R2 se selecciona independientemente de F, alquilo C1-C4, haloalquilo C1-C4, R3 se selecciona independientemente de H, F, alquilo C1-C4, haloalquilo C1-C4, R4 es alquilo C1-C4, R6 es H o un grupo protector y R7 se selecciona de H, Cl o trialquilsililo.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN201811003855 | 2018-02-01 | ||
| IN201811003859 | 2018-02-01 | ||
| IN201711042921 | 2018-05-30 | ||
| PCT/IN2019/050076 WO2019150392A1 (en) | 2018-02-01 | 2019-02-01 | Pyrazole compounds and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020008151A true MX2020008151A (es) | 2020-09-18 |
Family
ID=67478207
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020008151A MX2020008151A (es) | 2018-02-01 | 2019-02-01 | Compuestos de pirazol y su preparacion. |
| MX2025003379A MX2025003379A (es) | 2018-02-01 | 2020-07-31 | Compuestos de pirazol y su preparacion |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2025003379A MX2025003379A (es) | 2018-02-01 | 2020-07-31 | Compuestos de pirazol y su preparacion |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11873289B2 (es) |
| EP (1) | EP3746434A4 (es) |
| JP (1) | JP7402804B2 (es) |
| KR (1) | KR20200118025A (es) |
| CN (1) | CN111670184A (es) |
| AU (1) | AU2019213854C1 (es) |
| BR (1) | BR112020015692A2 (es) |
| CA (1) | CA3090204A1 (es) |
| IL (1) | IL276410B2 (es) |
| MA (1) | MA54677A (es) |
| MX (2) | MX2020008151A (es) |
| MY (1) | MY209060A (es) |
| SG (1) | SG11202007328UA (es) |
| WO (1) | WO2019150392A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3746434A4 (en) | 2018-02-01 | 2021-11-17 | MyoKardia, Inc. | PYRAZOLES AND THEIR PREPARATION |
| WO2025244956A1 (en) * | 2024-05-20 | 2025-11-27 | MyoKardia, Inc. | Methods of manufacturing danicamtiv |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007284386A (ja) * | 2006-04-18 | 2007-11-01 | Kumiai Chem Ind Co Ltd | ３−ピラゾリルフェニルスルフィド誘導体及びそれを有効成分として含有する殺虫・殺ダニ・殺線虫剤 |
| US8324178B2 (en) * | 2008-10-31 | 2012-12-04 | The Regents Of The University Of California | Method of treatment using alpha-1-adrenergic agonist compounds |
| US9260416B2 (en) * | 2011-05-27 | 2016-02-16 | Amira Pharmaceuticals, Inc. | Heterocyclic autotaxin inhibitors and uses thereof |
| ES2588386T3 (es) | 2012-08-30 | 2016-11-02 | Bayer Cropscience Ag | Procedimiento de descarboxilación de derivados de ácido 3,5-bis(haloalquil)-pirazol-4-carboxílico |
| WO2014089913A1 (zh) | 2012-12-12 | 2014-06-19 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的并环化合物 |
| WO2015063793A1 (en) | 2013-11-01 | 2015-05-07 | Srf Limited | Process for the preparation of pyrazole derivatives |
| EP3015458A1 (en) | 2014-11-03 | 2016-05-04 | Bayer CropScience AG | Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines |
| PH12017501279B1 (en) * | 2015-01-22 | 2023-06-16 | Myokardia Inc | 4-methylsulfonyl-substituted piperidine urea compounds for the treatment of dilated cardiomyopathy (dcm) |
| WO2018132372A1 (en) | 2017-01-10 | 2018-07-19 | Sanford Burnham Prebys Medical Discovery Institute | Small molecule activators of nicotinamide phosphoribosyltransferase (nampt) and uses thereof |
| CN111132964A (zh) * | 2017-04-11 | 2020-05-08 | 欧瑞克制药公司 | 糖皮质激素受体调节剂 |
| EP3746434A4 (en) | 2018-02-01 | 2021-11-17 | MyoKardia, Inc. | PYRAZOLES AND THEIR PREPARATION |
-
2019
- 2019-02-01 EP EP19747117.0A patent/EP3746434A4/en active Pending
- 2019-02-01 JP JP2020541983A patent/JP7402804B2/ja active Active
- 2019-02-01 CA CA3090204A patent/CA3090204A1/en active Pending
- 2019-02-01 IL IL276410A patent/IL276410B2/en unknown
- 2019-02-01 KR KR1020207022279A patent/KR20200118025A/ko active Pending
- 2019-02-01 CN CN201980011350.9A patent/CN111670184A/zh active Pending
- 2019-02-01 MX MX2020008151A patent/MX2020008151A/es unknown
- 2019-02-01 MY MYPI2020003963A patent/MY209060A/en unknown
- 2019-02-01 MA MA054677A patent/MA54677A/fr unknown
- 2019-02-01 WO PCT/IN2019/050076 patent/WO2019150392A1/en not_active Ceased
- 2019-02-01 SG SG11202007328UA patent/SG11202007328UA/en unknown
- 2019-02-01 AU AU2019213854A patent/AU2019213854C1/en active Active
- 2019-02-01 BR BR112020015692-2A patent/BR112020015692A2/pt unknown
- 2019-02-01 US US16/966,502 patent/US11873289B2/en active Active
-
2020
- 2020-07-31 MX MX2025003379A patent/MX2025003379A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA54677A (fr) | 2021-11-17 |
| US20210053940A1 (en) | 2021-02-25 |
| JP2021512127A (ja) | 2021-05-13 |
| WO2019150392A1 (en) | 2019-08-08 |
| AU2019213854C1 (en) | 2023-12-14 |
| MX2025003379A (es) | 2025-05-02 |
| KR20200118025A (ko) | 2020-10-14 |
| EP3746434A4 (en) | 2021-11-17 |
| SG11202007328UA (en) | 2020-08-28 |
| US11873289B2 (en) | 2024-01-16 |
| CN111670184A (zh) | 2020-09-15 |
| AU2019213854B2 (en) | 2023-06-15 |
| CA3090204A1 (en) | 2019-08-08 |
| BR112020015692A2 (pt) | 2020-12-08 |
| EP3746434A1 (en) | 2020-12-09 |
| JP7402804B2 (ja) | 2023-12-21 |
| IL276410B2 (en) | 2024-09-01 |
| IL276410A (en) | 2020-09-30 |
| IL276410B1 (en) | 2024-05-01 |
| AU2019213854A1 (en) | 2020-09-03 |
| MY209060A (en) | 2025-06-18 |
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