[go: up one dir, main page]

MX2020003566A - Metodos para la determinacion de una suspension de resina de cromatografia. - Google Patents

Metodos para la determinacion de una suspension de resina de cromatografia.

Info

Publication number
MX2020003566A
MX2020003566A MX2020003566A MX2020003566A MX2020003566A MX 2020003566 A MX2020003566 A MX 2020003566A MX 2020003566 A MX2020003566 A MX 2020003566A MX 2020003566 A MX2020003566 A MX 2020003566A MX 2020003566 A MX2020003566 A MX 2020003566A
Authority
MX
Mexico
Prior art keywords
concentration
resin
methods
suspension
present
Prior art date
Application number
MX2020003566A
Other languages
English (en)
Inventor
Eric Shierly
Scott Carver
Nathan Mao
Joseph Gallea
Raymond Feng
Tikiri Dissanayake
Bernhard Schilling
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2020003566A publication Critical patent/MX2020003566A/es

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/50Conditioning of the sorbent material or stationary liquid
    • G01N30/56Packing methods or coating methods
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/10Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B01D15/206Packing or coating
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/28Control of physical parameters of the fluid carrier
    • G01N30/32Control of physical parameters of the fluid carrier of pressure or speed
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01FMEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F23/00Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/28Control of physical parameters of the fluid carrier
    • G01N30/32Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/324Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/28Control of physical parameters of the fluid carrier
    • G01N30/32Control of physical parameters of the fluid carrier of pressure or speed
    • G01N2030/326Control of physical parameters of the fluid carrier of pressure or speed pumps
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/50Conditioning of the sorbent material or stationary liquid
    • G01N30/56Packing methods or coating methods
    • G01N2030/562Packing methods or coating methods packing
    • G01N2030/565Packing methods or coating methods packing slurry packing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8804Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 automated systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Fluid Mechanics (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

La presente invención hace referencia a métodos para la determinación de una concentración de suspensión para una suspensión de resina de cromatografía durante un empaque de columna. La presente invención proporciona un método más preciso y congruente para determinar una concentración de una suspensión para el empaque de una columna de cromatografía. El método de la presente invención utiliza una bomba automatizada para proporcionar una velocidad de flujo controlada para consolidar una muestra de resina. En función de la resina consolidada, es posible determinar una concentración de la suspensión. La concentración de la suspensión determinada puede utilizarse para empacar la resina en una columna de cromatografía con alturas de lecho altamente precisas.
MX2020003566A 2017-10-17 2018-10-15 Metodos para la determinacion de una suspension de resina de cromatografia. MX2020003566A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762573393P 2017-10-17 2017-10-17
PCT/US2018/055827 WO2019079159A1 (en) 2017-10-17 2018-10-15 METHODS OF DETERMINING CHROMATOGRAPHIC RESIN KETTLE

Publications (1)

Publication Number Publication Date
MX2020003566A true MX2020003566A (es) 2020-08-03

Family

ID=64051829

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020003566A MX2020003566A (es) 2017-10-17 2018-10-15 Metodos para la determinacion de una suspension de resina de cromatografia.
MX2023002917A MX2023002917A (es) 2017-10-17 2020-07-13 Metodos para la determinacion de una suspension de resina de cromatografia.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023002917A MX2023002917A (es) 2017-10-17 2020-07-13 Metodos para la determinacion de una suspension de resina de cromatografia.

Country Status (13)

Country Link
US (1) US12372502B2 (es)
EP (1) EP3697515A1 (es)
JP (2) JP7372231B2 (es)
KR (2) KR102706764B1 (es)
CN (1) CN111201072A (es)
AR (1) AR113776A1 (es)
AU (2) AU2018350886B2 (es)
CA (1) CA3078951A1 (es)
EA (1) EA202090777A1 (es)
IL (4) IL302722B2 (es)
MX (2) MX2020003566A (es)
TW (3) TWI846420B (es)
WO (1) WO2019079159A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3697515A1 (en) 2017-10-17 2020-08-26 Regeneron Pharmaceuticals, Inc. Methods for chromatography resin slurry determination
CN111939594B (zh) * 2020-07-25 2022-06-28 山东泰邦生物制品有限公司 一种吸附罐的搅拌方法
TWI864367B (zh) * 2021-03-17 2024-12-01 日商日水股份有限公司 純化的方法及純化的製品

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4755294A (en) * 1984-11-06 1988-07-05 Societe Anonyme Dite Compagnie Francaise De Raffinage Stationary phase, preparation thereof and chromatographic column containing same
WO2002010739A1 (en) 2000-07-28 2002-02-07 Euroflow (Uk) Limited Methods and apparatus for packing chromatography columns and chromatography column
SE0103403D0 (sv) * 2001-10-12 2001-10-12 Protista Internat Ab Separation medium, ITS preparation and ITS use
TWI293897B (en) 2002-08-21 2008-03-01 Toray Industries Modified substrates and process for producing the same
TW592785B (en) 2003-07-23 2004-06-21 Yi-Chung Fu Method for separating mucin and starch from a plant root or stem
WO2006001867A2 (en) * 2004-03-31 2006-01-05 Andrew Alaska Sweep-flow methods and clogging disrupters, for expanded bed chromatography of liquids with suspended particulates
JP2008514459A (ja) 2004-09-29 2008-05-08 3エイチ・インベンターズ・エーピーエス 粒子ペーストまたは懸濁液の押出を行う方法
US7452471B2 (en) 2005-10-21 2008-11-18 Ge Healthcare Bio-Sciences Ab Automated packing system and method for chromatography columns
US7674383B2 (en) 2005-10-25 2010-03-09 Phenomenex, Inc. Method and apparatus for packing chromatography columns
US20070215548A1 (en) * 2006-01-05 2007-09-20 Zhou Joe Xin H Systems and methods for packing chromatography columns
RU2458724C2 (ru) 2007-03-06 2012-08-20 Джи-И Хелткер Био-Сайенсиз Корп. Система и способ автоматизации набивки колонки средой
GB0704603D0 (en) 2007-03-09 2007-04-18 Ge Healthcare Bio Sciences Ab Packing system and method for chromatography columns
US8117901B2 (en) 2007-07-06 2012-02-21 Ge Healthcare Bio-Sciences Ab Determination of slurry concentration
US8664152B2 (en) 2007-08-31 2014-03-04 Jnc Corporation Porous cellulose gel, method for producing the same and use thereof
US9116150B2 (en) * 2007-11-19 2015-08-25 Emd Millipore Corporation Method of and device for packing a chromatography column
EP2235520B1 (en) * 2008-01-23 2018-04-04 GE Healthcare Bio-Sciences AB Column packing method
EP2291648B1 (en) * 2008-05-30 2014-07-30 GE Healthcare Bio-Sciences AB Column packing method
US8088277B2 (en) * 2008-06-11 2012-01-03 General Electric Company Methods and system for removing impurities from heavy fuel
CN105579843B (zh) 2013-09-30 2019-05-31 通用电气健康护理生物科学股份公司 用于传输浆料的方法
WO2015053276A1 (ja) 2013-10-08 2015-04-16 株式会社カネカ クロマトグラフィー用小径カラムの作製方法
CA2992018C (en) 2015-07-13 2023-06-13 Curtin University A measurement apparatus for measuring a volume of a desired solid component in a sample volume of a solid-liquid slurry
US10254256B2 (en) * 2015-10-01 2019-04-09 Thermo Hypersil-Keystone Llc Method of packing chromatographic columns, packed chromatographic columns for use at high pressures and uses thereof
EP3697515A1 (en) 2017-10-17 2020-08-26 Regeneron Pharmaceuticals, Inc. Methods for chromatography resin slurry determination

Also Published As

Publication number Publication date
TW202344839A (zh) 2023-11-16
TWI801436B (zh) 2023-05-11
KR102706764B1 (ko) 2024-09-19
MX2023002917A (es) 2023-04-10
IL273781B2 (en) 2023-02-01
JP7372231B2 (ja) 2023-10-31
IL310934A (en) 2024-04-01
JP7611340B2 (ja) 2025-01-09
IL302722A (en) 2023-07-01
WO2019079159A1 (en) 2019-04-25
IL273781B (en) 2022-10-01
CA3078951A1 (en) 2019-04-25
CN111201072A (zh) 2020-05-26
AU2024202294A1 (en) 2024-05-02
AU2018350886B2 (en) 2024-05-23
IL310934B1 (en) 2025-12-01
AU2018350886A1 (en) 2020-03-19
TWI846420B (zh) 2024-06-21
JP2020537740A (ja) 2020-12-24
IL296642B2 (en) 2023-10-01
IL302722B1 (en) 2024-03-01
EA202090777A1 (ru) 2020-07-07
IL296642A (en) 2022-11-01
IL302722B2 (en) 2024-07-01
KR20200070266A (ko) 2020-06-17
IL296642B1 (en) 2023-06-01
JP2024010016A (ja) 2024-01-23
US20190113485A1 (en) 2019-04-18
AR113776A1 (es) 2020-06-10
TW201930875A (zh) 2019-08-01
EP3697515A1 (en) 2020-08-26
BR112020002443A2 (pt) 2020-07-28
IL273781A (en) 2020-05-31
TW202434882A (zh) 2024-09-01
US12372502B2 (en) 2025-07-29
KR20240137718A (ko) 2024-09-20

Similar Documents

Publication Publication Date Title
MX2023002917A (es) Metodos para la determinacion de una suspension de resina de cromatografia.
MX390828B (es) Deteccion dinamica de la superficie de cemento (toc) durante la cementacion de una tuberia de revestimiento en un pozo.
BR112017019578A2 (pt) método de controle de fundo de poço e aparelho de completação de fundo de poço
AR110277A1 (es) Métodos para análisis del escalado de presión de cierre
EA201792190A1 (ru) Испытание пласта на наличие заполненных углеводородами трещин перед гидроразрывом сланца
MX2015002025A (es) Sistemas, metodos y aparatos para el monitoreo in situ de composiciones fluidas de cemento y procesos de endurecimiento de las mismas.
BR112016021678A2 (pt) método e sistema para determinar uma janela de peso de lama em um poço, e, meio legível por computador.
EA201591691A1 (ru) Способ и система для тампонирования скважины, а также использование взрывных зарядов при тампонировании
MY174838A (en) Cement spacer system for wellbores, methods of making, and methods of use
CO2017011619A2 (es) Método para evaluar la colocación de empaque de grava y de cemento en pozos por medio de materias primas que tienen bajos niveles de radioactividad
SA516380304B1 (ar) أنظمة وطرق لتحديد متغير انسيابية
PL418845A1 (pl) Indeksy rozróżnienia strukturalnego górnych stref wypełnienia wapienia ordowiku i sposób określania
AR107837A1 (es) Determinación de concentraciones residuales de reductores de fricción para fluidos de tratamiento subterráneo
GB2545133A (en) Packer setting tool with internal pump
EA201490909A1 (ru) Интеллектуальные метки - наночастицы для применения при подземных работах
EA201690615A1 (ru) Гидравлическая податливость ствола скважины
SA517381325B1 (ar) تحديد مقطع عرضي للالتقاط لمائع تغليف باستخدام نسبة معدل عد أشعة جاما
WO2017040457A3 (en) Coning transient multi-rate test
EA201291215A1 (ru) Способ и система для обработки подземного образования
MX2017008543A (es) Materiales trazadores no radioactivos para monitorear los fluidos de tratamiento en formaciones subterraneas.
GB2555301A (en) Swellable glass particles for reducing fluid flow in subterranean formations
GB2538374A (en) Determining formation gas composition during well drilling
EA201500594A1 (ru) Способ определения местоположения и глубины залегания источников магнитного поля в земной толще
NO20171618A1 (en) Methods, Apparatus, and Systems for Injecting and Detecting Compositions in Drilling Fluid Systems
Hu et al. Determination of P–V–T–x properties of the CO2–H2O system up to 573.15 K and 120 MPa—Experiments and model