MX2020003566A - Metodos para la determinacion de una suspension de resina de cromatografia. - Google Patents
Metodos para la determinacion de una suspension de resina de cromatografia.Info
- Publication number
- MX2020003566A MX2020003566A MX2020003566A MX2020003566A MX2020003566A MX 2020003566 A MX2020003566 A MX 2020003566A MX 2020003566 A MX2020003566 A MX 2020003566A MX 2020003566 A MX2020003566 A MX 2020003566A MX 2020003566 A MX2020003566 A MX 2020003566A
- Authority
- MX
- Mexico
- Prior art keywords
- concentration
- resin
- methods
- suspension
- present
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000002002 slurry Substances 0.000 title abstract 3
- 239000012539 chromatography resin Substances 0.000 title abstract 2
- 239000011347 resin Substances 0.000 abstract 3
- 229920005989 resin Polymers 0.000 abstract 3
- 239000000725 suspension Substances 0.000 abstract 3
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 238000012856 packing Methods 0.000 abstract 2
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/56—Packing methods or coating methods
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
- B01D15/206—Packing or coating
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/50—Conditioning of the sorbent material or stationary liquid
- G01N30/56—Packing methods or coating methods
- G01N2030/562—Packing methods or coating methods packing
- G01N2030/565—Packing methods or coating methods packing slurry packing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8804—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 automated systems
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Fluid Mechanics (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
La presente invención hace referencia a métodos para la determinación de una concentración de suspensión para una suspensión de resina de cromatografía durante un empaque de columna. La presente invención proporciona un método más preciso y congruente para determinar una concentración de una suspensión para el empaque de una columna de cromatografía. El método de la presente invención utiliza una bomba automatizada para proporcionar una velocidad de flujo controlada para consolidar una muestra de resina. En función de la resina consolidada, es posible determinar una concentración de la suspensión. La concentración de la suspensión determinada puede utilizarse para empacar la resina en una columna de cromatografía con alturas de lecho altamente precisas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762573393P | 2017-10-17 | 2017-10-17 | |
| PCT/US2018/055827 WO2019079159A1 (en) | 2017-10-17 | 2018-10-15 | METHODS OF DETERMINING CHROMATOGRAPHIC RESIN KETTLE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020003566A true MX2020003566A (es) | 2020-08-03 |
Family
ID=64051829
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020003566A MX2020003566A (es) | 2017-10-17 | 2018-10-15 | Metodos para la determinacion de una suspension de resina de cromatografia. |
| MX2023002917A MX2023002917A (es) | 2017-10-17 | 2020-07-13 | Metodos para la determinacion de una suspension de resina de cromatografia. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2023002917A MX2023002917A (es) | 2017-10-17 | 2020-07-13 | Metodos para la determinacion de una suspension de resina de cromatografia. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12372502B2 (es) |
| EP (1) | EP3697515A1 (es) |
| JP (2) | JP7372231B2 (es) |
| KR (2) | KR102706764B1 (es) |
| CN (1) | CN111201072A (es) |
| AR (1) | AR113776A1 (es) |
| AU (2) | AU2018350886B2 (es) |
| CA (1) | CA3078951A1 (es) |
| EA (1) | EA202090777A1 (es) |
| IL (4) | IL302722B2 (es) |
| MX (2) | MX2020003566A (es) |
| TW (3) | TWI846420B (es) |
| WO (1) | WO2019079159A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3697515A1 (en) | 2017-10-17 | 2020-08-26 | Regeneron Pharmaceuticals, Inc. | Methods for chromatography resin slurry determination |
| CN111939594B (zh) * | 2020-07-25 | 2022-06-28 | 山东泰邦生物制品有限公司 | 一种吸附罐的搅拌方法 |
| TWI864367B (zh) * | 2021-03-17 | 2024-12-01 | 日商日水股份有限公司 | 純化的方法及純化的製品 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4755294A (en) * | 1984-11-06 | 1988-07-05 | Societe Anonyme Dite Compagnie Francaise De Raffinage | Stationary phase, preparation thereof and chromatographic column containing same |
| WO2002010739A1 (en) | 2000-07-28 | 2002-02-07 | Euroflow (Uk) Limited | Methods and apparatus for packing chromatography columns and chromatography column |
| SE0103403D0 (sv) * | 2001-10-12 | 2001-10-12 | Protista Internat Ab | Separation medium, ITS preparation and ITS use |
| TWI293897B (en) | 2002-08-21 | 2008-03-01 | Toray Industries | Modified substrates and process for producing the same |
| TW592785B (en) | 2003-07-23 | 2004-06-21 | Yi-Chung Fu | Method for separating mucin and starch from a plant root or stem |
| WO2006001867A2 (en) * | 2004-03-31 | 2006-01-05 | Andrew Alaska | Sweep-flow methods and clogging disrupters, for expanded bed chromatography of liquids with suspended particulates |
| JP2008514459A (ja) | 2004-09-29 | 2008-05-08 | 3エイチ・インベンターズ・エーピーエス | 粒子ペーストまたは懸濁液の押出を行う方法 |
| US7452471B2 (en) | 2005-10-21 | 2008-11-18 | Ge Healthcare Bio-Sciences Ab | Automated packing system and method for chromatography columns |
| US7674383B2 (en) | 2005-10-25 | 2010-03-09 | Phenomenex, Inc. | Method and apparatus for packing chromatography columns |
| US20070215548A1 (en) * | 2006-01-05 | 2007-09-20 | Zhou Joe Xin H | Systems and methods for packing chromatography columns |
| RU2458724C2 (ru) | 2007-03-06 | 2012-08-20 | Джи-И Хелткер Био-Сайенсиз Корп. | Система и способ автоматизации набивки колонки средой |
| GB0704603D0 (en) | 2007-03-09 | 2007-04-18 | Ge Healthcare Bio Sciences Ab | Packing system and method for chromatography columns |
| US8117901B2 (en) | 2007-07-06 | 2012-02-21 | Ge Healthcare Bio-Sciences Ab | Determination of slurry concentration |
| US8664152B2 (en) | 2007-08-31 | 2014-03-04 | Jnc Corporation | Porous cellulose gel, method for producing the same and use thereof |
| US9116150B2 (en) * | 2007-11-19 | 2015-08-25 | Emd Millipore Corporation | Method of and device for packing a chromatography column |
| EP2235520B1 (en) * | 2008-01-23 | 2018-04-04 | GE Healthcare Bio-Sciences AB | Column packing method |
| EP2291648B1 (en) * | 2008-05-30 | 2014-07-30 | GE Healthcare Bio-Sciences AB | Column packing method |
| US8088277B2 (en) * | 2008-06-11 | 2012-01-03 | General Electric Company | Methods and system for removing impurities from heavy fuel |
| CN105579843B (zh) | 2013-09-30 | 2019-05-31 | 通用电气健康护理生物科学股份公司 | 用于传输浆料的方法 |
| WO2015053276A1 (ja) | 2013-10-08 | 2015-04-16 | 株式会社カネカ | クロマトグラフィー用小径カラムの作製方法 |
| CA2992018C (en) | 2015-07-13 | 2023-06-13 | Curtin University | A measurement apparatus for measuring a volume of a desired solid component in a sample volume of a solid-liquid slurry |
| US10254256B2 (en) * | 2015-10-01 | 2019-04-09 | Thermo Hypersil-Keystone Llc | Method of packing chromatographic columns, packed chromatographic columns for use at high pressures and uses thereof |
| EP3697515A1 (en) | 2017-10-17 | 2020-08-26 | Regeneron Pharmaceuticals, Inc. | Methods for chromatography resin slurry determination |
-
2018
- 2018-10-15 EP EP18796329.3A patent/EP3697515A1/en active Pending
- 2018-10-15 JP JP2020508490A patent/JP7372231B2/ja active Active
- 2018-10-15 IL IL302722A patent/IL302722B2/en unknown
- 2018-10-15 CA CA3078951A patent/CA3078951A1/en active Pending
- 2018-10-15 AU AU2018350886A patent/AU2018350886B2/en active Active
- 2018-10-15 MX MX2020003566A patent/MX2020003566A/es unknown
- 2018-10-15 IL IL310934A patent/IL310934B1/en unknown
- 2018-10-15 CN CN201880058488.XA patent/CN111201072A/zh active Pending
- 2018-10-15 IL IL296642A patent/IL296642B2/en unknown
- 2018-10-15 KR KR1020207011750A patent/KR102706764B1/ko active Active
- 2018-10-15 WO PCT/US2018/055827 patent/WO2019079159A1/en not_active Ceased
- 2018-10-15 KR KR1020247030321A patent/KR20240137718A/ko active Pending
- 2018-10-15 EA EA202090777A patent/EA202090777A1/ru unknown
- 2018-10-15 US US16/160,179 patent/US12372502B2/en active Active
- 2018-10-16 TW TW112113277A patent/TWI846420B/zh active
- 2018-10-16 TW TW107136397A patent/TWI801436B/zh active
- 2018-10-16 TW TW113119469A patent/TW202434882A/zh unknown
- 2018-10-17 AR ARP180103020A patent/AR113776A1/es unknown
-
2020
- 2020-04-02 IL IL273781A patent/IL273781B2/en unknown
- 2020-07-13 MX MX2023002917A patent/MX2023002917A/es unknown
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2023
- 2023-10-19 JP JP2023179943A patent/JP7611340B2/ja active Active
-
2024
- 2024-04-10 AU AU2024202294A patent/AU2024202294A1/en active Pending
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