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MX2020001207A - Metodos de tratamiento del cancer con inhibidores de farnesiltransferasa. - Google Patents

Metodos de tratamiento del cancer con inhibidores de farnesiltransferasa.

Info

Publication number
MX2020001207A
MX2020001207A MX2020001207A MX2020001207A MX2020001207A MX 2020001207 A MX2020001207 A MX 2020001207A MX 2020001207 A MX2020001207 A MX 2020001207A MX 2020001207 A MX2020001207 A MX 2020001207A MX 2020001207 A MX2020001207 A MX 2020001207A
Authority
MX
Mexico
Prior art keywords
bone marrow
blasts
methods
treating cancer
subject
Prior art date
Application number
MX2020001207A
Other languages
English (en)
Inventor
Gualberto Antonio
Original Assignee
Kura Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kura Oncology Inc filed Critical Kura Oncology Inc
Publication of MX2020001207A publication Critical patent/MX2020001207A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere al campo de la terapia contra el cáncer. Específicamente, se proporcionan métodos para tratar el cáncer en un sujeto que tenga signos clínicos de migración de células mieloides a la médula ósea, incluyendo neutropenia, neutropenia aislada, un bajo porcentaje de blastos de sangre periférica con o sin un alto porcentaje de blastos de médula ósea, y/o una baja relación de blastos de sangre periférica a blastos de médula ósea, con un inhibidor de farnesiltransferasa (FTI) que incluye determinar si el sujeto puede responder al tratamiento con FTI con base en las características hematológicas que indiquen la migración a la médula ósea de las células mieloides.
MX2020001207A 2017-08-07 2018-08-07 Metodos de tratamiento del cancer con inhibidores de farnesiltransferasa. MX2020001207A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762542202P 2017-08-07 2017-08-07
US201762596339P 2017-12-08 2017-12-08
US201862630686P 2018-02-14 2018-02-14
US201862646292P 2018-03-21 2018-03-21
PCT/US2018/045478 WO2019032489A1 (en) 2017-08-07 2018-08-07 METHODS OF TREATING CANCER WITH FARNESYLTRANSFERASE INHIBITORS

Publications (1)

Publication Number Publication Date
MX2020001207A true MX2020001207A (es) 2020-03-20

Family

ID=65271758

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020001207A MX2020001207A (es) 2017-08-07 2018-08-07 Metodos de tratamiento del cancer con inhibidores de farnesiltransferasa.

Country Status (15)

Country Link
US (1) US11291663B2 (es)
EP (1) EP3664804A4 (es)
JP (1) JP7325400B2 (es)
KR (1) KR20200051601A (es)
CN (1) CN111182899A (es)
AU (1) AU2018313738B2 (es)
BR (1) BR112020002591A2 (es)
CA (1) CA3071854A1 (es)
IL (1) IL272473A (es)
MX (1) MX2020001207A (es)
MY (1) MY200746A (es)
PH (1) PH12020550042A1 (es)
SG (1) SG11202000894TA (es)
TW (1) TW201919628A (es)
WO (1) WO2019032489A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220142983A1 (en) * 2019-03-01 2022-05-12 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors

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Also Published As

Publication number Publication date
WO2019032489A1 (en) 2019-02-14
TW201919628A (zh) 2019-06-01
SG11202000894TA (en) 2020-02-27
EP3664804A4 (en) 2021-04-14
JP7325400B2 (ja) 2023-08-14
US11291663B2 (en) 2022-04-05
MY200746A (en) 2024-01-13
JP2020530015A (ja) 2020-10-15
AU2018313738B2 (en) 2024-07-04
BR112020002591A2 (pt) 2020-07-28
CA3071854A1 (en) 2019-02-14
IL272473A (en) 2020-03-31
EP3664804A1 (en) 2020-06-17
AU2018313738A1 (en) 2020-02-27
PH12020550042A1 (en) 2020-10-19
CN111182899A (zh) 2020-05-19
KR20200051601A (ko) 2020-05-13
US20200246325A1 (en) 2020-08-06

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