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MX2019015371A - Derivados de dihidro-pirrolo-piridina. - Google Patents

Derivados de dihidro-pirrolo-piridina.

Info

Publication number
MX2019015371A
MX2019015371A MX2019015371A MX2019015371A MX2019015371A MX 2019015371 A MX2019015371 A MX 2019015371A MX 2019015371 A MX2019015371 A MX 2019015371A MX 2019015371 A MX2019015371 A MX 2019015371A MX 2019015371 A MX2019015371 A MX 2019015371A
Authority
MX
Mexico
Prior art keywords
sup
pyrrolo
dihydro
pyridine derivatives
compounds
Prior art date
Application number
MX2019015371A
Other languages
English (en)
Inventor
Lei Zhang
Matthew Frank Brown
Adam Matthew Gilbert
Michael Aaron Brodney
Christopher Ryan Butler
Erik Alphie Lachapelle
Laura Ann Mcallister
Elizabeth Mary Beck
Daniel Paul Uccello
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2019015371A publication Critical patent/MX2019015371A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención proporciona, en parte, compuestos de la fórmula I: (ver formula I) o un N-óxido del mismo, o una sal farmacéuticamente aceptable del compuesto o el N-óxido, en donde: (R1)a, (R2)b, (R3)c, L, A, y E son como se describen en la presente; procesos para la preparación de; intermedios utilizados en la preparación de; y composiciones que contienen tales compuestos, N-óxidos, o sales, y sus usos para tratar los trastornos mediados por M4 (o asociados con M4) que incluyen, por ejemplo, la enfermedad de Alzheimer, la esquizofrenia (por ejemplo, sus síntomas cognitivos y negativos), el dolor, la adicción y un trastorno del sueño.
MX2019015371A 2017-06-22 2018-06-14 Derivados de dihidro-pirrolo-piridina. MX2019015371A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762523306P 2017-06-22 2017-06-22
PCT/IB2018/054390 WO2018234953A1 (en) 2017-06-22 2018-06-14 Dihydro-pyrrolo-pyridine derivatives

Publications (1)

Publication Number Publication Date
MX2019015371A true MX2019015371A (es) 2020-07-20

Family

ID=62981279

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019015371A MX2019015371A (es) 2017-06-22 2018-06-14 Derivados de dihidro-pirrolo-piridina.

Country Status (19)

Country Link
US (1) US11198692B2 (es)
EP (1) EP3642202B1 (es)
JP (1) JP7263266B2 (es)
KR (1) KR20200013783A (es)
CN (1) CN110944998B (es)
AU (1) AU2018287787A1 (es)
BR (1) BR112019026955A2 (es)
CA (1) CA3066986A1 (es)
DK (1) DK3642202T3 (es)
ES (1) ES2937236T3 (es)
FI (1) FI3642202T3 (es)
HU (1) HUE060914T2 (es)
IL (1) IL271290B2 (es)
MX (1) MX2019015371A (es)
PL (1) PL3642202T3 (es)
PT (1) PT3642202T (es)
SG (1) SG11201913014YA (es)
TW (1) TWI680128B (es)
WO (1) WO2018234953A1 (es)

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JP7646653B2 (ja) * 2019-11-22 2025-03-17 エフ． ホフマン－ラ ロシュ アーゲー ピロリジン誘導体
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Also Published As

Publication number Publication date
KR20200013783A (ko) 2020-02-07
BR112019026955A2 (pt) 2020-06-30
PT3642202T (pt) 2023-02-02
WO2018234953A1 (en) 2018-12-27
CN110944998A (zh) 2020-03-31
NZ760036A (en) 2025-05-30
JP7263266B2 (ja) 2023-04-24
FI3642202T3 (fi) 2023-03-01
HUE060914T2 (hu) 2023-04-28
PL3642202T3 (pl) 2023-03-13
CN110944998B (zh) 2022-08-16
JP2020524687A (ja) 2020-08-20
EP3642202A1 (en) 2020-04-29
CA3066986A1 (en) 2018-12-27
IL271290A (en) 2020-01-30
US20200262833A1 (en) 2020-08-20
TWI680128B (zh) 2019-12-21
IL271290B2 (en) 2023-11-01
IL271290B1 (en) 2023-07-01
DK3642202T3 (da) 2023-01-30
US11198692B2 (en) 2021-12-14
AU2018287787A1 (en) 2020-01-16
SG11201913014YA (en) 2020-01-30
ES2937236T3 (es) 2023-03-27
EP3642202B1 (en) 2022-11-02
TW201920166A (zh) 2019-06-01

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