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MX2022010520A - Macrociclos peptidicos contra acinetobacter baumannii. - Google Patents

Macrociclos peptidicos contra acinetobacter baumannii.

Info

Publication number
MX2022010520A
MX2022010520A MX2022010520A MX2022010520A MX2022010520A MX 2022010520 A MX2022010520 A MX 2022010520A MX 2022010520 A MX2022010520 A MX 2022010520A MX 2022010520 A MX2022010520 A MX 2022010520A MX 2022010520 A MX2022010520 A MX 2022010520A
Authority
MX
Mexico
Prior art keywords
sup
acinetobacter baumannii
against acinetobacter
peptide macrocycles
macrocycles against
Prior art date
Application number
MX2022010520A
Other languages
English (en)
Inventor
Hans Hilpert
Hong Shen
taishan Hu
Sabine Kolczewski
Theodor Stoll
Konrad Bleicher
Bernhard Fasching
Alexander Alanine
Julien Beignet
Dwight Macdonald
Stephen Jackson
Carsten Kroll
Adrian Schaeublin
Helmut Thomas
Amal Wahhab
Claudia Zampaloni
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2022010520A publication Critical patent/MX2022010520A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención proporciona compuestos de fórmula (I) (ver Fórmula) (I) en donde de X1 a X8 y de R1 a R8 son tal como se definen en el presente documento, así como sales farmacéuticamente aceptables de los mismos. Además, la presente invención se refiere a la fabricación de compuestos de fórmula (I), composiciones farmacéuticas que los comprenden y su uso como medicamentos para el tratamiento de enfermedades e infecciones causadas por Acinetobacter baumannii.
MX2022010520A 2015-10-27 2018-04-26 Macrociclos peptidicos contra acinetobacter baumannii. MX2022010520A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15191743 2015-10-27
CN2016100125 2016-09-26

Publications (1)

Publication Number Publication Date
MX2022010520A true MX2022010520A (es) 2022-09-19

Family

ID=57200005

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018005236A MX2018005236A (es) 2015-10-27 2016-10-24 Macrociclos peptidicos contra acinetobacter baumannii.
MX2022010520A MX2022010520A (es) 2015-10-27 2018-04-26 Macrociclos peptidicos contra acinetobacter baumannii.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018005236A MX2018005236A (es) 2015-10-27 2016-10-24 Macrociclos peptidicos contra acinetobacter baumannii.

Country Status (26)

Country Link
US (3) US10030047B2 (es)
EP (1) EP3368544B1 (es)
JP (2) JP7286317B2 (es)
KR (1) KR102701379B1 (es)
CN (1) CN108350028B (es)
AU (1) AU2016347456B2 (es)
CL (1) CL2018000978A1 (es)
CO (1) CO2017013708A2 (es)
CR (1) CR20180232A (es)
DK (1) DK3368544T3 (es)
ES (1) ES2811911T3 (es)
HR (1) HRP20201273T1 (es)
HU (1) HUE050053T2 (es)
IL (1) IL258060B (es)
MX (2) MX2018005236A (es)
MY (1) MY193014A (es)
PE (1) PE20180796A1 (es)
PH (1) PH12018500904A1 (es)
PL (1) PL3368544T3 (es)
PT (1) PT3368544T (es)
RS (1) RS60662B1 (es)
RU (1) RU2729609C2 (es)
SI (1) SI3368544T1 (es)
TW (1) TWI720042B (es)
UA (1) UA124303C2 (es)
WO (1) WO2017072062A1 (es)

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Also Published As

Publication number Publication date
US20170233437A1 (en) 2017-08-17
HRP20201273T1 (hr) 2020-11-13
CL2018000978A1 (es) 2018-08-24
IL258060A (en) 2018-05-31
AU2016347456A1 (en) 2018-01-18
US20220411468A1 (en) 2022-12-29
CO2017013708A2 (es) 2018-03-20
IL258060B (en) 2021-05-31
US11098080B2 (en) 2021-08-24
TWI720042B (zh) 2021-03-01
ES2811911T3 (es) 2021-03-15
NZ738307A (en) 2024-02-23
US20180362578A1 (en) 2018-12-20
PE20180796A1 (es) 2018-05-09
RU2729609C2 (ru) 2020-08-11
EP3368544B1 (en) 2020-06-17
CR20180232A (es) 2018-05-31
TW201718565A (zh) 2017-06-01
CN108350028B (zh) 2021-12-07
UA124303C2 (uk) 2021-08-25
SI3368544T1 (sl) 2020-10-30
US10030047B2 (en) 2018-07-24
AU2016347456B2 (en) 2018-12-13
HUE050053T2 (hu) 2020-11-30
MY193014A (en) 2022-09-22
RU2018113426A (ru) 2019-11-28
KR20180063138A (ko) 2018-06-11
CN108350028A (zh) 2018-07-31
HK1258443A1 (zh) 2019-11-15
RS60662B1 (sr) 2020-09-30
DK3368544T3 (da) 2020-08-24
PL3368544T3 (pl) 2020-11-16
JP2022024009A (ja) 2022-02-08
EP3368544A1 (en) 2018-09-05
JP2018535960A (ja) 2018-12-06
JP7286317B2 (ja) 2023-06-05
RU2018113426A3 (es) 2020-01-31
KR102701379B1 (ko) 2024-09-02
CA2992926A1 (en) 2017-05-04
WO2017072062A1 (en) 2017-05-04
PT3368544T (pt) 2020-08-20
MX2018005236A (es) 2018-08-15
US12012466B2 (en) 2024-06-18
PH12018500904A1 (en) 2018-11-05

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