MX2019010169A - Compuestos novedosos utiles como abridores del canal de potasio. - Google Patents
Compuestos novedosos utiles como abridores del canal de potasio.Info
- Publication number
- MX2019010169A MX2019010169A MX2019010169A MX2019010169A MX2019010169A MX 2019010169 A MX2019010169 A MX 2019010169A MX 2019010169 A MX2019010169 A MX 2019010169A MX 2019010169 A MX2019010169 A MX 2019010169A MX 2019010169 A MX2019010169 A MX 2019010169A
- Authority
- MX
- Mexico
- Prior art keywords
- groups
- substituted
- unsubstituted
- potassium channel
- novel compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 229940127315 Potassium Channel Openers Drugs 0.000 title abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- -1 cyclopentathienyl groups Chemical group 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
- C07C323/44—X or Y being nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cosmetics (AREA)
- Fertilizers (AREA)
Abstract
La descripción actual describe compuestos novedosos que son útiles como abridores del canal de potasio, en particular como abridores del canal de potasio Kv7.4. Los compuestos novedosos son compuestos de acuerdo con la fórmula I, (ver fórmula) en donde - n = 0 o 1, - RL es un sustituyente seleccionado del grupo que consiste de grupos cicloalquilo sustituidos o no sustituidos, en particular grupos bicicloalquilo, grupos fenilo sustituidos o no sustituidos, grupos tienilo sustituidos o no sustituidos o grupos ciclopentatienilo, y grupos indanilo sustituidos o no sustituidos, que opcionalmente contienen heteroátomos, y - RR es un sustituyente seleccionado del grupo que consiste de grupos fenilo sustituidos o no sustituidos o grupos bencilo sustituidos o no sustituidos, que opcionalmente contienen heteroátomos, - o un estereoisómero, un tautómero, un profármaco o una sal, preferiblemente sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17158326.3A EP3366683A1 (en) | 2017-02-28 | 2017-02-28 | Cyclic amides, acteamides and ureas useful as potassium channel openers |
| PCT/EP2018/054820 WO2018158256A2 (en) | 2017-02-28 | 2018-02-27 | Novel compounds useful as potassium channel openers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019010169A true MX2019010169A (es) | 2019-10-21 |
| MX378574B MX378574B (es) | 2025-03-10 |
Family
ID=58192162
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020010866A MX390303B (es) | 2017-02-28 | 2018-02-27 | Compuestos novedosos utiles como abridores del canal de potasio |
| MX2019010169A MX378574B (es) | 2017-02-28 | 2018-02-27 | Compuestos novedosos utiles como abridores del canal de potasio |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020010866A MX390303B (es) | 2017-02-28 | 2018-02-27 | Compuestos novedosos utiles como abridores del canal de potasio |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11034665B2 (es) |
| EP (3) | EP3366683A1 (es) |
| JP (3) | JP6795713B2 (es) |
| KR (2) | KR102443685B1 (es) |
| CN (2) | CN110312710B (es) |
| AU (2) | AU2018227005B2 (es) |
| BR (2) | BR112019017184B1 (es) |
| CA (2) | CA3052359C (es) |
| CL (2) | CL2019002445A1 (es) |
| CY (2) | CY1123114T1 (es) |
| DK (2) | DK3567034T3 (es) |
| ES (2) | ES2813064T3 (es) |
| HR (2) | HRP20201159T1 (es) |
| HU (2) | HUE051854T2 (es) |
| IL (1) | IL268931B (es) |
| LT (2) | LT3567034T (es) |
| MX (2) | MX390303B (es) |
| PH (1) | PH12019550146A1 (es) |
| PL (2) | PL3567034T3 (es) |
| PT (2) | PT3484863T (es) |
| RS (2) | RS61254B1 (es) |
| SI (2) | SI3567034T1 (es) |
| SM (2) | SMT202000471T1 (es) |
| WO (1) | WO2018158256A2 (es) |
| ZA (1) | ZA201905198B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3366683A1 (en) * | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
| EP4414029A3 (en) | 2019-09-17 | 2024-11-06 | Knopp Biosciences LLC | Methods of use for kv7 channel activators |
| EP4143165A1 (en) | 2020-04-29 | 2023-03-08 | Idorsia Pharmaceuticals Ltd | Spirourea derivatives |
| EP4172140A1 (en) | 2020-06-25 | 2023-05-03 | Idorsia Pharmaceuticals Ltd | Cyclobutyl-urea derivatives |
| CA3198930A1 (en) * | 2020-11-19 | 2022-05-27 | Acousia Therapeutics Gmbh | Non-aqueous gel composition |
| CN116535353A (zh) * | 2022-01-25 | 2023-08-04 | 上海挚盟医药科技有限公司 | 作为钾通道调节剂的酰胺类化合物及其制备和应用 |
| EP4279061A1 (en) * | 2022-05-18 | 2023-11-22 | Acousia Therapeutics GmbH | Aqueous gel composition |
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| JPH0594034A (ja) | 1990-06-29 | 1993-04-16 | Xerox Corp | クラツクのない電子写真画像形成デバイス |
| DK0957099T3 (da) * | 1998-04-15 | 2003-03-17 | Pfizer Prod Inc | Heterocykliske carboxamider |
| DE19929076A1 (de) * | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10061876A1 (de) * | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| WO2002080898A2 (en) | 2001-04-04 | 2002-10-17 | Wyeth | Methods for treating hyperactive gastric motility |
| US7273866B2 (en) * | 2002-12-20 | 2007-09-25 | Bristol-Myers Squibb Company | 2-aryl thiazole derivatives as KCNQ modulators |
| MXPA05010000A (es) | 2003-03-21 | 2005-11-17 | Lundbeck & Co As H | Derivados de p-diaminobenceno substituidos. |
| TWI357901B (en) | 2004-03-12 | 2012-02-11 | Lundbeck & Co As H | Substituted morpholine and thiomorpholine derivati |
| UA89503C2 (uk) | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| US20060188445A1 (en) | 2005-02-22 | 2006-08-24 | Fred Hutchinson Cancer Research Center | Assay for compounds that protect against sensory hair cell death and compounds identified by same |
| US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| WO2007087424A2 (en) | 2006-01-25 | 2007-08-02 | The Johns Hopkins University | Method of treating kcnq related disorders using organozinc compounds |
| WO2007138112A2 (en) | 2006-06-01 | 2007-12-06 | Devgen N.V. | Compounds that interact with ion channels, in particular with ion channels from the kv family |
| US20090118274A1 (en) | 2007-02-15 | 2009-05-07 | Darin Allen | Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
| DE102007063673B4 (de) | 2007-07-10 | 2018-02-08 | Heraeus Electro-Nite International N.V. | Messverfahren |
| UA97847C2 (ru) * | 2007-08-01 | 2012-03-26 | Х. Луннбек А/С | Применение соединений, которые открывают калиевые каналы kcnq, для лечения дефицита внимания/гиперактивности (adhd) или агрессии |
| WO2009052062A1 (en) | 2007-10-17 | 2009-04-23 | Sanofi-Aventis | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
| CN101896461A (zh) * | 2007-12-13 | 2010-11-24 | 安姆根有限公司 | γ分泌酶调节剂 |
| US7786171B2 (en) * | 2008-04-04 | 2010-08-31 | Abbott Laboratories | Amide derivatives as positive allosteric modulators and methods of use thereof |
| TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
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| WO2011085351A2 (en) | 2010-01-11 | 2011-07-14 | The Johns Hopkins University | Method of treating kcnq related disorders |
| DE102010007281A1 (de) | 2010-02-08 | 2011-08-11 | EMC microcollections GmbH, 72070 | Neue Aminoalkyl-oxazol- und Aminoalkyl-thiazolcarbonsäureamide und ihre Anwendung zur Stimulation der endogenen situ Regeneration von Haarsinneszellen im Corti'schen Organ des Innenohres beim Säuger |
| US8586604B2 (en) * | 2010-08-20 | 2013-11-19 | Boehringer Ingelheim International Gmbh | Inhibitors of the microsomal prostaglandin E2 synthase-1 |
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| AU2013323206B2 (en) | 2012-09-28 | 2017-07-20 | Fred Hutchinson Cancer Center | Compounds and methods for preventing, treating and/or protecting against sensory hair cell death |
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| WO2014145205A2 (en) * | 2013-03-15 | 2014-09-18 | St. Jude Children's Research Hospital | Methods and compositions of p27kip1 transcription modulators |
| PL404138A1 (pl) * | 2013-05-31 | 2014-12-08 | Warszawski Uniwersytet Medyczny | Pochodne kwasu benzoesowego jako inhibitory receptora IL-15Rα |
| US20150126507A1 (en) * | 2013-09-05 | 2015-05-07 | Fate Therapeutics, Inc. | Compounds to treat hearing loss |
| JP6378774B2 (ja) * | 2013-11-05 | 2018-08-22 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 自己免疫疾患を処置するためのＲＯＲｃモジュレーターとしての５，６，７，８−テトラヒドロ−５，８−メタノシンノリン誘導体 |
| ES2607752T3 (es) * | 2013-11-12 | 2017-04-03 | Acousia Therapeutics Gmbh | Compuestos nuevos para regeneración de células y tejidos terminalmente diferenciados |
| CN105017085B (zh) | 2014-04-28 | 2018-06-29 | 中国科学院上海药物研究所 | 一类kcnq钾通道激动剂、其制备方法和用途 |
| US10399994B2 (en) * | 2015-02-06 | 2019-09-03 | University Of Washington | Compounds and methods for preventing or treating sensory hair cell death |
| GB201601301D0 (en) | 2016-01-25 | 2016-03-09 | Takeda Pharmaceutical | Novel compounds |
| EP3366683A1 (en) | 2017-02-28 | 2018-08-29 | Acousia Therapeutics GmbH | Cyclic amides, acteamides and ureas useful as potassium channel openers |
-
2017
- 2017-02-28 EP EP17158326.3A patent/EP3366683A1/en not_active Withdrawn
-
2018
- 2018-02-27 CA CA3052359A patent/CA3052359C/en active Active
- 2018-02-27 JP JP2019567399A patent/JP6795713B2/ja active Active
- 2018-02-27 HR HRP20201159TT patent/HRP20201159T1/hr unknown
- 2018-02-27 ES ES18707374T patent/ES2813064T3/es active Active
- 2018-02-27 SI SI201830189T patent/SI3567034T1/sl unknown
- 2018-02-27 ES ES19179900T patent/ES2846772T3/es active Active
- 2018-02-27 HU HUE18707374A patent/HUE051854T2/hu unknown
- 2018-02-27 US US16/487,933 patent/US11034665B2/en active Active
- 2018-02-27 SI SI201830113T patent/SI3484863T1/sl unknown
- 2018-02-27 PT PT187073747T patent/PT3484863T/pt unknown
- 2018-02-27 WO PCT/EP2018/054820 patent/WO2018158256A2/en not_active Ceased
- 2018-02-27 DK DK19179900.6T patent/DK3567034T3/da active
- 2018-02-27 CA CA3238405A patent/CA3238405A1/en active Pending
- 2018-02-27 BR BR112019017184-3A patent/BR112019017184B1/pt active IP Right Grant
- 2018-02-27 CN CN201880014217.4A patent/CN110312710B/zh active Active
- 2018-02-27 KR KR1020217035304A patent/KR102443685B1/ko active Active
- 2018-02-27 PL PL19179900T patent/PL3567034T3/pl unknown
- 2018-02-27 HU HUE19179900A patent/HUE052703T2/hu unknown
- 2018-02-27 PL PL18707374T patent/PL3484863T3/pl unknown
- 2018-02-27 DK DK18707374.7T patent/DK3484863T3/da active
- 2018-02-27 LT LTEP19179900.6T patent/LT3567034T/lt unknown
- 2018-02-27 BR BR122020025103-4A patent/BR122020025103B1/pt active IP Right Grant
- 2018-02-27 PT PT191799006T patent/PT3567034T/pt unknown
- 2018-02-27 KR KR1020197023369A patent/KR102382795B1/ko active Active
- 2018-02-27 LT LTEP18707374.7T patent/LT3484863T/lt unknown
- 2018-02-27 SM SM20200471T patent/SMT202000471T1/it unknown
- 2018-02-27 AU AU2018227005A patent/AU2018227005B2/en active Active
- 2018-02-27 CN CN202111376413.6A patent/CN114105942B/zh active Active
- 2018-02-27 EP EP19179900.6A patent/EP3567034B1/en active Active
- 2018-02-27 MX MX2020010866A patent/MX390303B/es unknown
- 2018-02-27 SM SM20210053T patent/SMT202100053T1/it unknown
- 2018-02-27 RS RS20201546A patent/RS61254B1/sr unknown
- 2018-02-27 RS RS20200895A patent/RS60648B1/sr unknown
- 2018-02-27 MX MX2019010169A patent/MX378574B/es unknown
- 2018-02-27 EP EP18707374.7A patent/EP3484863B1/en active Active
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2019
- 2019-08-06 ZA ZA2019/05198A patent/ZA201905198B/en unknown
- 2019-08-19 PH PH12019550146A patent/PH12019550146A1/en unknown
- 2019-08-26 CL CL2019002445A patent/CL2019002445A1/es unknown
- 2019-08-26 IL IL268931A patent/IL268931B/en unknown
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2020
- 2020-07-09 CY CY20201100634T patent/CY1123114T1/el unknown
- 2020-09-29 JP JP2020163507A patent/JP2021008479A/ja not_active Withdrawn
- 2020-11-09 CY CY20201101052T patent/CY1123488T1/el unknown
- 2020-12-07 HR HRP20201961TT patent/HRP20201961T1/hr unknown
-
2021
- 2021-05-11 US US17/316,823 patent/US11884642B2/en active Active
- 2021-05-12 CL CL2021001243A patent/CL2021001243A1/es unknown
- 2021-10-22 AU AU2021254653A patent/AU2021254653B2/en active Active
-
2022
- 2022-08-01 JP JP2022122598A patent/JP7474289B2/ja active Active
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