MX2019009687A - Procesos para la preparación de derivados de benzodiazepina. - Google Patents
Procesos para la preparación de derivados de benzodiazepina.Info
- Publication number
- MX2019009687A MX2019009687A MX2019009687A MX2019009687A MX2019009687A MX 2019009687 A MX2019009687 A MX 2019009687A MX 2019009687 A MX2019009687 A MX 2019009687A MX 2019009687 A MX2019009687 A MX 2019009687A MX 2019009687 A MX2019009687 A MX 2019009687A
- Authority
- MX
- Mexico
- Prior art keywords
- processes
- preparation
- benzodiazepine derivatives
- present
- intermediates
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 4
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 150000001557 benzodiazepines Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 3
- 241000725643 Respiratory syncytial virus Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a procesos y productos intermedios útiles en la preparación de moléculas biológicamente activas, especialmente en la síntesis de inhibidores del virus sincitial respiratorio (VSR). La presente invención se refiere además a procesos y productos intermedios para la preparación de compuestos de la fórmula (I). En particular, la presente invención se refiere además a procesos y productos intermedios para la preparación del compuesto (I-a).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762459953P | 2017-02-16 | 2017-02-16 | |
| US201762459955P | 2017-02-16 | 2017-02-16 | |
| PCT/US2018/018511 WO2018152413A1 (en) | 2017-02-16 | 2018-02-16 | Processes for the preparation of benzodiazepine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019009687A true MX2019009687A (es) | 2019-12-18 |
| MX379326B MX379326B (es) | 2025-03-11 |
Family
ID=63166545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019009687A MX379326B (es) | 2017-02-16 | 2018-02-16 | Procesos para la preparación de derivados de benzodiazepina |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10358441B2 (es) |
| EP (1) | EP3582784B1 (es) |
| JP (1) | JP7076459B2 (es) |
| KR (1) | KR102573499B1 (es) |
| CN (1) | CN110809472B (es) |
| AU (1) | AU2018221820B2 (es) |
| CA (1) | CA3065368A1 (es) |
| ES (1) | ES2923521T3 (es) |
| IL (1) | IL268737B2 (es) |
| MX (1) | MX379326B (es) |
| NZ (1) | NZ756805A (es) |
| WO (1) | WO2018152413A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS63653B1 (sr) | 2015-07-22 | 2022-11-30 | Enanta Pharm Inc | Benzodiazepinski derivati kao inhibitori rsv |
| WO2017123884A1 (en) | 2016-01-15 | 2017-07-20 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
| WO2018129287A1 (en) | 2017-01-06 | 2018-07-12 | Enanta Pharmaceuticals, Inc. | Heteroaryldiazepine derivatives as rsv inhibitors |
| WO2018152413A1 (en) | 2017-02-16 | 2018-08-23 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
| WO2018226801A1 (en) | 2017-06-07 | 2018-12-13 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as rsv inhibitors |
| WO2019006291A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| WO2019067864A1 (en) | 2017-09-29 | 2019-04-04 | Enanta Pharmaceuticals, Inc. | PHARMACEUTICAL AGENTS IN COMBINATION AS INHIBITORS OF RSV |
| CN111343990B (zh) | 2017-11-13 | 2023-08-04 | 英安塔制药有限公司 | 苯并二氮杂䓬-2-酮和苯并氮杂䓬-2-酮衍生物的拆分方法 |
| US10647711B2 (en) | 2017-11-13 | 2020-05-12 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as RSV inhibitors |
| US10975094B2 (en) | 2018-04-11 | 2021-04-13 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| UY38614A (es) | 2019-03-18 | 2020-10-30 | Enanta Pharm Inc | Derivados de benzodiazepinas como inhibidores del rsv |
| WO2020210246A1 (en) | 2019-04-09 | 2020-10-15 | Enanta Pharmaceuticals, Inc, | Heterocyclic compounds as rsv inhibitors |
| GB201911944D0 (en) | 2019-08-20 | 2019-10-02 | Reviral Ltd | Pharmaceutical compounds |
| US11505558B1 (en) | 2019-10-04 | 2022-11-22 | Enanta Pharmaceuticals, Inc. | Antiviral heterocyclic compounds |
| MX2022003984A (es) | 2019-10-04 | 2022-07-27 | Enanta Pharm Inc | Compuestos heterociclicos antivirales. |
| GB201915932D0 (en) | 2019-11-01 | 2019-12-18 | Reviral Ltd | Pharmaceutical compounds |
| UY39032A (es) | 2020-01-24 | 2021-07-30 | Enanta Pharm Inc | Compuestos heterocíclicos como agentes antivirales |
| US11534439B2 (en) | 2020-07-07 | 2022-12-27 | Enanta Pharmaceuticals, Inc. | Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors |
| WO2022086840A1 (en) | 2020-10-19 | 2022-04-28 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as anti-viral agents |
| KR20230161976A (ko) | 2021-02-26 | 2023-11-28 | 이난타 파마슈티칼스, 인코포레이티드 | 항바이러스성 헤테로사이클릭 화합물 |
| AR129003A1 (es) | 2022-04-07 | 2024-07-03 | Enanta Pharm Inc | Compuestos heterocíclicos antivirales |
| WO2023211997A1 (en) | 2022-04-27 | 2023-11-02 | Enanta Pharmaceuticals, Inc. | Antiviral compounds |
| WO2025034929A2 (en) * | 2023-08-09 | 2025-02-13 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of oxadiazolylamino benzodiazepine derivatives |
| US20250145603A1 (en) * | 2023-11-07 | 2025-05-08 | Enanta Pharmaceuticals, Inc. | Crystal forms of an anti-rsv agent |
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| RS63653B1 (sr) | 2015-07-22 | 2022-11-30 | Enanta Pharm Inc | Benzodiazepinski derivati kao inhibitori rsv |
| WO2017123884A1 (en) | 2016-01-15 | 2017-07-20 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as rsv inhibitors |
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| WO2018129287A1 (en) | 2017-01-06 | 2018-07-12 | Enanta Pharmaceuticals, Inc. | Heteroaryldiazepine derivatives as rsv inhibitors |
| WO2018152413A1 (en) | 2017-02-16 | 2018-08-23 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of benzodiazepine derivatives |
| WO2018226801A1 (en) | 2017-06-07 | 2018-12-13 | Enanta Pharmaceuticals, Inc. | Aryldiazepine derivatives as rsv inhibitors |
| WO2019006291A1 (en) | 2017-06-30 | 2019-01-03 | Enanta Pharmaceuticals, Inc. | HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS |
| US11091501B2 (en) | 2017-06-30 | 2021-08-17 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
| WO2019067864A1 (en) | 2017-09-29 | 2019-04-04 | Enanta Pharmaceuticals, Inc. | PHARMACEUTICAL AGENTS IN COMBINATION AS INHIBITORS OF RSV |
| CN111343990B (zh) | 2017-11-13 | 2023-08-04 | 英安塔制药有限公司 | 苯并二氮杂䓬-2-酮和苯并氮杂䓬-2-酮衍生物的拆分方法 |
| US10647711B2 (en) | 2017-11-13 | 2020-05-12 | Enanta Pharmaceuticals, Inc. | Azepin-2-one derivatives as RSV inhibitors |
| US10975094B2 (en) | 2018-04-11 | 2021-04-13 | Enanta Pharmaceuticals, Inc. | Heterocyclic compounds as RSV inhibitors |
-
2018
- 2018-02-16 WO PCT/US2018/018511 patent/WO2018152413A1/en not_active Ceased
- 2018-02-16 ES ES18753994T patent/ES2923521T3/es active Active
- 2018-02-16 US US15/898,387 patent/US10358441B2/en active Active
- 2018-02-16 JP JP2019543850A patent/JP7076459B2/ja active Active
- 2018-02-16 AU AU2018221820A patent/AU2018221820B2/en active Active
- 2018-02-16 EP EP18753994.5A patent/EP3582784B1/en active Active
- 2018-02-16 CN CN201880024791.8A patent/CN110809472B/zh active Active
- 2018-02-16 IL IL268737A patent/IL268737B2/en unknown
- 2018-02-16 CA CA3065368A patent/CA3065368A1/en active Pending
- 2018-02-16 MX MX2019009687A patent/MX379326B/es unknown
- 2018-02-16 NZ NZ756805A patent/NZ756805A/en unknown
- 2018-02-16 KR KR1020197026685A patent/KR102573499B1/ko active Active
-
2019
- 2019-06-24 US US16/449,946 patent/US10906895B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018221820A1 (en) | 2019-09-19 |
| EP3582784B1 (en) | 2022-06-08 |
| EP3582784A4 (en) | 2020-09-16 |
| US20180237425A1 (en) | 2018-08-23 |
| CN110809472A (zh) | 2020-02-18 |
| US20190308964A1 (en) | 2019-10-10 |
| MX379326B (es) | 2025-03-11 |
| JP7076459B2 (ja) | 2022-05-27 |
| KR102573499B1 (ko) | 2023-08-31 |
| WO2018152413A1 (en) | 2018-08-23 |
| IL268737A (en) | 2019-10-31 |
| IL268737B2 (en) | 2024-02-01 |
| JP2020507595A (ja) | 2020-03-12 |
| US10906895B2 (en) | 2021-02-02 |
| BR112019016914A2 (pt) | 2020-04-14 |
| CA3065368A1 (en) | 2018-08-23 |
| CN110809472B (zh) | 2023-05-23 |
| ES2923521T3 (es) | 2022-09-28 |
| RU2019128300A3 (es) | 2021-06-25 |
| KR20190130129A (ko) | 2019-11-21 |
| IL268737B1 (en) | 2023-10-01 |
| US10358441B2 (en) | 2019-07-23 |
| NZ756805A (en) | 2025-10-31 |
| RU2019128300A (ru) | 2021-03-17 |
| AU2018221820B2 (en) | 2023-11-02 |
| EP3582784A1 (en) | 2019-12-25 |
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