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MX2017002288A - Nucleosidos de 2'-cloro-aminopirimidinona y pirimidin-diona. - Google Patents

Nucleosidos de 2'-cloro-aminopirimidinona y pirimidin-diona.

Info

Publication number
MX2017002288A
MX2017002288A MX2017002288A MX2017002288A MX2017002288A MX 2017002288 A MX2017002288 A MX 2017002288A MX 2017002288 A MX2017002288 A MX 2017002288A MX 2017002288 A MX2017002288 A MX 2017002288A MX 2017002288 A MX2017002288 A MX 2017002288A
Authority
MX
Mexico
Prior art keywords
pyrimidine dione
nucleosides
aminopyrimidinone
chloro
chloro aminopyrimidinone
Prior art date
Application number
MX2017002288A
Other languages
English (en)
Inventor
Siegel Dustin
L Mackman Richard
O´ Neil Hanrahan CLARKE Michael
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MX2017002288A publication Critical patent/MX2017002288A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

En la presente solicitud se proveen formulaciones, métodos y compuestos sustituidos de 2'-cloro-aminopirimidinona y pirimidin-diona de la fórmula (I) para tratar infecciones por virus Pneumovirinae, incluyendo infecciones por virus del sincitio respiratorio, así como métodos e intermediarios para la síntesis de compuestos sustituidos de 2'-cloro-aminopirimidinona y pirimidin-diona.
MX2017002288A 2014-08-21 2015-08-19 Nucleosidos de 2'-cloro-aminopirimidinona y pirimidin-diona. MX2017002288A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462040349P 2014-08-21 2014-08-21
PCT/US2015/045849 WO2016028866A1 (en) 2014-08-21 2015-08-19 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides

Publications (1)

Publication Number Publication Date
MX2017002288A true MX2017002288A (es) 2017-05-22

Family

ID=54066190

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017002288A MX2017002288A (es) 2014-08-21 2015-08-19 Nucleosidos de 2'-cloro-aminopirimidinona y pirimidin-diona.

Country Status (17)

Country Link
US (6) US9617295B2 (es)
EP (2) EP3183261B1 (es)
JP (2) JP6765364B2 (es)
KR (1) KR102528928B1 (es)
CN (1) CN106573954A (es)
AR (1) AR101561A1 (es)
AU (1) AU2015305593C1 (es)
BR (1) BR112017003242A2 (es)
CA (1) CA2958546C (es)
EA (1) EA201790234A1 (es)
ES (1) ES2808868T3 (es)
IL (1) IL250426A0 (es)
MX (1) MX2017002288A (es)
NZ (1) NZ728707A (es)
SG (1) SG11201700810SA (es)
TW (1) TWI673283B (es)
WO (1) WO2016028866A1 (es)

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Also Published As

Publication number Publication date
WO2016028866A1 (en) 2016-02-25
AR101561A1 (es) 2016-12-28
JP6765364B2 (ja) 2020-10-07
EP3183261A1 (en) 2017-06-28
KR20170042643A (ko) 2017-04-19
CA2958546A1 (en) 2016-02-25
JP2017525699A (ja) 2017-09-07
JP2020111608A (ja) 2020-07-27
US20190202852A1 (en) 2019-07-04
EP3183261B1 (en) 2020-06-17
US20170327526A1 (en) 2017-11-16
CA2958546C (en) 2020-06-23
EP3738969A1 (en) 2020-11-18
KR102528928B1 (ko) 2023-05-08
CN106573954A (zh) 2017-04-19
SG11201700810SA (en) 2017-03-30
US20200157137A1 (en) 2020-05-21
AU2015305593C1 (en) 2018-11-15
US20200087337A1 (en) 2020-03-19
IL250426A0 (en) 2017-03-30
US9982006B2 (en) 2018-05-29
AU2015305593B2 (en) 2018-05-17
US9617295B2 (en) 2017-04-11
EA201790234A1 (ru) 2017-07-31
NZ728707A (en) 2018-06-29
TWI673283B (zh) 2019-10-01
US20160052953A1 (en) 2016-02-25
ES2808868T3 (es) 2021-03-02
US20180340004A1 (en) 2018-11-29
TW201619178A (zh) 2016-06-01
AU2015305593A1 (en) 2017-02-23
BR112017003242A2 (pt) 2017-11-28

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