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MX2019009135A - Ingenieria metabolica para la produccion microbiana de productos terpenoides. - Google Patents

Ingenieria metabolica para la produccion microbiana de productos terpenoides.

Info

Publication number
MX2019009135A
MX2019009135A MX2019009135A MX2019009135A MX2019009135A MX 2019009135 A MX2019009135 A MX 2019009135A MX 2019009135 A MX2019009135 A MX 2019009135A MX 2019009135 A MX2019009135 A MX 2019009135A MX 2019009135 A MX2019009135 A MX 2019009135A
Authority
MX
Mexico
Prior art keywords
metabolic engineering
microbial production
terpenoid
terpenoid products
products
Prior art date
Application number
MX2019009135A
Other languages
English (en)
Inventor
Parayil Kumaran Ajikumar
Donald Jason
Tseng Hsien-Chung
PHILIPPE Ryan
LIM Chin-giaw
Ghosh Souvik
Pirie Christopher
Love Aaron
Nan Hong
Nicole S Santos Christine
Original Assignee
Manus Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Manus Bio Inc filed Critical Manus Bio Inc
Publication of MX2019009135A publication Critical patent/MX2019009135A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
    • C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
    • C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/0109—All-trans-octaprenyl-diphosphate synthase (2.5.1.90)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

En varios aspectos y modalidades, la invención se refiere a cepas bacterianas y métodos para elaborar terpeno y productos terpenoides. La invención proporciona cepas bacterianas con flujo de carbono mejorado a través de la vía de MEP, para de este modo aumentar el rendimiento de terpenos y/o producto terpenoide mediante fermentación con fuentes de carbono tales como glucosa.
MX2019009135A 2017-02-03 2018-02-05 Ingenieria metabolica para la produccion microbiana de productos terpenoides. MX2019009135A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762454121P 2017-02-03 2017-02-03
PCT/US2018/016848 WO2018144996A1 (en) 2017-02-03 2018-02-05 Metabolic engineering for microbial production of terpenoid products

Publications (1)

Publication Number Publication Date
MX2019009135A true MX2019009135A (es) 2019-10-09

Family

ID=63041209

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019009135A MX2019009135A (es) 2017-02-03 2018-02-05 Ingenieria metabolica para la produccion microbiana de productos terpenoides.

Country Status (10)

Country Link
US (3) US10662442B2 (es)
EP (1) EP3577212A4 (es)
JP (2) JP7433048B2 (es)
KR (1) KR20190139202A (es)
CN (1) CN110869487B (es)
AU (1) AU2018215537B2 (es)
BR (1) BR112019016036A2 (es)
CA (1) CA3051463A1 (es)
MX (1) MX2019009135A (es)
WO (1) WO2018144996A1 (es)

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JP7330888B2 (ja) * 2017-01-26 2023-08-22 マナス バイオ インコーポレイテッド テルペノイド産物を微生物生産するための代謝工学
WO2018144996A1 (en) * 2017-02-03 2018-08-09 Manus Bio, Inc. Metabolic engineering for microbial production of terpenoid products
EP3759230A4 (en) 2018-02-27 2022-05-25 Manus Bio Inc. MICROBIAL PRODUCTION OF TRITERPENOIDS INCLUDING MOGROSIDES
EP3847268A4 (en) 2018-09-06 2022-06-08 Manus Bio Inc. MICROBIAL PRODUCTION OF ROTUNDONE
WO2020072908A1 (en) * 2018-10-05 2020-04-09 Manus Bio, Inc. Biosynthesis and recovery of secondary metabolites
CN109370937A (zh) * 2018-10-29 2019-02-22 河南中烟工业有限责任公司 一种烟草薄片质量调节用复合微生物菌剂
EP3877519A4 (en) 2018-11-09 2022-08-24 Ginkgo Bioworks, Inc. BIOSYNTHESIS OF MOGROSIDS
EP3683227A1 (en) * 2019-01-16 2020-07-22 Biosyntia ApS Cell factories for improved production of compounds and proteins dependent on iron sulfur clusters
EP4077649A4 (en) 2019-12-16 2024-07-10 Manus Bio Inc. MICROBIAL PRODUCTION OF MOGROL AND MOGROSIDES
US20230374526A1 (en) * 2020-03-26 2023-11-23 Asklepios Biopharmaceutical, Inc. Forskolin-inducible promoters and hypoxia-inducible promoters
JP7742602B2 (ja) * 2021-03-26 2025-09-22 国立研究開発法人産業技術総合研究所 イソプレノイド類産生能を有する遺伝子改変微生物およびこれを用いたイソプレノイド類製造方法
NL2031120B1 (en) * 2022-02-16 2023-08-22 Sestina Bio Llc Engineered alpha-guaiene synthases
CN117165502A (zh) * 2022-05-26 2023-12-05 牛津大学(苏州)科技有限公司 一种合成萜类化合物的共培养系统和方法
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CN116732081B (zh) * 2023-08-07 2023-12-29 中国科学院天津工业生物技术研究所 一种提高枯草芽孢杆菌合成七烯甲萘醌的方法、获得重组菌株及其应用

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Also Published As

Publication number Publication date
US11339412B2 (en) 2022-05-24
US10662442B2 (en) 2020-05-26
WO2018144996A1 (en) 2018-08-09
US20220364127A1 (en) 2022-11-17
CN110869487A (zh) 2020-03-06
EP3577212A1 (en) 2019-12-11
CA3051463A1 (en) 2018-08-09
US20180245103A1 (en) 2018-08-30
US20200299735A1 (en) 2020-09-24
KR20190139202A (ko) 2019-12-17
US12227783B2 (en) 2025-02-18
BR112019016036A2 (pt) 2020-05-26
JP2020505930A (ja) 2020-02-27
CN110869487B (zh) 2024-01-02
JP7433048B2 (ja) 2024-02-19
EP3577212A4 (en) 2020-12-16
AU2018215537B2 (en) 2023-11-09
JP2023171783A (ja) 2023-12-05
AU2018215537A1 (en) 2019-08-22

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