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MX2019008882A - Ingeniería metabólica para la producción microbiana de productos terpenoides. - Google Patents

Ingeniería metabólica para la producción microbiana de productos terpenoides.

Info

Publication number
MX2019008882A
MX2019008882A MX2019008882A MX2019008882A MX2019008882A MX 2019008882 A MX2019008882 A MX 2019008882A MX 2019008882 A MX2019008882 A MX 2019008882A MX 2019008882 A MX2019008882 A MX 2019008882A MX 2019008882 A MX2019008882 A MX 2019008882A
Authority
MX
Mexico
Prior art keywords
metabolic engineering
microbial production
terpenoid products
terpenoid
products
Prior art date
Application number
MX2019008882A
Other languages
English (en)
Inventor
Parayil Kumaran Ajikumar
Lim Ryan
Donald Jason
Tseng Hsien-Chung
Santos Christine
PHILIPPE Ryan
Original Assignee
Manus Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Manus Bio Inc filed Critical Manus Bio Inc
Publication of MX2019008882A publication Critical patent/MX2019008882A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/07—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with an iron-sulfur protein as acceptor (1.2.7)
    • C12Y102/07001—Pyruvate synthase (1.2.7.1), i.e. pyruvate ferredoxin oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
    • C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
    • C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La invencion se refiere a metodos y cepas bacterianas para elaborar productos terpenoides y terpenos, las cepas bacterianas que tienen mejor empuje de carbono a traves de la via MEP y hacia una via de sintesis recombinante posterior.
MX2019008882A 2017-01-26 2018-01-26 Ingeniería metabólica para la producción microbiana de productos terpenoides. MX2019008882A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762450707P 2017-01-26 2017-01-26
PCT/US2018/015527 WO2018140778A1 (en) 2017-01-26 2018-01-26 Metabolic engineering for microbial production of terpenoid products

Publications (1)

Publication Number Publication Date
MX2019008882A true MX2019008882A (es) 2019-12-16

Family

ID=62977213

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019008882A MX2019008882A (es) 2017-01-26 2018-01-26 Ingeniería metabólica para la producción microbiana de productos terpenoides.

Country Status (13)

Country Link
US (4) US10480015B2 (es)
EP (1) EP3574095B1 (es)
JP (1) JP7330888B2 (es)
KR (1) KR102656420B1 (es)
CN (1) CN110869500B (es)
AU (1) AU2018211953B2 (es)
BR (1) BR112019015454A2 (es)
CA (1) CA3051472C (es)
DK (1) DK3574095T5 (es)
ES (1) ES2959508T3 (es)
MX (1) MX2019008882A (es)
UA (1) UA127758C2 (es)
WO (1) WO2018140778A1 (es)

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JP7330888B2 (ja) * 2017-01-26 2023-08-22 マナス バイオ インコーポレイテッド テルペノイド産物を微生物生産するための代謝工学
WO2018144996A1 (en) * 2017-02-03 2018-08-09 Manus Bio, Inc. Metabolic engineering for microbial production of terpenoid products
EP3759230A4 (en) 2018-02-27 2022-05-25 Manus Bio Inc. MICROBIAL PRODUCTION OF TRITERPENOIDS INCLUDING MOGROSIDES
EP3847268A4 (en) 2018-09-06 2022-06-08 Manus Bio Inc. MICROBIAL PRODUCTION OF ROTUNDONE
CN109321494B (zh) * 2018-09-30 2020-06-23 浙江工业大学 中间克吕沃尔菌zjb-17004及其应用
WO2020072908A1 (en) * 2018-10-05 2020-04-09 Manus Bio, Inc. Biosynthesis and recovery of secondary metabolites
CN109913380B (zh) * 2019-03-25 2021-12-10 南京工业大学 生产(-)-α-红没药醇的重组解脂耶氏酵母菌及其构建方法和应用
CN110106129B (zh) * 2019-05-20 2022-08-30 福建师范大学 谷氨酸脱氢酶基因受抑制的类球红细菌及其制备方法和法尼醇的生产方法
EP4077649A4 (en) 2019-12-16 2024-07-10 Manus Bio Inc. MICROBIAL PRODUCTION OF MOGROL AND MOGROSIDES
US11813549B1 (en) * 2020-03-04 2023-11-14 Eco-Logic Environmental Engineering Inc. Devices and methods for essential oils, terpenes, flavonoids, and hydrosols extraction
JPWO2022102763A1 (es) * 2020-11-13 2022-05-19
CN112342163A (zh) * 2020-11-13 2021-02-09 华中农业大学 一种伯克霍尔德菌及其应用
CN114990147A (zh) * 2021-03-01 2022-09-02 深圳蓝晶生物科技有限公司 构建生产香叶醇的重组需钠弧菌的方法以及通过该方法构建的重组需钠弧菌及其应用
WO2023015279A1 (en) * 2021-08-05 2023-02-09 Miami University Methods for the production of methylated tryptamine derivatives, intermediates or side products
KR102518841B1 (ko) * 2021-11-09 2023-04-10 경상국립대학교산학협력단 레티노이드 제조용 조성물 및 이를 이용한 레티노이드의 제조 방법
WO2023150533A1 (en) * 2022-02-01 2023-08-10 Conagen Inc. Microorganisms and methods for producing menaquinone-7
CN114921463B (zh) * 2022-04-11 2023-12-01 中国农业科学院生物技术研究所 一种调控萜类化合物合成产量的人工非编码RNA分子CsiY及其应用
CN115927427B (zh) * 2022-07-25 2024-10-11 中国科学院青岛生物能源与过程研究所 一种可合成瓦伦烯的工程藻株及其制备方法
CN115948456B (zh) * 2022-10-18 2024-09-17 重庆大学 一种可提升广藿香醇合成量的融合基因及方法
CN119736218A (zh) * 2023-09-19 2025-04-01 西安卓虹超源生物科技有限公司 一种萜类化合物的生产及菌株
WO2025111429A1 (en) 2023-11-22 2025-05-30 Bp Corporation North America Inc. Recombinant microorganisms with increased accumulation and/or flux of cytidine triphosphate (ctp)
WO2025155822A1 (en) * 2024-01-19 2025-07-24 Bp Corporation North America Inc. Engineered dxp pathway for improved isoprenoid production in e. coli
CN118256412B (zh) * 2024-04-01 2024-09-27 湖北大学 运动发酵单胞菌的工程菌株、制备方法及应用
WO2026010860A1 (en) 2024-07-02 2026-01-08 Bp Corporation North America Inc. Recombinant microorganisms for isoprene production
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Also Published As

Publication number Publication date
UA127758C2 (uk) 2023-12-27
US10480015B2 (en) 2019-11-19
EP3574095A1 (en) 2019-12-04
DK3574095T5 (da) 2024-09-02
US20180216137A1 (en) 2018-08-02
DK3574095T3 (da) 2023-10-02
KR20190113851A (ko) 2019-10-08
BR112019015454A2 (pt) 2020-03-24
US20210002672A1 (en) 2021-01-07
CN110869500B (zh) 2023-10-27
EP3574095B1 (en) 2023-07-05
JP7330888B2 (ja) 2023-08-22
US20220251607A1 (en) 2022-08-11
US11352648B2 (en) 2022-06-07
AU2018211953B2 (en) 2024-11-14
US20200002733A1 (en) 2020-01-02
CA3051472A1 (en) 2018-08-02
CA3051472C (en) 2024-05-28
WO2018140778A1 (en) 2018-08-02
AU2018211953A1 (en) 2019-08-15
US10774346B2 (en) 2020-09-15
JP2020505051A (ja) 2020-02-20
ES2959508T3 (es) 2024-02-26
KR102656420B1 (ko) 2024-04-09
EP3574095A4 (en) 2020-12-02
CN110869500A (zh) 2020-03-06

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