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MX2019008159A - Producción acelular de azúcares. - Google Patents

Producción acelular de azúcares.

Info

Publication number
MX2019008159A
MX2019008159A MX2019008159A MX2019008159A MX2019008159A MX 2019008159 A MX2019008159 A MX 2019008159A MX 2019008159 A MX2019008159 A MX 2019008159A MX 2019008159 A MX2019008159 A MX 2019008159A MX 2019008159 A MX2019008159 A MX 2019008159A
Authority
MX
Mexico
Prior art keywords
cell
sugars
free production
starch
sugar
Prior art date
Application number
MX2019008159A
Other languages
English (en)
Inventor
S Cunningham Drew
MACEACHRAN Daniel
Jeremy Blake William
Eduardo Moura Matthew
Original Assignee
Greenlight Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Greenlight Biosciences Inc filed Critical Greenlight Biosciences Inc
Publication of MX2019008159A publication Critical patent/MX2019008159A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/02—Monosaccharides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01049—Cellodextrin phosphorylase (2.4.1.49)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
    • C12Y503/01009—Glucose-6-phosphate isomerase (5.3.1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02002—Phosphoglucomutase (5.4.2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02005—Phosphoglucomutase (glucose-cofactor) (5.4.2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/02—Phosphotransferases (phosphomutases) (5.4.2)
    • C12Y504/02006—Beta-phosphoglucomutase (5.4.2.6)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

Se proporcionan en el presente documento, en algunas realizaciones, sistemas, metodos y composiciones (por ejemplo, celulas y lisados celulares) para convertir enzimáticamente una glucosa carbohidrato polimerica (por ejemplo, almidon) en azucar.
MX2019008159A 2017-01-06 2018-01-05 Producción acelular de azúcares. MX2019008159A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762443447P 2017-01-06 2017-01-06
US201762538181P 2017-07-28 2017-07-28
PCT/US2018/012516 WO2018129275A1 (en) 2017-01-06 2018-01-05 Cell-free production of sugars

Publications (1)

Publication Number Publication Date
MX2019008159A true MX2019008159A (es) 2019-12-09

Family

ID=62790918

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019008159A MX2019008159A (es) 2017-01-06 2018-01-05 Producción acelular de azúcares.

Country Status (12)

Country Link
US (6) US10316342B2 (es)
EP (1) EP3565892A4 (es)
JP (1) JP7186167B2 (es)
KR (1) KR20190100386A (es)
CN (1) CN110300800A (es)
AU (1) AU2018205503A1 (es)
BR (1) BR112019013853A2 (es)
CA (1) CA3049386A1 (es)
CL (1) CL2019001844A1 (es)
CO (1) CO2019007857A2 (es)
MX (1) MX2019008159A (es)
WO (1) WO2018129275A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20170485A (es) 2015-03-30 2018-02-05 Greenlight Biosciences Inc Producción de ácido ribonucleico libre de células
KR102536687B1 (ko) 2016-04-06 2023-05-25 그린라이트 바이오사이언시스, 아이엔씨. 리보핵산의 무세포 생산
JP7625237B2 (ja) 2016-12-14 2025-02-03 ボヌモーズ、インコーポレイテッド Ｄ－アルロースの酵素的生産
MX2019008159A (es) 2017-01-06 2019-12-09 Greenlight Biosciences Inc Producción acelular de azúcares.
WO2018169957A1 (en) * 2017-03-13 2018-09-20 Bonumose Llc Enzymatic production of hexoses
CR20200192A (es) 2017-10-11 2020-11-02 Greenlight Biosciences Inc Métodos y composiciones para la producción de nucleósido trifosfatos y ácidos ribonucleicos
WO2020092315A1 (en) * 2018-10-29 2020-05-07 Bonumose Llc Enzymatic production of hexoses
KR102233375B1 (ko) 2018-12-11 2021-03-31 씨제이제일제당 주식회사 신규 싸이코스-6-인산의 탈인산화 효소, 이를 포함하는 싸이코스 생산용 조성물, 및 이를 이용한 싸이코스 제조방법
JP2022514684A (ja) * 2018-12-21 2022-02-14 グリーンライト バイオサイエンシーズ インコーポレーテッド アルロースの無細胞生成
BR112021015855A2 (pt) 2019-02-12 2021-10-05 Bonumose Inc Produção enzimática de manose
KR102080886B1 (ko) 2019-05-21 2020-02-24 씨제이제일제당 주식회사 부반응성이 낮은 리불로스-인산 3-에피머화 효소의 모티프 및 이를 포함하는 효소
EP3976777A4 (en) * 2019-05-31 2023-08-09 Bonumose LLC Enzymatic production of fructose
CA3177145A1 (en) * 2020-05-18 2021-11-25 Bonumose, Inc. Enzymatic production of allulose
CN112760305B (zh) * 2021-01-25 2022-04-29 浙江工业大学 一种栖热腔菌磷酸酶突变体及其应用
EP4433604A1 (en) * 2021-11-19 2024-09-25 Greenlight Biosciences, Inc. Compositions and methods for the production of allulose
WO2024182327A1 (en) * 2023-02-28 2024-09-06 Cargill, Incorporated Genetically modified microorganism and fermentation process for the production of d-allulose

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4266034A (en) 1978-04-14 1981-05-05 Exxon Research And Engineering Company Method for producing microbial cells and use thereof to produce oxidation products
DE3660768D1 (en) 1985-05-13 1988-10-27 Unitika Ltd Process for producing physiologically active substance
KR0177841B1 (ko) 1992-01-30 1999-04-01 나까무라 간노스께 시티딘 디인산 콜린의 제조방법
US6537776B1 (en) 1999-06-14 2003-03-25 Diversa Corporation Synthetic ligation reassembly in directed evolution
US20020160459A1 (en) 1997-01-14 2002-10-31 Alan Berry Process for production of n-glucosamine
US6168931B1 (en) 1999-03-17 2001-01-02 The Board Of Trustees Of The Leland Stanford Junior University Enhanced in vitro synthesis of biological macromolecules using a novel ATP regeneration system
US6994986B2 (en) 1999-03-17 2006-02-07 The Board Of Trustees Of The Leland Stanford University In vitro synthesis of polypeptides by optimizing amino acid metabolism
EP1177311B1 (en) 1999-03-17 2014-11-12 The Board Of Trustees Of The Leland Stanford Junior University In vitro macromolecule biosynthesis methods using exogenous amino acids and a novel atp regeneration system
WO2000062804A2 (en) 1999-04-15 2000-10-26 The Regents Of The University Of California Identification of sortase gene
US6284483B1 (en) 1999-10-06 2001-09-04 Board Of Trustees Operating Michigan State University Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate
CA2293852A1 (fr) 1999-12-30 2001-06-30 Purecell Technologies Inc. Procede de preparation d'extraits de plantes actifs et utiles a la capture de radicaux libres; les extraits, et compositions et dispositifs les comprenant
US6548276B2 (en) 2000-09-06 2003-04-15 The Board Of Trustees Of The Leland Stanford Junior University Enhanced in vitro synthesis of active proteins containing disulfide bonds
US7041479B2 (en) 2000-09-06 2006-05-09 The Board Of Trustess Of The Leland Stanford Junior University Enhanced in vitro synthesis of active proteins containing disulfide bonds
DE60229050D1 (de) 2001-04-04 2008-11-06 Genencor Int Verfahren zur herstellung von ascorbinsäurezwischenprodukten in wirtszellen
WO2002088325A2 (en) 2001-05-02 2002-11-07 University Of South Florida Vector system for selection of genes encoding secreted proteins and membrane-bound proteins
WO2003038117A2 (en) 2001-10-30 2003-05-08 The Board Of Trustees Of The Leland Stanford Junior University Enhanced in vitro nucleic acid synthesis using nucleoside monophosphates
US20040038250A1 (en) 2002-04-04 2004-02-26 Astur-Pharma, S.A. Gene cluster for thienamycin biosynthesis, genetic manipulation and utility
DE10219714A1 (de) 2002-05-02 2003-11-27 Holland Sweetener Co Verfahren zur mikrobielien Herstellung von aromatischen Aminosäuren und anderen Metaboliten des aromatischen Aminosäurebiosyntheseweges
WO2004003175A2 (en) 2002-07-01 2004-01-08 Arkion Life Sciences Llc Process and materials for production of glucosamine and n-acetylglucosamine
ES2334126T3 (es) 2002-08-19 2010-03-05 The Board Of Trustees Of The Leland Stanford Junior University Procedimientos mejorados de sintesis de proteinas in vitro.
KR20050065547A (ko) 2002-09-30 2005-06-29 아처 다니엘 미드랜드 캄파니 글루코사민의 무세포 생산
JP2007502623A (ja) 2003-05-09 2007-02-15 リサーチ ディベロップメント ファウンデーション 膜タンパク質におけるフリンプロテアーゼ開裂部位の挿入およびその使用法
US20050054044A1 (en) 2003-07-18 2005-03-10 The Board Of Trustees Of The Leland Stanford Junior University Method of alleviating nucleotide limitations for in vitro protein synthesis
US7341852B2 (en) 2003-07-18 2008-03-11 The Board Of Trustees Of The Leland Stanford Junior University Methods of decoupling reaction scale and protein synthesis yield in batch mode
CN1856579A (zh) 2003-09-23 2006-11-01 密苏里大学 使用热稳定酶合成多核苷酸的方法
KR101232656B1 (ko) 2003-11-20 2013-02-13 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 시험관내 단백질 합성의 개선된 방법
US20080021205A1 (en) 2003-12-11 2008-01-24 Helen Blau Methods and Compositions for Use in Preparing Hairpin Rnas
CN1934276A (zh) 2004-03-25 2007-03-21 利兰·斯坦福青年大学托管委员会 通过加入消泡剂来提高无细胞蛋白质合成系统的蛋白质表达率
WO2005106008A2 (en) 2004-04-27 2005-11-10 Archer-Daniels-Midland Company Enzymatic decarboxylation of 2-keto-l-gulonic acid to produce xylose
CN1973037B (zh) 2004-06-25 2011-10-19 协和发酵生化株式会社 二肽或二肽衍生物的制造方法
KR20060059622A (ko) * 2004-11-29 2006-06-02 주식회사 엔지뱅크 내열성 효소를 이용하여 전분으로부터 6-인산과당을제조하는 방법
EP1819813A2 (en) 2004-12-10 2007-08-22 DSMIP Assets B.V. Production of beta-lactam antibiotics by genetically modified non-naturally producing microorganisms
KR100744479B1 (ko) 2005-06-01 2007-08-01 씨제이 주식회사 사이코스 에피머화 효소에 의한 사이코스의 생산 방법
US7351563B2 (en) 2005-06-10 2008-04-01 The Board Of Trustees Of The Leland Stanford Junior University Cell-free extracts and synthesis of active hydrogenase
US7312049B2 (en) 2005-06-14 2007-12-25 The Board Of Trustees Of The Leland Stanford Junior University Total amino acid stabilization during cell-free protein synthesis
WO2007030772A2 (en) 2005-09-09 2007-03-15 The Johns Hopkins University Improved production of clavulanic acid by genetic engineering of streptomyces clavuligerus
JP5383197B2 (ja) 2005-10-31 2014-01-08 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 膜結合ポリペプチドの無細胞合成法
US7579005B2 (en) 2005-11-28 2009-08-25 E. I. Du Pont De Nemours And Company Process for recombinant expression and purification of antimicrobial peptides using periplasmic targeting signals as precipitable hydrophobic tags
GB0606112D0 (en) 2006-03-28 2006-05-03 Product and process
WO2007137144A2 (en) 2006-05-17 2007-11-29 University Of Medicine And Dentistry Of New Jersey Single protein production in living cells facilitated by a messenger rna interferase
WO2007140816A1 (en) 2006-06-09 2007-12-13 Metabolic Explorer Glycolic acid production by fermentation from renewable resources
WO2007144018A1 (en) 2006-06-12 2007-12-21 Metabolic Explorer Ethanolamine production by fermentation
US20110129438A1 (en) 2006-06-28 2011-06-02 James Robert Swartz Immunogenic protein constructs
WO2008002661A2 (en) 2006-06-28 2008-01-03 The Board Of Trustees Of The Leland Stanford Junior University Fusion protein constructs
AU2007325952B8 (en) 2006-06-29 2013-06-27 The Board Of Trustees Of The Leland Stanford Junior University Cell-free synthesis of proteins containing unnatural amino acids
WO2008002673A2 (en) 2006-06-29 2008-01-03 The Board Of Trustees Of The Leland Stanford Junior University Cell-free synthesis of virus like particles
US8011739B2 (en) 2006-09-13 2011-09-06 Wirtgen Gmbh Replaceable wear pad
US8293894B2 (en) 2006-11-20 2012-10-23 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of carbapenem antibiotic
KR100832740B1 (ko) 2007-01-17 2008-05-27 한국과학기술원 분지쇄 아미노산 생성능이 개선된 변이 미생물 및 이를이용한 분지쇄 아미노산의 제조방법
JP2010516251A (ja) 2007-01-18 2010-05-20 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ ジスルフィド結合を含む活性なタンパク質の増強された無細胞合成の方法
WO2008094546A2 (en) 2007-01-31 2008-08-07 The Regents Of The University Of California Genetically modified host cells for increased p450 activity levels and methods of use thereof
US20090124012A1 (en) 2007-08-08 2009-05-14 Mazef Biosciences, Llc Toxin/antitoxin systems and methods for regulating cellular growth, metabolic engineering and production of recombinant proteins
US20110099670A1 (en) 2008-02-14 2011-04-28 Andries Jurriaan Koops Nucleotide sequences coding for cis-aconitic decarboxylase and use thereof
WO2009111672A1 (en) 2008-03-05 2009-09-11 Genomatica, Inc. Primary alcohol producing organisms
WO2009135074A2 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
EP2313489B1 (en) 2008-07-28 2015-04-29 B.R.A.I.N. Biotechnology Research and Information Network AG Production method
GB0819563D0 (en) 2008-10-24 2008-12-03 Isis Innovation Methods for preparing heterocyclic rings
EP2350298A1 (en) 2008-10-27 2011-08-03 ButamaxTM Advanced Biofuels LLC Carbon pathway optimized production hosts for the production of isobutanol
EP2346998B1 (en) 2008-10-31 2016-01-27 GEVO, Inc. Engineered microorganisms capable of producing target compounds under anaerobic conditions
EP2371952B1 (en) 2008-11-05 2016-07-27 Mitsui Chemicals, Inc. Bacterium capable of producing 2-deoxy-scyllo-inosose (doi), and process for producing 2-deoxy-scyllo-inosose (doi) by using same
US9637746B2 (en) 2008-12-15 2017-05-02 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
KR20110134380A (ko) 2008-12-22 2011-12-14 그린라이트 바이오사이언시스, 아이엔씨. 화합물의 제조를 위한 조성물 및 방법
CN102307987B (zh) * 2008-12-24 2016-11-16 帝斯曼知识产权资产管理有限公司 木糖异构酶基因及其在戊糖发酵中的用途
EP2204453B1 (en) 2008-12-30 2013-03-13 Süd-Chemie IP GmbH & Co. KG Process for cell-free production of chemicals
US8597923B2 (en) 2009-05-06 2013-12-03 SyntheZyme, LLC Oxidation of compounds using genetically modified Candida
US8272816B2 (en) 2009-05-12 2012-09-25 TDY Industries, LLC Composite cemented carbide rotary cutting tools and rotary cutting tool blanks
US10385367B2 (en) 2009-06-01 2019-08-20 Ginkgo Bioworks, Inc. Methods and molecules for yield improvement involving metabolic engineering
WO2011003864A1 (de) 2009-07-09 2011-01-13 Basf Se Kaltsiegelbare, durch emulsionspolymerisation in gegenwart von ethylen/(meth)acrylsäure copolymer hergestellte polymerdispersion
WO2011017560A1 (en) 2009-08-05 2011-02-10 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
KR20110035805A (ko) 2009-09-30 2011-04-06 씨제이제일제당 (주) 사이코스-에피머화 효소의 고정화 및 이를 이용한 사이코스의 제조방법
WO2011072287A2 (en) 2009-12-11 2011-06-16 The Johns Hopkins University Method for late introduction of the (8r)-hydroxyl group in carbapenem beta-lactam antibiotic synthesis
WO2011130544A2 (en) 2010-04-14 2011-10-20 Sutro Biopharma, Inc. Monitoring a dynamic system by liquid chromatography-mass spectrometry
WO2011140516A2 (en) 2010-05-07 2011-11-10 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through enzyme relocation
KR101988063B1 (ko) 2010-08-31 2019-09-30 그린라이트 바이오사이언시스, 아이엔씨. 프로테아제 조작을 통한 대사 경로에서 유동의 제어 방법
US9574735B2 (en) 2010-09-23 2017-02-21 Light Prescriptions Innovators, Llc Shell integrator
WO2012109274A1 (en) * 2011-02-07 2012-08-16 The Regents Of The University Of California Enhanced cellodextrin metabolism
WO2012135902A1 (en) 2011-04-08 2012-10-11 James Cook University Protease activity assay
JP5800218B2 (ja) 2011-07-20 2015-10-28 国立大学法人広島大学 Ａｔｐの製造方法およびその利用
BR112014002661A2 (pt) 2011-08-04 2019-09-24 Danisco Us Inc produção de isopreno, precursores de isoprenoide, e isoprenoides com o uso de acetoacetil-coa sintase
KR101203856B1 (ko) 2011-08-24 2012-11-21 씨제이제일제당 (주) 열 안정성이 향상된 사이코스 에피머화 효소 변이체 및 이를 이용한 사이코스의 연속적 생산
WO2013036787A2 (en) 2011-09-09 2013-03-14 Greenlight Biosciences, Inc. Cell-free preparation of carbapenems
GB2508586B (en) 2012-09-27 2020-09-02 Tate & Lyle Ingredients Americas Llc A protein
US9792836B2 (en) * 2012-10-30 2017-10-17 Truinject Corp. Injection training apparatus using 3D position sensor
HK1216547A1 (zh) 2012-12-21 2016-11-18 Greenlight Biosciences Inc. 用於將甲烷轉化成燃料、丙酮酸或異丁醇的無細胞系統
CN105164265B (zh) 2013-03-15 2019-05-10 孟山都技术有限公司 用于产生和递送rna的组合物和方法
US9580705B2 (en) 2013-03-15 2017-02-28 Butamax Advanced Biofuels Llc DHAD variants and methods of screening
KR101455624B1 (ko) 2013-04-12 2014-10-28 주식회사한국야쿠르트 기능성 희귀당 사이코스의 생산능을 지닌 신규 클로스트리디움 볼티에 유래의 사이코스-3-에피머화 효소 및 이를 이용한 사이코스 생산방법
DK3005461T3 (en) 2013-06-05 2018-10-15 Tianjin Inst Ind Biotechnology Cas COMPLETE OXIDATION OF SUGARS FOR ELECTRICITY USING CELL-FREE SYNTHETIC ENZYMATIC ROADS
JP2016520324A (ja) 2013-06-05 2016-07-14 グリーンライト バイオサイエンシーズ インコーポレーテッドＧｒｅｅｎｌｉｇｈｔ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． 無細胞生合成系における代謝フラックスの制御
AU2014306074B2 (en) 2013-08-05 2018-08-30 Greenlight Biosciences, Inc. Engineered proteins with a protease cleavage site
CN105814191A (zh) * 2013-08-15 2016-07-27 拉勒曼德匈牙利流动管理有限责任公司 通过甘油回收改进微生物中的产物产率和生产的方法
US20180273985A1 (en) 2015-03-19 2018-09-27 William Jeremy Blake Cell-free production of butanol
WO2016152819A1 (ja) 2015-03-26 2016-09-29 松谷化学工業株式会社 アルロース含有甘味料組成物の製造方法
CR20170485A (es) 2015-03-30 2018-02-05 Greenlight Biosciences Inc Producción de ácido ribonucleico libre de células
JP6993227B2 (ja) * 2015-07-02 2022-01-13 協和発酵バイオ株式会社 希少糖の製造法
CN105219822A (zh) 2015-09-24 2016-01-06 北京化工大学 一种体外酶法生产谷胱甘肽的方法
EP3322803B1 (en) 2015-10-02 2021-03-24 Bonumose LLC Enzymatic production of d-tagatose
KR101944103B1 (ko) 2015-12-07 2019-01-30 주식회사 삼양사 마이크로박테리움 속 균주 및 이를 이용한 사이코스 생산방법
KR102069301B1 (ko) 2015-12-21 2020-01-22 주식회사 삼양사 과당으로부터 알로오스를 생산하는 균주 및 이를 이용한 알로오스 생산방법
WO2017111563A1 (ko) 2015-12-23 2017-06-29 씨제이제일제당(주) D-사이코스 3-에피머화 효소 및 염을 포함하는 d-사이코스 제조용 조성물 및 이를 이용한 d-사이코스의 제조 방법
KR102536687B1 (ko) 2016-04-06 2023-05-25 그린라이트 바이오사이언시스, 아이엔씨. 리보핵산의 무세포 생산
JP7625237B2 (ja) 2016-12-14 2025-02-03 ボヌモーズ、インコーポレイテッド Ｄ－アルロースの酵素的生産
BR112019013694A2 (pt) 2016-12-30 2020-02-04 Ntxbio, Llc sistema de expressão isento de células tendo nova regeneração de energia com base em polifosfato inorgânico
MX2019008159A (es) * 2017-01-06 2019-12-09 Greenlight Biosciences Inc Producción acelular de azúcares.
WO2018169957A1 (en) 2017-03-13 2018-09-20 Bonumose Llc Enzymatic production of hexoses
JP2022514684A (ja) 2018-12-21 2022-02-14 グリーンライト バイオサイエンシーズ インコーポレーテッド アルロースの無細胞生成

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