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MX2017014736A - Metodos terapeuticos y diagnosticos para cancer. - Google Patents

Metodos terapeuticos y diagnosticos para cancer.

Info

Publication number
MX2017014736A
MX2017014736A MX2017014736A MX2017014736A MX2017014736A MX 2017014736 A MX2017014736 A MX 2017014736A MX 2017014736 A MX2017014736 A MX 2017014736A MX 2017014736 A MX2017014736 A MX 2017014736A MX 2017014736 A MX2017014736 A MX 2017014736A
Authority
MX
Mexico
Prior art keywords
methods
bladder cancer
cancer
patient
therapeutic
Prior art date
Application number
MX2017014736A
Other languages
English (en)
Other versions
MX392671B (es
Inventor
Fine Gregg
Bourgon Richard
Mariathasan Sanjeev
KOWANETZ Marcin
Hegde Priti
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56236061&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017014736(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2017014736A publication Critical patent/MX2017014736A/es
Publication of MX392671B publication Critical patent/MX392671B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G01N33/57557—
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Medicinal Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Wood Science & Technology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
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  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Cell Biology (AREA)

Abstract

La presente invención proporciona métodos y composiciones terapéuticas y diagnósticos para el cáncer, por ejemplo, cáncer de vejiga. La invención proporciona métodos de tratamiento de cáncer de vejiga, métodos de determinación de si un paciente que está padeciendo cáncer de vejiga probablemente responda al tratamiento que comprende un antagonista de unión al eje de PD-L1, métodos de predicción de la capacidad de respuesta de un paciente que está padeciendo de cáncer de vejiga al tratamiento que comprende un antagonista de unión al eje de PD-L1 y métodos para seleccionar una terapia para un paciente que está padeciendo de cáncer de vejiga, en base a niveles de expresión de un biomarcador de la invención (por ejemplo, niveles de expresión de PD-L1 en células inmunes infiltrantes de tumores en una muestra de tumor obtenida del paciente) y/o sobre la base de la determinación de un subtipo de muestra de tumor.
MX2017014736A 2015-05-29 2016-05-27 Antagonistas de unión a pd-l1 y usos de los mismos para el tratamiento de cáncer MX392671B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562168669P 2015-05-29 2015-05-29
US201662301599P 2016-02-29 2016-02-29
PCT/US2016/034664 WO2016196298A1 (en) 2015-05-29 2016-05-27 Therapeutic and diagnolstic methods for cancer

Publications (2)

Publication Number Publication Date
MX2017014736A true MX2017014736A (es) 2018-03-23
MX392671B MX392671B (es) 2025-03-24

Family

ID=56236061

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017014736A MX392671B (es) 2015-05-29 2016-05-27 Antagonistas de unión a pd-l1 y usos de los mismos para el tratamiento de cáncer
MX2022006075A MX2022006075A (es) 2015-05-29 2017-11-16 Antagonistas de union a pd-l1 y usos de los mismos para el tratamiento de cancer.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022006075A MX2022006075A (es) 2015-05-29 2017-11-16 Antagonistas de union a pd-l1 y usos de los mismos para el tratamiento de cancer.

Country Status (13)

Country Link
US (3) US20180037655A1 (es)
EP (3) EP3708681A1 (es)
JP (3) JP7144935B2 (es)
KR (2) KR102868124B1 (es)
CN (1) CN107532217A (es)
AU (2) AU2016270625B2 (es)
CA (1) CA2984003A1 (es)
ES (1) ES2789500T5 (es)
HK (1) HK1248773A1 (es)
IL (2) IL294138A (es)
MX (2) MX392671B (es)
PL (1) PL3303632T5 (es)
WO (1) WO2016196298A1 (es)

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