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GB9710807D0 - Nucleic acid binding proteins - Google Patents

Nucleic acid binding proteins

Info

Publication number
GB9710807D0
GB9710807D0 GBGB9710807.0A GB9710807A GB9710807D0 GB 9710807 D0 GB9710807 D0 GB 9710807D0 GB 9710807 A GB9710807 A GB 9710807A GB 9710807 D0 GB9710807 D0 GB 9710807D0
Authority
GB
United Kingdom
Prior art keywords
nucleic acid
binding proteins
acid binding
proteins
nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB9710807.0A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Original Assignee
Medical Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council filed Critical Medical Research Council
Priority to GBGB9710807.0A priority Critical patent/GB9710807D0/en
Publication of GB9710807D0 publication Critical patent/GB9710807D0/en
Priority to AU75424/98A priority patent/AU7542498A/en
Priority to PCT/GB1998/001514 priority patent/WO1998053059A1/en
Pending legal-status Critical Current

Links

GBGB9710807.0A 1997-05-23 1997-05-23 Nucleic acid binding proteins Pending GB9710807D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GBGB9710807.0A GB9710807D0 (en) 1997-05-23 1997-05-23 Nucleic acid binding proteins
AU75424/98A AU7542498A (en) 1997-05-23 1998-05-26 Nucleic acid binding proteins
PCT/GB1998/001514 WO1998053059A1 (en) 1997-05-23 1998-05-26 Nucleic acid binding proteins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9710807.0A GB9710807D0 (en) 1997-05-23 1997-05-23 Nucleic acid binding proteins

Publications (1)

Publication Number Publication Date
GB9710807D0 true GB9710807D0 (en) 1997-07-23

Family

ID=10813048

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9710807.0A Pending GB9710807D0 (en) 1997-05-23 1997-05-23 Nucleic acid binding proteins

Country Status (3)

Country Link
AU (1) AU7542498A (en)
GB (1) GB9710807D0 (en)
WO (1) WO1998053059A1 (en)

Families Citing this family (406)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6140466A (en) 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US7262055B2 (en) 1998-08-25 2007-08-28 Gendaq Limited Regulated gene expression in plants
AU698152B2 (en) 1994-08-20 1998-10-22 Gendaq Limited Improvements in or relating to binding proteins for recognition of DNA
GB9824544D0 (en) * 1998-11-09 1999-01-06 Medical Res Council Screening system
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6410248B1 (en) 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
ATE466952T1 (en) 1998-03-02 2010-05-15 Massachusetts Inst Technology POLY ZINC FINGER PROTEINS WITH IMPROVED LINKERS
ATE336578T1 (en) * 1998-03-17 2006-09-15 Gendaq Ltd NUCLEIC ACID BINDING PROTEINS
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US7013219B2 (en) 1999-01-12 2006-03-14 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6599692B1 (en) 1999-09-14 2003-07-29 Sangamo Bioscience, Inc. Functional genomics using zinc finger proteins
US7070934B2 (en) 1999-01-12 2006-07-04 Sangamo Biosciences, Inc. Ligand-controlled regulation of endogenous gene expression
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
US7030215B2 (en) 1999-03-24 2006-04-18 Sangamo Biosciences, Inc. Position dependent recognition of GNN nucleotide triplets by zinc fingers
US20030104526A1 (en) 1999-03-24 2003-06-05 Qiang Liu Position dependent recognition of GNN nucleotide triplets by zinc fingers
US7943731B1 (en) 1999-08-11 2011-05-17 Massachusetts Institute Of Technology Dimerizing peptides
DE60023936T2 (en) 1999-12-06 2006-05-24 Sangamo Biosciences Inc., Richmond METHODS OF USING RANDOMIZED ZINCFINGER PROTEIN LIBRARIES FOR IDENTIFYING GENERAL FUNCTIONS
AU2693501A (en) 2000-01-24 2001-07-31 Gendaq Ltd Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules
WO2001083819A2 (en) 2000-04-28 2001-11-08 Sangamo Biosciences, Inc. Methods for designing exogenous regulatory molecules
US7923542B2 (en) 2000-04-28 2011-04-12 Sangamo Biosciences, Inc. Libraries of regulatory sequences, methods of making and using same
ATE374249T1 (en) 2000-04-28 2007-10-15 Sangamo Biosciences Inc DATABASES OF REGULATORY SEQUENCES, METHODS OF THEIR PRODUCTION AND USE
AU2001257421A1 (en) 2000-04-28 2001-11-12 Sangamo Biosciences, Inc. Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
AU2001252428A1 (en) * 2000-05-08 2001-11-20 Gendaq Limited Nucleic acid binding polypeptides
AU2001278496A1 (en) * 2000-07-21 2002-02-05 Syngenta Participations Ag Zinc finger domain recognition code and uses thereof
WO2002018648A2 (en) * 2000-08-25 2002-03-07 President And Fellows Of Harvard College Analysis of binding interactions
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
EP1341914A2 (en) 2000-12-07 2003-09-10 Sangamo Biosciences Inc. Regulation of angiogenesis with zinc finger proteins
US7067317B2 (en) 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
CA2435394C (en) 2001-01-22 2018-01-09 Sangamo Biosciences, Inc. Modified zinc finger binding proteins
WO2002057308A2 (en) * 2001-01-22 2002-07-25 Sangamo Biosciences, Inc. Zinc finger polypeptides and their use
EP1435779A4 (en) 2001-09-24 2005-06-01 Sangamo Biosciences Inc Modulation of stem cells using zinc finger proteins
US7262054B2 (en) 2002-01-22 2007-08-28 Sangamo Biosciences, Inc. Zinc finger proteins for DNA binding and gene regulation in plants
BRPI0307383B1 (en) 2002-01-23 2019-12-31 The Univ Of Utah Research Foundation directed genetic recombination method in host plant cell
SI1504108T1 (en) 2002-02-01 2013-07-31 Oxford Biomedica (Uk) Limited Lentiviral vector
CA2493364A1 (en) 2002-07-26 2004-02-12 Basf Plant Science Gmbh Inversion of the negative-selective effect of negative marker proteins using selection methods
US7361635B2 (en) 2002-08-29 2008-04-22 Sangamo Biosciences, Inc. Simultaneous modulation of multiple genes
CA2497913C (en) 2002-09-05 2014-06-03 California Institute Of Technology Use of chimeric nucleases to stimulate gene targeting
GB0228289D0 (en) 2002-12-04 2003-01-08 Genome Inst Of Singapore Nat U Method
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
US11311574B2 (en) 2003-08-08 2022-04-26 Sangamo Therapeutics, Inc. Methods and compositions for targeted cleavage and recombination
WO2005014791A2 (en) 2003-08-08 2005-02-17 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
CA2539439C (en) 2003-09-19 2012-10-23 Sangamo Biosciences, Inc. Engineered zinc finger proteins for regulation of gene expression
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
JP4564052B2 (en) 2004-04-08 2010-10-20 サンガモ バイオサイエンシズ インコーポレイテッド Methods and compositions for modulating myocardial contractility
US20050282193A1 (en) 2004-04-23 2005-12-22 Bulyk Martha L Space efficient polymer sets
CA2579677A1 (en) 2004-09-16 2006-03-30 Sangamo Biosciences, Inc. Compositions and methods for protein production
JP4988606B2 (en) 2005-02-28 2012-08-01 サンガモ バイオサイエンシズ インコーポレイテッド Anti-angiogenic methods and compositions
US20090263900A1 (en) 2008-04-14 2009-10-22 Sangamo Biosciences, Inc. Linear donor constructs for targeted integration
CA2615532C (en) 2005-07-26 2016-06-28 Sangamo Biosciences, Inc. Targeted integration and expression of exogenous nucleic acid sequences
JP5266210B2 (en) 2006-05-25 2013-08-21 サンガモ バイオサイエンシズ インコーポレイテッド Modified cleavage half-domain
ES2378333T3 (en) 2006-05-25 2012-04-11 Sangamo Biosciences, Inc. Methods and compositions for gene inactivation
CN105296527B (en) 2006-08-11 2020-11-27 陶氏益农公司 Zinc finger nuclease-mediated homologous recombination
CA2667414C (en) * 2006-11-13 2015-12-29 Sangamo Biosciences, Inc. Methods and compositions for modification of the human glucocorticoid receptor locus
ES2586210T3 (en) 2006-12-14 2016-10-13 Sangamo Biosciences, Inc. Optimized non-canon zinc finger proteins
US8110379B2 (en) 2007-04-26 2012-02-07 Sangamo Biosciences, Inc. Targeted integration into the PPP1R12C locus
CN101883850B (en) 2007-07-12 2014-11-12 桑格摩生物科学股份有限公司 Methods and compositions for inactivating alpha-1,6 fucosyltransferase (FUT 8) gene expression
CA2700231C (en) 2007-09-27 2018-09-18 Sangamo Biosciences, Inc. Rapid in vivo identification of biologically active nucleases
US11235026B2 (en) 2007-09-27 2022-02-01 Sangamo Therapeutics, Inc. Methods and compositions for modulating PD1
PT2205749T (en) 2007-09-27 2016-07-20 Dow Agrosciences Llc Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
EP2205752B1 (en) 2007-10-25 2016-08-10 Sangamo BioSciences, Inc. Methods and compositions for targeted integration
WO2009130695A2 (en) 2008-04-21 2009-10-29 Danziger Innovation Ltd. Plant viral expression vectors and use of same for generating genotypic variations in plant genomes
US10316288B2 (en) 2008-04-30 2019-06-11 Sanbio, Inc. Neural regenerating cells with alterations in DNA methylation
JP2011521643A (en) 2008-05-28 2011-07-28 サンガモ バイオサイエンシーズ, インコーポレイテッド Composition for linking a DNA binding domain and a cleavage domain
WO2009151591A2 (en) 2008-06-10 2009-12-17 Sangamo Biosciences, Inc. Methods and compositions for generation of bax- and bak-deficient cell lines
KR20160015400A (en) 2008-08-22 2016-02-12 상가모 바이오사이언스 인코포레이티드 Methods and compositions for targeted single-stranded cleavage and targeted integration
US8153399B2 (en) 2008-10-29 2012-04-10 Sangamo Biosciences, Inc. Methods and compositions for inactivating glutamine synthetase gene expression
JP5681114B2 (en) 2008-12-04 2015-03-04 サンガモ バイオサイエンシーズ, インコーポレイテッド Rat genome editing using zinc finger nuclease
BRPI0922641B1 (en) 2008-12-17 2021-10-26 Dow Agrosciences Llc METHOD OF INTEGRATION OF ONE OR MORE EXOGENOUS NUCLEIC ACID SEQUENCES INTO THE GENOME OF A PLANT CELL
US8551945B2 (en) 2009-02-04 2013-10-08 Sangamo Biosciences, Inc. Methods and compositions for treating neuropathies
WO2010107493A2 (en) 2009-03-20 2010-09-23 Sangamo Biosciences, Inc. Modification of cxcr4 using engineered zinc finger proteins
AU2010235161B2 (en) 2009-04-09 2015-01-22 Sangamo Therapeutics, Inc. Targeted integration into stem cells
US8772008B2 (en) 2009-05-18 2014-07-08 Sangamo Biosciences, Inc. Methods and compositions for increasing nuclease activity
AU2010266705B2 (en) 2009-06-30 2014-06-05 Sangamo Therapeutics, Inc. Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
EP2461819A4 (en) 2009-07-28 2013-07-31 Sangamo Biosciences Inc Methods and compositions for treating trinucleotide repeat disorders
DK2462230T3 (en) 2009-08-03 2015-10-19 Recombinetics Inc METHODS AND COMPOSITIONS FOR TARGETED RE-MODIFICATION
KR20120038020A (en) 2009-08-11 2012-04-20 상가모 바이오사이언스 인코포레이티드 Organisms homozygous for targeted modification
US9476060B2 (en) 2009-10-21 2016-10-25 Danziger Innovations Ltd. Generating genotypic variations in plant genomes by gamete infection
AR078740A1 (en) 2009-10-22 2011-11-30 Dow Agrosciences Llc PROTEINS WITH ZINC FINGERS DESIGNED BY ENGINEERING THAT HAVE THE OBJECTIVE OF VEGETABLE GENES INCLUDED IN THE BIOSINTESIS OF FATTY ACIDS
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
CA2782014C (en) 2009-11-27 2021-08-31 Basf Plant Science Company Gmbh Optimized endonucleases and uses thereof
UA118328C2 (en) 2010-01-22 2019-01-10 Дау Агросайєнсіз Ллс Targeted gemomic alteration
PT2534173T (en) 2010-02-08 2019-10-31 Sangamo Therapeutics Inc Engineered cleavage half-domains
EP2660318A1 (en) 2010-02-09 2013-11-06 Sangamo BioSciences, Inc. Targeted genomic modification with partially single-stranded donor molecules
CA2796600C (en) 2010-04-26 2019-08-13 Sangamo Biosciences, Inc. Genome editing of a rosa locus using zinc-finger nucleases
LT2566972T (en) 2010-05-03 2020-03-10 Sangamo Therapeutics, Inc. Compositions for linking zinc finger modules
EP3156062A1 (en) 2010-05-17 2017-04-19 Sangamo BioSciences, Inc. Novel dna-binding proteins and uses thereof
WO2012012667A2 (en) 2010-07-21 2012-01-26 Sangamo Biosciences, Inc. Methods and compositions for modification of a hla locus
EP2622090B1 (en) 2010-09-27 2019-06-19 Sangamo Therapeutics, Inc. Compositions for inhibiting viral entry into cells
ES2562421T3 (en) 2010-10-12 2016-03-04 The Children's Hospital Of Philadelphia Methods and compositions to treat hemophilia B
WO2012094132A1 (en) 2011-01-05 2012-07-12 Sangamo Biosciences, Inc. Methods and compositions for gene correction
WO2012139045A1 (en) 2011-04-08 2012-10-11 Gilead Biologics, Inc. Methods and compositions for normalization of tumor vasculature by inhibition of loxl2
AU2012286901B2 (en) 2011-07-25 2016-10-27 Sangamo Therapeutics, Inc. Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene
IL293650B2 (en) 2011-09-21 2024-10-01 Sangamo Therapeutics Inc Methods and preparations for regulating transgene expression
JP6188703B2 (en) 2011-10-27 2017-08-30 サンガモ セラピューティクス, インコーポレイテッド Methods and compositions for modifying the HPRT locus
JP6144691B2 (en) 2011-11-16 2017-06-07 サンガモ セラピューティクス, インコーポレイテッド Modified DNA binding proteins and uses thereof
HK1199200A1 (en) 2012-01-27 2015-06-26 Sanbio, Inc. Methods and compositions for modulating angiogenesis and vasculogenesis
MX374399B (en) 2012-02-29 2025-03-06 Sangamo Biosciences Inc COMPOSITIONS AND THEIR USES FOR TREATING AND PREVENTING HUNTINGTON'S DISEASE.
WO2013158309A2 (en) 2012-04-18 2013-10-24 The Board Of Trustees Of The Leland Stanford Junior University Non-disruptive gene targeting
WO2013163628A2 (en) 2012-04-27 2013-10-31 Duke University Genetic correction of mutated genes
RU2658437C2 (en) 2012-05-02 2018-06-21 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Targeted modification of malate dehydrogenase
JP6559063B2 (en) 2012-05-07 2019-08-14 サンガモ セラピューティクス, インコーポレイテッド Methods and compositions for nuclease-mediated targeted integration of transgenes
US11120889B2 (en) 2012-05-09 2021-09-14 Georgia Tech Research Corporation Method for synthesizing a nuclease with reduced off-site cleavage
CA2878037C (en) 2012-07-11 2021-08-31 Sangamo Biosciences, Inc. Methods and compositions for delivery of biologics
AU2013289206B2 (en) 2012-07-11 2018-08-09 Sangamo Therapeutics, Inc. Methods and compositions for the treatment of lysosomal storage diseases
US10648001B2 (en) 2012-07-11 2020-05-12 Sangamo Therapeutics, Inc. Method of treating mucopolysaccharidosis type I or II
ES2812599T3 (en) 2012-08-29 2021-03-17 Sangamo Therapeutics Inc Procedures and compositions for the treatment of a genetic condition
UA118090C2 (en) 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
JP6775953B2 (en) 2012-09-07 2020-10-28 ダウ アグロサイエンシィズ エルエルシー FAD3 performance locus and corresponding target site-specific binding proteins capable of inducing targeted cleavage
UA119135C2 (en) 2012-09-07 2019-05-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Engineered transgene integration platform (etip) for gene targeting and trait stacking
CA2886684C (en) 2012-10-10 2023-09-19 Sangamo Biosciences, Inc. T cell modifying compounds and uses thereof
JP2016500254A (en) 2012-12-05 2016-01-12 サンガモ バイオサイエンシーズ, インコーポレイテッド Methods and compositions for the regulation of metabolic diseases
EP2931901A1 (en) 2012-12-13 2015-10-21 Dow AgroSciences LLC Precision gene targeting to a particular locus in maize
CA2901676C (en) 2013-02-25 2023-08-22 Sangamo Biosciences, Inc. Methods and compositions for enhancing nuclease-mediated gene disruption
US9828582B2 (en) 2013-03-19 2017-11-28 Duke University Compositions and methods for the induction and tuning of gene expression
AU2014235968B2 (en) 2013-03-21 2018-05-24 Ospedale San Raffaele Srl Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
UA121197C2 (en) 2013-04-05 2020-04-27 Доу Агросайенсіс Ллс Methods and compositions for integration of an exogenous sequence within the genome of plants
WO2014186435A2 (en) 2013-05-14 2014-11-20 University Of Georgia Research Foundation, Inc. Compositions and methods for reducing neointima formation
EP3730615A3 (en) 2013-05-15 2020-12-09 Sangamo Therapeutics, Inc. Methods and compositions for treatment of a genetic condition
EP3591045B1 (en) 2013-08-28 2024-07-17 Sangamo Therapeutics, Inc. Compositions for linking dna-binding domains and cleavage domains
WO2015057976A1 (en) 2013-10-17 2015-04-23 Sangamo Biosciences, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
CN116836957A (en) 2013-10-17 2023-10-03 桑格摩生物科学股份有限公司 Delivery methods and compositions for nuclease-mediated genome engineering
MX358066B (en) 2013-11-04 2018-08-03 Dow Agrosciences Llc Optimal soybean loci.
CA2928855A1 (en) 2013-11-04 2015-05-07 Dow Agrosciences Llc Optimal maize loci
MX362066B (en) 2013-11-04 2019-01-07 Dow Agrosciences Llc Optimal soybean loci.
US10273493B2 (en) 2013-11-04 2019-04-30 Dow Agrosciences Llc Optimal maize loci
WO2015070212A1 (en) 2013-11-11 2015-05-14 Sangamo Biosciences, Inc. Methods and compositions for treating huntington's disease
SI3068881T1 (en) 2013-11-13 2019-05-31 Children's Medical Center Corporation Nuclease-mediated regulation of gene expression
US9932607B2 (en) 2013-11-15 2018-04-03 The Board Of Trustees Of The Leland Stanford Junior University Site-specific integration of transgenes into human cells
CN105874071B (en) 2013-12-09 2020-04-14 桑格摩生物科学股份有限公司 Methods and compositions for genome engineering
US10774338B2 (en) 2014-01-16 2020-09-15 The Regents Of The University Of California Generation of heritable chimeric plant traits
HRP20201038T1 (en) 2014-02-03 2020-10-16 Sangamo Therapeutics, Inc. PROCEDURES AND PREPARATIONS FOR THE TREATMENT OF BETA THALASEMIA
JP6606088B2 (en) 2014-02-24 2019-11-13 サンガモ セラピューティクス, インコーポレイテッド Methods and compositions for nuclease-mediated targeted integration
TW201538518A (en) 2014-02-28 2015-10-16 Dow Agrosciences Llc Root specific expression conferred by chimeric gene regulatory elements
AU2015231353B2 (en) 2014-03-18 2020-11-05 Sangamo Therapeutics, Inc. Methods and compositions for regulation of zinc finger protein expression
EP3119895B1 (en) 2014-03-21 2023-12-20 The Board of Trustees of the Leland Stanford Junior University Genome editing without nucleases
US10507232B2 (en) 2014-04-02 2019-12-17 University Of Florida Research Foundation, Incorporated Materials and methods for the treatment of latent viral infection
US9522936B2 (en) 2014-04-24 2016-12-20 Sangamo Biosciences, Inc. Engineered transcription activator like effector (TALE) proteins
BR112016025849A2 (en) 2014-05-08 2017-10-17 Chdi Foundation Inc methods and compositions for the treatment of huntington's disease
US10272019B2 (en) 2014-05-09 2019-04-30 Yale University Topical formulation of hyperbranched polyglycerol-coated particles thereof
US11918695B2 (en) 2014-05-09 2024-03-05 Yale University Topical formulation of hyperbranched polymer-coated particles
US9574211B2 (en) 2014-05-13 2017-02-21 Sangamo Biosciences, Inc. Methods and compositions for prevention or treatment of a disease
EP3152319A4 (en) 2014-06-05 2017-12-27 Sangamo BioSciences, Inc. Methods and compositions for nuclease design
WO2016005449A1 (en) 2014-07-08 2016-01-14 Vib Vzw Means and methods to increase plant yield
MX2017000555A (en) 2014-07-14 2017-08-10 Univ Washington State Nanos knock-out that ablates germline cells.
CA2954414A1 (en) 2014-07-15 2016-01-21 Juno Therapeutics, Inc. Engineered cells for adoptive cell therapy
US11278572B2 (en) 2014-07-18 2022-03-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells
WO2016014837A1 (en) 2014-07-25 2016-01-28 Sangamo Biosciences, Inc. Gene editing for hiv gene therapy
WO2016014794A1 (en) 2014-07-25 2016-01-28 Sangamo Biosciences, Inc. Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
US9616090B2 (en) 2014-07-30 2017-04-11 Sangamo Biosciences, Inc. Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
JP6722176B2 (en) 2014-09-16 2020-07-15 サンガモ セラピューティクス, インコーポレイテッド Methods and compositions for nuclease-mediated genomic engineering and correction in hematopoietic stem cells
US10889834B2 (en) 2014-12-15 2021-01-12 Sangamo Therapeutics, Inc. Methods and compositions for enhancing targeted transgene integration
WO2016118726A2 (en) 2015-01-21 2016-07-28 Sangamo Biosciences, Inc. Methods and compositions for identification of highly specific nucleases
EP3250680A4 (en) 2015-01-26 2018-12-05 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
US10676726B2 (en) 2015-02-09 2020-06-09 Duke University Compositions and methods for epigenome editing
ES2959608T3 (en) 2015-04-03 2024-02-27 Dana Farber Cancer Inst Inc Composition and editing methods of the B cell genome
BR112017021703B1 (en) 2015-04-15 2023-11-28 Corteva Agriscience Llc PLANT PROMOTER FOR TRANSGENE EXPRESSION
KR20170136549A (en) 2015-04-15 2017-12-11 다우 아그로사이언시즈 엘엘씨 Plant promoters for transgen expression
CN108026566A (en) 2015-05-04 2018-05-11 特拉维夫大学拉莫特有限公司 For making the method and kit of DNA fragmentation
US10179918B2 (en) 2015-05-07 2019-01-15 Sangamo Therapeutics, Inc. Methods and compositions for increasing transgene activity
EP3294866A4 (en) 2015-05-12 2018-12-05 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
EP3303586A1 (en) 2015-05-29 2018-04-11 Juno Therapeutics, Inc. Composition and methods for regulating inhibitory interactions in genetically engineered cells
US9957501B2 (en) 2015-06-18 2018-05-01 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
AU2016291778B2 (en) 2015-07-13 2021-05-06 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
MA42895A (en) 2015-07-15 2018-05-23 Juno Therapeutics Inc MODIFIED CELLS FOR ADOPTIVE CELL THERAPY
BR112018002417A2 (en) 2015-08-06 2018-09-18 Univ Missouri non-human animal or descendant thereof or an animal cell, swine animal, descendant or cell, cell, descendant, reproduction method, animal population, method for increasing an animal resistance, nucleic acid molecule, nucleic acid and nucleic acid isolated
TW201718862A (en) 2015-09-22 2017-06-01 Dow Agrosciences Llc Plant promoter and 3' UTR for transgene expression
TW201718861A (en) 2015-09-22 2017-06-01 道禮責任有限公司 Plant promoter and 3'UTR for transgene expression
ES3032775T3 (en) 2015-09-23 2025-07-24 Sangamo Therapeutics Inc Htt repressors and uses thereof
WO2017066497A2 (en) 2015-10-13 2017-04-20 Duke University Genome engineering with type i crispr systems in eukaryotic cells
EP3365451B1 (en) 2015-10-22 2020-06-24 Dow Agrosciences LLC Plant promoter for transgene expression
EP3371314B1 (en) 2015-11-04 2023-07-05 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
US20170121726A1 (en) 2015-11-04 2017-05-04 Dow Agrosciences Llc Plant promoter for transgene expression
AU2016348342B2 (en) 2015-11-04 2023-07-06 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
WO2017091512A1 (en) 2015-11-23 2017-06-01 Sangamo Biosciences, Inc. Methods and compositions for engineering immunity
KR20250044471A (en) 2015-11-30 2025-03-31 듀크 유니버시티 Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use
CN108778297B (en) 2015-12-18 2024-02-09 桑格摩生物治疗股份有限公司 Targeted destruction of T cell receptors
SG11201805157TA (en) 2015-12-18 2018-07-30 Sangamo Therapeutics Inc Targeted disruption of the mhc cell receptor
AU2017207818B2 (en) 2016-01-15 2024-03-28 Regents Of The University Of Minnesota Methods and compositions for the treatment of neurologic disease
EP3411056A4 (en) 2016-02-02 2019-10-02 Sangamo Therapeutics, Inc. COMPOSITIONS FOR BINDING DNA BINDING DOMAINS AND CLEAVAGE DOMAINS
CA3014792A1 (en) 2016-02-16 2017-08-24 Carnegie Mellon University Compositions for enhancing targeted gene editing and methods of use thereof
US20200308590A1 (en) 2016-02-16 2020-10-01 Yale University Compositions and methods for treatment of cystic fibrosis
CA3016504A1 (en) 2016-03-23 2017-09-28 Dana-Farber Cancer Institute, Inc. Methods for enhancing the efficiency of gene editing
WO2017173453A1 (en) 2016-04-01 2017-10-05 The Brigham And Women's Hospital, Inc. Stimuli-responsive nanoparticles for biomedical applications
WO2017180915A2 (en) 2016-04-13 2017-10-19 Duke University Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
US11514331B2 (en) 2016-04-27 2022-11-29 Massachusetts Institute Of Technology Sequence-controlled polymer random access memory storage
WO2017189870A1 (en) 2016-04-27 2017-11-02 Massachusetts Institute Of Technology Stable nanoscale nucleic acid assemblies and methods thereof
CN110291402B (en) 2016-06-27 2023-09-01 朱诺治疗学股份有限公司 Methods of identifying peptide epitopes, molecules that bind such epitopes, and related uses
MA45491A (en) 2016-06-27 2019-05-01 Juno Therapeutics Inc CMH-E RESTRICTED EPITOPES, BINDING MOLECULES AND RELATED METHODS AND USES
ES2938210T3 (en) 2016-07-13 2023-04-05 Vertex Pharma Methods, compositions and kits to increase the efficiency of genome editing
JP7490211B2 (en) 2016-07-19 2024-05-27 デューク ユニバーシティ Therapeutic Applications of CPF1-Based Genome Editing
CN109789128A (en) 2016-07-27 2019-05-21 凯斯西储大学 Compounds and methods for promoting myelination
EP3497213B1 (en) 2016-08-09 2023-10-18 Vib Vzw Cellulose synthase inhibitors and mutant plants
BR112019003327A2 (en) 2016-08-24 2019-07-02 Sangamo Therapeutics, Inc. specific target engineered nucleases
DK3504229T3 (en) 2016-08-24 2021-12-20 Sangamo Therapeutics Inc REGULATION OF GENEPRESSION USING MANIPULATED NUCLEASES
JP7256739B2 (en) 2016-09-07 2023-04-12 サンガモ セラピューティクス, インコーポレイテッド Modulation of liver genes
CN109996436B (en) 2016-10-03 2023-09-29 科迪华农业科技有限责任公司 Plant promoters for transgene expression
EP3519433A1 (en) 2016-10-03 2019-08-07 Juno Therapeutics, Inc. Hpv-specific binding molecules
EP3519574B1 (en) 2016-10-03 2022-01-19 Corteva Agriscience LLC Plant promoter for transgene expression
WO2018067826A1 (en) 2016-10-05 2018-04-12 Cellular Dynamics International, Inc. Generating mature lineages from induced pluripotent stem cells with mecp2 disruption
MA50839A (en) 2016-10-13 2019-08-21 Juno Therapeutics Inc METHODS AND COMPOSITIONS OF IMMUNOTHERAPY INVOLVING MODULATORS OF THE TRYPTOPHAN METABOLIC PATHWAY
JP7042263B2 (en) 2016-10-20 2022-03-25 サンガモ セラピューティクス, インコーポレイテッド Methods and compositions for the treatment of Fabry disease
US11766400B2 (en) 2016-10-24 2023-09-26 Yale University Biodegradable contraceptive implants
AU2017347928A1 (en) 2016-10-31 2019-05-09 Sangamo Therapeutics, Inc. Gene correction of scid-related genes in hematopoietic stem and progenitor cells
US11504389B2 (en) 2016-12-01 2022-11-22 Sangamo Therapeutics, Inc. Tau modulators and methods and compositions for delivery thereof
US11793833B2 (en) 2016-12-02 2023-10-24 Juno Therapeutics, Inc. Engineered B cells and related compositions and methods
CA3045338A1 (en) 2016-12-05 2018-06-14 Juno Therapeutics, Inc. Production of engineered cells for adoptive cell therapy
ES2968892T3 (en) 2016-12-08 2024-05-14 Univ Case Western Reserve Methods and compositions to increase the production of functional myelin
US20200085758A1 (en) 2016-12-16 2020-03-19 The Brigham And Women's Hospital, Inc. Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
CA3054031A1 (en) 2017-02-22 2018-08-30 Crispr Therapeutics Ag Compositions and methods for gene editing
WO2018187493A1 (en) 2017-04-04 2018-10-11 Yale University Compositions and methods for in utero delivery
SG11201906948UA (en) 2017-04-20 2019-08-27 Univ Oregon Health & Science Human gene correction
WO2018204469A2 (en) 2017-05-03 2018-11-08 Sangamo Therapeutics, Inc. Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (cftr) gene
US11512287B2 (en) 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
EP3654763A4 (en) 2017-06-28 2021-06-09 Dow Agrosciences LLC PLANT PROMOTER FOR TRANSGENIC EXPRESSION
KR102669445B1 (en) 2017-08-08 2024-05-28 상가모 테라퓨틱스, 인코포레이티드 Chimeric antigen receptor-mediated cell targeting
EP3692063A1 (en) 2017-10-03 2020-08-12 Juno Therapeutics, Inc. Hpv-specific binding molecules
WO2019089982A1 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Method of assessing activity of recombinant antigen receptors
BR112020008568A2 (en) 2017-11-09 2020-10-06 Sangamo Therapeutics, Inc. genetic modification of protein gene containing cytokine-inducible sh2 (cish)
WO2019094928A1 (en) 2017-11-10 2019-05-16 Massachusetts Institute Of Technology Microbial production of pure single stranded nucleic acids
EP3713644B1 (en) 2017-11-20 2024-08-07 University of Georgia Research Foundation, Inc. Compositions and methods for modulating hif-2a to improve muscle generation and repair
BR112020010883A2 (en) 2017-12-01 2020-11-10 Encoded Therapeutics, Inc. engineered dna binding proteins
US11459577B2 (en) 2017-12-18 2022-10-04 Syngenta Participations Ag Targeted insertion sites in the maize genome
EP3728563B1 (en) 2017-12-22 2025-06-18 Fate Therapeutics, Inc. Enhanced immune effector cells and use thereof
KR20200110685A (en) 2018-01-17 2020-09-24 버텍스 파마슈티칼스 인코포레이티드 DNA-PK inhibitor
AU2019209290B2 (en) 2018-01-17 2024-03-07 Vertex Pharmaceuticals Incorporated DNA-PK inhibitors
MA51623A (en) 2018-01-17 2021-04-14 Vertex Pharma QUINOXALINONE COMPOUNDS, COMPOSITIONS, METHODS AND KITS FOR INCREASING GENOME EDITING EFFICIENCY
WO2019144061A1 (en) 2018-01-19 2019-07-25 Duke University Genome engineering with crispr-cas systems in eukaryotes
KR20200118468A (en) 2018-02-08 2020-10-15 상가모 테라퓨틱스, 인코포레이티드 Engineered target specific nuclease
US20210024959A1 (en) 2018-03-29 2021-01-28 Fate Therapeutics, Inc. Engineered immune effector cells and use thereof
BR112020020245A2 (en) 2018-04-05 2021-04-06 Editas Medicine, Inc. METHODS OF PRODUCING CELLS EXPRESSING A RECOMBINANT RECEIVER AND RELATED COMPOSITIONS
MX2020010461A (en) 2018-04-05 2021-01-15 Juno Therapeutics Inc T cells expressing a recombinant receptor, related polynucleotides and methods.
KR102764123B1 (en) 2018-04-05 2025-02-05 주노 쎄러퓨티크스 인코퍼레이티드 T cell receptor and engineered cells expressing it
CN112313246B (en) 2018-04-18 2025-05-13 桑格摩生物治疗股份有限公司 Zinc finger protein composition for regulating huntingtin protein (HTT)
BR112020022879A2 (en) 2018-05-11 2021-02-23 Crispr Therapeutics Ag methods and compositions for cancer treatment
US11690921B2 (en) 2018-05-18 2023-07-04 Sangamo Therapeutics, Inc. Delivery of target specific nucleases
GB201809273D0 (en) 2018-06-06 2018-07-25 Vib Vzw Novel mutant plant cinnamoyl-coa reductase proteins
US11827892B2 (en) 2018-06-07 2023-11-28 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Nucleic acid constructs and methods of using same
WO2019234750A1 (en) 2018-06-07 2019-12-12 The State Of Israel, Ministry Of Agriculture & Rural Development, Agricultural Research Organization (Aro) (Volcani Center) Methods of regenerating and transforming cannabis
WO2020028617A1 (en) 2018-08-01 2020-02-06 University Of Georgia Research Foundation, Inc. Compositions and methods for improving embryo development
WO2020041249A1 (en) 2018-08-23 2020-02-27 Sangamo Therapeutics, Inc. Engineered target specific base editors
MX2021002266A (en) 2018-08-31 2021-05-27 Univ Yale Compositions and methods for enhancing triplex and nuclease-based gene editing.
MX2021002265A (en) 2018-08-31 2021-05-27 Univ Yale Compositions and methods for enhancing donor oligonucleotide-base d gene editing.
JP2022500052A (en) 2018-09-18 2022-01-04 サンガモ セラピューティクス, インコーポレイテッド Programmed cell death 1 (PD1) specific nuclease
EP3852911B1 (en) 2018-09-21 2025-01-22 Acuitas Therapeutics, Inc. Systems and methods for manufacturing lipid nanoparticles and liposomes
EP3860618B1 (en) 2018-10-02 2026-02-04 Sangamo Therapeutics, Inc. Compositions for treating tauopathy
KR20210089707A (en) 2018-11-07 2021-07-16 크리스퍼 테라퓨틱스 아게 Anti-LIV1 Immune Cell Cancer Therapy
CA3118830A1 (en) 2018-11-07 2020-05-14 Crispr Therapeutics Ag Anti-ptk7 immune cell cancer therapy
CA3118816A1 (en) 2018-11-07 2020-05-14 Crispr Therapeutics Ag Anti-cd33 immune cell cancer therapy
WO2020112195A1 (en) 2018-11-30 2020-06-04 Yale University Compositions, technologies and methods of using plerixafor to enhance gene editing
CA3121128A1 (en) 2018-12-02 2020-06-11 Fate Therapeutics, Inc. Immunotherapies using enhanced ipsc derived effector cells
AU2019391114B2 (en) 2018-12-05 2026-01-29 Vertex Pharmaceuticals Incorporated Gene-editing systems for editing a cystic fibrosis transmembrane regulator (CFTR) gene
GB201820109D0 (en) 2018-12-11 2019-01-23 Vib Vzw Plants with a lignin trait and udp-glycosyltransferase mutation
EP4450487A3 (en) 2019-01-11 2024-12-25 Acuitas Therapeutics, Inc. Lipids for lipid nanoparticle delivery of active agents
US12156877B1 (en) 2019-01-15 2024-12-03 The Regents Of The University Of California Methods of treating conditions related to a thiamine deficiency, a thiamine-dependent enzyme, or an associated cofactor
US11419932B2 (en) 2019-01-24 2022-08-23 Massachusetts Institute Of Technology Nucleic acid nanostructure platform for antigen presentation and vaccine formulations formed therefrom
WO2020162978A1 (en) 2019-02-06 2020-08-13 Sangamo Therapeutics, Inc. Method for the treatment of mucopolysaccharidosis type i
KR20210148106A (en) 2019-03-08 2021-12-07 옵시디안 테라퓨틱스, 인크. CD40L compositions and methods for tunable modulation
KR20210146986A (en) 2019-04-02 2021-12-06 상가모 테라퓨틱스, 인코포레이티드 Methods of treating beta-thalassemia
TW202521561A (en) 2019-04-23 2025-06-01 美商聖加莫治療股份有限公司 Modulators of chromosome 9 open reading frame 72 gene expression and uses thereof
MX2021013219A (en) 2019-05-01 2022-02-17 Juno Therapeutics Inc CELLS EXPRESSING A RECOMBINANT RECEPTOR OF A MODIFIED TGFBR2 LOCUS, RELATED POLYNUCLEOTIDES AND METHODS.
SG11202111372VA (en) 2019-05-01 2021-11-29 Juno Therapeutics Inc Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods
SG11202113048SA (en) 2019-05-29 2021-12-30 Encoded Therapeutics Inc Compositions and methods for selective gene regulation
US11905532B2 (en) 2019-06-25 2024-02-20 Massachusetts Institute Of Technology Compositions and methods for molecular memory storage and retrieval
BR112021026382A2 (en) 2019-06-27 2022-02-08 Crispr Therapeutics Ag Use of chimeric antigen receptor t cells and nk cell inhibitors for cancer treatment
WO2021011919A1 (en) 2019-07-17 2021-01-21 Fate Therapeutics, Inc. Immune effector cell engineering and use thereof
US20220267732A1 (en) 2019-08-01 2022-08-25 Sana Biotechnology, Inc. Dux4 expressing cells and uses thereof
AU2020336302A1 (en) 2019-08-23 2022-03-03 Sana Biotechnology, Inc. CD24 expressing cells and uses thereof
AU2020336992A1 (en) 2019-08-30 2022-04-14 Yale University Compositions and methods for delivery of nucleic acids to cells
US12344656B2 (en) 2019-09-06 2025-07-01 Crispr Therapeutics Ag Genetically engineered T cells having improved persistence in culture
EP4041271A1 (en) 2019-10-02 2022-08-17 Sangamo Therapeutics, Inc. Zinc finger protein transcription factors for treatment of prion disease
US20220324928A1 (en) 2019-10-02 2022-10-13 Sangamo Therapeutics, Inc. Zinc Finger Protein Transcription Factors for Repressing Alpha-Synuclein Expression
US20210130828A1 (en) 2019-11-01 2021-05-06 Sangamo Therapeutics, Inc. Gin recombinase variants
TW202130812A (en) 2019-11-01 2021-08-16 美商聖加莫治療股份有限公司 Compositions and methods for genome engineering
MX2022008415A (en) 2020-01-08 2022-08-08 Obsidian Therapeutics Inc Compositions and methods for tunable regulation of transcription.
KR20220131273A (en) 2020-01-22 2022-09-27 상가모 테라퓨틱스, 인코포레이티드 Zinc Finger Protein Transcription Factor to Inhibit Tau Expression
EP4097124A1 (en) 2020-01-28 2022-12-07 The Broad Institute Inc. Base editors, compositions, and methods for modifying the mitochondrial genome
KR20220158046A (en) 2020-03-25 2022-11-29 사나 바이오테크놀로지, 인크. Immunocompromised Neuronal Cells for Treatment of Nervous System Disorders and Conditions
US12534744B2 (en) 2020-05-06 2026-01-27 Cellectis S.A. Methods to genetically modify cells for delivery of therapeutic proteins
AU2021268253A1 (en) 2020-05-06 2022-12-08 Cellectis S.A. Methods for targeted insertion of exogenous sequences in cellular genomes
CN115835873A (en) 2020-05-13 2023-03-21 朱诺治疗学股份有限公司 Method for producing donor batch cells expressing recombinant receptors
US20230190871A1 (en) 2020-05-20 2023-06-22 Sana Biotechnology, Inc. Methods and compositions for treatment of viral infections
WO2021247836A1 (en) 2020-06-03 2021-12-09 Board Of Regents, The University Of Texas System Methods for targeting shp-2 to overcome resistance
BR112022025806A2 (en) 2020-06-19 2023-03-07 Fate Therapeutics Inc IPSC-DERIVED EFFECTOR CELL TYPE COMBINATION FOR USE IN IMMUNOTHERAPY
JP2023531531A (en) 2020-06-26 2023-07-24 ジュノ セラピューティクス ゲーエムベーハー Engineered T Cells Conditionally Expressing Recombinant Receptors, Related Polynucleotides, and Methods
EP4182297B1 (en) 2020-07-16 2025-09-03 Acuitas Therapeutics, Inc. Cationic lipids for use in lipid nanoparticles
KR20230074718A (en) 2020-08-13 2023-05-31 사나 바이오테크놀로지, 인크. Methods of treating patients sensitized with hypoimmunogenic cells and related methods and compositions
EP4501951A3 (en) 2020-08-25 2025-04-30 Kite Pharma, Inc. T cells with improved functionality
AU2021331785A1 (en) 2020-08-31 2023-03-30 Gennao Bio, Inc. Compositions and methods for delivery of nucleic acids to cells
CA3192280A1 (en) 2020-09-23 2022-03-31 Mary-Lee Dequeant Genetically engineered t cells with regnase-1 and/or tgfbrii disruption have improved functionality and persistence
US20240043829A1 (en) 2020-09-25 2024-02-08 Sangamo Therapeutics, Inc. Zinc finger fusion proteins for nucleobase editing
CN116917335A (en) 2020-10-02 2023-10-20 桑格摩生物治疗股份有限公司 Novel zinc finger protein transcription factor for repressing α-synuclein (SYNUCLEIN) expression
JP2023549780A (en) 2020-11-04 2023-11-29 ジュノー セラピューティクス インコーポレイテッド Cells expressing chimeric receptors from engineered invariant CD3 immunoglobulin superfamily chain loci and related polynucleotides and methods
CA3200855A1 (en) 2020-11-16 2022-05-19 Pig Improvement Company Uk Limited Influenza a-resistant animals having edited anp32 genes
EP4255922A1 (en) 2020-12-03 2023-10-11 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
US20220193134A1 (en) 2020-12-23 2022-06-23 Crispr Therapeutics Ag Co-use of lenalidomide with car-t cells
JP2024501971A (en) 2020-12-31 2024-01-17 サナ バイオテクノロジー,インコーポレイテッド Methods and compositions for modulating CAR-T activity
WO2022155265A2 (en) 2021-01-12 2022-07-21 Mitolab Inc. Context-dependent, double-stranded dna-specific deaminases and uses thereof
WO2022189967A1 (en) 2021-03-09 2022-09-15 Crispr Therapeutics Ag Genetically engineered t cells with ptpn2 knockout have improved functionality and anti-tumor activity
KR20230158573A (en) 2021-03-22 2023-11-20 주노 쎄러퓨티크스 인코퍼레이티드 Methods for Assessing Potency of Viral Vector Particles
AU2022253223A1 (en) 2021-04-07 2023-09-28 Century Therapeutics, Inc. Combined artificial cell death/reporter system polypeptide for chimeric antigen receptor cell and uses thereof
CA3214473A1 (en) 2021-04-07 2022-10-13 Century Therapeutics, Inc. Compositions and methods for generating alpha-beta t cells from induced pluripotent stem cells
KR20230170703A (en) 2021-04-07 2023-12-19 센츄리 쎄라퓨틱스 인코포레이티드 Compositions and methods for generating gamma-delta T cells from induced pluripotent stem cells
AU2022269643A1 (en) 2021-05-05 2023-11-02 FUJIFILM Cellular Dynamics, Inc. Methods and compositions for ipsc-derived microglia
CA3220168A1 (en) 2021-05-26 2022-12-01 Sarah DICKERSON Methods to prevent rapid silencing of genes in pluripotent stem cells
WO2022251367A1 (en) 2021-05-27 2022-12-01 Sana Biotechnology, Inc. Hypoimmunogenic cells comprising engineered hla-e or hla-g
WO2023287827A2 (en) 2021-07-14 2023-01-19 Sana Biotechnology, Inc. Altered expression of y chromosome-linked antigens in hypoimmunogenic cells
US20240252684A1 (en) 2021-07-30 2024-08-01 Tune Therapeutics, Inc. Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
US20240254483A1 (en) 2021-07-30 2024-08-01 Tune Therapeutics, Inc. Compositions and methods for modulating expression of frataxin (fxn)
WO2023019226A1 (en) 2021-08-11 2023-02-16 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
EP4384188A1 (en) 2021-08-11 2024-06-19 Sana Biotechnology, Inc. Inducible systems for altering gene expression in hypoimmunogenic cells
JP2024531234A (en) 2021-08-11 2024-08-29 サナ バイオテクノロジー,インコーポレイテッド Genetically modified primary cells for allogeneic cell therapy
JP2024535677A (en) 2021-08-11 2024-10-02 サナ バイオテクノロジー,インコーポレイテッド Genetically modified cells for allogeneic cell therapy to reduce immediate blood-borne inflammatory responses
EP4384598A1 (en) 2021-08-11 2024-06-19 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce complement-mediated inflammatory reactions
KR20240055838A (en) 2021-09-10 2024-04-29 후지필름 셀룰러 다이내믹스, 인코포레이티드 Compositions of cells derived from induced pluripotent stem cells and methods of using the same
US20230128917A1 (en) 2021-09-14 2023-04-27 Crispr Therapeutics Ag Genetically engineered immune cells having a disrupted cd83 gene
WO2023070043A1 (en) 2021-10-20 2023-04-27 Yale University Compositions and methods for targeted editing and evolution of repetitive genetic elements
EP4419676A1 (en) 2021-10-21 2024-08-28 Vertex Pharmaceuticals Incorporated Hypoimmune cells
WO2023069790A1 (en) 2021-10-22 2023-04-27 Sana Biotechnology, Inc. Methods of engineering allogeneic t cells with a transgene in a tcr locus and associated compositions and methods
US20240409934A1 (en) 2021-10-25 2024-12-12 Board Of Regents, The University Of Texas System Foxo1-targeted therapy for the treatment of cancer
JP2024541964A (en) 2021-10-29 2024-11-13 フジフィルム セルラー ダイナミクス,インコーポレイテッド Dopaminergic neurons containing mutations and methods of use thereof
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
WO2023105244A1 (en) 2021-12-10 2023-06-15 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
WO2023111913A1 (en) 2021-12-15 2023-06-22 Crispr Therapeutics Ag Engineered anti-liv1 cell with regnase-1 and/or tgfbrii disruption
CN118647600A (en) 2021-12-16 2024-09-13 爱康泰生治疗公司 Lipids for lipid nanoparticle formulation
US20230346836A1 (en) 2021-12-22 2023-11-02 Crispr Therapeutics Ag Genetically engineered t cells with disrupted casitas b-lineage lymphoma proto-oncogene-b (cblb) and uses thereof
AU2022421236A1 (en) 2021-12-22 2024-06-27 Sangamo Therapeutics, Inc. Novel zinc finger fusion proteins for nucleobase editing
KR20240137574A (en) 2021-12-23 2024-09-20 사나 바이오테크놀로지, 인크. CHIMERIC ANTIGEN RECEPTOR (CAR) T CELLS FOR THERAPY OF AUTOIMMUNE DISEASES AND RELATED METHODS
AU2022423987A1 (en) 2021-12-29 2024-07-11 Century Therapeutics, Inc. Genetically engineered cells having anti-cd19 / anti-cd22 chimeric antigen receptors, and uses thereof
WO2023131616A1 (en) 2022-01-05 2023-07-13 Vib Vzw Means and methods to increase abiotic stress tolerance in plants
WO2023131637A1 (en) 2022-01-06 2023-07-13 Vib Vzw Improved silage grasses
US20250154503A1 (en) 2022-01-14 2025-05-15 Tune Therapeutics, Inc. Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
CA3247928A1 (en) 2022-01-14 2023-07-20 Tune Therapeutics, Inc. Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
WO2023144199A1 (en) 2022-01-26 2023-08-03 Vib Vzw Plants having reduced levels of bitter taste metabolites
US20250302953A1 (en) 2022-02-14 2025-10-02 Sana Biotechnology, Inc. Methods of treating patients exhibiting a prior failed therapy with hypoimmunogenic cells
EP4479416A1 (en) 2022-02-17 2024-12-25 Sana Biotechnology, Inc. Engineered cd47 proteins and uses thereof
TW202340457A (en) 2022-02-28 2023-10-16 美商凱特製藥公司 Allogeneic therapeutic cells
CA3245130A1 (en) 2022-03-01 2023-09-07 Crispr Therapeutics Ag Methods and compositions for treating angiopoietin-like 3 (angptl3) related conditions
WO2023173123A1 (en) 2022-03-11 2023-09-14 Sana Biotechnology, Inc. Genetically modified cells and compositions and uses thereof
EP4496891A1 (en) 2022-03-21 2025-01-29 CRISPR Therapeutics AG Methods and compositions for treating lipoprotein-related diseases
US20230303713A1 (en) 2022-03-23 2023-09-28 Crispr Therapeutics Ag Anti-cd19 car-t cells with multiple gene edits and therapeutic uses thereof
WO2023180967A1 (en) 2022-03-23 2023-09-28 Crispr Therapeutics Ag Anti-cd83 car-t cells with regnase-1 and/or tgfbrii disruption
US20230302423A1 (en) 2022-03-28 2023-09-28 Massachusetts Institute Of Technology Rna scaffolded wireframe origami and methods thereof
WO2023196982A1 (en) 2022-04-08 2023-10-12 Fate Therapeutics, Inc. Chimeric antigen receptor for tumor targeting
KR20250005097A (en) 2022-04-08 2025-01-09 페이트 세러퓨틱스, 인코포레이티드 Cells having solid tumor targeting scaffolds and uses thereof
WO2023230613A1 (en) 2022-05-27 2023-11-30 The Broad Institute, Inc. Improved mitochondrial base editors and methods for editing mitochondrial dna
JP2025519448A (en) 2022-06-08 2025-06-26 センチュリー セラピューティクス,インコーポレイテッド Immune effector cells derived from induced pluripotent stem cells genetically engineered with membrane-bound il12 and uses thereof
EP4536696A1 (en) 2022-06-08 2025-04-16 Century Therapeutics, Inc. Genetically engineered cells expressing cd16 variants and nkg2d and uses thereof
WO2023240212A2 (en) 2022-06-08 2023-12-14 Century Therapeutics, Inc. Genetically engineered cells having anti-cd133 / anti-egfr chimeric antigen receptors, and uses thereof
WO2023242827A2 (en) 2022-06-17 2023-12-21 Crispr Therapeutics Ag LIPID NANOPARTICLES (LNPs)-BASED OCULAR DELIVERY
WO2023248147A1 (en) 2022-06-21 2023-12-28 Crispr Therapeutics Ag Methods and compositions for in vivo editing of stem cells
WO2023248145A1 (en) 2022-06-21 2023-12-28 Crispr Therapeutics Ag Compositions and methods for treating human immunodeficiency virus
AU2023289696A1 (en) 2022-06-24 2025-01-16 Tune Therapeutics, Inc. Compositions, systems, and methods for reducing low-density lipoprotein through targeted gene repression
CN119452078A (en) 2022-06-29 2025-02-14 富士胶片控股美国公司 IPSC-derived astrocytes and methods of using the same
JP2025522812A (en) 2022-06-29 2025-07-17 クリスパー セラピューティクス アクチェンゲゼルシャフト Chimeric antigen receptors targeting GPC-3 and immune cells expressing such chimeric antigen receptors for therapeutic use
CA3261865A1 (en) 2022-07-12 2024-01-18 Tune Therapeutics, Inc. Compositions, systems, and methods for targeted transcriptional activation
WO2024013514A2 (en) 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance
JP2025523965A (en) 2022-07-22 2025-07-25 ザ・ジョンズ・ホプキンス・ユニバーシティー Dendrimer-enabled targeted intracellular CRISPR/CAS system delivery and gene editing
WO2024023804A2 (en) 2022-07-29 2024-02-01 Crispr Therapeutics Ag Genetically engineered immune cells having disrupted transporter associated with antigen processing binding protein (tapbp) gene
WO2024023802A2 (en) 2022-07-29 2024-02-01 Crispr Therapeutics Ag Genetically engineered immune cells having disrupted transporter associated with antigen processing-2 (tap-2) gene
WO2024023801A2 (en) 2022-07-29 2024-02-01 Crispr Therapeutics Ag Genetically engineered immune cells having disrupted transporter associated with antigen processing-1 (tap-1) gene
KR20250077608A (en) 2022-08-19 2025-05-30 튠 쎄라퓨틱스, 인코포레이티드 Compositions, systems and methods for controlling hepatitis B virus through targeted gene inhibition
WO2024064642A2 (en) 2022-09-19 2024-03-28 Tune Therapeutics, Inc. Compositions, systems, and methods for modulating t cell function
WO2024062388A2 (en) 2022-09-20 2024-03-28 Crispr Therapeutics Ag Genetically engineered immune cells expressing chimeric antigen receptor targeting cd20
AU2023361162A1 (en) 2022-10-11 2025-05-29 Yale University Compositions and methods of using cell-penetrating antibodies
EP4615960A1 (en) 2022-11-09 2025-09-17 C3S2 GmbH Methods for manufacturing engineered immune cells
WO2024102838A1 (en) 2022-11-09 2024-05-16 Century Therapeutics, Inc. Engineered interleukin-7 receptors and uses thereof
IL320650A (en) 2022-11-10 2025-07-01 Century Therapeutics Inc Genetically engineered cells having anti-nectin4 chimeric antigen receptors, and uses thereof
WO2024119101A1 (en) 2022-12-01 2024-06-06 Yale University Stimuli-responsive traceless engineering platform for intracellular payload delivery
US20240269189A1 (en) 2022-12-19 2024-08-15 FUJIFILM Holdings America Corporation Extracellular vesicle-enriched secretome composition derived from induced pluripotent stem cell derived-microglia and methods of use thereof
WO2024131917A1 (en) 2022-12-23 2024-06-27 益杰立科(上海)生物科技有限公司 Complex and use thereof
CN120476211A (en) 2022-12-23 2025-08-12 益杰立科新加坡有限公司 Fusions and their uses
WO2024151541A1 (en) 2023-01-09 2024-07-18 Sana Biotechnology, Inc. Type-1 diabetes autoimmune mouse
WO2024163678A2 (en) 2023-02-01 2024-08-08 Tune Therapeutics, Inc. Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
WO2024163683A2 (en) 2023-02-01 2024-08-08 Tune Therapeutics, Inc. Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
JP2026504491A (en) 2023-02-03 2026-02-05 ツェー3エス2 ゲーエムベーハー Methods for non-viral production of engineered immune cells
CN120712355A (en) 2023-02-15 2025-09-26 阿伯生物技术公司 A gene editing method for inhibiting aberrant splicing in the inhibitory microtubule assembly protein 2 (STMN2) transcript
WO2024192108A1 (en) 2023-03-14 2024-09-19 Evolveimmune Therapeutics, Inc. Genetically modified car t cells and methods of making and using the same
AU2024257643A1 (en) 2023-04-21 2025-10-16 Kite Pharma, Inc. Allogenic therapeutic cells with reduced risk of immune rejection
AU2024264889A1 (en) 2023-05-03 2025-11-13 Sana Biotechnology, Inc. Methods of dosing and administration of engineered islet cells
WO2024238723A1 (en) 2023-05-16 2024-11-21 Omega Therapeutics, Inc. Methods and compositions for modulating pcsk9 expression
WO2024238726A1 (en) 2023-05-16 2024-11-21 Omega Therapeutics, Inc. Methods and compositions for modulating methylation of a target gene
WO2024243236A2 (en) 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
WO2025004001A1 (en) 2023-06-30 2025-01-02 Takeda Pharmaceutical Company Limited Htt repressors and uses thereof
WO2025019742A1 (en) 2023-07-19 2025-01-23 Omega Therapeutics, Inc. Methods and compositions for modulating ctnnb1 expression
AU2024301706A1 (en) 2023-07-21 2026-02-05 Crispr Therapeutics Ag Modulating expression of alas1 (5'-aminolevulinate synthase 1) gene
WO2025029840A1 (en) 2023-07-31 2025-02-06 Tune Therapeutics, Inc. Compositions and methods for multiplexed activation and repression of t cell gene expression
WO2025029835A1 (en) 2023-07-31 2025-02-06 Tune Therapeutics, Inc. Compositions and methods for modulating il-2 gene expression
WO2025038494A1 (en) 2023-08-11 2025-02-20 Tune Therapeutics, Inc. Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation
WO2025059073A1 (en) 2023-09-11 2025-03-20 Tune Therapeutics, Inc. Epigenetic editing methods and systems for differentiating stem cells
WO2025101938A2 (en) 2023-11-10 2025-05-15 Century Therapeutics, Inc. Genetically engineered cells having multi-transmembrane domain chimeric antigen receptors utilizing g protein-coupled receptor scaffolds, and uses thereof
WO2025106626A1 (en) 2023-11-15 2025-05-22 Century Therapeutics, Inc. Genetically engineered cells expressing c-x-c chemokine receptor type 4, and uses thereof
WO2025186726A1 (en) 2024-03-05 2025-09-12 Crispr Therapeutics Ag Modulating expression of agt (angiotensinogen) gene
WO2025194124A1 (en) 2024-03-14 2025-09-18 Tessera Therapeutics, Inc. Modified st1cas9 guide nucleic acids
WO2025207798A1 (en) 2024-03-26 2025-10-02 Century Therapeutics, Inc. Genetically engineered cells having anti-cd123 chimeric antigen receptors, and uses thereof
WO2025207795A1 (en) 2024-03-26 2025-10-02 Juno Therapeutics, Inc. Genetically engineered cells having anti-cd33 / anti-cd123 chimeric antigen receptors, and uses thereof
WO2025224715A1 (en) 2024-04-26 2025-10-30 King Abdullah Univeristy Of Science And Technology Methods for improving precise genome modification and reducing unwanted mutations by crispr-cas editing
WO2025235563A1 (en) 2024-05-07 2025-11-13 Omega Therapeutics, Inc. Epigenetic modulation for upregulation of genes
WO2025235851A1 (en) 2024-05-10 2025-11-13 Juno Therapeutics, Inc. Genetically engineered t cells expressing a cd19 chimeric antigen receptor (car) and uses thereof for allogeneic cell therapy
WO2025260068A1 (en) 2024-06-14 2025-12-18 Tune Therapeutics, Inc. Lipid nanoparticle formulation for delivery of nucleic acids to cells
WO2026006832A1 (en) 2024-06-28 2026-01-02 University Of Connecticut Gene modulation for treating cancer
WO2026015647A1 (en) 2024-07-09 2026-01-15 Tune Therapeutics, Inc. Compositions, systems, and methods for cell differentiation using targeted gene activation of dll4 and/or vcam1

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU698152B2 (en) * 1994-08-20 1998-10-22 Gendaq Limited Improvements in or relating to binding proteins for recognition of DNA

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