MX2019003459A - Método para preparar un compuesto de fenilalanina. - Google Patents
Método para preparar un compuesto de fenilalanina.Info
- Publication number
- MX2019003459A MX2019003459A MX2019003459A MX2019003459A MX2019003459A MX 2019003459 A MX2019003459 A MX 2019003459A MX 2019003459 A MX2019003459 A MX 2019003459A MX 2019003459 A MX2019003459 A MX 2019003459A MX 2019003459 A MX2019003459 A MX 2019003459A
- Authority
- MX
- Mexico
- Prior art keywords
- preparing
- fluorobenzoyl
- phenyl
- target compound
- phenylalanine compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 title 1
- -1 phenylalanine compound Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- QNLWMPLUWMWDMQ-UHFFFAOYSA-N 3-[4-(2-carbazol-9-ylethoxy)phenyl]-2-[2-(4-fluorobenzoyl)anilino]propanoic acid Chemical compound C=1C=C(OCCN2C3=CC=CC=C3C3=CC=CC=C32)C=CC=1CC(C(=O)O)NC1=CC=CC=C1C(=O)C1=CC=C(F)C=C1 QNLWMPLUWMWDMQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Abstract
Se divulga un método para preparar el ácido 2-(2-(4- fluorobenzoil)fenilamino)-3-(4-(2-(9H-carbazol-9-il)etoxi)fenil)p ropanoico. En el método, el etanol mesilato de 9-carbazol y el 2-[2-(4-fluorobenzoil)fenil)amino]-3-(4- hidroxifenil)propionato de metilo se utilizan como materiales de partida, y se someten a condensación, hidrólisis y acidificación, para obtener el compuesto diana. El método de preparación de la presente invención es adecuado para la producción industrial, y el compuesto diana tiene alta pureza.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610855107.3A CN107868033B (zh) | 2016-09-27 | 2016-09-27 | 一种苯丙氨酸类化合物的制备方法 |
| PCT/CN2017/103618 WO2018059427A1 (zh) | 2016-09-27 | 2017-09-27 | 一种苯丙氨酸类化合物的制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019003459A true MX2019003459A (es) | 2019-10-15 |
Family
ID=61752185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019003459A MX2019003459A (es) | 2016-09-27 | 2017-09-27 | Método para preparar un compuesto de fenilalanina. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10640465B2 (es) |
| EP (1) | EP3524592B1 (es) |
| JP (1) | JP6884857B2 (es) |
| KR (1) | KR102264868B1 (es) |
| CN (1) | CN107868033B (es) |
| AU (1) | AU2017333054B2 (es) |
| CA (1) | CA3038381C (es) |
| DK (1) | DK3524592T3 (es) |
| ES (1) | ES2930284T3 (es) |
| MX (1) | MX2019003459A (es) |
| PL (1) | PL3524592T3 (es) |
| RU (1) | RU2708243C1 (es) |
| TW (1) | TWI646081B (es) |
| WO (1) | WO2018059427A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107868032B (zh) * | 2016-09-27 | 2020-12-15 | 深圳微芯生物科技股份有限公司 | 一种取代的苯基丙酸化合物对映异构体及其制备方法、组合物和应用 |
| CN110467560B (zh) * | 2018-05-09 | 2025-11-25 | 深圳微芯生物科技股份有限公司 | 一种苯基氨基丙酸钠衍生物、其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7268157B2 (en) * | 2002-11-26 | 2007-09-11 | Shenzhen Chipscreen Biosciences, Ltd. | Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity |
| CN1257893C (zh) * | 2003-06-17 | 2006-05-31 | 深圳微芯生物科技有限责任公司 | 具有优异降糖降酯活性的芳烷基氨基酸类ppar全激活剂 |
| CN1882537A (zh) * | 2003-09-25 | 2006-12-20 | 惠氏公司 | 取代的吲哚酸衍生物及其作为pai－1抑制剂的应用 |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| CN104744282A (zh) * | 2015-02-17 | 2015-07-01 | 南通恒盛精细化工有限公司 | 一种胰岛素增敏剂的制备工艺 |
-
2016
- 2016-09-27 CN CN201610855107.3A patent/CN107868033B/zh active Active
-
2017
- 2017-09-27 RU RU2019112470A patent/RU2708243C1/ru active
- 2017-09-27 PL PL17854877.2T patent/PL3524592T3/pl unknown
- 2017-09-27 EP EP17854877.2A patent/EP3524592B1/en active Active
- 2017-09-27 ES ES17854877T patent/ES2930284T3/es active Active
- 2017-09-27 DK DK17854877.2T patent/DK3524592T3/da active
- 2017-09-27 MX MX2019003459A patent/MX2019003459A/es unknown
- 2017-09-27 AU AU2017333054A patent/AU2017333054B2/en active Active
- 2017-09-27 KR KR1020197011254A patent/KR102264868B1/ko active Active
- 2017-09-27 US US16/337,207 patent/US10640465B2/en active Active
- 2017-09-27 CA CA3038381A patent/CA3038381C/en active Active
- 2017-09-27 JP JP2019517775A patent/JP6884857B2/ja active Active
- 2017-09-27 WO PCT/CN2017/103618 patent/WO2018059427A1/zh not_active Ceased
- 2017-09-27 TW TW106133222A patent/TWI646081B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190049883A (ko) | 2019-05-09 |
| EP3524592B1 (en) | 2022-08-24 |
| BR112019005986A2 (pt) | 2019-06-25 |
| CN107868033B (zh) | 2021-05-18 |
| DK3524592T3 (da) | 2022-09-05 |
| JP2019536746A (ja) | 2019-12-19 |
| ES2930284T3 (es) | 2022-12-09 |
| EP3524592A1 (en) | 2019-08-14 |
| CA3038381C (en) | 2021-05-25 |
| CN107868033A (zh) | 2018-04-03 |
| TWI646081B (zh) | 2019-01-01 |
| TW201813956A (zh) | 2018-04-16 |
| AU2017333054B2 (en) | 2019-11-21 |
| CA3038381A1 (en) | 2018-04-05 |
| KR102264868B1 (ko) | 2021-06-14 |
| WO2018059427A1 (zh) | 2018-04-05 |
| US10640465B2 (en) | 2020-05-05 |
| US20190225582A1 (en) | 2019-07-25 |
| RU2708243C1 (ru) | 2019-12-05 |
| EP3524592A4 (en) | 2020-04-01 |
| PL3524592T3 (pl) | 2022-12-19 |
| AU2017333054A1 (en) | 2019-05-02 |
| JP6884857B2 (ja) | 2021-06-09 |
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