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MX2019003272A - Conjugados de afinidad-oligonucleotidos y usos de los mismos. - Google Patents

Conjugados de afinidad-oligonucleotidos y usos de los mismos.

Info

Publication number
MX2019003272A
MX2019003272A MX2019003272A MX2019003272A MX2019003272A MX 2019003272 A MX2019003272 A MX 2019003272A MX 2019003272 A MX2019003272 A MX 2019003272A MX 2019003272 A MX2019003272 A MX 2019003272A MX 2019003272 A MX2019003272 A MX 2019003272A
Authority
MX
Mexico
Prior art keywords
affinity
oligonucleotide conjugates
compositions
methods
single cell
Prior art date
Application number
MX2019003272A
Other languages
English (en)
Inventor
Vigneault Francois
J Belmont Brian
Adrian Briggs Wrangham
J Goldfless Stephen
Original Assignee
Abvitro Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abvitro Llc filed Critical Abvitro Llc
Priority claimed from PCT/US2017/013274 external-priority patent/WO2018057051A1/en
Publication of MX2019003272A publication Critical patent/MX2019003272A/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/159—Microreactors, e.g. emulsion PCR or sequencing, droplet PCR, microcapsules, i.e. non-liquid containers with a range of different permeability's for different reaction components
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
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    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/185—Nucleic acid dedicated to use as a hidden marker/bar code, e.g. inclusion of nucleic acids to mark art objects or animals
    • C—CHEMISTRY; METALLURGY
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/7051—T-cell receptor (TcR)-CD3 complex
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70514—CD4
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70517—CD8
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

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Abstract

En la presente se proporcionan métodos y composiciones para la caracterización de células individuales usando conjugados de afinidad-oligonucleótidos. Se proporcionan en la presente métodos y composiciones para la caracterización de células individuales usando conjugados de tetrámerooligonucleótido.
MX2019003272A 2015-09-24 2017-01-12 Conjugados de afinidad-oligonucleotidos y usos de los mismos. MX2019003272A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562232209P 2015-09-24 2015-09-24
PCT/US2016/053598 WO2017053905A1 (en) 2015-09-24 2016-09-24 Affinity-oligonucleotide conjugates and uses thereof
PCT/US2017/013274 WO2018057051A1 (en) 2016-09-24 2017-01-12 Affinity-oligonucleotide conjugates and uses thereof

Publications (1)

Publication Number Publication Date
MX2019003272A true MX2019003272A (es) 2019-09-13

Family

ID=57121536

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2018003532A MX2018003532A (es) 2015-09-24 2016-09-24 Conjugados de afinidad-oligonucleotido y usos de los mismos.
MX2019003272A MX2019003272A (es) 2015-09-24 2017-01-12 Conjugados de afinidad-oligonucleotidos y usos de los mismos.
MX2022012937A MX2022012937A (es) 2015-09-24 2018-03-22 Conjugados de afinidad-oligonucleotido y usos de los mismos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018003532A MX2018003532A (es) 2015-09-24 2016-09-24 Conjugados de afinidad-oligonucleotido y usos de los mismos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022012937A MX2022012937A (es) 2015-09-24 2018-03-22 Conjugados de afinidad-oligonucleotido y usos de los mismos.

Country Status (17)

Country Link
US (4) US11156611B2 (es)
EP (3) EP3933047A1 (es)
JP (2) JP6869233B2 (es)
KR (2) KR20180085717A (es)
CN (2) CN108291257B (es)
AU (1) AU2016326737B2 (es)
BR (1) BR112018005937A2 (es)
CA (2) CA2999888C (es)
ES (1) ES2928681T3 (es)
IL (1) IL258248B (es)
MX (3) MX2018003532A (es)
MY (2) MY193806A (es)
PH (2) PH12018500647A1 (es)
RU (1) RU2763554C2 (es)
SA (1) SA518391159B1 (es)
SG (1) SG10201912906RA (es)
WO (1) WO2017053905A1 (es)

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