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MX2019001103A - Sistema de suministro transdermico de donepezilo. - Google Patents

Sistema de suministro transdermico de donepezilo.

Info

Publication number
MX2019001103A
MX2019001103A MX2019001103A MX2019001103A MX2019001103A MX 2019001103 A MX2019001103 A MX 2019001103A MX 2019001103 A MX2019001103 A MX 2019001103A MX 2019001103 A MX2019001103 A MX 2019001103A MX 2019001103 A MX2019001103 A MX 2019001103A
Authority
MX
Mexico
Prior art keywords
transdermal delivery
donepezil
delivery system
therapeutic agent
donepezil transdermal
Prior art date
Application number
MX2019001103A
Other languages
English (en)
Other versions
MX394249B (es
Inventor
Singh Parminder
Soo Lee Eun
K Jain Amit
Original Assignee
Corium Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corium Int Inc filed Critical Corium Int Inc
Publication of MX2019001103A publication Critical patent/MX2019001103A/es
Publication of MX394249B publication Critical patent/MX394249B/es

Links

Classifications

    • AHUMAN NECESSITIES
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    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
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    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/16Amides, e.g. hydroxamic acids
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    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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    • A61K9/7084Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08KUse of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00Use of organic ingredients
    • C08K5/0008Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
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    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describe un sistema de suministro transdérmico para el suministro sistémico de donepezilo, donde el sistema comprende una capa de depósito de fármaco comprendida de un copolímero de acrilato, glicerina, y base de donepezilo generada in situ mediante la reacción de donepezilo HCl y una sal alcalina. El sistema se proporciona para el tratamiento de enfermedad de Alzheimer y logra el suministro transdérmico del agente terapéutico que es equivalente a la administración del agente terapéutico oralmente.
MX2019001103A 2016-07-27 2017-07-26 Sistema de suministro transdermico de donepezilo. MX394249B (es)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662367502P 2016-07-27 2016-07-27
US201662367542P 2016-07-27 2016-07-27
US201662423133P 2016-11-16 2016-11-16
US201762444763P 2017-01-10 2017-01-10
US201762444745P 2017-01-10 2017-01-10
US201762457794P 2017-02-10 2017-02-10
US201762504408P 2017-05-10 2017-05-10
US201762504391P 2017-05-10 2017-05-10
PCT/US2017/044050 WO2018022817A1 (en) 2016-07-27 2017-07-26 Donepezil transdermal delivery system

Publications (2)

Publication Number Publication Date
MX2019001103A true MX2019001103A (es) 2019-09-27
MX394249B MX394249B (es) 2025-03-24

Family

ID=59523314

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019001103A MX394249B (es) 2016-07-27 2017-07-26 Sistema de suministro transdermico de donepezilo.
MX2022006681A MX2022006681A (es) 2016-07-27 2019-01-25 Sistema de suministro transdermico de donepezilo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2022006681A MX2022006681A (es) 2016-07-27 2019-01-25 Sistema de suministro transdermico de donepezilo.

Country Status (10)

Country Link
US (13) US9993466B2 (es)
EP (3) EP3490558A1 (es)
JP (6) JP7071330B2 (es)
KR (9) KR20230109782A (es)
CN (5) CN116270551A (es)
AU (7) AU2017301928B2 (es)
CA (2) CA3031945C (es)
MX (2) MX394249B (es)
SG (1) SG11201900692WA (es)
WO (3) WO2018022816A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016105499A1 (en) 2014-12-23 2016-06-30 Intellectual Property Associates, Llc Methods and formulations for transdermal administration
EP3376852B1 (en) * 2015-11-18 2025-06-04 Commonwealth Scientific and Industrial Research Organisation Rice grain with thickened aleurone
US10835499B2 (en) 2015-12-30 2020-11-17 Corium, Inc. Systems and methods for long term transdermal administration
US11541018B2 (en) 2016-06-23 2023-01-03 Corium, Llc Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
CA3032103A1 (en) 2016-07-27 2018-02-01 Corium International, Inc. Memantine transdermal delivery systems
KR20230109782A (ko) 2016-07-27 2023-07-20 코리움, 엘엘씨 아민 약물의 나트륨 바이카보네이트 제자리 전환 구동된경피성 전달
MX2020000651A (es) * 2017-07-26 2020-07-29 Corium Inc Sistema de administracion transdermica con una membrana microporosa que tiene poros llenos de solvente.
EP3681479B1 (en) * 2017-09-15 2024-01-31 Dyve Biosciences, Inc. Sodium bicarbonate for use in the treatment of gout and related disorders
US11173132B2 (en) 2017-12-20 2021-11-16 Corium, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
KR102710072B1 (ko) * 2018-08-31 2024-09-24 에스케이케미칼 주식회사 장기 투여용 리바스티그민 패취
KR102823139B1 (ko) * 2018-08-31 2025-06-19 에스케이케미칼 주식회사 장기 투여용 리바스티그민 패취
KR102115102B1 (ko) 2018-12-21 2020-05-26 동아에스티 주식회사 안정화된 도네페질 함유 경피 흡수제제
US11101101B2 (en) * 2019-05-15 2021-08-24 Fei Company Laser-based phase plate image contrast manipulation
KR102372630B1 (ko) * 2019-05-15 2022-03-14 주식회사 대웅제약 고함량의 도네페질 또는 그의 염을 포함하는 경피흡수제제
EP4048247B1 (en) * 2019-10-24 2024-04-03 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system for the transdermal administration of fingolimod
JP7202450B2 (ja) * 2019-11-26 2023-01-11 久光製薬株式会社 ロピニロール含有貼付剤の粘着剤層保持力向上方法、及びロピニロール含有保持力改善貼付剤
CN114829580A (zh) * 2019-12-18 2022-07-29 先锋国际良种公司 用于提高植物籽粒产量的组合物和方法
CA3175771A1 (en) * 2020-04-14 2021-10-21 Fotios M. Plakogiannis Transdermal and/or topical delivery system comprising hydroxychloroquine and/or chloroquine
JP2022044038A (ja) * 2020-09-04 2022-03-16 株式会社大石膏盛堂 ドネペジル含有経皮吸収液剤およびその製造方法
CN112656778A (zh) * 2020-12-28 2021-04-16 广东红珊瑚药业有限公司 一种压敏胶基质以及一种贴剂
US12270039B2 (en) * 2021-05-14 2025-04-08 Board Of Trustees Of Southern Illinois University Compositions and methods to increase oleic acid content in soybeans
US12270040B2 (en) * 2021-05-27 2025-04-08 Board Of Trustees Of Southern Illinois University Soybean lines with low saturated fatty acid and high oleic acid contents
CA3226147A1 (en) * 2021-07-08 2023-01-12 Monsanto Technology Llc Novel insect inhibitory proteins
CN118660621A (zh) * 2022-01-12 2024-09-17 伊纳瑞农业技术有限公司 高度降低的玉米
WO2025103446A1 (zh) * 2023-11-16 2025-05-22 宜昌人福药业有限责任公司 含有多奈哌齐的透皮贴剂及其制备方法

Family Cites Families (151)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3391142A (en) 1966-02-09 1968-07-02 Lilly Co Eli Adamantyl secondary amines
NL134681C (es) 1966-04-26
US3546141A (en) 1966-08-08 1970-12-08 Mc Donnell Douglas Corp Phosphorus-nitrogen polymers and process
CH603545A5 (es) 1972-04-20 1978-08-31 Merz & Co
DE2856393C2 (de) 1978-12-27 1983-04-28 Merz + Co GmbH & Co, 6000 Frankfurt Arzneimittel zur Behandlung von Morbus Parkinson
ATE45735T1 (de) 1984-12-22 1989-09-15 Thomae Gmbh Dr K Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel.
US4880633A (en) 1986-03-12 1989-11-14 Merck & Co., Inc. Transdermal drug delivery system
US4797284A (en) * 1986-03-12 1989-01-10 Merck & Co., Inc. Transdermal drug delivery system
DE3634016A1 (de) 1986-04-17 1987-10-29 Lohmann Gmbh & Co Kg Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
US4837027A (en) 1987-11-09 1989-06-06 Alza Corporation Transdermal drug delivery device
US4781924A (en) 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US4849224A (en) 1987-11-12 1989-07-18 Theratech Inc. Device for administering an active agent to the skin or mucosa
US5026556A (en) 1988-11-10 1991-06-25 Norwich Eaton Pharmaceuticals, Inc. Compositions for the transdermal delivery of pharmaceutical actives
CA2007181C (en) * 1989-01-06 1998-11-24 Angelo Mario Morella Sustained release pharmaceutical composition
ATE94384T1 (de) 1989-04-14 1993-10-15 Merz & Co Gmbh & Co Verwendung von adamantan-derivaten zur praevention und behandlung der cerebralen ischaemie.
DE3913734C2 (de) * 1989-04-26 1998-08-20 Roehm Gmbh Verwendung einer wäßrigen Hauthaftkleberlösung zur Herstellung einer mit Wasser leicht abwaschbaren Klebschicht
MY115126A (en) * 1990-04-27 2003-04-30 Seikisui Chemical Co Ltd Percutaneously absorbable eperisone or tolperisone preparation.
US5252588A (en) * 1990-04-27 1993-10-12 Sekisui Kagaku Kogyo Kabushiki Kaisha Percutaneously absorbable crosslinked polyvinylpyrrolidone eperisone or tolperisone preparation
WO1992001445A1 (en) 1990-07-23 1992-02-06 Alza Corporation Oral osmotic device for delivering nicotine
US5614560A (en) 1991-04-04 1997-03-25 Children's Medical Center Corporation Method of preventing NMDA receptor-mediated neuronal damage
US5123900A (en) 1991-08-16 1992-06-23 Bertek, Inc. Moisture permeable double disk
JPH06199659A (ja) 1992-10-28 1994-07-19 Hisamitsu Pharmaceut Co Inc 経皮治療用装置
DE4310012A1 (de) * 1993-03-27 1994-09-29 Roehm Gmbh Dermales therapeutisches System aus einer schmelzfähigen Poly(meth)acrylat-Mischung
US5424077A (en) 1993-07-13 1995-06-13 Church & Dwight Co., Inc. Co-micronized bicarbonate salt compositions
WO1995028914A1 (en) 1994-04-21 1995-11-02 Hisamitsu Pharmaceutical Co., Inc. Percutaneously administrable base composition and percutaneously administrable drug composition prepared therefrom
NZ293849A (en) 1994-09-14 1998-10-28 Minnesota Mining & Mfg Transdermal delivery matrix comprising a macromonomer containing acrylate or metacrylate copolymer, a softener and a drug
US5635203A (en) * 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
CA2208132A1 (en) 1994-12-21 1996-06-27 Theratech, Inc. Transdermal delivery system with adhesive overlay and peel seal disc
AU6032696A (en) 1995-06-07 1996-12-30 Cygnus Therapeutic Systems Pressure sensitive acrylate adhesive composition cross-linke d with aluminum acetylacetonate and containing a drug having a reactive aromatic hydroxyl group
DE19531342B4 (de) 1995-08-25 2007-11-29 Merz Pharma Gmbh & Co. Kgaa Verwendung von Aminoadamantan-Verbindungen als Immunregulatoren
US6929801B2 (en) 1996-02-19 2005-08-16 Acrux Dds Pty Ltd Transdermal delivery of antiparkinson agents
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
US5958919A (en) 1996-09-20 1999-09-28 Washington University Treatment of presymptomatic alzheimer's disease to prevent neuronal degeneration
WO1998017315A2 (en) 1996-10-24 1998-04-30 Alza Corporation Permeation enhancers for transdermal drug delivery compositions, devices, and methods
CN1174031A (zh) * 1997-04-23 1998-02-25 谢先运 双氯芬酸钠透皮控释贴膏
US5866585A (en) 1997-05-22 1999-02-02 Synchroneuron, Llc Methods of treating tardive dyskinesia using NMDA receptor antagonists
US20040018241A1 (en) * 1997-09-26 2004-01-29 Noven Pharmaceuticals, Inc. Bioadhesive compositions and methods for topical administration of active agents
US6193993B1 (en) 1998-03-03 2001-02-27 Eisai Co., Ltd. Suppository containing an antidementia medicament
JP4205778B2 (ja) * 1998-04-17 2009-01-07 久光製薬株式会社 貼付製剤
DE19820999A1 (de) 1998-05-11 1999-11-18 Lohmann Therapie Syst Lts Laminat zum Aufbringen auf einen Akzeptor
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6383471B1 (en) 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US20020192243A1 (en) * 1999-12-16 2002-12-19 Tsung-Min Hsu Transdermal and topical administration of drugs for the treatment of Alzheimer's disease using basic enhancers
US6562368B2 (en) * 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers
US6455066B1 (en) 2000-03-10 2002-09-24 Epicept Corporation Intradermal-penetration agents for topical local anesthetic administration
US7276249B2 (en) 2002-05-24 2007-10-02 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
MXPA03003957A (es) * 2000-11-06 2003-08-19 Samyang Corp Sistema de liberacion transdermica de farmacos, con propiedades mejoradas de adhesion y absorbencia de agua.
US20040028724A1 (en) * 2000-11-07 2004-02-12 Takaaki Terahara Pharmaceutical preparation of percutaneous absorption type
JP4850346B2 (ja) * 2001-03-15 2012-01-11 救急薬品工業株式会社 粘膜貼付剤
JP4116447B2 (ja) 2001-05-01 2008-07-09 エイ.ブイ.トップチーブ インスティテュート オブ ペトロケミカル シンセシス ヒドロゲル組成物
CA2457011C (en) 2001-08-20 2012-04-24 Maiken Nedergaard Treatment of glial tumors with glutamate antagonists
KR100640039B1 (ko) * 2001-09-04 2006-10-31 트롬스도르프 게엠베하 운트 코. 카게 알츠나이미텔 세르타코나졸을 포함하며, 손발톱의 기능장애와 질환을치료하기 위한 플라스터
CN1571664A (zh) * 2001-10-17 2005-01-26 久光制药株式会社 经皮吸收型制剂
ITMI20012827A1 (it) * 2001-12-28 2003-06-28 Fidia Farmaceutici Formulazioni adesive transdermiche di diclofenac sodico
US7273619B2 (en) 2002-01-17 2007-09-25 Samyang Corporation Transdermal composition of an antivomiting agent
WO2004037234A2 (en) 2002-10-24 2004-05-06 Merz Pharma Gmbh & Co. Kgaa Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors
MXPA06003316A (es) 2003-10-10 2006-06-08 Antares Pharma Ipl Ag Formulacion farmaceutica transdermica para minimizar los residuos en la piel.
EP1682060A1 (en) * 2003-10-14 2006-07-26 Dermatrends, Inc. Enhancing transdermal administration of hydrophilic drugs
JP2007509165A (ja) 2003-10-22 2007-04-12 メルツ・ファルマ・ゲゼルシヤフト・ミト・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンデイトゲゼルシヤフト・アウフ・アクティーン アミロイドパシーにおいて、フィブリロジェニックAβペプチドの沈着を改変するために、1−アミノシクロヘキサン誘導体を使用する方法
CA2543295A1 (en) 2003-10-23 2005-05-06 Trans1 Inc. Tools and tool kits for performing minimally invasive procedures on the spine
JP2007512338A (ja) 2003-11-21 2007-05-17 メモリー・ファーマシューティカルズ・コーポレイション L型カルシウムチャンネルブロッカーとコリンエステラーゼ阻害剤を用いた組成物及び処置方法
US7176185B2 (en) 2003-11-25 2007-02-13 Tsrl, Inc. Short peptide carrier system for cellular delivery of agent
JP5179757B2 (ja) 2004-02-17 2013-04-10 トランセプト ファーマシューティカルズ, インコーポレイティド 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法
US7670838B2 (en) 2004-05-24 2010-03-02 The Board Of Trustees Of The Leland Stanford Junior University Coupling of excitation and neurogenesis in neural stem/progenitor cells
US20080038328A1 (en) 2004-05-28 2008-02-14 Naruhito Higo Pasting Preparation
TW200616608A (en) 2004-07-09 2006-06-01 Forest Laboratories Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
TW200628175A (en) 2004-10-08 2006-08-16 Noven Pharma Transdermal drug delivert device including an occlusive backing
DE602005010812D1 (de) 2004-11-22 2008-12-18 Hisamitsu Pharmaceutical Co Transdermales Pflaster enthaltend einen schmelzpunktsenkenden Hilfsstoff
US8058291B2 (en) 2005-04-06 2011-11-15 Adamas Pharmaceuticals, Inc. Methods and compositions for the treatment of CNS-related conditions
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
US20060205822A1 (en) 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
HRP20090676T1 (hr) 2005-01-11 2010-01-31 Teva Pharmaceutical Fine Chemicals S.R.L. Postupak dobivanja 1-amino-3,5-dimetiladamantan-hidroklorida
WO2006082728A1 (ja) * 2005-02-04 2006-08-10 Hisamitsu Pharmaceutical Co., Inc. 経皮吸収貼付剤
US20060188558A1 (en) 2005-02-18 2006-08-24 Mylan Technologies, Inc. Transdermal systems having control delivery system
US7888422B2 (en) 2005-11-09 2011-02-15 Mylan Technologies Inc. Long-wearing removable pressure sensitive adhesive
ATE468219T1 (de) * 2006-03-28 2010-06-15 Amcor Flexibles Transpac B V B Für aromaverbindungen undurchlässige, halogenfreie mehrschichtfolie
CN1895242B (zh) * 2006-04-13 2011-08-31 沈阳药科大学 双氯芬酸盐的透皮贴剂及制备方法
IL175338A0 (en) 2006-05-01 2006-09-05 Biota Ltd Orally administrable films and preparation thereof
CN101460156B (zh) 2006-05-08 2011-06-08 帝国制药株式会社 抗痴呆药的经皮吸收制剂
JP5097359B2 (ja) * 2006-05-09 2012-12-12 久光製薬株式会社 ドネペジル経皮吸収型製剤
TW200815045A (en) 2006-06-29 2008-04-01 Jazz Pharmaceuticals Inc Pharmaceutical compositions of ropinirole and methods of use thereof
US9248104B2 (en) 2006-08-17 2016-02-02 Core Tech Solutions, Inc. Transdermal methods and systems for treating Alzheimer's disease
US20080107719A1 (en) 2006-11-08 2008-05-08 Sukhon Likitlersuang Transdermal drug delivery system
TW200838479A (en) * 2006-12-01 2008-10-01 Nitto Denko Corp Percutaneously absorbable preparation
CA2671081C (en) 2006-12-01 2014-06-03 Nitto Denko Corporation Stabilized adhesive preparation containing donepezil
US20100048628A1 (en) 2006-12-01 2010-02-25 Sumiyo Nishi Method for suppressing discoloration over time of adhesive preparation containing donepezil
JP5403948B2 (ja) 2007-06-07 2014-01-29 久光製薬株式会社 メマンチン含有経皮吸収製剤
AU2008275101B2 (en) 2007-07-10 2014-08-21 Agile Therapeutics, Inc. Dermal delivery device with in situ seal
US9017301B2 (en) 2007-09-04 2015-04-28 Mylan Technologies, Inc. Transdermal drug delivery systems comprising a coated release liner
JP2009203213A (ja) * 2008-02-28 2009-09-10 Kosumedei Seiyaku Kk 経皮吸収医薬組成物
DE102008013701A1 (de) * 2008-03-11 2009-09-17 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System mit stabilisierter Membran
KR101454362B1 (ko) 2008-03-24 2014-10-23 아이큐어 주식회사 도네페질을 유효성분으로 함유하는 치매 치료용경피흡수제제
EP2111857A1 (de) 2008-04-25 2009-10-28 Acino AG Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff hiervon
US20090291127A1 (en) 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
AR074062A1 (es) 2008-10-31 2010-12-22 Lexicon Pharmaceuticals Inc Agonistas del receptor s1p para el tratamiento de la malaria cerebral y forma farmaceutica
US20100178037A1 (en) 2009-01-12 2010-07-15 Te-Wei Chen Display apparatus, video generation apparatus, and method thereof
AU2010204986B2 (en) 2009-01-14 2016-06-02 Corium International, Inc. Transdermal administration of tamsulosin
TWI552773B (zh) 2009-05-01 2016-10-11 久光製藥股份有限公司 經皮吸收型製劑
CN102630160B (zh) 2009-09-16 2014-05-07 株式会社三养生物制药 透皮递送系统、其制备方法以及使用所述系统的透皮递送方法
RU2545696C2 (ru) 2009-10-21 2015-04-10 Тейкоку Сейяку Ко., Лтд. Трансдермально абсорбируемый состав, содержащий донепезил
CN102048678A (zh) * 2009-10-30 2011-05-11 北京隆旗生物科技有限公司 一种奥昔布宁的透皮吸收制剂及其制备方法与药物应用
GB0921481D0 (en) 2009-12-08 2010-01-20 Vectura Ltd Process and product
JP2012236773A (ja) * 2009-12-16 2012-12-06 Goto Takeshi 抗認知症薬物の経皮吸収製剤
PT2519225E (pt) * 2009-12-30 2015-07-27 Novartis Ag Tiras finas de nicotina extrudidas por fusão
US20100178307A1 (en) * 2010-01-13 2010-07-15 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
JP5615898B2 (ja) 2010-02-24 2014-10-29 久光製薬株式会社 貼付剤
US20110244023A1 (en) * 2010-03-30 2011-10-06 Phosphagenics Limited Transdermal delivery patch
US20130053358A1 (en) 2010-04-28 2013-02-28 Hisamitsu Pharmaceutical Co., Inc. Transdermally absorbable donepezil-containing preparation
US9012511B2 (en) 2010-05-19 2015-04-21 Alkermes Pharma Ireland Limited Nanoparticulate cinacalcet compositions
DE102010024105A1 (de) 2010-06-17 2011-12-22 Grünenthal GmbH Transdermale Verabreichung von Memantin
NZ605352A (en) * 2010-06-30 2013-10-25 Nal Pharmaceuticals Ltd Process for producing glycosaminoglycans
US20140370076A1 (en) 2010-06-30 2014-12-18 Nal Pharmaceuticals, Ltd. Transdermal drug delivery system containing donepezil
EP3434257A1 (en) 2010-07-29 2019-01-30 Allergan, Inc. Preservative free brimonidine and timolol solutions
BR112013008985A2 (pt) 2010-10-12 2016-07-05 Cerecor Inc composições antitussígenas compreendendo memantina
JP5699554B2 (ja) 2010-11-11 2015-04-15 富士通株式会社 ベクトル処理回路、命令発行制御方法、及びプロセッサシステム
BR112013012156A2 (pt) 2010-11-17 2017-12-05 Hexal Ag sistema terapêutico transdérmico e método de produção de um sistema terapêutico transdérmico
WO2012084969A1 (en) 2010-12-22 2012-06-28 Hexal Ag Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition
BR112013016998A2 (pt) * 2010-12-29 2016-10-25 Pharmafilm S R L emplastro medicamentoso para a permeação transdérmica melhorada de diclofenaco dietilamônio
TWI433904B (zh) 2011-01-12 2014-04-11 Taiwan Biotech Co Ltd 多奈哌齊經皮貼片
CN102775476B (zh) 2011-05-12 2015-01-07 上海天伟生物制药有限公司 一种米卡芬净钠盐的制备方法
US8673338B2 (en) 2011-07-29 2014-03-18 Massachusetts Eye And Ear Infirmary Methods of delivering pharmaceutical agents
JP5808214B2 (ja) 2011-09-30 2015-11-10 株式会社トクヤマ 貼付剤
KR101239150B1 (ko) 2012-02-28 2013-03-06 에스케이케미칼주식회사 도네페질-함유 경피흡수제제 및 그의 제조방법
US9408802B1 (en) * 2012-03-22 2016-08-09 Prosolus, Inc. Seven day drug in adhesive transdermal delivery
US9145907B2 (en) 2012-08-28 2015-09-29 Hsiutao Liang Pipe connector
US20140256690A1 (en) 2013-03-08 2014-09-11 Agile Therapeutics, Inc. Contraceptive method
WO2014174564A1 (ja) 2013-04-22 2014-10-30 祐徳薬品工業株式会社 メマンチン含有経皮吸収型貼付製剤
JP5415645B1 (ja) * 2013-06-28 2014-02-12 久光製薬株式会社 貼付剤の製造方法、貼付剤及び包装体
US20160199317A1 (en) * 2013-08-30 2016-07-14 3M Innovative Properties Company Estradiol containing transdermal drug delivery systems and compositions
KR101827980B1 (ko) 2013-10-07 2018-02-13 테이코쿠 팔마 유에스에이, 인코포레이티드 덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
WO2015053878A1 (en) * 2013-10-11 2015-04-16 Teikoku Pharma Usa, Inc. Topical sphingosine-1-phosphate receptor agonist formulations and methods of using the same
JP6502855B2 (ja) 2013-11-17 2019-04-17 株式会社 メドレックス 経皮吸収型コロイド液剤
KR101485822B1 (ko) 2014-01-22 2015-01-23 주식회사 대웅제약 도네페질 또는 그의 염을 함유하는 경피흡수제제
JP2015151370A (ja) 2014-02-14 2015-08-24 日東電工株式会社 貼付製剤
JP2017519837A (ja) 2014-06-24 2017-07-20 カット トランスダーマルズ エルエルシー 経皮送達システム
EP3169318B1 (en) * 2014-07-18 2020-04-01 Buzzz Pharmaceuticals Limited Abuse deterrent opiod/opiod-antagonist transdermal patch
WO2016035808A1 (ja) 2014-09-03 2016-03-10 日東電工株式会社 ビスホスホネート剤を含む細胞性免疫用ワクチン医薬組成物
WO2016046675A1 (en) 2014-09-28 2016-03-31 Mohan M Alapati Compositions and methods for the treatment of neurological diseases
CA2970276C (en) 2014-12-18 2023-08-01 Icure Pharmaceutical, Inc Transdermal composition containing donepezil as active ingredient
EP3250219A4 (en) 2015-01-28 2018-10-03 DNX Biotech, LLC Compositions and methods of using a soluble tnf-alpha receptor modified for increased half-life
WO2016209982A1 (en) 2015-06-22 2016-12-29 Corium International, Inc. Transdermal adhesive composition comprising a poorly soluble therapeutic agent
CN107847488A (zh) * 2015-07-27 2018-03-27 久光制药株式会社 含有阿塞那平的贴剂的制造方法
US10835499B2 (en) * 2015-12-30 2020-11-17 Corium, Inc. Systems and methods for long term transdermal administration
CN105693556A (zh) * 2016-03-01 2016-06-22 巴斯特医药科技(常州)有限公司 卡巴拉汀酒石酸盐的转化方法及其产物制成的贴片
US11541018B2 (en) 2016-06-23 2023-01-03 Corium, Llc Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
AU2017302305A1 (en) 2016-07-27 2019-02-14 Corium, LLC. Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
CA3032103A1 (en) 2016-07-27 2018-02-01 Corium International, Inc. Memantine transdermal delivery systems
KR20230109782A (ko) 2016-07-27 2023-07-20 코리움, 엘엘씨 아민 약물의 나트륨 바이카보네이트 제자리 전환 구동된경피성 전달
MX2020000651A (es) * 2017-07-26 2020-07-29 Corium Inc Sistema de administracion transdermica con una membrana microporosa que tiene poros llenos de solvente.

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US20250375395A1 (en) 2025-12-11
WO2018022817A1 (en) 2018-02-01
US20220016045A1 (en) 2022-01-20
CN116270551A (zh) 2023-06-23
AU2023203616A1 (en) 2023-07-06
AU2017302306A1 (en) 2019-02-14
US20180028663A1 (en) 2018-02-01
JP2022121629A (ja) 2022-08-19
CA3031945C (en) 2025-09-23
US20180028512A1 (en) 2018-02-01
US9993466B2 (en) 2018-06-12
WO2018022816A1 (en) 2018-02-01
EP3490541B1 (en) 2025-07-09
KR102545643B1 (ko) 2023-06-21
JP2022140751A (ja) 2022-09-27
WO2018022815A3 (en) 2018-03-08
JP2019523268A (ja) 2019-08-22
SG11201900692WA (en) 2019-02-27
US20180028463A1 (en) 2018-02-01
AU2023203618A1 (en) 2023-07-06
CN109789105A (zh) 2019-05-21
KR20190032512A (ko) 2019-03-27
AU2017301928A1 (en) 2019-02-14
CA3032044A1 (en) 2018-02-01
KR20230098349A (ko) 2023-07-03
US20190247321A1 (en) 2019-08-15
JP7071330B2 (ja) 2022-05-18
MX2022006681A (es) 2022-07-11
CN109789133A (zh) 2019-05-21
JP2019525932A (ja) 2019-09-12
KR20230109782A (ko) 2023-07-20
KR102406528B1 (ko) 2022-06-08
KR102545649B1 (ko) 2023-06-22
JP2019523270A (ja) 2019-08-22
AU2023204240A1 (en) 2023-07-27
WO2018022815A2 (en) 2018-02-01
AU2025205205A1 (en) 2025-07-24
US20240156747A1 (en) 2024-05-16
US20180235901A1 (en) 2018-08-23
KR20190034601A (ko) 2019-04-02
CA3032148A1 (en) 2018-02-01
AU2017302307A1 (en) 2019-02-14
AU2023203618B2 (en) 2025-09-18
CA3032044C (en) 2024-10-01
KR20190035801A (ko) 2019-04-03
RU2019105279A (ru) 2020-08-27
US20190247320A1 (en) 2019-08-15
KR20230097203A (ko) 2023-06-30
CN109789105B (zh) 2022-12-27
US20250375396A1 (en) 2025-12-11
US10307379B2 (en) 2019-06-04
EP3490541A2 (en) 2019-06-05
KR102406482B1 (ko) 2022-06-08
CN116966166A (zh) 2023-10-31
KR20220082929A (ko) 2022-06-17
KR20220082928A (ko) 2022-06-17
CN109789106A (zh) 2019-05-21
JP2022093707A (ja) 2022-06-23
KR102555208B1 (ko) 2023-07-17
US20210015761A1 (en) 2021-01-21
AU2017301928B2 (en) 2023-04-06
JP7153010B2 (ja) 2022-10-13
CA3031945A1 (en) 2018-02-01
CN109789106B (zh) 2023-06-27
US20180028462A1 (en) 2018-02-01
US20250325496A1 (en) 2025-10-23
US11103463B2 (en) 2021-08-31
RU2019105279A3 (es) 2020-12-23
US10300025B2 (en) 2019-05-28
MX394249B (es) 2025-03-24
KR102406536B1 (ko) 2022-06-08
EP3490558A1 (en) 2019-06-05

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