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MX2019000022A - Células veto generadas a partir de linfocitos t de memoria. - Google Patents

Células veto generadas a partir de linfocitos t de memoria.

Info

Publication number
MX2019000022A
MX2019000022A MX2019000022A MX2019000022A MX2019000022A MX 2019000022 A MX2019000022 A MX 2019000022A MX 2019000022 A MX2019000022 A MX 2019000022A MX 2019000022 A MX2019000022 A MX 2019000022A MX 2019000022 A MX2019000022 A MX 2019000022A
Authority
MX
Mexico
Prior art keywords
cells
memory
lymphocytes
population
tmc
Prior art date
Application number
MX2019000022A
Other languages
English (en)
Inventor
Reisner Yair
Lask Assaf
Or-Geva Noga
Bachar-Lustig Esther
GIDRON BUDOVSKY Rotem
KAGAN Sivan
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of MX2019000022A publication Critical patent/MX2019000022A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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Abstract

Se desvela un procedimiento de generación de población aislada de células que no inducen enfermedad de injerto contra hospedador (EIcH) que comprenden un fenotipo de linfocito T de memoria central (Tmc), siendo las células, células inductoras de tolerancia y/o dotadas con actividad antienfermedad, y capaces de migrar de forma dirigida a los ganglios linfáticos después del trasplante. Comprendiendo el procedimiento: (a) proporcionar una población de al menos el 70 % de linfocitos T de memoria; (b) poner la población de linfocitos T de memoria con un antígeno o antígenos para permitir el enriquecimiento de células reactivas a antígeno; y (c) cultivar las células que resultan de la etapa (b) en la presencia de citoquinas para permitir la proliferación de células que comprenden el fenotipo de Tmc. También se desvelan células generadas mediante el procedimiento, composiciones farmacéuticas y procedimientos de tratamiento.
MX2019000022A 2016-06-27 2017-06-27 Células veto generadas a partir de linfocitos t de memoria. MX2019000022A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662354950P 2016-06-27 2016-06-27
PCT/IL2017/050716 WO2018002924A1 (en) 2016-06-27 2017-06-27 Veto cells generated from memory t cells

Publications (1)

Publication Number Publication Date
MX2019000022A true MX2019000022A (es) 2019-09-18

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ID=59351006

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019000022A MX2019000022A (es) 2016-06-27 2017-06-27 Células veto generadas a partir de linfocitos t de memoria.

Country Status (11)

Country Link
US (3) US10961504B2 (es)
EP (1) EP3475414B1 (es)
JP (1) JP7334043B2 (es)
KR (1) KR102444170B1 (es)
CN (1) CN109661463B (es)
AU (1) AU2017289879B2 (es)
ES (1) ES3034019T3 (es)
IL (1) IL263924B2 (es)
MX (1) MX2019000022A (es)
SG (1) SG11201811563RA (es)
WO (1) WO2018002924A1 (es)

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IL256916B2 (en) 2015-07-16 2024-04-01 Yeda Res & Dev Genetically modified anti-third party central memory t cells and use of same in immunotherapy
WO2018002924A1 (en) 2016-06-27 2018-01-04 Yeda Research And Development Co. Ltd. Veto cells generated from memory t cells
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JP7337373B2 (ja) * 2019-07-29 2023-09-04 サイアス株式会社 抗原特異的ｔ細胞の製造方法
CN114466925A (zh) * 2019-08-06 2022-05-10 耶达研究及发展有限公司 单倍体相合的干细胞移植中的抗病毒中央型记忆cd8+反抑细胞
WO2021090321A1 (en) * 2019-11-05 2021-05-14 Yeda Research And Development Co. Ltd. Use of veto cells in treatment of t cell mediated autoimmune diseases
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MX2023001771A (es) * 2020-08-11 2023-04-25 Yeda Res & Dev Celulas car-t de veto.
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WO2018002924A1 (en) 2016-06-27 2018-01-04 Yeda Research And Development Co. Ltd. Veto cells generated from memory t cells

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WO2018002924A1 (en) 2018-01-04
JP2019520823A (ja) 2019-07-25
IL263924B2 (en) 2025-03-01
US20230383254A1 (en) 2023-11-30
US12391916B2 (en) 2025-08-19
RU2019101826A3 (es) 2020-09-03
KR20190022828A (ko) 2019-03-06
AU2017289879A1 (en) 2019-02-07
AU2017289879B2 (en) 2023-04-20
CA3029001A1 (en) 2018-01-04
IL263924B1 (en) 2024-11-01
CN109661463A (zh) 2019-04-19
SG11201811563RA (en) 2019-01-30
IL263924A (en) 2019-02-03
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US20190316087A1 (en) 2019-10-17
US10961504B2 (en) 2021-03-30
KR102444170B1 (ko) 2022-09-16
US11773372B2 (en) 2023-10-03
EP3475414A1 (en) 2019-05-01
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RU2019101826A (ru) 2020-07-28
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