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AU2101600A - Porcine cells incapable of expressing cd40 antigen, for xenotransplantation - Google Patents

Porcine cells incapable of expressing cd40 antigen, for xenotransplantation

Info

Publication number
AU2101600A
AU2101600A AU21016/00A AU2101600A AU2101600A AU 2101600 A AU2101600 A AU 2101600A AU 21016/00 A AU21016/00 A AU 21016/00A AU 2101600 A AU2101600 A AU 2101600A AU 2101600 A AU2101600 A AU 2101600A
Authority
AU
Australia
Prior art keywords
xenotransplantation
antigen
expressing
porcine cells
cells incapable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU21016/00A
Inventor
Stuart Rushworth
Simon Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9828705.5A external-priority patent/GB9828705D0/en
Priority claimed from GBGB9902940.7A external-priority patent/GB9902940D0/en
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU2101600A publication Critical patent/AU2101600A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU21016/00A 1998-12-24 1999-12-22 Porcine cells incapable of expressing cd40 antigen, for xenotransplantation Abandoned AU2101600A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9828705.5A GB9828705D0 (en) 1998-12-24 1998-12-24 Organic compounds
GB9828705 1998-12-24
GBGB9902940.7A GB9902940D0 (en) 1999-02-10 1999-02-10 Organic compounds
GB9902940 1999-02-10
PCT/EP1999/010332 WO2000039294A1 (en) 1998-12-24 1999-12-22 Porcine cells incapable of expressing cd40 antigen, for xenotransplantation

Publications (1)

Publication Number Publication Date
AU2101600A true AU2101600A (en) 2000-07-31

Family

ID=26314930

Family Applications (1)

Application Number Title Priority Date Filing Date
AU21016/00A Abandoned AU2101600A (en) 1998-12-24 1999-12-22 Porcine cells incapable of expressing cd40 antigen, for xenotransplantation

Country Status (2)

Country Link
AU (1) AU2101600A (en)
WO (1) WO2000039294A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1158999A2 (en) * 1999-03-05 2001-12-05 Diacrin, Inc. Methods for improving graft acceptance in a recipient by administration of a cytokine profile altering agent
US20040136972A1 (en) * 2001-09-07 2004-07-15 Yeda Research And Development Co. Ltd. Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
US7780993B2 (en) 2001-09-07 2010-08-24 Yeda Research And Development Co. Ltd. Therapeutic transplantation using developing, human or porcine, renal or hepatic, grafts
IL165425A0 (en) 2004-11-28 2006-01-15 Yeda Res & Dev Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
HUE031063T2 (en) 2010-09-08 2017-06-28 Yeda Res & Dev Use of anti third party central memory t cells for anti-leukemia/lymphoma treatment
WO2013013708A1 (en) * 2011-07-26 2013-01-31 Fundació Institut D'investigació Biomèdica De Bellvitge Treatment of acute rejection in renal transplant
RU2636503C2 (en) 2011-09-08 2017-11-23 Иеда Рисеч Энд Девелопмент Ко. Лтд. Central memory t-cells of against third party, methods for their production and their application in transplantation and diseases treatment
IL256916B2 (en) 2015-07-16 2024-04-01 Yeda Res & Dev T cells against a third party, with a central memory phenotype, and genetically modified, and their use in immunotherapy
WO2017042814A1 (en) 2015-09-10 2017-03-16 Yeda Research And Development Co. Ltd. Use of perforin positive immature dendritic cells in disease treatment
WO2018002924A1 (en) 2016-06-27 2018-01-04 Yeda Research And Development Co. Ltd. Veto cells generated from memory t cells
KR102738812B1 (en) * 2021-12-16 2024-12-09 주식회사 옵티팜 Transgenic cloned piglets defecting porcine GGTA1, CMAH, beta4GalNT2 and CD40 gene for xenotransplantation, and producing method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69713499T3 (en) * 1996-03-20 2010-05-06 Bristol-Myers Squibb Co., Seattle PROCEDURE FOR INHIBITING THE IMMUNE REACTION BY BLOCKING THE GP39 / CD40 AND CTLA4 / CD28 / B7 ROUTES AND COMPOSITION TO THEIR USE

Also Published As

Publication number Publication date
WO2000039294A1 (en) 2000-07-06

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase