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MX2017003625A - Reactivos y metodos para identificar, enriquecer y/o expander celulas t especificas de antigeno. - Google Patents

Reactivos y metodos para identificar, enriquecer y/o expander celulas t especificas de antigeno.

Info

Publication number
MX2017003625A
MX2017003625A MX2017003625A MX2017003625A MX2017003625A MX 2017003625 A MX2017003625 A MX 2017003625A MX 2017003625 A MX2017003625 A MX 2017003625A MX 2017003625 A MX2017003625 A MX 2017003625A MX 2017003625 A MX2017003625 A MX 2017003625A
Authority
MX
Mexico
Prior art keywords
cells
enriching
reagents
identifying
methods
Prior art date
Application number
MX2017003625A
Other languages
English (en)
Other versions
MX383271B (es
Inventor
Schneck Jonathan
Oelke Mathias
Perica Karlo
Glick Bieler Joan
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of MX2017003625A publication Critical patent/MX2017003625A/es
Publication of MX383271B publication Critical patent/MX383271B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/02—Bacterial antigens
    • A61K39/07—Bacillus
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
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    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/42—Cancer antigens
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    • C07—ORGANIC CHEMISTRY
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
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  • Wood Science & Technology (AREA)
  • Hematology (AREA)
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  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
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  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
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Abstract

Las células T específicas de antígeno, que incluyen las células T sin tratamiento, e incluyen células precursoras inusuales se enriquecen y expanden en cultivo. El enriquecimiento y la expansión proporcionan una plataforma para una inmunoterapia más eficaz por transferencia adoptiva, así como plataformas para personalizar la inmunoterapia mediante la determinación de la reactividad de células T con un banco de antígenos peptídicos candidatos.
MX2017003625A 2014-09-17 2015-09-17 Reactivos y metodos para identificar, enriquecer y/o expandir celulas t especificas de antigeno. MX383271B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051660P 2014-09-17 2014-09-17
US201562170541P 2015-06-03 2015-06-03
PCT/US2015/050593 WO2016044530A1 (en) 2014-09-17 2015-09-17 Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells

Publications (2)

Publication Number Publication Date
MX2017003625A true MX2017003625A (es) 2017-10-11
MX383271B MX383271B (es) 2025-03-13

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MX2017003625A MX383271B (es) 2014-09-17 2015-09-17 Reactivos y metodos para identificar, enriquecer y/o expandir celulas t especificas de antigeno.

Country Status (11)

Country Link
US (3) US10987412B2 (es)
EP (1) EP3194577A4 (es)
JP (2) JP7029294B2 (es)
KR (3) KR20210032011A (es)
CN (2) CN113791208B (es)
AU (2) AU2015317712B2 (es)
CA (2) CA3017170C (es)
IL (1) IL251261B (es)
MX (1) MX383271B (es)
SG (1) SG11201702191YA (es)
WO (1) WO2016044530A1 (es)

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