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MX2018015521A - Moleculas de acido nucleico para la reduccion de arnm de papd5 o papd7 para tratar la infeccion por hepatitis b. - Google Patents

Moleculas de acido nucleico para la reduccion de arnm de papd5 o papd7 para tratar la infeccion por hepatitis b.

Info

Publication number
MX2018015521A
MX2018015521A MX2018015521A MX2018015521A MX2018015521A MX 2018015521 A MX2018015521 A MX 2018015521A MX 2018015521 A MX2018015521 A MX 2018015521A MX 2018015521 A MX2018015521 A MX 2018015521A MX 2018015521 A MX2018015521 A MX 2018015521A
Authority
MX
Mexico
Prior art keywords
papd5
infection
papd7
hbv infection
reduction
Prior art date
Application number
MX2018015521A
Other languages
English (en)
Other versions
MX367543B (es
Inventor
Javanbakht Hassan
Ottosen Søren
PEDERSEN Lykke
Mueller Henrik
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2018015521A publication Critical patent/MX2018015521A/es
Publication of MX367543B publication Critical patent/MX367543B/es

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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Abstract

La presente invención se refiere a un método para identificar un compuesto que previene, alivia y/o inhibe una infección por virus de la hepatitis B (VHB), en donde un compuesto que reduce la expresión y/o actividad de proteína que contiene dominio asociado a PAP 5 (PAPD5) y/o que contiene dominio asociado a PAP 7 (PAPD7) se identifica como un compuesto que previene, alivia y/o inhibe una infección por VHB. La invención también proporciona inhibidores de PAPD5 o PAPD7 para su uso en el tratamiento y/o la prevención de una infección por VHB; así como un preparado combinado que comprende un inhibidor de PAPD5 y un inhibidor de PAPD7 para su uso simultáneo o secuencial en el tratamiento o la prevención de una infección por VHB. La presente invención también comprende una composición farmacéutica para su uso en el tratamiento y/o la prevención de una infección por VHB y un método para supervisar el éxito terapéutico durante el tratamiento de una infección por VHB.
MX2018015521A 2016-06-17 2017-06-19 MOLÉCULAS DE ÁCIDO NUCLEICO PARA LA REDUCCIÓN DE ARNm DE PAPD5 O PAPD7 PARA TRATAR LA INFECCIÓN POR HEPATITIS B. MX367543B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16175045 2016-06-17
PCT/EP2017/064980 WO2017216390A1 (en) 2016-06-17 2017-06-19 Nucleic acid molecules for reduction of papd5 or papd7 mrna for treating hepatitis b infection

Publications (2)

Publication Number Publication Date
MX2018015521A true MX2018015521A (es) 2019-03-18
MX367543B MX367543B (es) 2019-08-22

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Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018015521A MX367543B (es) 2016-06-17 2017-06-19 MOLÉCULAS DE ÁCIDO NUCLEICO PARA LA REDUCCIÓN DE ARNm DE PAPD5 O PAPD7 PARA TRATAR LA INFECCIÓN POR HEPATITIS B.
MX2018015516A MX367541B (es) 2016-06-17 2017-06-19 Inhibidores de papd5 y papd7 para tratar la infeccion por hepatitis b.

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MX2018015516A MX367541B (es) 2016-06-17 2017-06-19 Inhibidores de papd5 y papd7 para tratar la infeccion por hepatitis b.

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