MX2018012951A - Compuestos de heteroaril-1,2,4-triazol y heteroaril-tetrazol para controlar ectoparasitos. - Google Patents
Compuestos de heteroaril-1,2,4-triazol y heteroaril-tetrazol para controlar ectoparasitos.Info
- Publication number
- MX2018012951A MX2018012951A MX2018012951A MX2018012951A MX2018012951A MX 2018012951 A MX2018012951 A MX 2018012951A MX 2018012951 A MX2018012951 A MX 2018012951A MX 2018012951 A MX2018012951 A MX 2018012951A MX 2018012951 A MX2018012951 A MX 2018012951A
- Authority
- MX
- Mexico
- Prior art keywords
- heteroaryl
- triazole
- controlling ectoparasites
- alkoxy
- alkyl
- Prior art date
Links
- 244000078703 ectoparasite Species 0.000 title abstract 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical group C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Chemical group C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 150000004892 pyridazines Chemical class 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente invención proporciona compuestos de fórmula: (I) en donde: X es O o S; Q1 y Q2 son independientemente CR5 o N, siempre que al menos uno de Q1 y Q2 sea N; Y es un enlace directo o CH2; R1 es H, alquilo, alquenilo, alquinilo, cicloalquilalquilo, bencilo opcionalmente sustituido u oxetan-3-iI-CH2-; R2 es fenilo, piridina, pirimidina, pirazina o piridazina opcionalmente sustituido; R3 es alquilo o haloalquilo; R4 es piridina, pirimidina, pirazina o piridazina opcionalmente sustituida; R5 es H, alquilo, haloalquilo, cicloalquilo, alcoxi, alcoxi C(O)- o (alcoxi)2CH-; o una sal del mismo. Los compuestos son útiles para controlar ectoparásitos en animales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662332004P | 2016-05-05 | 2016-05-05 | |
| PCT/US2017/030082 WO2017192385A1 (en) | 2016-05-05 | 2017-04-28 | Heteroaryl-1,2,4-triazole and heteroaryl-tetrazole compounds for controlling ectoparasites |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018012951A true MX2018012951A (es) | 2019-01-21 |
| MX373315B MX373315B (es) | 2020-04-30 |
Family
ID=58672822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018012951A MX373315B (es) | 2016-05-05 | 2017-04-28 | Compuestos de heteroaril-1,2,4-triazol y heteroaril-tetrazol para controlar ectoparásitos. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10287276B2 (es) |
| EP (1) | EP3452460B1 (es) |
| JP (1) | JP6370504B2 (es) |
| KR (1) | KR102174828B1 (es) |
| CN (1) | CN109311841B (es) |
| AR (1) | AR108222A1 (es) |
| AU (1) | AU2017261187B2 (es) |
| BR (1) | BR112018069578B1 (es) |
| CA (1) | CA3023208C (es) |
| CL (1) | CL2018003021A1 (es) |
| CO (1) | CO2018011825A2 (es) |
| DK (1) | DK3452460T3 (es) |
| EA (1) | EA036478B1 (es) |
| ES (1) | ES2776850T3 (es) |
| MX (1) | MX373315B (es) |
| NZ (1) | NZ746361A (es) |
| PL (1) | PL3452460T3 (es) |
| PT (1) | PT3452460T (es) |
| TW (2) | TWI696615B (es) |
| WO (1) | WO2017192385A1 (es) |
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| UY38184A (es) * | 2018-04-17 | 2019-10-31 | Bayer Ag | Compuestos heteroarilo-triazol y heteroarilo-tetrazol novedosos como plaguicidas |
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| CN110386932A (zh) | 2018-04-20 | 2019-10-29 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
| SG11202010068VA (en) | 2018-04-25 | 2020-11-27 | Bayer Ag | Novel heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides |
| JP2021523150A (ja) | 2018-05-08 | 2021-09-02 | シンジェンタ クロップ プロテクション アクチェンゲゼルシャフト | 植物、その繁殖及び植物に由来する産物に対する損傷を防除するために１種以上の特定のヘテロアリール−１，２，４−トリアゾール及びヘテロアリール−テトラゾール化合物を適用する方法 |
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| CN103261188A (zh) * | 2010-12-17 | 2013-08-21 | 先正达参股股份有限公司 | 杀虫化合物 |
| SI2925757T1 (en) * | 2012-11-19 | 2018-01-31 | Novartis Ag | Compounds and compositions for the treatment of parasitic diseases |
| WO2014202510A1 (de) * | 2013-06-20 | 2014-12-24 | Bayer Cropscience Ag | Arylsulfid- und arylsulfoxid-derivate als akarizide und insektizide |
| TWI647222B (zh) * | 2014-03-06 | 2019-01-11 | 德商拜耳作物科學股份有限公司 | 作為殺蟲劑之雜環化合物 |
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