MX2018009170A - Biomarcadores de la enfermedad del higado graso no alcoholico (nafld) y esteatohepatitis no alcoholica (nash) y usos de estos. - Google Patents
Biomarcadores de la enfermedad del higado graso no alcoholico (nafld) y esteatohepatitis no alcoholica (nash) y usos de estos.Info
- Publication number
- MX2018009170A MX2018009170A MX2018009170A MX2018009170A MX2018009170A MX 2018009170 A MX2018009170 A MX 2018009170A MX 2018009170 A MX2018009170 A MX 2018009170A MX 2018009170 A MX2018009170 A MX 2018009170A MX 2018009170 A MX2018009170 A MX 2018009170A
- Authority
- MX
- Mexico
- Prior art keywords
- nonalcoholic
- nafld
- nash
- liver disease
- fatty liver
- Prior art date
Links
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 title abstract 6
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 title abstract 3
- 239000000090 biomarker Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 230000007863 steatosis Effects 0.000 abstract 2
- 231100000240 steatosis hepatitis Toxicity 0.000 abstract 2
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 210000003494 hepatocyte Anatomy 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
- G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
Se proporcionan métodos, composiciones y kits para determinar si un sujeto padece la enfermedad del hígado graso no alcohólico (NAFLD), y más específicamente uno o más de las siguientes afecciones asociadas de esteatosis, inflamación lobular, dilatación de hepatocitos y fibrosis. Asimimo, se proporcionan métodos, composiciones y kits para determinar si un sujeto padece esteatosis no alcohólica. También se proporcionan métodos, composiciones y kits para determinar si un sujeto tiene esteatohepatitis no alcohólica (NASH).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662292582P | 2016-02-08 | 2016-02-08 | |
| US201662362019P | 2016-07-13 | 2016-07-13 | |
| PCT/US2017/016798 WO2017139254A1 (en) | 2016-02-08 | 2017-02-07 | Nonalcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash) biomarkers and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018009170A true MX2018009170A (es) | 2018-11-19 |
Family
ID=58044222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018009170A MX2018009170A (es) | 2016-02-08 | 2017-02-07 | Biomarcadores de la enfermedad del higado graso no alcoholico (nafld) y esteatohepatitis no alcoholica (nash) y usos de estos. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20210215711A1 (es) |
| EP (2) | EP4513191A3 (es) |
| KR (1) | KR102687249B1 (es) |
| CN (2) | CN116008563B (es) |
| ES (1) | ES3009593T3 (es) |
| MX (1) | MX2018009170A (es) |
| WO (1) | WO2017139254A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4513191A3 (en) * | 2016-02-08 | 2025-06-04 | SomaLogic Operating Co., Inc. | Nonalcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash) biomarkers and uses thereof |
| US20200340060A1 (en) * | 2017-11-13 | 2020-10-29 | Gilead Sciences, Inc. | Compositions and methods for identifying and treating liver diseases and monitoring treatment outcomes |
| US12372530B2 (en) | 2017-11-15 | 2025-07-29 | Beth Israel Deaconess Medical Center, Inc. | Markers for the diagnosis and treatment of non-alcoholic steatohepatitis (NASH) and advanced liver fibrosis |
| KR102341336B1 (ko) * | 2019-11-20 | 2021-12-21 | 숙명여자대학교산학협력단 | 만성간질환의 예후 예측용 바이오마커 조성물 |
| WO2021101146A1 (ko) * | 2019-11-20 | 2021-05-27 | 숙명여자대학교산학협력단 | 만성간질환의 예후 예측 또는 진행 단계 판별용 바이오마커 조성물 |
| EP4103948A1 (en) * | 2020-02-10 | 2022-12-21 | SomaLogic Operating Co., Inc. | Nonalcoholic steatohepatitis (nash) biomarkers and uses thereof |
| WO2022014580A1 (ja) * | 2020-07-13 | 2022-01-20 | 国立大学法人信州大学 | 非アルコール性脂肪性肝疾患マーカー、非アルコール性脂肪性肝疾患を検出するための方法、それに用いる試薬及び分析用キット |
| EP4211468A4 (en) * | 2020-09-11 | 2024-10-09 | Glympse Bio, Inc. | DETECTION OF EX VIVO PROTEASE ACTIVITY FOR DETECTION/DIAGNOSTIC, STAGING, MONITORING AND TREATMENT OF DISEASES |
| WO2022139943A2 (en) * | 2020-10-23 | 2022-06-30 | Remmie, Inc. | Machine learning for ear disease diagnosis assistance |
| CN112626198A (zh) * | 2020-12-25 | 2021-04-09 | 杭州师范大学附属医院 | 一种肝病重症化的分子标志物及其应用 |
| CN114525329B (zh) * | 2021-04-08 | 2023-08-25 | 四川大学华西第二医院 | 血管分泌因子在制备检测非酒精性脂肪性肝炎的生物标记物中的应用 |
| EP4348261A4 (en) * | 2021-06-01 | 2025-02-19 | The University of Hong Kong | FIBROSIS BIOMARKERS FOR NONALCOHOLIC FATTY LIVER DISEASE |
| WO2023008673A1 (ko) * | 2021-07-30 | 2023-02-02 | 숙명여자대학교산학협력단 | 머신러닝 기반 비알코올성 지방간염 판별용 복합 마커 및 이의 용도 |
| KR102779238B1 (ko) | 2022-03-03 | 2025-03-07 | 충남대학교산학협력단 | miRNA204를 포함하는 비알코올성 지방간 질환 진단용 바이오마커 조성물 |
| US20240071625A1 (en) * | 2022-08-29 | 2024-02-29 | Cedars-Sinai Medical Center | Nafld identification and prediction systems and methods |
| CN115938525A (zh) * | 2022-10-17 | 2023-04-07 | 东南大学 | 一种基于电子病历信息的非酒精性脂肪肝疾病信息处理方法 |
| EP4553173A1 (en) | 2023-11-07 | 2025-05-14 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Markers for detecting and monitoring liver fibrosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6001577A (en) | 1998-06-08 | 1999-12-14 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex |
| EP1493825A3 (en) | 1990-06-11 | 2005-02-09 | Gilead Sciences, Inc. | Method for producing nucleic acid ligands |
| US5705337A (en) | 1990-06-11 | 1998-01-06 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chemi-SELEX |
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5580737A (en) | 1990-06-11 | 1996-12-03 | Nexstar Pharmaceuticals, Inc. | High-affinity nucleic acid ligands that discriminate between theophylline and caffeine |
| US5763177A (en) | 1990-06-11 | 1998-06-09 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex |
| US6458539B1 (en) | 1993-09-17 | 2002-10-01 | Somalogic, Inc. | Photoselection of nucleic acid ligands |
| US6242246B1 (en) | 1997-12-15 | 2001-06-05 | Somalogic, Inc. | Nucleic acid ligand diagnostic Biochip |
| US20110152115A1 (en) | 2003-09-03 | 2011-06-23 | The United States of America, as represented by the Secretary, Department of Health and | Methods for identifying, diagnosing, and predicting survival of lymphomas |
| CA2607213A1 (en) * | 2005-05-05 | 2006-11-16 | Regents Of The University Of Minnesota | Use of nk cell inhibition to facilitate persistence of engrafted mhc- i negative cells |
| US8232065B2 (en) | 2006-05-08 | 2012-07-31 | Tethys Bioscience, Inc. | Systems and methods for developing diagnostic tests based on biomarker information from legacy clinical sample sets |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| US7855054B2 (en) | 2007-01-16 | 2010-12-21 | Somalogic, Inc. | Multiplexed analyses of test samples |
| WO2008156662A1 (en) | 2007-06-14 | 2008-12-24 | George Mason Intellectual Properties, Inc. | Methods of diagnosing non-alcoholic steatohepatitis (nash) |
| CN101809167B (zh) | 2007-07-17 | 2015-04-01 | 私募蛋白质体公司 | 产生具有改良的解离速率的适配体的方法 |
| WO2010000835A1 (en) | 2008-07-03 | 2010-01-07 | One Way Liver Genomics, S.L. | Proteomic fingerprint for the diagnosis of non-alcoholic steatohepatitis (nash) and/or steatosis |
| EP2591357A4 (en) | 2010-07-09 | 2014-01-01 | Somalogic Inc | Lung cancer biomarkers and uses thereof |
| WO2012021795A2 (en) * | 2010-08-13 | 2012-02-16 | Somalogic, Inc. | Pancreatic cancer biomarkers and uses thereof |
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| WO2012069511A1 (en) | 2010-11-24 | 2012-05-31 | F. Hoffmann-La Roche Ag | Methods for detecting low grade inflammation |
| US20140228233A1 (en) | 2011-06-07 | 2014-08-14 | Traci Pawlowski | Circulating biomarkers for cancer |
| SG10201906900QA (en) * | 2011-09-30 | 2019-09-27 | Somalogic Inc | Cardiovascular risk event prediction and uses thereof |
| US20150232837A1 (en) * | 2012-08-31 | 2015-08-20 | Aptamir Therapeutics, Inc. | Mirna modulators of chronic visceral inflammation |
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| US9103837B2 (en) | 2012-11-07 | 2015-08-11 | Somalogic, Inc. | Chronic obstructive pulmonary disease (COPD) biomarkers and uses thereof |
| EP2962100B1 (en) * | 2013-02-28 | 2021-07-28 | Caprion Proteomics Inc. | Tuberculosis biomarkers and uses thereof |
| WO2014150198A2 (en) | 2013-03-15 | 2014-09-25 | Somalogic, Inc. | Nonalcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash) biomarkers and uses thereof |
| US20170335395A1 (en) * | 2014-10-27 | 2017-11-23 | The Trustees Of The University Of Pennsylvania | A parkinson's disease diagnostic biomarker panel |
| WO2016126844A1 (en) | 2015-02-03 | 2016-08-11 | The Trustees Of The University Of Pennsylvania | Novel methods for early identification of bone healing ability in injured patients |
| CN114923837B (zh) | 2015-02-09 | 2025-09-19 | 弹弓生物科学公司 | 具有可调光学性质的水凝胶颗粒以及使用其的方法 |
| CA2986791A1 (en) | 2015-06-01 | 2016-12-08 | Adelaide Research & Innovation Pty Ltd | Methods and products for enriching and isolating stem cells |
| EP3303629A1 (en) | 2015-06-05 | 2018-04-11 | Regulus Therapeutics Inc. | Non-alcoholic fatty liver disease biomarkers |
| EP4321626A3 (en) | 2015-06-19 | 2024-05-22 | Sera Prognostics, Inc. | Biomarker pairs for predicting preterm birth |
| EP4513191A3 (en) | 2016-02-08 | 2025-06-04 | SomaLogic Operating Co., Inc. | Nonalcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash) biomarkers and uses thereof |
| US9725769B1 (en) | 2016-10-07 | 2017-08-08 | Oncology Venture ApS | Methods for predicting drug responsiveness in cancer patients |
| JP7273022B2 (ja) | 2017-07-19 | 2023-05-12 | バイオ―ラッド ヨーロッパ ゲーエムベーハー | 非アルコール性脂肪性肝炎及び肝線維症ステータスを同時に評価するバイオマーカの組み合わせ |
| US12352767B2 (en) | 2018-07-16 | 2025-07-08 | University Of Virginia Patent Foundation | Method of treating cognitive decline associated with neurological diseases based on a decrease in FLT4 expression or activity |
-
2017
- 2017-02-07 EP EP24209629.5A patent/EP4513191A3/en active Pending
- 2017-02-07 WO PCT/US2017/016798 patent/WO2017139254A1/en not_active Ceased
- 2017-02-07 ES ES17705281T patent/ES3009593T3/es active Active
- 2017-02-07 KR KR1020187022435A patent/KR102687249B1/ko active Active
- 2017-02-07 CN CN202310026602.3A patent/CN116008563B/zh active Active
- 2017-02-07 MX MX2018009170A patent/MX2018009170A/es unknown
- 2017-02-07 US US16/074,181 patent/US20210215711A1/en not_active Abandoned
- 2017-02-07 CN CN201780008244.6A patent/CN108603887B/zh active Active
- 2017-02-07 EP EP17705281.8A patent/EP3414575B1/en active Active
-
2023
- 2023-07-28 US US18/227,421 patent/US12510550B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN116008563B (zh) | 2025-12-19 |
| KR20180105156A (ko) | 2018-09-27 |
| US12510550B2 (en) | 2025-12-30 |
| EP4513191A2 (en) | 2025-02-26 |
| CN108603887B (zh) | 2023-01-13 |
| ES3009593T3 (en) | 2025-03-27 |
| CN108603887A (zh) | 2018-09-28 |
| US20210215711A1 (en) | 2021-07-15 |
| BR112018014842A8 (pt) | 2022-10-18 |
| CN116008563A (zh) | 2023-04-25 |
| US20240094222A1 (en) | 2024-03-21 |
| BR112018014842A2 (pt) | 2018-12-18 |
| KR102687249B1 (ko) | 2024-07-22 |
| WO2017139254A1 (en) | 2017-08-17 |
| EP3414575A1 (en) | 2018-12-19 |
| EP3414575C0 (en) | 2024-12-11 |
| EP3414575B1 (en) | 2024-12-11 |
| EP4513191A3 (en) | 2025-06-04 |
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