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MX2019011349A - Explante de tejido macro, métodos y del mismo. - Google Patents

Explante de tejido macro, métodos y del mismo.

Info

Publication number
MX2019011349A
MX2019011349A MX2019011349A MX2019011349A MX2019011349A MX 2019011349 A MX2019011349 A MX 2019011349A MX 2019011349 A MX2019011349 A MX 2019011349A MX 2019011349 A MX2019011349 A MX 2019011349A MX 2019011349 A MX2019011349 A MX 2019011349A
Authority
MX
Mexico
Prior art keywords
methods
tissue explant
uses therefor
macro tissue
macro
Prior art date
Application number
MX2019011349A
Other languages
English (en)
Inventor
Carlo Giovanni Traverso
Robert S Langer
Erlach Thomas Christian Von
Sarah Saxton
Daniel Minahan
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of MX2019011349A publication Critical patent/MX2019011349A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0679—Cells of the gastro-intestinal tract
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/04—Screening or testing on artificial tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2531/00—Microcarriers

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Se proporcionan explantes de tejido del tracto gastrointestinal. También se proporcionan métodos para fabricar y usar los explantes de tejido, junto con sustratos diseñados para los explantes de tejido descritos.
MX2019011349A 2017-03-24 2018-03-23 Explante de tejido macro, métodos y del mismo. MX2019011349A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762476181P 2017-03-24 2017-03-24
US201762560485P 2017-09-19 2017-09-19
PCT/US2018/023982 WO2018175861A1 (en) 2017-03-24 2018-03-23 Macro tissue explant, methods and uses therefor

Publications (1)

Publication Number Publication Date
MX2019011349A true MX2019011349A (es) 2020-08-03

Family

ID=62047023

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019011349A MX2019011349A (es) 2017-03-24 2018-03-23 Explante de tejido macro, métodos y del mismo.

Country Status (12)

Country Link
US (2) US20190064153A1 (es)
EP (1) EP3601527A1 (es)
JP (2) JP7196091B2 (es)
KR (1) KR102648282B1 (es)
CN (1) CN110678544B (es)
AU (2) AU2018237324A1 (es)
BR (1) BR112019019920A2 (es)
CA (1) CA3057577A1 (es)
IL (1) IL269557B2 (es)
MX (1) MX2019011349A (es)
RU (1) RU2019133660A (es)
WO (1) WO2018175861A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3093581A1 (en) 2018-05-15 2019-11-21 The University Of North Carolina At Chapel Hill Devices, systems and apparatuses for generating self-sustaining hypoxic conditions and gaseous and non-gaseous chemical gradients for in vitro cell culture
US20230098968A1 (en) 2018-05-25 2023-03-30 The University Of North Carolina At Chapel Hill Formation of arrays of planar intestinal crypts possessing a stem/proliferative cell compartment and differentiated cell zone
JP2022511375A (ja) * 2018-11-16 2022-01-31 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル インビトロ細胞培養粘液系
US20210106525A1 (en) 2019-10-11 2021-04-15 Massachusetts Institute Of Technology Formulations for gastrointestinal delivery of oligonucleotides
WO2021119326A1 (en) 2019-12-10 2021-06-17 Massachusetts Institute Of Technology Methods and compositions for investigating multiple drug-drug transporter interactions
CN112970859B (zh) * 2021-04-07 2022-11-01 盐城恒喜生物科技有限公司 一种大豆调和食用油及其调配工艺
US20230101335A1 (en) 2021-05-06 2023-03-30 Massachusetts Institute Of Technology Ex vivo tissue explant and graft platform and uses thereof
US20240350646A1 (en) * 2021-08-20 2024-10-24 Nutech Ventures Methods and compositions for delivery to and across the blood brain barrier
CN114181066B (zh) * 2021-11-12 2024-11-05 安徽理工大学 一种无溶剂uv光固化可生物降解仿生粘合剂
GB202206352D0 (en) 2022-04-29 2022-06-15 Aelius Biotech Ltd Purified mucus
WO2024182622A1 (en) * 2023-03-01 2024-09-06 Research Institute At Nationwide Children's Hospital Systems, devices, and processes for miniaturized physiological mimicry
CN121358465A (zh) 2023-04-26 2026-01-16 维沃特克斯公司 用于改善渗透的治疗剂的调配物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4798824A (en) 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US4938961A (en) 1989-04-28 1990-07-03 Geoffrey Collins Organ preservation solution containing pokyethylene gycol and method of performing cardioplegia
DE60009339T2 (de) * 1999-12-22 2004-08-19 Acell, Inc., Cambridge Zusammensetzung zur gewebsregeneration
WO2003053217A2 (en) * 2001-12-07 2003-07-03 Kropp Bradley P Tissue graft compositions and methods for producing same
EP2279245B1 (en) * 2008-04-23 2013-08-21 AlphaGene Bioscience, Inc. Drug discovery methods involving a preclinical, in vitro isolated gastrointestinal epithelial stem cell-like progenitor cell system
US9464275B2 (en) * 2008-08-21 2016-10-11 The Board Of Trustees Of The Leland Stanford Junior University Ex vivo culture, proliferation and expansion of intestinal epithelium
CA3009153A1 (en) * 2015-01-30 2016-08-04 The University Of North Carolina At Chapel Hill Methods to generate gastrointestinal epithelial tissue constructs
WO2021119326A1 (en) * 2019-12-10 2021-06-17 Massachusetts Institute Of Technology Methods and compositions for investigating multiple drug-drug transporter interactions
US20230101335A1 (en) * 2021-05-06 2023-03-30 Massachusetts Institute Of Technology Ex vivo tissue explant and graft platform and uses thereof

Also Published As

Publication number Publication date
US20190064153A1 (en) 2019-02-28
AU2018237324A1 (en) 2019-10-31
US20250060360A1 (en) 2025-02-20
WO2018175861A1 (en) 2018-09-27
IL269557A (en) 2019-11-28
RU2019133660A3 (es) 2021-12-27
JP7430241B2 (ja) 2024-02-09
IL269557B2 (en) 2025-01-01
JP2020513825A (ja) 2020-05-21
AU2024227101A1 (en) 2024-10-24
JP2023025261A (ja) 2023-02-21
EP3601527A1 (en) 2020-02-05
CN110678544A (zh) 2020-01-10
CN110678544B (zh) 2024-03-29
CA3057577A1 (en) 2018-09-27
IL269557B1 (en) 2024-09-01
KR102648282B1 (ko) 2024-03-14
BR112019019920A2 (pt) 2020-04-22
RU2019133660A (ru) 2021-04-26
KR20190133715A (ko) 2019-12-03
JP7196091B2 (ja) 2022-12-26

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