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MX2018008358A - Anticuerpo anti cadena ligera reguladora de miosina (anti-myl9). - Google Patents

Anticuerpo anti cadena ligera reguladora de miosina (anti-myl9).

Info

Publication number
MX2018008358A
MX2018008358A MX2018008358A MX2018008358A MX2018008358A MX 2018008358 A MX2018008358 A MX 2018008358A MX 2018008358 A MX2018008358 A MX 2018008358A MX 2018008358 A MX2018008358 A MX 2018008358A MX 2018008358 A MX2018008358 A MX 2018008358A
Authority
MX
Mexico
Prior art keywords
myl9
antibody
mouse
human
monoclonal antibody
Prior art date
Application number
MX2018008358A
Other languages
English (en)
Inventor
Sakamoto Yoshimasa
Imai Toshio
Hirayama Toshifumi
Nakayama Toshinori
Kimura Motoko
HAYASHIZAKI Koji
KAKUTA Jungo
Gejima Ryu
Tokita Daisuke
Muramoto Kenzo
Original Assignee
Univ Chiba Nat Univ Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Chiba Nat Univ Corp filed Critical Univ Chiba Nat Univ Corp
Publication of MX2018008358A publication Critical patent/MX2018008358A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención proporciona un anticuerpo anti-Myl9 o un fragmento de unión a Myl9 de este que se une a Myl9 y puede inhibir la interacción entre Myl9 y CD69 en seres humanos, así como también una composición farmacéutica que los comprende. Se obtuvo un anticuerpo monoclonal anti-Myl9 humana/de ratón que tienen afinidad de unión respecto a Myl9, y se identificó la secuencia de la región determinante de la complementariedad (CDR) de el anticuerpo monoclonal de ratón anti-Myl9 humana/de ratón. En consecuencia, se produjo un anticuerpo humanizado que comprende la secuencia CDR de el anticuerpo monoclonal de ratón anti-Myl9 humana/de ratón en la región variable de las cadenas pesada y ligera.
MX2018008358A 2016-01-12 2017-01-11 Anticuerpo anti cadena ligera reguladora de miosina (anti-myl9). MX2018008358A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016003429 2016-01-12
PCT/JP2017/000605 WO2017122666A1 (ja) 2016-01-12 2017-01-11 抗Ｍｙｌ９抗体

Publications (1)

Publication Number Publication Date
MX2018008358A true MX2018008358A (es) 2018-09-21

Family

ID=59311587

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018008358A MX2018008358A (es) 2016-01-12 2017-01-11 Anticuerpo anti cadena ligera reguladora de miosina (anti-myl9).

Country Status (14)

Country Link
US (1) US10513561B2 (es)
EP (1) EP3404040B1 (es)
JP (1) JP6872756B2 (es)
KR (1) KR102800024B1 (es)
CN (1) CN108431037B (es)
AU (1) AU2017207082B2 (es)
BR (1) BR112018013807A2 (es)
CA (1) CA3008786A1 (es)
ES (1) ES2913162T3 (es)
IL (1) IL260083B2 (es)
MA (1) MA43869A (es)
MX (1) MX2018008358A (es)
RU (1) RU2741802C2 (es)
WO (1) WO2017122666A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021007108A1 (en) * 2019-07-05 2021-01-14 Icahn School Of Medicine At Mount Sinai Method for preventing hair loss
EP4244392A1 (en) * 2020-11-16 2023-09-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for predicting and treating uveal melanoma
WO2024080377A1 (ja) * 2022-10-14 2024-04-18 国立大学法人千葉大学 肺高血圧症の検出方法及び肺高血圧症の治療薬若しくは予防薬
CN118440198B (zh) * 2024-04-03 2024-11-15 武汉爱博泰克生物科技有限公司 抗人cd69蛋白的兔单克隆抗体及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2298895A1 (en) * 2005-07-27 2011-03-23 Oncotherapy Science, Inc. Method of diagnosing small cell lung cancer
WO2007019563A2 (en) 2005-08-09 2007-02-15 University Of Virginia Patent Foundation Methods and compositions for inhibition of vascular permeablility
JP4777785B2 (ja) * 2006-01-31 2011-09-21 独立行政法人科学技術振興機構 ケモカインレセプターｃｃｒ５のｎ末端領域に対する抗体酵素
WO2008105058A1 (ja) * 2007-02-27 2008-09-04 Asahi Kasei Pharma Corporation スルホンアミド化合物
PL2423228T3 (pl) * 2009-04-20 2016-06-30 Kyowa Hakko Kirin Co Ltd Przeciwciało zawierające IGG2 mającą wprowadzoną do niej mutację aminokwasową
WO2010124188A1 (en) * 2009-04-23 2010-10-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-human ror1 antibodies
BR112012002819B1 (pt) * 2009-08-07 2022-11-22 Kyowa Kirin Co., Ltd Anticorpo humanizado antioligômero de amiloide-b, seus usos, e formulação farmacêutica
KR20150036274A (ko) * 2012-07-19 2015-04-07 알레시아 바이오쎄라퓨틱스 인코포레이티드 항-siglec-15 항체
WO2014074847A1 (en) * 2012-11-09 2014-05-15 The Johns Hopkins University A genetic assay to determine prognosis in polycythemia vera patients
WO2014192915A1 (ja) * 2013-05-30 2014-12-04 国立大学法人 千葉大学 抗ミオシン調節軽鎖ポリペプチド抗体を含む炎症疾患治療用組成物
JP6563389B2 (ja) * 2013-06-27 2019-08-21 モナッシュ ユニバーシティ Ｉｌ−２１結合タンパク質及びその使用
EP3156072B1 (en) 2014-06-11 2020-08-19 IDAC Theranostics, Inc. Method for reducing side effects of immune checkpoint control agent

Also Published As

Publication number Publication date
KR20180098570A (ko) 2018-09-04
IL260083B1 (en) 2023-05-01
WO2017122666A1 (ja) 2017-07-20
IL260083A (en) 2018-07-31
AU2017207082B2 (en) 2023-07-13
AU2017207082A1 (en) 2018-07-05
RU2018124601A3 (es) 2020-04-30
BR112018013807A2 (pt) 2018-12-11
US20190002588A1 (en) 2019-01-03
JPWO2017122666A1 (ja) 2018-11-01
RU2018124601A (ru) 2020-02-14
CN108431037A (zh) 2018-08-21
CA3008786A1 (en) 2017-07-20
CN108431037B (zh) 2021-12-17
KR102800024B1 (ko) 2025-04-28
EP3404040A4 (en) 2019-08-07
EP3404040A1 (en) 2018-11-21
IL260083B2 (en) 2023-09-01
RU2741802C2 (ru) 2021-01-28
US10513561B2 (en) 2019-12-24
JP6872756B2 (ja) 2021-05-19
MA43869A (fr) 2018-11-21
ES2913162T3 (es) 2022-05-31
EP3404040B1 (en) 2022-03-02

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