[go: up one dir, main page]

MX2018009264A - Anticuerpo de trombina, fragmento de antigeno y sus usos farmaceuticos. - Google Patents

Anticuerpo de trombina, fragmento de antigeno y sus usos farmaceuticos.

Info

Publication number
MX2018009264A
MX2018009264A MX2018009264A MX2018009264A MX2018009264A MX 2018009264 A MX2018009264 A MX 2018009264A MX 2018009264 A MX2018009264 A MX 2018009264A MX 2018009264 A MX2018009264 A MX 2018009264A MX 2018009264 A MX2018009264 A MX 2018009264A
Authority
MX
Mexico
Prior art keywords
antigen
antibody
binding fragment
thrombin
thrombin antibody
Prior art date
Application number
MX2018009264A
Other languages
English (en)
Inventor
Hu Qiyue
Sun Piaoyang
Zhang Ling
Tao Weikang
Fu Yayuan
Zhang Haoying
Ying Hua
Liu Jiajian
Sun Jiakang
Zhang Lianshan
Original Assignee
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu Hengrui Medicine Co filed Critical Jiangsu Hengrui Medicine Co
Publication of MX2018009264A publication Critical patent/MX2018009264A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se proporciona un anticuerpo de trombina, un fragmento de enlace a antígeno y sus usos farmacéuticos. Se proporciona además un anticuerpo quimérico y un anticuerpo humanizado que comprenden un región CDR de anticuerpo de trombina, y una composición farmacéutica que comprende el anticuerpo de trombina y el fragmento de enlace a antígeno del mismo, así como el uso del mismo como un fármaco anticoagulante. En particular, se proporciona un uso del anticuerpo de trombina humanizado en la preparación de un fármaco para tratar una enfermedad o condición mediada por trombina.
MX2018009264A 2016-02-05 2017-02-03 Anticuerpo de trombina, fragmento de antigeno y sus usos farmaceuticos. MX2018009264A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610083070 2016-02-05
CN201610223995 2016-04-11
PCT/CN2017/072850 WO2017133673A1 (zh) 2016-02-05 2017-02-03 凝血酶抗体、其抗原结合片段及医药用途

Publications (1)

Publication Number Publication Date
MX2018009264A true MX2018009264A (es) 2018-08-28

Family

ID=59500319

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018009264A MX2018009264A (es) 2016-02-05 2017-02-03 Anticuerpo de trombina, fragmento de antigeno y sus usos farmaceuticos.

Country Status (11)

Country Link
US (1) US20190315886A1 (es)
EP (1) EP3412688A4 (es)
JP (1) JP2019510474A (es)
CN (1) CN107531797B (es)
AU (1) AU2017214132A1 (es)
BR (1) BR112018015090A2 (es)
CA (1) CA3013254A1 (es)
MX (1) MX2018009264A (es)
RU (1) RU2018129180A (es)
TW (1) TW201728603A (es)
WO (1) WO2017133673A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111094354B (zh) * 2017-11-20 2022-11-18 江苏恒瑞医药股份有限公司 凝血酶抗体、其抗原结合片段及医药用途
WO2019186276A2 (en) * 2018-03-28 2019-10-03 Axon Neuroscience Se Antibody-based methods of detecting and treating alzheimer's disease
MX2021000235A (es) 2018-07-17 2021-03-25 Jiangsu Hengrui Medicine Co Anticuerpo anti-abeta, fragmento de union a antigeno del mismo y aplicacion del mismo.
CN109260462B (zh) * 2018-08-24 2021-05-11 上海交通大学医学院附属瑞金医院 一种凝血酶原突变体蛋白及其编码核酸的应用
CN110205301A (zh) * 2019-06-14 2019-09-06 扬州大学 一种杂交瘤细胞克隆化的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1261395A (en) * 1994-12-05 1996-06-26 Gralnick, Harvey R Antibodies which inhibit the binding of thrombin to platelets
GB201121513D0 (en) * 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
GB201310948D0 (en) * 2013-06-19 2013-07-31 Cambridge Entpr Ltd Screening methods

Also Published As

Publication number Publication date
AU2017214132A1 (en) 2018-08-30
CN107531797A (zh) 2018-01-02
BR112018015090A2 (pt) 2018-12-26
RU2018129180A3 (es) 2020-07-16
TW201728603A (zh) 2017-08-16
WO2017133673A1 (zh) 2017-08-10
CN107531797B (zh) 2021-07-02
EP3412688A1 (en) 2018-12-12
RU2018129180A (ru) 2020-03-05
CA3013254A1 (en) 2017-08-10
US20190315886A1 (en) 2019-10-17
EP3412688A4 (en) 2019-12-04
JP2019510474A (ja) 2019-04-18

Similar Documents

Publication Publication Date Title
ZA202004701B (en) Anti-b7-h4 antibody, antigen-binding fragment thereof and pharmaceutical use thereof
PH12016501120A1 (en) Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
MX2018015393A (es) Anticuerpo lag-3, fragmento de union al antigeno del mismo y aplicacion farmaceutica del mismo.
MX2021005396A (es) Anticuerpo anti-cd73, fragmento de union a antigeno y aplicacion del mismo.
MY208022A (en) Anti-claudin 18.2 antibody and application thereof
MX2020007406A (es) Anticuerpo pd-l1, fragmento de union al antigeno del mismo y uso farmaceutico del mismo.
MX2017012965A (es) Anticuerpo anti-c-met y conjugado de farmaco citotoxico de anticuerpo anti-c-met y uso farmaceutico del mismo.
EP4631978A3 (en) Humanized or chimeric cd3 antibodies
MX2022014914A (es) Compuestos de interaccion con glicanos y metodos de uso.
MX2020002750A (es) Anticuerpo il-6r y fragmento de union a antigeno y uso medico.
JOP20190002A1 (ar) أجسام مضادة (أنتي – بي دي – 1) وطريقة الإنتاج وطريقة استخدام كل منهم
EA201890162A1 (ru) Антитела к cd40 с повышенной агонистической активностью
PH12016501366A1 (en) Novel anti-baff antibodies
EA201890305A1 (ru) Гуманизированные или химерные cd3-антитела
NZ727020A (en) Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
NZ630610A (en) Tau peptides, anti-tau antibodies, and methods of use thereof
EP4603508A3 (en) Anti-frizzled antibodies and methods of use
NZ759835A (en) Cd38 modulating antibody
MX2019014375A (es) Anticuerpo anti-cd40, fragmento de union a antigeno del mismo, y uso medico del mismo.
MX2019015914A (es) Anticuerpos quiméricos para el tratamiento de enfermedades por deposición de amiloide.
MX2018009264A (es) Anticuerpo de trombina, fragmento de antigeno y sus usos farmaceuticos.
MX2020008122A (es) Anticuerpos anti-pd-1.
MX2020002406A (es) Anticuerpo anti-epha4.
MX2021002531A (es) Anticuerpo anti-cd38, fragmento de union al antigeno y uso farmaceutico.
ZA202201946B (en) Anti-bcma antibody, antigen-binding fragment thereof and medical use thereof