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MX2018008168A - Inhibidores de antigenos de membrana especificos de la prostata (psma) basados en la urea para imaginologia y terapia. - Google Patents

Inhibidores de antigenos de membrana especificos de la prostata (psma) basados en la urea para imaginologia y terapia.

Info

Publication number
MX2018008168A
MX2018008168A MX2018008168A MX2018008168A MX2018008168A MX 2018008168 A MX2018008168 A MX 2018008168A MX 2018008168 A MX2018008168 A MX 2018008168A MX 2018008168 A MX2018008168 A MX 2018008168A MX 2018008168 A MX2018008168 A MX 2018008168A
Authority
MX
Mexico
Prior art keywords
psma
urea
inhibitors
therapy
imaging
Prior art date
Application number
MX2018008168A
Other languages
English (en)
Inventor
F Kung Hank
Wu Zehui
Rye Choi Seok
Ploessl Karl
Zha Zhihao
Original Assignee
Five Eleven Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Five Eleven Pharma Inc filed Critical Five Eleven Pharma Inc
Publication of MX2018008168A publication Critical patent/MX2018008168A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nuclear Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a compuestos de acuerdo con la fórmula I y la fórmula IV. Estos compuestos muestran muy buenas afinidades de unión a los sitios de unión de PSMA. Estos se pueden marcar con [68Ga]GaCI3 con grandes rendimientos y excelente pureza radioquímica. La presente invención hace referencia también a composiciones farmacéuticas que comprenden un portador farmacéuticamente aceptable y un compuesto de la fórmula I o la fórmula IV o una sal farmacéuticamente aceptable de estos.
MX2018008168A 2015-12-31 2016-12-22 Inhibidores de antigenos de membrana especificos de la prostata (psma) basados en la urea para imaginologia y terapia. MX2018008168A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562273786P 2015-12-31 2015-12-31
US15/385,490 US10688200B2 (en) 2015-12-31 2016-12-20 Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy
PCT/US2016/068327 WO2017116994A1 (en) 2015-12-31 2016-12-22 Urea-based prostate specific membrane antigen (psma) inhibitors for imaging and therapy

Publications (1)

Publication Number Publication Date
MX2018008168A true MX2018008168A (es) 2019-02-20

Family

ID=59225798

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018008168A MX2018008168A (es) 2015-12-31 2016-12-22 Inhibidores de antigenos de membrana especificos de la prostata (psma) basados en la urea para imaginologia y terapia.

Country Status (13)

Country Link
US (1) US10688200B2 (es)
EP (1) EP3397968B1 (es)
JP (1) JP6850027B2 (es)
KR (1) KR102766172B1 (es)
CN (1) CN108541302B (es)
AU (2) AU2016380151A1 (es)
CA (1) CA3010295C (es)
DK (1) DK3397968T3 (es)
EA (1) EA201891544A1 (es)
IL (1) IL260342A (es)
MX (1) MX2018008168A (es)
SG (1) SG11201805380YA (es)
WO (1) WO2017116994A1 (es)

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* Cited by examiner, † Cited by third party
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US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
TN2016000137A1 (en) 2013-10-18 2017-10-06 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer.
ES3013992T3 (en) 2013-11-14 2025-04-16 Endocyte Inc Compounds for positron emission tomography
US10688200B2 (en) 2015-12-31 2020-06-23 Five Eleven Pharma Inc. Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy
EP4385981A1 (en) * 2016-03-22 2024-06-19 The Johns Hopkins University Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
US11491247B2 (en) 2017-05-02 2022-11-08 Cornell University Methods and reagents for tumor targeting with greater efficacy and less toxicity
US11478558B2 (en) * 2017-05-30 2022-10-25 The Johns Hopkins University Prostate-specific membrane antigen targeted high-affinity agents for endoradiotherapy of prostate cancer
TN2020000072A1 (en) 2017-12-11 2022-01-06 Univ Muenchen Tech Psma ligands for imaging and endoradiotherapy
US20190184040A1 (en) * 2017-12-15 2019-06-20 Wisconsin Alumni Research Foundation Targeted Macrocyclic Agents for Dual Modality PET and MRI Imaging of Cancer
MX380340B (es) * 2018-03-14 2025-03-11 Instituto Nac De Investigaciones Nucleares 177lu-dota-hynic-ipsma como un radiofarmaco terapeutico dirigido al antigeno prostatico especifico de membrana.
WO2019204335A1 (en) 2018-04-17 2019-10-24 Endocyte, Inc. Methods of treating cancer
EP3636635A1 (en) 2018-10-11 2020-04-15 Academisch Ziekenhuis Leiden h.o.d.n. LUMC Imaging agents
CN109438517B (zh) * 2018-12-27 2021-01-08 北京久杰净化工程技术有限公司 一种与羰基金属核心配位的双功能连接剂的配合物及其制备方法
CA3136979A1 (en) 2019-04-17 2020-10-22 Provincial Health Services Authority Radiolabelled compounds for diagnosis or treatment of prostate-spe cific membrane antigen-expressing cancer
MX2021013055A (es) * 2019-04-26 2021-12-10 Five Eleven Pharma Inc Inhibidores de antigenos de membrana especificos de prostata (psma) como agentes diagnosticos y terapeuticos con radionuclidos.
EP3972627A4 (en) 2019-05-20 2023-06-21 Endocyte, Inc. Methods for preparing psma conjugates
CN114401947B (zh) 2019-06-21 2024-11-29 省卫生服务机构 靶向前列腺特异性膜抗原的放射性标记化合物
EP4107279A4 (en) * 2020-02-18 2024-07-17 Endocyte, Inc. METHOD FOR TREATING CANCERS EXPRESSING PSMA
WO2022072292A1 (en) * 2020-10-01 2022-04-07 Cornell University Methods and compositions for increasing uptake, internalization, and/or retention of small molecule ligands
CN112358422B (zh) * 2020-10-16 2023-06-23 中国辐射防护研究院 一种新型螯合剂nbed的制备方法
EP4029523A1 (en) * 2021-01-19 2022-07-20 Orano Med Psma-targeting conjugate and uses thereof
CN117561448A (zh) * 2021-03-17 2024-02-13 五一一制药股份有限公司 一种[18F]AlF标记的PSMA靶向分子探针及其制备方法
CN113372285B (zh) * 2021-05-28 2024-06-18 西南医科大学附属医院 前列腺特异性膜抗原抑制剂、其放射性核素标记物及制法和应用
CN114316075B (zh) * 2021-11-12 2023-03-14 青岛农业大学 一种聚集诱导发光高分子及其制备方法和应用
CN114436905A (zh) * 2022-01-24 2022-05-06 攀枝花学院 3-醛基-4-羟基苯乙酸甲酯的纯化方法
US20250108139A1 (en) * 2022-01-30 2025-04-03 Bivision Pharmaceuticals, Inc Peptide urea derivative, pharmaceutical composition containing peptide urea derivative, and application of peptide urea derivative
CN114874122A (zh) * 2022-05-31 2022-08-09 南京航空航天大学 一种新的小分子抑制剂及其制备方法和应用
WO2024021556A1 (zh) * 2023-02-02 2024-02-01 北京师范大学 一种靶向前列腺特异性膜抗原的放射性金属配合物及其标记配体
WO2023231452A1 (zh) * 2023-02-14 2023-12-07 北京师范大学 含硝基芳香杂环基团的psma靶向放射性金属配合物及其制备
CN118496299A (zh) * 2023-02-16 2024-08-16 无锡诺宇医药科技有限公司 Psma靶向放射性诊疗一体化药物及其合成和应用
CN117924253A (zh) * 2023-08-17 2024-04-26 厦门大学 谷氨酸尿素类化合物及其制备方法和应用、核素靶向探针及其制备方法和应用、药物组合物
WO2025151982A1 (zh) * 2024-01-15 2025-07-24 中国医学科学院北京协和医院 双靶向肿瘤细胞的化合物及其制备方法和应用
CN119775345A (zh) * 2024-12-26 2025-04-08 厦门大学 一种地拉罗司衍生物、核素标记物及其制备方法与应用

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EP1472541B1 (en) 2002-01-10 2009-09-16 The Johns Hopkins University Imaging agents and methods of imaging naaladase of psma
US8338565B2 (en) 2008-08-20 2012-12-25 Ensemble Therapeutics Corporation Macrocyclic compounds for inhibition of tumor necrosis factor alpha
ES2657863T3 (es) * 2011-06-15 2018-03-07 Cancer Targeted Technology Llc Inhibidores quelados de PSMA
US8926944B2 (en) * 2011-08-05 2015-01-06 Molecular Insight Pharmaceuticals Radiolabeled prostate specific membrane antigen inhibitors
CN113149921B (zh) * 2011-11-30 2024-11-29 约翰霍普金斯大学 前列腺特异性膜抗原(psma)的同源多价抑制剂和异源多价抑制剂以及其用途
EP3875082A1 (en) * 2012-11-15 2021-09-08 Endocyte, Inc. Conjugates for treating diseases caused by psma expressing cells
ES2738474T3 (es) * 2013-01-14 2020-01-23 Molecular Insight Pharm Inc Radiofármacos a base de triazina y agentes radioimagenológicos
US10406246B2 (en) 2013-10-17 2019-09-10 Deutsches Kresbsforschungszentrum Double-labeled probe for molecular imaging and use thereof
EP2862857A1 (en) * 2013-10-18 2015-04-22 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
TN2016000137A1 (en) 2013-10-18 2017-10-06 Deutsches Krebsforsch Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer.
ES3013992T3 (en) * 2013-11-14 2025-04-16 Endocyte Inc Compounds for positron emission tomography
EP3536345A1 (en) * 2014-05-06 2019-09-11 The Johns Hopkins University Metal/radiometal-labeled psma inhibitors for psma-targeted imaging and radiotherapy
US10688200B2 (en) 2015-12-31 2020-06-23 Five Eleven Pharma Inc. Urea-based prostate specific membrane antigen (PSMA) inhibitors for imaging and therapy

Also Published As

Publication number Publication date
CA3010295C (en) 2023-09-26
EA201891544A1 (ru) 2018-11-30
EP3397968A4 (en) 2019-11-27
WO2017116994A1 (en) 2017-07-06
CN108541302A (zh) 2018-09-14
AU2023203682A1 (en) 2023-07-06
EP3397968B1 (en) 2021-09-29
KR20180098373A (ko) 2018-09-03
CA3010295A1 (en) 2017-07-06
JP6850027B2 (ja) 2021-03-31
US10688200B2 (en) 2020-06-23
EP3397968A1 (en) 2018-11-07
HK1255215A1 (zh) 2019-08-09
CN108541302B (zh) 2023-02-14
US20170189568A1 (en) 2017-07-06
IL260342A (en) 2018-08-30
SG11201805380YA (en) 2018-07-30
JP2019508374A (ja) 2019-03-28
KR102766172B1 (ko) 2025-02-12
AU2016380151A1 (en) 2018-07-19
DK3397968T3 (da) 2021-11-01
AU2023203682B2 (en) 2025-07-24

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